EOG85XB93 GO:0006886 15/115 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG85XB93 GO:0016192 15/115 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG85XB93 GO:0030117 15/115 membrane coat cellular_component "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] EOG85XB93 GO:0007367 4/115 segment polarity determination biological_process "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG85XB93 GO:0045296 4/115 cadherin binding molecular_function "Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] EOG85XB93 GO:0008134 3/115 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG85XB93 GO:0014017 3/115 neuroblast fate commitment biological_process "The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585] EOG85XB93 GO:0005912 3/115 adherens junction cellular_component "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG85XB93 GO:0016055 3/115 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG85XB93 GO:0007155 3/115 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG85XB93 GO:0030057 2/115 desmosome cellular_component "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181] EOG85XB93 GO:0005667 2/115 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG85XB93 GO:0003713 2/115 transcription coactivator activity molecular_function "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG85XB93 GO:0016342 2/115 catenin complex cellular_component "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323] EOG85XB93 GO:0005916 2/115 fascia adherens cellular_component "A cell-cell adherens junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:mtg_muscle, PMID:11732910] EOG85XB93 GO:0005829 2/115 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG85XB93 GO:0005886 2/115 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG85XB93 GO:0005198 2/115 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG85XB93 GO:0005915 2/115 zonula adherens cellular_component "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208] EOG85XB93 GO:0003136 2/115 negative regulation of heart induction by canonical Wnt signaling pathway biological_process "Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329] EOG85XB93 GO:0019901 2/115 protein kinase binding molecular_function "Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] EOG85XB93 GO:0048599 2/115 oocyte development biological_process "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators] EOG85XB93 GO:0009898 2/115 cytoplasmic side of plasma membrane cellular_component "The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] EOG85XB93 GO:0007399 2/115 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG85XB93 GO:0045294 2/115 alpha-catenin binding molecular_function "Interacting selectively and non-covalently with the alpha subunit of the catenin complex." [GOC:bf] EOG85XB93 GO:0000902 2/115 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG85XB93 GO:0016337 2/115 single organismal cell-cell adhesion biological_process "The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb] EOG85XB93 GO:0007016 2/115 cytoskeletal anchoring at plasma membrane biological_process "A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323] EOG85XB93 GO:0030018 2/115 Z disc cellular_component "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] EOG85XB93 GO:0016323 2/115 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG85XB93 GO:0000122 2/115 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG85XB93 GO:0016324 1/115 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG85XB93 GO:0001745 1/115 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG85XB93 GO:0060914 1/115 heart formation biological_process "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart] EOG85XB93 GO:0035147 1/115 branch fusion, open tracheal system biological_process "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584] EOG85XB93 GO:0008360 1/115 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG85XB93 GO:0030720 1/115 oocyte localization involved in germarium-derived egg chamber formation biological_process "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] EOG85XB93 GO:0071896 1/115 protein localization to adherens junction biological_process "Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:BHF, GOC:mah] EOG85XB93 GO:0035293 1/115 chitin-based larval cuticle pattern formation biological_process "The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG85XB93 GO:0048477 1/115 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG85XB93 GO:0016327 1/115 apicolateral plasma membrane cellular_component "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] EOG85XB93 GO:0045186 1/115 zonula adherens assembly biological_process "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf] EOG85XB93 GO:0048754 1/115 branching morphogenesis of an epithelial tube biological_process "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid] EOG85XB93 GO:0007507 1/115 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG85XB93 GO:0035019 1/115 somatic stem cell population maintenance biological_process "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089] EOG85XB93 GO:0019900 1/115 kinase binding molecular_function "Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] EOG85XB93 GO:0072659 1/115 protein localization to plasma membrane biological_process "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah] EOG85XB93 GO:0035017 1/115 cuticle pattern formation biological_process "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf] EOG85XB93 GO:0048526 1/115 imaginal disc-derived wing expansion biological_process "The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing." [GOC:mtg_sensu, GOC:rc] EOG85XB93 GO:0007163 1/115 establishment or maintenance of cell polarity biological_process "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] EOG85XB93 GO:0014019 1/115 neuroblast development biological_process "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585] EOG85XB93 GO:0007370 1/115 ventral furrow formation biological_process "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238] EOG85XB93 GO:0030139 1/115 endocytic vesicle cellular_component "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797] EOG85XB93 GO:0007391 1/115 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG85XB93 GO:0032403 1/115 protein complex binding molecular_function "Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:mah] EOG85XB93 GO:0005737 1/115 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG85XB93 GO:0005914 1/115 spot adherens junction cellular_component "A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298] EOG85XB93 GO:0007472 1/115 wing disc morphogenesis biological_process "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG85XB93 GO:0005634 1/115 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG85XB93 GO:0007616 1/115 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG85XB93 GO:0045944 1/115 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG85XB93 GO:0008092 1/115 cytoskeletal protein binding molecular_function "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] EOG85XB93 GO:0046530 1/115 photoreceptor cell differentiation biological_process "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732] EOG85XB93 GO:0030707 1/115 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG85XB93 GO:0045893 1/115 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG85XB93 GO:0035153 1/115 epithelial cell type specification, open tracheal system biological_process "Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940] EOG85XB93 GO:0060232 1/115 delamination biological_process "The process of negative regulation of cell adhesion that results in a cell or sheet of cells splitting off from an existing epithelial sheet." [GOC:dph, PMID:16962574, PMID:18343170] EOG85XB93 GO:0046667 1/115 compound eye retinal cell programmed cell death biological_process "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672] EOG85XB93 GO:0016331 1/115 morphogenesis of embryonic epithelium biological_process "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl] EOG85XB93 GO:0030424 1/115 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG85XB93 GO:0007369 1/115 gastrulation biological_process "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] EOG85XB93 GO:0005515 1/115 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG85XB93 GO:0001709 1/115 cell fate determination biological_process "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]