EOG8QRKN0 GO:0017183 1/64 peptidyl-diphthamide biosynthetic process from peptidyl-histidine biological_process "The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380, RESID:AA0040] EOG8QRKN0 GO:0046872 1/64 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai]