EOG8S4RWH GO:0000166 25/91 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8S4RWH GO:0005634 24/91 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8S4RWH GO:0003723 23/91 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8S4RWH GO:0006397 23/91 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG8S4RWH GO:0003676 1/91 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8S4RWH GO:0003729 1/91 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8S4RWH GO:0071011 1/91 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8S4RWH GO:0000381 1/91 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8S4RWH GO:0000398 1/91 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8S4RWH GO:0071013 1/91 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]