EOG83FK9Q GO:0004721 2/127 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG83FK9Q GO:0042058 1/127 regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG83FK9Q GO:0045197 1/127 establishment or maintenance of epithelial cell apical/basal polarity biological_process "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah] EOG83FK9Q GO:0045169 1/127 fusome cellular_component "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] EOG83FK9Q GO:0005918 1/127 septate junction cellular_component "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298] EOG83FK9Q GO:0046425 1/127 regulation of JAK-STAT cascade biological_process "Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf] EOG83FK9Q GO:0007472 1/127 wing disc morphogenesis biological_process "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG83FK9Q GO:0005179 1/127 hormone activity molecular_function "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732] EOG83FK9Q GO:0000902 1/127 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG83FK9Q GO:0031594 1/127 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG83FK9Q GO:0016327 1/127 apicolateral plasma membrane cellular_component "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] EOG83FK9Q GO:0042048 1/127 olfactory behavior biological_process "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] EOG83FK9Q GO:0045186 1/127 zonula adherens assembly biological_process "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf] EOG83FK9Q GO:0019991 1/127 septate junction assembly biological_process "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] EOG83FK9Q GO:0045198 1/127 establishment of epithelial cell apical/basal polarity biological_process "The specification and formation of the apicobasal polarity of an epithelial cell." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] EOG83FK9Q GO:0001708 1/127 cell fate specification biological_process "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators] EOG83FK9Q GO:0008593 1/127 regulation of Notch signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG83FK9Q GO:0008285 1/127 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG83FK9Q GO:0007318 1/127 pole plasm protein localization biological_process "Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] EOG83FK9Q GO:0030714 1/127 anterior/posterior axis specification, follicular epithelium biological_process "Polarization of the follicle cells of an insect ovary along the anterior/posterior axis." [GOC:bf] EOG83FK9Q GO:0045823 1/127 positive regulation of heart contraction biological_process "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators] EOG83FK9Q GO:0048863 1/127 stem cell differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete] EOG83FK9Q GO:0008283 1/127 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG83FK9Q GO:0016333 1/127 morphogenesis of follicular epithelium biological_process "The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl] EOG83FK9Q GO:0045571 1/127 negative regulation of imaginal disc growth biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators] EOG83FK9Q GO:0007391 1/127 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG83FK9Q GO:0005576 1/127 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG83FK9Q GO:0004672 1/127 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG83FK9Q GO:0072089 1/127 stem cell proliferation biological_process "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] EOG83FK9Q GO:0072002 1/127 Malpighian tubule development biological_process "The process whose specific outcome is the progression of the Malpighian tubule over time, from its formation to the mature structure. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [FBbt:00005786, GOC:mtg_kidney_jan10, PMID:19783135] EOG83FK9Q GO:0005524 1/127 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG83FK9Q GO:0060581 1/127 cell fate commitment involved in pattern specification biological_process "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph] EOG83FK9Q GO:0048749 1/127 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG83FK9Q GO:0001737 1/127 establishment of imaginal disc-derived wing hair orientation biological_process "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465] EOG83FK9Q GO:0016328 1/127 lateral plasma membrane cellular_component "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr] EOG83FK9Q GO:0050803 1/127 regulation of synapse structure or activity biological_process "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] EOG83FK9Q GO:0007464 1/127 R3/R4 cell fate commitment biological_process "The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] EOG83FK9Q GO:0051726 1/127 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG83FK9Q GO:0016323 1/127 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG83FK9Q GO:0005923 1/127 bicellular tight junction cellular_component "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181] EOG83FK9Q GO:0016335 1/127 morphogenesis of larval imaginal disc epithelium biological_process "The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl] EOG83FK9Q GO:0016331 1/127 morphogenesis of embryonic epithelium biological_process "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl] EOG83FK9Q GO:0016332 1/127 establishment or maintenance of polarity of embryonic epithelium biological_process "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah] EOG83FK9Q GO:0005515 1/127 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG83FK9Q GO:0000122 1/127 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG83FK9Q GO:0050680 1/127 negative regulation of epithelial cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai] EOG83FK9Q GO:0007608 1/127 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG83FK9Q GO:0042067 1/127 establishment of ommatidial planar polarity biological_process "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883] EOG83FK9Q GO:0016336 1/127 establishment or maintenance of polarity of larval imaginal disc epithelium biological_process "Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium." [GOC:jl, GOC:mah] EOG83FK9Q GO:0008105 1/127 asymmetric protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma] EOG83FK9Q GO:0030707 1/127 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG83FK9Q GO:0035088 1/127 establishment or maintenance of apical/basal cell polarity biological_process "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483] EOG83FK9Q GO:0016334 1/127 establishment or maintenance of polarity of follicular epithelium biological_process "Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah] EOG83FK9Q GO:0030100 1/127 regulation of endocytosis biological_process "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators] EOG83FK9Q GO:0001738 1/127 morphogenesis of a polarized epithelium biological_process "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]