EOG8GF5WR	GO:0009253	197/521	peptidoglycan catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
EOG8GF5WR	GO:0008745	196/521	N-acetylmuramoyl-L-alanine amidase activity	molecular_function	"Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]
EOG8GF5WR	GO:0008270	180/521	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GF5WR	GO:0045087	14/521	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8GF5WR	GO:0005576	12/521	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8GF5WR	GO:0042834	11/521	peptidoglycan binding	molecular_function	"Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226]
EOG8GF5WR	GO:0006955	10/521	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8GF5WR	GO:0050830	5/521	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GF5WR	GO:0005515	4/521	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8GF5WR	GO:0061057	3/521	peptidoglycan recognition protein signaling pathway	biological_process	"A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280]
EOG8GF5WR	GO:0002221	3/521	pattern recognition receptor signaling pathway	biological_process	"Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
EOG8GF5WR	GO:0016019	3/521	peptidoglycan receptor activity	molecular_function	"Combining with a peptidoglycan and transmitting the signal to initiate a change in cell activity." [PMID:14698226]
EOG8GF5WR	GO:0045824	3/521	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG8GF5WR	GO:0008329	2/521	signaling pattern recognition receptor activity	molecular_function	"Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity." [GOC:ar, PMID:12507420, PMID:12925128, PMID:14523544, Wikipedia:Pattern_recognition_receptor]
EOG8GF5WR	GO:0008340	2/521	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8GF5WR	GO:0009617	2/521	response to bacterium	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]
EOG8GF5WR	GO:0005887	2/521	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GF5WR	GO:0019731	2/521	antibacterial humoral response	biological_process	"An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8GF5WR	GO:0006964	1/521	positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
EOG8GF5WR	GO:0042742	1/521	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8GF5WR	GO:0044214	1/521	spanning component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:ecd]
EOG8GF5WR	GO:0006965	1/521	positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475]
EOG8GF5WR	GO:0001875	1/521	lipopolysaccharide receptor activity	molecular_function	"Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [PMID:14609719, PMID:15379975]
EOG8GF5WR	GO:0000270	1/521	peptidoglycan metabolic process	biological_process	"The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
EOG8GF5WR	GO:0008233	1/521	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8GF5WR	GO:0046983	1/521	protein dimerization activity	molecular_function	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]
EOG8GF5WR	GO:0032500	1/521	muramyl dipeptide binding	molecular_function	"Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan." [GOC:rl]
EOG8GF5WR	GO:0008592	1/521	regulation of Toll signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8GF5WR	GO:0051607	1/521	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG8GF5WR	GO:0031240	1/521	external side of cell outer membrane	cellular_component	"The side of the outer membrane that is opposite to the side that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu]
EOG8GF5WR	GO:0045089	1/521	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8GF5WR	GO:0006963	1/521	positive regulation of antibacterial peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475]
EOG8GF5WR	GO:0008063	1/521	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8GF5WR	GO:0016327	1/521	apicolateral plasma membrane	cellular_component	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
EOG8GF5WR	GO:0005875	1/521	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8GF5WR	GO:0016021	1/521	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GF5WR	GO:0007165	1/521	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8GF5WR	GO:0031663	1/521	lipopolysaccharide-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [GOC:mah, GOC:signaling, PMID:15379975]
EOG8GF5WR	GO:0006909	1/521	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8GF5WR	GO:0004040	1/521	amidase activity	molecular_function	"Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4]
EOG8GF5WR	GO:0032494	1/521	response to peptidoglycan	biological_process	"Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464]
EOG8GF5WR	GO:0050829	1/521	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GF5WR	GO:0035007	1/521	regulation of melanization defense response	biological_process	"Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf]
EOG8GF5WR	GO:0019730	1/521	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG8GF5WR	GO:0004180	1/521	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8GF5WR	GO:0046329	1/521	negative regulation of JNK cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8GF5WR	GO:0002920	1/521	regulation of humoral immune response	biological_process	"Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add]
EOG8GF5WR	GO:0061060	1/521	negative regulation of peptidoglycan recognition protein signaling pathway	biological_process	"Any process that decreases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph]