EOG88SK79 GO:0005524 27/87 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG88SK79 GO:0015991 26/87 ATP hydrolysis coupled proton transport biological_process "The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw] EOG88SK79 GO:0016820 26/87 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances molecular_function "Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah] EOG88SK79 GO:0046034 25/87 ATP metabolic process biological_process "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] EOG88SK79 GO:0033180 23/87 proton-transporting V-type ATPase, V1 domain cellular_component "A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553] EOG88SK79 GO:0033178 2/87 proton-transporting two-sector ATPase complex, catalytic domain cellular_component "A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056] EOG88SK79 GO:0007035 1/87 vacuolar acidification biological_process "Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid] EOG88SK79 GO:0048471 1/87 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG88SK79 GO:0005903 1/87 brush border cellular_component "Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] EOG88SK79 GO:0033181 1/87 plasma membrane proton-transporting V-type ATPase complex cellular_component "A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah] EOG88SK79 GO:0000221 1/87 vacuolar proton-transporting V-type ATPase, V1 domain cellular_component "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] EOG88SK79 GO:0005886 1/87 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG88SK79 GO:0005769 1/87 early endosome cellular_component "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]