GO:0005549	odorant binding	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0038023	signaling receptor activity	Gains
GO:0004970	ionotropic glutamate receptor activity	Gains
GO:0022824	transmitter-gated ion channel activity	Gains
GO:0022835	transmitter-gated channel activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
GO:0008066	glutamate receptor activity	Gains
GO:0030594	neurotransmitter receptor activity	Gains
GO:0036081	extracellular ammonia-gated ion channel activity	Gains
GO:0004872	receptor activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0005230	extracellular ligand-gated ion channel activity	Gains
GO:0008527	taste receptor activity	Gains
GO:0015276	ligand-gated ion channel activity	Gains
GO:0022834	ligand-gated channel activity	Gains
GO:0022857	transmembrane transporter activity	Gains
GO:0004497	monooxygenase activity	Gains
GO:0005216	ion channel activity	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0015267	channel activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0009703	nitrate reductase (NADH) activity	Gains
GO:0097109	neuroligin family protein binding	Gains
GO:0045735	nutrient reservoir activity	Gains
GO:0004507	steroid 11-beta-monooxygenase activity	Gains
GO:0008940	nitrate reductase activity	Gains
GO:0034185	apolipoprotein binding	Gains
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	Gains
GO:0001093	TFIIB-class transcription factor binding	Gains
GO:0070735	protein-glycine ligase activity	Gains
GO:0070736	protein-glycine ligase activity, initiating	Gains
GO:0070737	protein-glycine ligase activity, elongating	Gains
GO:0008473	ornithine cyclodeaminase activity	Gains
GO:0047749	cholestanetriol 26-monooxygenase activity	Gains
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	Gains
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
GO:0022836	gated channel activity	Gains
GO:0005215	transporter activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0022891	substrate-specific transmembrane transporter activity	Gains
GO:0004371	glycerone kinase activity	Gains
GO:0033041	sweet taste receptor activity	Gains
GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	Gains
GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Gains
GO:0052832	inositol monophosphate 3-phosphatase activity	Gains
GO:0052833	inositol monophosphate 4-phosphatase activity	Gains
GO:0052834	inositol monophosphate phosphatase activity	Gains
GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Gains
GO:0015927	trehalase activity	Gains
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Gains
GO:0004555	alpha,alpha-trehalase activity	Gains
GO:0004503	monophenol monooxygenase activity	Gains
GO:0016084	myostimulatory hormone activity	Gains
GO:0008934	inositol monophosphate 1-phosphatase activity	Gains
GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Gains
GO:0001092	TFIIA-class transcription factor binding	Gains
GO:0004806	triglyceride lipase activity	Gains
GO:0020037	heme binding	Gains
GO:0046906	tetrapyrrole binding	Gains
GO:0005216	ion channel activity	Losses
GO:0022838	substrate-specific channel activity	Losses
GO:0015267	channel activity	Losses
GO:0022803	passive transmembrane transporter activity	Losses
GO:0046873	metal ion transmembrane transporter activity	Losses
GO:0099600	transmembrane receptor activity	Losses
GO:0015075	ion transmembrane transporter activity	Losses
GO:0004871	signal transducer activity	Losses
GO:0005261	cation channel activity	Losses
GO:0022836	gated channel activity	Losses
GO:0004872	receptor activity	Losses
GO:0060089	molecular transducer activity	Losses
GO:0022843	voltage-gated cation channel activity	Losses
GO:0038023	signaling receptor activity	Losses
GO:0004888	transmembrane signaling receptor activity	Losses
GO:0008324	cation transmembrane transporter activity	Losses
GO:0022891	substrate-specific transmembrane transporter activity	Losses
GO:0022890	inorganic cation transmembrane transporter activity	Losses
GO:0022857	transmembrane transporter activity	Losses
GO:0022892	substrate-specific transporter activity	Losses
GO:0005267	potassium channel activity	Losses
GO:0005244	voltage-gated ion channel activity	Losses
GO:0022832	voltage-gated channel activity	Losses
GO:0016502	nucleotide receptor activity	Losses
