GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0008270	zinc ion binding	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0046914	transition metal ion binding	Gains
GO:0004175	endopeptidase activity	Gains
GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
GO:0008233	peptidase activity	Gains
GO:0003676	nucleic acid binding	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0022824	transmitter-gated ion channel activity	Gains
GO:0022835	transmitter-gated channel activity	Gains
GO:0004970	ionotropic glutamate receptor activity	Gains
GO:0008066	glutamate receptor activity	Gains
GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
GO:0038023	signaling receptor activity	Gains
GO:0030594	neurotransmitter receptor activity	Gains
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
GO:0004521	endoribonuclease activity	Gains
GO:0008378	galactosyltransferase activity	Gains
GO:0004872	receptor activity	Gains
GO:0004252	serine-type endopeptidase activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0005230	extracellular ligand-gated ion channel activity	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0004519	endonuclease activity	Gains
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0036081	extracellular ammonia-gated ion channel activity	Gains
GO:0004518	nuclease activity	Gains
GO:0042302	structural constituent of cuticle	Gains
GO:0046872	metal ion binding	Gains
GO:0043169	cation binding	Gains
GO:0017171	serine hydrolase activity	Gains
GO:0030246	carbohydrate binding	Gains
GO:0015276	ligand-gated ion channel activity	Gains
GO:0022834	ligand-gated channel activity	Gains
GO:0030414	peptidase inhibitor activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0005549	odorant binding	Gains
GO:0008236	serine-type peptidase activity	Gains
GO:0004540	ribonuclease activity	Gains
GO:0004803	transposase activity	Gains
GO:0031409	pigment binding	Gains
GO:0008061	chitin binding	Gains
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Gains
GO:0061134	peptidase regulator activity	Gains
GO:0004312	fatty acid synthase activity	Gains
GO:1901363	heterocyclic compound binding	Gains
GO:0097159	organic cyclic compound binding	Gains
GO:0016209	antioxidant activity	Gains
GO:0004104	cholinesterase activity	Gains
GO:0005215	transporter activity	Gains
GO:0035250	UDP-galactosyltransferase activity	Gains
GO:0004857	enzyme inhibitor activity	Gains
GO:0004601	peroxidase activity	Gains
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Gains
GO:0003990	acetylcholinesterase activity	Gains
GO:0003678	DNA helicase activity	Gains
GO:0046906	tetrapyrrole binding	Gains
GO:0019825	oxygen binding	Gains
GO:0001871	pattern binding	Gains
GO:0030247	polysaccharide binding	Gains
GO:0052689	carboxylic ester hydrolase activity	Gains
GO:0020037	heme binding	Gains
GO:0008234	cysteine-type peptidase activity	Gains
GO:0004656	procollagen-proline 4-dioxygenase activity	Gains
GO:0015232	heme transporter activity	Gains
GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	Gains
GO:0031545	peptidyl-proline 4-dioxygenase activity	Gains
GO:0008527	taste receptor activity	Gains
GO:0031543	peptidyl-proline dioxygenase activity	Gains
GO:0005344	oxygen carrier activity	Gains
GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
GO:0004806	triglyceride lipase activity	Gains
GO:0008010	structural constituent of chitin-based larval cuticle	Gains
GO:0016229	steroid dehydrogenase activity	Gains
GO:0005213	structural constituent of chorion	Gains
GO:0000182	rDNA binding	Gains
GO:0004798	thymidylate kinase activity	Gains
GO:0004555	alpha,alpha-trehalase activity	Gains
GO:0050062	long-chain-fatty-acyl-CoA reductase activity	Gains
GO:0001872	(1->3)-beta-D-glucan binding	Gains
GO:0008020	G-protein coupled photoreceptor activity	Gains
GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity	Gains
GO:0043874	acireductone synthase activity	Gains
GO:0015927	trehalase activity	Gains
GO:0005199	structural constituent of cell wall	Gains
GO:0016649	oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	Gains
GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	Gains
GO:0016630	protochlorophyllide reductase activity	Gains
GO:0022836	gated channel activity	Losses
GO:0022838	substrate-specific channel activity	Losses
GO:0015267	channel activity	Losses
GO:0022803	passive transmembrane transporter activity	Losses
GO:0005216	ion channel activity	Losses
GO:0005261	cation channel activity	Losses
GO:0046873	metal ion transmembrane transporter activity	Losses
GO:0099094	ligand-gated cation channel activity	Losses
GO:0005227	calcium activated cation channel activity	Losses
GO:0022890	inorganic cation transmembrane transporter activity	Losses
GO:0015079	potassium ion transmembrane transporter activity	Losses
GO:0016791	phosphatase activity	Losses
GO:0022839	ion gated channel activity	Losses
GO:0099600	transmembrane receptor activity	Losses
GO:0004721	phosphoprotein phosphatase activity	Losses
GO:0005267	potassium channel activity	Losses
GO:0015276	ligand-gated ion channel activity	Losses
GO:0022834	ligand-gated channel activity	Losses
GO:0001637	G-protein coupled chemoattractant receptor activity	Losses
GO:0004950	chemokine receptor activity	Losses
GO:0022857	transmembrane transporter activity	Losses
GO:0004871	signal transducer activity	Losses
GO:0022891	substrate-specific transmembrane transporter activity	Losses
GO:0005230	extracellular ligand-gated ion channel activity	Losses
GO:0004888	transmembrane signaling receptor activity	Losses
GO:0008484	sulfuric ester hydrolase activity	Losses
GO:0022892	substrate-specific transporter activity	Losses
GO:0008324	cation transmembrane transporter activity	Losses
GO:0060089	molecular transducer activity	Losses
GO:0140096	catalytic activity, acting on a protein	Losses
GO:0005310	dicarboxylic acid transmembrane transporter activity	Losses
GO:0004896	cytokine receptor activity	Losses
GO:0017153	sodium:dicarboxylate symporter activity	Losses
GO:0015075	ion transmembrane transporter activity	Losses
GO:0015085	calcium ion transmembrane transporter activity	Losses
GO:0008092	cytoskeletal protein binding	Losses
GO:0004872	receptor activity	Losses
GO:0038023	signaling receptor activity	Losses
GO:0016788	hydrolase activity, acting on ester bonds	Losses
GO:0072509	divalent inorganic cation transmembrane transporter activity	Losses
GO:0015269	calcium-activated potassium channel activity	Losses
GO:0019894	kinesin binding	Losses
GO:0005262	calcium channel activity	Losses
GO:0042578	phosphoric ester hydrolase activity	Losses
GO:0008188	neuropeptide receptor activity	Losses
GO:0005509	calcium ion binding	Losses
GO:0005254	chloride channel activity	Losses
GO:0019901	protein kinase binding	Losses
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
GO:0005253	anion channel activity	Losses
GO:0009008	DNA-methyltransferase activity	Losses
GO:0015291	secondary active transmembrane transporter activity	Losses
GO:0005057	signal transducer activity, downstream of receptor	Losses
GO:0005244	voltage-gated ion channel activity	Losses
GO:0022832	voltage-gated channel activity	Losses
GO:0015081	sodium ion transmembrane transporter activity	Losses
GO:0015108	chloride transmembrane transporter activity	Losses
GO:0060090	molecular adaptor activity	Losses
GO:0008528	G-protein coupled peptide receptor activity	Losses
GO:0015103	inorganic anion transmembrane transporter activity	Losses
GO:0005215	transporter activity	Losses
GO:0001653	peptide receptor activity	Losses
GO:0030594	neurotransmitter receptor activity	Losses
GO:0004713	protein tyrosine kinase activity	Losses
GO:0022843	voltage-gated cation channel activity	Losses
GO:0050254	rhodopsin kinase activity	Losses
GO:0003824	catalytic activity	Losses
GO:0004983	neuropeptide Y receptor activity	Losses
GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity	Losses
GO:0004672	protein kinase activity	Losses
GO:0000166	nucleotide binding	Losses
GO:1901265	nucleoside phosphate binding	Losses
GO:0004536	deoxyribonuclease activity	Losses
