GO:0005216	ion channel activity	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0015267	channel activity	Gains
GO:0022836	gated channel activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0005261	cation channel activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0004252	serine-type endopeptidase activity	Gains
GO:0015075	ion transmembrane transporter activity	Gains
GO:0005549	odorant binding	Gains
GO:0038023	signaling receptor activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0022857	transmembrane transporter activity	Gains
GO:0004872	receptor activity	Gains
GO:0046873	metal ion transmembrane transporter activity	Gains
GO:0008236	serine-type peptidase activity	Gains
GO:0017171	serine hydrolase activity	Gains
GO:0022891	substrate-specific transmembrane transporter activity	Gains
GO:0022890	inorganic cation transmembrane transporter activity	Gains
GO:0008324	cation transmembrane transporter activity	Gains
GO:0022843	voltage-gated cation channel activity	Gains
GO:0022892	substrate-specific transporter activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0005215	transporter activity	Gains
GO:0005267	potassium channel activity	Gains
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
GO:0005249	voltage-gated potassium channel activity	Gains
GO:0022832	voltage-gated channel activity	Gains
GO:0005244	voltage-gated ion channel activity	Gains
GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
GO:0015079	potassium ion transmembrane transporter activity	Gains
GO:0004568	chitinase activity	Gains
GO:0005227	calcium activated cation channel activity	Gains
GO:0005262	calcium channel activity	Gains
GO:0022839	ion gated channel activity	Gains
GO:0022834	ligand-gated channel activity	Gains
GO:0015276	ligand-gated ion channel activity	Gains
GO:0004175	endopeptidase activity	Gains
GO:0008233	peptidase activity	Gains
GO:0017128	phospholipid scramblase activity	Gains
GO:0008331	high voltage-gated calcium channel activity	Gains
GO:0005415	nucleoside:sodium symporter activity	Gains
GO:0031418	L-ascorbic acid binding	Gains
GO:0022824	transmitter-gated ion channel activity	Gains
GO:0022835	transmitter-gated channel activity	Gains
GO:0004970	ionotropic glutamate receptor activity	Gains
GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
GO:0005230	extracellular ligand-gated ion channel activity	Gains
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
GO:0048029	monosaccharide binding	Gains
GO:0008066	glutamate receptor activity	Gains
GO:0005326	neurotransmitter transporter activity	Gains
GO:0004657	proline dehydrogenase activity	Gains
GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity	Gains
GO:0015927	trehalase activity	Gains
GO:0008332	low voltage-gated calcium channel activity	Gains
GO:0008452	RNA ligase activity	Gains
GO:0004821	histidine-tRNA ligase activity	Gains
GO:0003997	acyl-CoA oxidase activity	Gains
GO:0004555	alpha,alpha-trehalase activity	Gains
GO:0015085	calcium ion transmembrane transporter activity	Gains
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Losses
GO:0008171	O-methyltransferase activity	Losses
GO:0016788	hydrolase activity, acting on ester bonds	Losses
GO:0030798	trans-aconitate 2-methyltransferase activity	Losses
GO:0008934	inositol monophosphate 1-phosphatase activity	Losses
GO:0052832	inositol monophosphate 3-phosphatase activity	Losses
GO:0052833	inositol monophosphate 4-phosphatase activity	Losses
GO:0052834	inositol monophosphate phosphatase activity	Losses
GO:0015288	porin activity	Losses
GO:0004064	arylesterase activity	Losses
GO:0051010	microtubule plus-end binding	Losses
GO:0004462	lactoylglutathione lyase activity	Losses
GO:0050113	inositol oxygenase activity	Losses
GO:0033961	cis-stilbene-oxide hydrolase activity	Losses
GO:0004540	ribonuclease activity	Losses
GO:0016830	carbon-carbon lyase activity	Losses
GO:0004518	nuclease activity	Losses
GO:0016831	carboxy-lyase activity	Losses
GO:0003824	catalytic activity	Losses
GO:0030247	polysaccharide binding	Losses
GO:0001871	pattern binding	Losses
GO:0003713	transcription coactivator activity	Losses
GO:0004067	asparaginase activity	Losses
GO:0008329	signaling pattern recognition receptor activity	Losses
GO:0022829	wide pore channel activity	Losses
GO:0038187	pattern recognition receptor activity	Losses
GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0016787	hydrolase activity	Losses
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0004180	carboxypeptidase activity	Losses
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	Losses
GO:0051766	inositol trisphosphate kinase activity	Losses
GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
GO:0008514	organic anion transmembrane transporter activity	Losses
GO:0004519	endonuclease activity	Losses
GO:0016829	lyase activity	Losses
GO:0016803	ether hydrolase activity	Losses
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	Losses
GO:0008484	sulfuric ester hydrolase activity	Losses
GO:0019203	carbohydrate phosphatase activity	Losses
GO:0008242	omega peptidase activity	Losses
GO:0008083	growth factor activity	Losses
GO:0004527	exonuclease activity	Losses
GO:0019239	deaminase activity	Losses
GO:0008509	anion transmembrane transporter activity	Losses
GO:0016740	transferase activity	Losses
GO:0016846	carbon-sulfur lyase activity	Losses
GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Losses
GO:0042834	peptidoglycan binding	Losses
GO:0008121	ubiquinol-cytochrome-c reductase activity	Losses
GO:0000987	core promoter proximal region sequence-specific DNA binding	Losses
GO:0001159	core promoter proximal region DNA binding	Losses
GO:0031208	POZ domain binding	Losses
GO:0004521	endoribonuclease activity	Losses
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Extinctions
GO:0015288	porin activity	Extinctions
GO:0003713	transcription coactivator activity	Extinctions
GO:0016779	nucleotidyltransferase activity	Extinctions
GO:0051010	microtubule plus-end binding	Extinctions
GO:0004462	lactoylglutathione lyase activity	Extinctions
GO:0050113	inositol oxygenase activity	Extinctions
GO:0022829	wide pore channel activity	Extinctions
GO:0016830	carbon-carbon lyase activity	Extinctions
GO:0004540	ribonuclease activity	Extinctions
GO:0016846	carbon-sulfur lyase activity	Extinctions
GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Extinctions
GO:0008121	ubiquinol-cytochrome-c reductase activity	Extinctions
GO:0016831	carboxy-lyase activity	Extinctions
GO:0034062	5'-3' RNA polymerase activity	Extinctions
GO:0097747	RNA polymerase activity	Extinctions
GO:0004518	nuclease activity	Extinctions
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Extinctions
GO:0003712	transcription cofactor activity	Extinctions
GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0030785	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	Extinctions
GO:0070742	C2H2 zinc finger domain binding	Extinctions
GO:0008903	hydroxypyruvate isomerase activity	Extinctions
GO:0046525	xylosylprotein 4-beta-galactosyltransferase activity	Extinctions
GO:0016503	pheromone receptor activity	Extinctions
GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity	Extinctions
GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	Extinctions
GO:0034038	deoxyhypusine synthase activity	Extinctions
GO:0008488	gamma-glutamyl carboxylase activity	Extinctions
GO:0008478	pyridoxal kinase activity	Extinctions
GO:0005125	cytokine activity	Extinctions
GO:0004371	glycerone kinase activity	Extinctions
GO:0004325	ferrochelatase activity	Extinctions
GO:0018271	biotin-protein ligase activity	Extinctions
GO:0015266	protein channel activity	Extinctions
GO:0033897	ribonuclease T2 activity	Extinctions
GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity	Extinctions
GO:0003867	4-aminobutyrate transaminase activity	Extinctions
GO:0003868	4-hydroxyphenylpyruvate dioxygenase activity	Extinctions
GO:0004419	hydroxymethylglutaryl-CoA lyase activity	Extinctions
GO:0004163	diphosphomevalonate decarboxylase activity	Extinctions
GO:0017050	D-erythro-sphingosine kinase activity	Extinctions
GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	Extinctions
GO:0044748	3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing	Extinctions
GO:0051748	UTP-monosaccharide-1-phosphate uridylyltransferase activity	Extinctions
GO:0004590	orotidine-5'-phosphate decarboxylase activity	Extinctions
GO:0003999	adenine phosphoribosyltransferase activity	Extinctions
GO:0004588	orotate phosphoribosyltransferase activity	Extinctions
GO:0004573	mannosyl-oligosaccharide glucosidase activity	Extinctions
GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity	Extinctions
GO:0140098	catalytic activity, acting on RNA	Extinctions
GO:0004519	endonuclease activity	Extinctions
GO:0030247	polysaccharide binding	Extinctions
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Extinctions
GO:0001871	pattern binding	Extinctions
GO:0000988	transcription factor activity, protein binding	Extinctions
GO:0000989	transcription factor activity, transcription factor binding	Extinctions
GO:0004521	endoribonuclease activity	Extinctions