GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0004519	endonuclease activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0004518	nuclease activity	Gains
GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
GO:0005230	extracellular ligand-gated ion channel activity	Gains
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
GO:0016740	transferase activity	Gains
GO:0070279	vitamin B6 binding	Gains
GO:0030170	pyridoxal phosphate binding	Gains
GO:0003993	acid phosphatase activity	Gains
GO:0022834	ligand-gated channel activity	Gains
GO:0015276	ligand-gated ion channel activity	Gains
GO:0019842	vitamin binding	Gains
GO:0004521	endoribonuclease activity	Gains
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Gains
GO:0004869	cysteine-type endopeptidase inhibitor activity	Gains
GO:0016788	hydrolase activity, acting on ester bonds	Gains
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
GO:0005216	ion channel activity	Gains
GO:0008455	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Gains
GO:0008273	calcium, potassium:sodium antiporter activity	Gains
GO:0004499	N,N-dimethylaniline monooxygenase activity	Gains
GO:0004446	inositol-hexakisphosphate phosphatase activity	Gains
GO:0045159	myosin II binding	Gains
GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0048037	cofactor binding	Gains
GO:0022836	gated channel activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0015267	channel activity	Gains
GO:0016832	aldehyde-lyase activity	Gains
GO:0020037	heme binding	Gains
GO:0061783	peptidoglycan muralytic activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0046906	tetrapyrrole binding	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0003824	catalytic activity	Gains
GO:0005506	iron ion binding	Gains
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Gains
GO:0004033	aldo-keto reductase (NADP) activity	Gains
GO:0030898	actin-dependent ATPase activity	Gains
GO:0005487	nucleocytoplasmic transporter activity	Gains
GO:0008106	alcohol dehydrogenase (NADP+) activity	Gains
GO:0022821	potassium ion antiporter activity	Gains
GO:0032296	double-stranded RNA-specific ribonuclease activity	Gains
GO:0019825	oxygen binding	Gains
GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Gains
GO:0004525	ribonuclease III activity	Gains
GO:0004872	receptor activity	Losses
GO:0004888	transmembrane signaling receptor activity	Losses
GO:0099600	transmembrane receptor activity	Losses
GO:0038023	signaling receptor activity	Losses
GO:0060089	molecular transducer activity	Losses
GO:0004930	G-protein coupled receptor activity	Losses
GO:0004871	signal transducer activity	Losses
GO:0004984	olfactory receptor activity	Losses
GO:0005549	odorant binding	Losses
GO:0008188	neuropeptide receptor activity	Losses
GO:0042834	peptidoglycan binding	Losses
GO:0008527	taste receptor activity	Losses
GO:0033777	lithocholate 6beta-hydroxylase activity	Losses
GO:0008020	G-protein coupled photoreceptor activity	Losses
GO:0005200	structural constituent of cytoskeleton	Losses
GO:0008528	G-protein coupled peptide receptor activity	Losses
GO:0001653	peptide receptor activity	Losses
GO:0005085	guanyl-nucleotide exchange factor activity	Losses
GO:0042302	structural constituent of cuticle	Losses
GO:0005088	Ras guanyl-nucleotide exchange factor activity	Losses
GO:0050591	quinine 3-monooxygenase activity	Losses
GO:0016418	S-acetyltransferase activity	Losses
GO:0005214	structural constituent of chitin-based cuticle	Losses
GO:0042562	hormone binding	Losses
GO:0016500	protein-hormone receptor activity	Losses
GO:0009881	photoreceptor activity	Losses
GO:0005539	glycosaminoglycan binding	Losses
GO:0003682	chromatin binding	Losses
GO:0048365	Rac GTPase binding	Losses
GO:0030676	Rac guanyl-nucleotide exchange factor activity	Losses
GO:0008010	structural constituent of chitin-based larval cuticle	Losses
GO:0004497	monooxygenase activity	Losses
GO:0020037	heme binding	Losses
GO:0046906	tetrapyrrole binding	Losses
GO:0005509	calcium ion binding	Losses
GO:0019199	transmembrane receptor protein kinase activity	Losses
GO:0051020	GTPase binding	Losses
GO:0008061	chitin binding	Losses
GO:0004781	sulfate adenylyltransferase (ATP) activity	Losses
GO:0004779	sulfate adenylyltransferase activity	Losses
GO:0017016	Ras GTPase binding	Losses
GO:0005198	structural molecule activity	Losses
GO:0004068	aspartate 1-decarboxylase activity	Losses
GO:0004020	adenylylsulfate kinase activity	Losses
GO:0008321	Ral guanyl-nucleotide exchange factor activity	Losses
GO:0035013	myosuppressin receptor activity	Losses
GO:0035049	juvenile hormone acid methyltransferase activity	Losses
GO:0016503	pheromone receptor activity	Losses
GO:0048495	Roundabout binding	Losses
GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Losses
GO:0004351	glutamate decarboxylase activity	Losses
GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Losses
GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Losses
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Losses
GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Losses
GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Losses
GO:0047886	farnesol dehydrogenase activity	Losses
GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Losses
GO:0008747	N-acetylneuraminate lyase activity	Losses
GO:0032500	muramyl dipeptide binding	Losses
GO:0050431	transforming growth factor beta binding	Losses
GO:0004167	dopachrome isomerase activity	Losses
GO:0004139	deoxyribose-phosphate aldolase activity	Losses
GO:0016019	peptidoglycan receptor activity	Losses
GO:0050111	mycocerosate synthase activity	Losses
GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Losses
GO:0048763	calcium-induced calcium release activity	Losses
GO:0035274	diphenyl phthalate binding	Losses
GO:0035275	dibutyl phthalate binding	Losses
GO:0004782	sulfinoalanine decarboxylase activity	Losses
GO:0004720	protein-lysine 6-oxidase activity	Losses
GO:0015277	kainate selective glutamate receptor activity	Losses
GO:0016361	activin receptor activity, type I	Losses
GO:0004802	transketolase activity	Losses
GO:0000293	ferric-chelate reductase activity	Losses
GO:0036400	short neuropeptide F receptor activity	Losses
GO:0001875	lipopolysaccharide receptor activity	Losses
GO:0004587	ornithine-oxo-acid transaminase activity	Losses
GO:0003920	GMP reductase activity	Losses
GO:0008986	pyruvate, water dikinase activity	Losses
GO:0005025	transforming growth factor beta receptor activity, type I	Losses
GO:0005034	osmosensor activity	Losses
GO:0019010	farnesoic acid O-methyltransferase activity	Losses
GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Losses
GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Losses
GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Losses
GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Losses
GO:0031267	small GTPase binding	Losses
GO:0099600	transmembrane receptor activity	Extinctions
GO:0004888	transmembrane signaling receptor activity	Extinctions
GO:0004872	receptor activity	Extinctions
GO:0008527	taste receptor activity	Extinctions
GO:0060089	molecular transducer activity	Extinctions
GO:0038023	signaling receptor activity	Extinctions
GO:0004930	G-protein coupled receptor activity	Extinctions
GO:0004871	signal transducer activity	Extinctions
GO:0004984	olfactory receptor activity	Extinctions
GO:0005549	odorant binding	Extinctions
GO:0003682	chromatin binding	Extinctions
GO:0005088	Ras guanyl-nucleotide exchange factor activity	Extinctions
GO:0004022	alcohol dehydrogenase (NAD) activity	Extinctions
GO:0046873	metal ion transmembrane transporter activity	Extinctions
GO:0004020	adenylylsulfate kinase activity	Extinctions
GO:0008321	Ral guanyl-nucleotide exchange factor activity	Extinctions
GO:0048495	Roundabout binding	Extinctions
GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity	Extinctions
GO:0004139	deoxyribose-phosphate aldolase activity	Extinctions
GO:0048763	calcium-induced calcium release activity	Extinctions
GO:0004720	protein-lysine 6-oxidase activity	Extinctions
GO:0000293	ferric-chelate reductase activity	Extinctions
GO:0004587	ornithine-oxo-acid transaminase activity	Extinctions
GO:0003920	GMP reductase activity	Extinctions
GO:0008986	pyruvate, water dikinase activity	Extinctions
GO:0005034	osmosensor activity	Extinctions
GO:0005200	structural constituent of cytoskeleton	Extinctions
GO:0004713	protein tyrosine kinase activity	Extinctions
GO:0005216	ion channel activity	Extinctions
GO:0009881	photoreceptor activity	Extinctions
GO:0022838	substrate-specific channel activity	Extinctions
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Extinctions