EOG883GJD	GO:0003676	64/244	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG883GJD	GO:0003743	8/244	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG883GJD	GO:0016246	2/244	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG883GJD	GO:0030422	2/244	production of siRNA involved in RNA interference	biological_process	"Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674]
EOG883GJD	GO:0005515	2/244	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG883GJD	GO:0007367	2/244	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG883GJD	GO:0030423	2/244	targeting of mRNA for destruction involved in RNA interference	biological_process	"The process in which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674]
EOG883GJD	GO:0005737	2/244	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG883GJD	GO:0046872	1/244	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG883GJD	GO:0030727	1/244	germarium-derived female germ-line cyst formation	biological_process	"Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902]
EOG883GJD	GO:0051607	1/244	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG883GJD	GO:0070578	1/244	RISC-loading complex	cellular_component	"A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP.  This complex has endorobonuclease activity." [GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710]
EOG883GJD	GO:0035197	1/244	siRNA binding	molecular_function	"Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme." [PMID:15066275, PMID:15066283]
EOG883GJD	GO:0007416	1/244	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG883GJD	GO:0007279	1/244	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG883GJD	GO:0035279	1/244	mRNA cleavage involved in gene silencing by miRNA	biological_process	"The process in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism." [GOC:dph, GOC:mtg_lung, PMID:14744438, PMID:15196554]
EOG883GJD	GO:0005524	1/244	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG883GJD	GO:0035196	1/244	production of miRNAs involved in gene silencing by miRNA	biological_process	"Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein." [GOC:dph, GOC:tb, PMID:15066275, PMID:15066283]
EOG883GJD	GO:0019899	1/244	enzyme binding	molecular_function	"Interacting selectively and non-covalently with any enzyme." [GOC:jl]
EOG883GJD	GO:0035071	1/244	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG883GJD	GO:0035195	1/244	gene silencing by miRNA	biological_process	"Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortgening and subsequent degredation of the mRNA." [PMID:14744438, PMID:15066275, PMID:15066283, PMID:23209154]
EOG883GJD	GO:0048102	1/244	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG883GJD	GO:0035190	1/244	syncytial nuclear migration	biological_process	"The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839]
EOG883GJD	GO:0006342	1/244	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG883GJD	GO:0036099	1/244	female germ-line stem cell population maintenance	biological_process	"The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart]
EOG883GJD	GO:0035198	1/244	miRNA binding	molecular_function	"Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283]
EOG883GJD	GO:0006402	1/244	mRNA catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]
EOG883GJD	GO:0017148	1/244	negative regulation of translation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG883GJD	GO:0045071	1/244	negative regulation of viral genome replication	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication." [GOC:go_curators]
EOG883GJD	GO:0030529	1/244	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG883GJD	GO:0007294	1/244	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG883GJD	GO:0033227	1/244	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG883GJD	GO:0004521	1/244	endoribonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG883GJD	GO:0048471	1/244	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG883GJD	GO:0009047	1/244	dosage compensation by hyperactivation of X chromosome	biological_process	"Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577]
EOG883GJD	GO:0016032	1/244	viral process	biological_process	"A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah]
EOG883GJD	GO:0035087	1/244	siRNA loading onto RISC involved in RNA interference	biological_process	"The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference." [GOC:bf, GOC:mah, PMID:14512631]
EOG883GJD	GO:0090502	1/244	RNA phosphodiester bond hydrolysis, endonucleolytic	biological_process	"The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
EOG883GJD	GO:0007349	1/244	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG883GJD	GO:0016442	1/244	RISC complex	cellular_component	"A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]
EOG883GJD	GO:0005634	1/244	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG883GJD	GO:0070868	1/244	heterochromatin organization involved in chromatin silencing	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah]