EOG8V19DP GO:0003677 11/15 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8V19DP GO:0005524 11/15 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8V19DP GO:0007275 2/15 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8V19DP GO:0005634 2/15 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8V19DP GO:0000775 1/15 chromosome, centromeric region cellular_component "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] EOG8V19DP GO:0016568 1/15 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG8V19DP GO:0005721 1/15 pericentric heterochromatin cellular_component "Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [PMID:12019236, PMID:20206496, PMID:22729156] EOG8V19DP GO:0005700 1/15 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8V19DP GO:0006333 1/15 chromatin assembly or disassembly biological_process "The formation or destruction of chromatin structures." [GOC:mah] EOG8V19DP GO:0006260 1/15 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8V19DP GO:0005724 1/15 nuclear telomeric heterochromatin cellular_component "Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus." [GOC:ai] EOG8V19DP GO:0008156 1/15 negative regulation of DNA replication biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators] EOG8V19DP GO:0031507 1/15 heterochromatin assembly biological_process "The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent." [GOC:mah] EOG8V19DP GO:0000792 1/15 heterochromatin cellular_component "A compact and highly condensed form of chromatin." [GOC:elh] EOG8V19DP GO:0051276 1/15 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8V19DP GO:0005694 1/15 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8V19DP GO:0042023 1/15 DNA endoreduplication biological_process "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw] EOG8V19DP GO:0032877 1/15 positive regulation of DNA endoreduplication biological_process "Any process that activates or increases the frequency, rate or extent of DNA endoreduplication." [GOC:mah] EOG8V19DP GO:0003682 1/15 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8V19DP GO:0005725 1/15 intercalary heterochromatin cellular_component "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245]