GO:0001614	purinergic nucleotide receptor activity	Losses
GO:0008475	procollagen-lysine 5-dioxygenase activity	Losses
GO:0004983	neuropeptide Y receptor activity	Losses
GO:0015079	potassium ion transmembrane transporter activity	Losses
GO:0004930	G-protein coupled receptor activity	Losses
GO:0016917	GABA receptor activity	Losses
GO:0005249	voltage-gated potassium channel activity	Losses
GO:0070815	peptidyl-lysine 5-dioxygenase activity	Losses
GO:0035586	purinergic receptor activity	Losses
GO:0033743	peptide-methionine (R)-S-oxide reductase activity	Losses
GO:1901618	organic hydroxy compound transmembrane transporter activity	Losses
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Losses
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
GO:0004497	monooxygenase activity	Losses
GO:0015276	ligand-gated ion channel activity	Losses
GO:0022834	ligand-gated channel activity	Losses
GO:0045289	luciferin monooxygenase activity	Losses
GO:0046982	protein heterodimerization activity	Losses
GO:0004518	nuclease activity	Losses
GO:0005215	transporter activity	Losses
GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	Losses
GO:0008307	structural constituent of muscle	Losses
GO:0015370	solute:sodium symporter activity	Losses
GO:0015081	sodium ion transmembrane transporter activity	Losses
GO:0005343	organic acid:sodium symporter activity	Losses
GO:0008017	microtubule binding	Losses
GO:0016301	kinase activity	Losses
GO:0005328	neurotransmitter:sodium symporter activity	Losses
GO:0005245	voltage-gated calcium channel activity	Losses
GO:0004965	G-protein coupled GABA receptor activity	Losses
GO:0046983	protein dimerization activity	Losses
GO:0015631	tubulin binding	Losses
GO:0003824	catalytic activity	Losses
GO:0008188	neuropeptide receptor activity	Losses
GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Losses
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	Losses
GO:0070330	aromatase activity	Losses
GO:0003677	DNA binding	Losses
GO:0015294	solute:cation symporter activity	Losses
GO:0005326	neurotransmitter transporter activity	Losses
GO:0015085	calcium ion transmembrane transporter activity	Losses
GO:0004362	glutathione-disulfide reductase activity	Losses
GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	Losses
GO:0034597	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	Losses
GO:0018676	(S)-limonene 7-monooxygenase activity	Losses
GO:0004321	fatty-acyl-CoA synthase activity	Losses
GO:0034584	piRNA binding	Losses
GO:0005329	dopamine transmembrane transporter activity	Losses
GO:0070577	lysine-acetylated histone binding	Losses
GO:0004454	ketohexokinase activity	Losses
GO:0036263	L-DOPA monooxygenase activity	Losses
GO:0036264	dopamine monooxygenase activity	Losses
GO:0033904	dextranase activity	Losses
GO:0045309	protein phosphorylated amino acid binding	Losses
GO:0042071	leucokinin receptor activity	Losses
GO:0042943	D-amino acid transmembrane transporter activity	Losses
GO:0004791	thioredoxin-disulfide reductase activity	Losses
GO:0017151	DEAD/H-box RNA helicase binding	Losses
GO:0017128	phospholipid scramblase activity	Losses
GO:0051011	microtubule minus-end binding	Losses
GO:0001784	phosphotyrosine residue binding	Losses
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	Losses
GO:0004516	nicotinate phosphoribosyltransferase activity	Losses
GO:0004508	steroid 17-alpha-monooxygenase activity	Losses
GO:0000827	inositol-1,3,4,5,6-pentakisphosphate kinase activity	Losses
GO:0005534	galactose binding	Losses
GO:0035381	ATP-gated ion channel activity	Losses
GO:0047372	acylglycerol lipase activity	Losses
GO:0019113	limonene monooxygenase activity	Losses
GO:0008086	light-activated voltage-gated calcium channel activity	Losses
GO:0033857	diphosphoinositol-pentakisphosphate kinase activity	Losses
GO:0050473	arachidonate 15-lipoxygenase activity	Losses
GO:0008927	mannonate dehydratase activity	Losses
GO:0009045	xylose isomerase activity	Losses
GO:0008908	isochorismatase activity	Losses
GO:0004097	catechol oxidase activity	Losses
GO:0010461	light-activated ion channel activity	Losses
GO:0015175	neutral amino acid transmembrane transporter activity	Losses
GO:0140033	acetylation-dependent protein binding	Losses
GO:0004931	extracellularly ATP-gated cation channel activity	Losses
GO:0015277	kainate selective glutamate receptor activity	Losses
GO:0005003	ephrin receptor activity	Losses
GO:0015222	serotonin transmembrane transporter activity	Losses
GO:0060072	large conductance calcium-activated potassium channel activity	Losses
GO:0019811	cocaine binding	Losses
GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity	Losses
GO:0016443	bidentate ribonuclease III activity	Losses
GO:0106017	phosphatidylinositol-3,4-bisphosphate phosphatase activity	Losses
GO:0005262	calcium channel activity	Losses
GO:0008528	G-protein coupled peptide receptor activity	Losses
GO:0004713	protein tyrosine kinase activity	Losses
GO:0001653	peptide receptor activity	Losses
GO:0051213	dioxygenase activity	Losses
GO:0008144	drug binding	Losses
GO:0099094	ligand-gated cation channel activity	Losses
GO:0003993	acid phosphatase activity	Losses
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Losses
GO:0015293	symporter activity	Losses
GO:0005230	extracellular ligand-gated ion channel activity	Losses
GO:0072509	divalent inorganic cation transmembrane transporter activity	Losses
GO:0015291	secondary active transmembrane transporter activity	Losses
GO:0005549	odorant binding	Novel expansions
GO:0046914	transition metal ion binding	Novel expansions
GO:0046872	metal ion binding	Novel expansions
GO:0043169	cation binding	Novel expansions
GO:0008270	zinc ion binding	Novel expansions
GO:0004507	steroid 11-beta-monooxygenase activity	Novel expansions
GO:0047749	cholestanetriol 26-monooxygenase activity	Novel expansions
GO:0022857	transmembrane transporter activity	Novel expansions
GO:0005215	transporter activity	Novel expansions
GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Novel expansions
GO:0036081	extracellular ammonia-gated ion channel activity	Novel expansions
GO:0008395	steroid hydroxylase activity	Novel expansions
GO:0016502	nucleotide receptor activity	Extinctions
GO:0001614	purinergic nucleotide receptor activity	Extinctions
GO:0035586	purinergic receptor activity	Extinctions
GO:0005216	ion channel activity	Extinctions
GO:0022838	substrate-specific channel activity	Extinctions
GO:0015075	ion transmembrane transporter activity	Extinctions
GO:0015267	channel activity	Extinctions
GO:0022803	passive transmembrane transporter activity	Extinctions
GO:0022891	substrate-specific transmembrane transporter activity	Extinctions
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Extinctions
GO:0022892	substrate-specific transporter activity	Extinctions
GO:0004454	ketohexokinase activity	Extinctions
GO:0035381	ATP-gated ion channel activity	Extinctions
GO:0047372	acylglycerol lipase activity	Extinctions
GO:0050473	arachidonate 15-lipoxygenase activity	Extinctions
GO:0008927	mannonate dehydratase activity	Extinctions
GO:0009045	xylose isomerase activity	Extinctions
GO:0004931	extracellularly ATP-gated cation channel activity	Extinctions
GO:0022857	transmembrane transporter activity	Extinctions
GO:0004983	neuropeptide Y receptor activity	Extinctions
GO:0005261	cation channel activity	Extinctions
GO:0008324	cation transmembrane transporter activity	Extinctions
GO:0003834	beta-carotene 15,15'-monooxygenase activity	Extinctions
GO:0015054	gastrin receptor activity	Extinctions
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Extinctions
GO:0046873	metal ion transmembrane transporter activity	Extinctions
GO:0022890	inorganic cation transmembrane transporter activity	Extinctions
GO:0099600	transmembrane receptor activity	Extinctions
GO:0008140	cAMP response element binding protein binding	Extinctions
GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Extinctions
GO:0004565	beta-galactosidase activity	Extinctions
GO:0004657	proline dehydrogenase activity	Extinctions
GO:0015321	sodium-dependent phosphate transmembrane transporter activity	Extinctions
GO:0033743	peptide-methionine (R)-S-oxide reductase activity	Extinctions
GO:0004035	alkaline phosphatase activity	Extinctions
GO:0017040	ceramidase activity	Extinctions
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Extinctions
GO:0038023	signaling receptor activity	Extinctions
GO:0005432	calcium:sodium antiporter activity	Extinctions
GO:0015925	galactosidase activity	Extinctions