EOG8WQ3GG GO:0008565 26/99 protein transporter activity molecular_function "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] EOG8WQ3GG GO:0006886 26/99 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8WQ3GG GO:0030131 25/99 clathrin adaptor complex cellular_component "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah] EOG8WQ3GG GO:0016192 23/99 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8WQ3GG GO:0015031 3/99 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8WQ3GG GO:0005886 3/99 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8WQ3GG GO:0048488 3/99 synaptic vesicle endocytosis biological_process "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] EOG8WQ3GG GO:0005905 3/99 coated pit cellular_component "A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835] EOG8WQ3GG GO:0030100 1/99 regulation of endocytosis biological_process "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators] EOG8WQ3GG GO:0006901 1/99 vesicle coating biological_process "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid] EOG8WQ3GG GO:0008104 1/99 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8WQ3GG GO:0008021 1/99 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8WQ3GG GO:0007269 1/99 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8WQ3GG GO:0045807 1/99 positive regulation of endocytosis biological_process "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators] EOG8WQ3GG GO:0022008 1/99 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8WQ3GG GO:0048489 1/99 synaptic vesicle transport biological_process "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr] EOG8WQ3GG GO:0008356 1/99 asymmetric cell division biological_process "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] EOG8WQ3GG GO:0006897 1/99 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8WQ3GG GO:0030122 1/99 AP-2 adaptor complex cellular_component "A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499] EOG8WQ3GG GO:0030135 1/99 coated vesicle cellular_component "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] EOG8WQ3GG GO:0016183 1/99 synaptic vesicle coating biological_process "A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:curators, PMID:10099709]