GO:0015293	symporter activity	Losses
GO:0022824	transmitter-gated ion channel activity	Losses
GO:0022835	transmitter-gated channel activity	Losses
GO:0004970	ionotropic glutamate receptor activity	Losses
GO:0004707	MAP kinase activity	Losses
GO:0008172	S-methyltransferase activity	Losses
GO:0005343	organic acid:sodium symporter activity	Losses
GO:0015370	solute:sodium symporter activity	Losses
GO:0016787	hydrolase activity	Losses
GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
GO:0019900	kinase binding	Losses
GO:0005249	voltage-gated potassium channel activity	Losses
GO:0004520	endodeoxyribonuclease activity	Losses
GO:0005524	ATP binding	Losses
GO:0032559	adenyl ribonucleotide binding	Losses
GO:0003950	NAD+ ADP-ribosyltransferase activity	Losses
GO:0035591	signaling adaptor activity	Losses
GO:0004385	guanylate kinase activity	Losses
GO:1901682	sulfur compound transmembrane transporter activity	Losses
GO:0070888	E-box binding	Losses
GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Losses
GO:0005225	volume-sensitive anion channel activity	Losses
GO:0005219	ryanodine-sensitive calcium-release channel activity	Losses
GO:0004728	signal transducer, downstream of receptor, with protein tyrosine phosphatase activity	Losses
GO:0070513	death domain binding	Losses
GO:0015499	formate transmembrane transporter activity	Losses
GO:0016990	arginine deiminase activity	Losses
GO:0043914	NADPH:sulfur oxidoreductase activity	Losses
GO:0004824	lysine-tRNA ligase activity	Losses
GO:0004802	transketolase activity	Losses
GO:0004807	triose-phosphate isomerase activity	Losses
GO:0001760	aminocarboxymuconate-semialdehyde decarboxylase activity	Losses
GO:0001784	phosphotyrosine residue binding	Losses
GO:0015106	bicarbonate transmembrane transporter activity	Losses
GO:0050093	methanol dehydrogenase activity	Losses
GO:0015250	water channel activity	Losses
GO:0047453	ATP-dependent NAD(P)H-hydrate dehydratase activity	Losses
GO:0003941	L-serine ammonia-lyase activity	Losses
GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Losses
GO:0015277	kainate selective glutamate receptor activity	Losses
GO:0032028	myosin head/neck binding	Losses
GO:0018834	dichloromethane dehalogenase activity	Losses
GO:0031489	myosin V binding	Losses
GO:0106017	phosphatidylinositol-3,4-bisphosphate phosphatase activity	Losses
GO:0016312	inositol bisphosphate phosphatase activity	Losses
GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity	Losses
GO:0047150	betaine-homocysteine S-methyltransferase activity	Losses
GO:0018580	nitronate monooxygenase activity	Losses
GO:0017020	myosin phosphatase regulator activity	Losses
GO:0070984	SET domain binding	Losses
GO:0046570	methylthioribulose 1-phosphate dehydratase activity	Losses
GO:0019531	oxalate transmembrane transporter activity	Losses
GO:0016403	dimethylargininase activity	Losses
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Losses
GO:0036401	pyrokinin receptor activity	Losses
GO:0005026	transforming growth factor beta receptor activity, type II	Losses
GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	Losses
GO:0034597	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	Losses
GO:0005003	ephrin receptor activity	Losses
GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	Losses
GO:0045309	protein phosphorylated amino acid binding	Losses
GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	Losses
GO:0043890	N-acetylgalactosamine-6-sulfatase activity	Losses
GO:0005368	taurine transmembrane transporter activity	Losses
GO:0005369	taurine:sodium symporter activity	Losses
GO:0005372	water transmembrane transporter activity	Losses
GO:0047623	adenosine-phosphate deaminase activity	Losses
GO:0004490	methylglutaconyl-CoA hydratase activity	Losses
GO:0060072	large conductance calcium-activated potassium channel activity	Losses
GO:0004423	iduronate-2-sulfatase activity	Losses
GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity	Losses
GO:0003876	AMP deaminase activity	Losses
GO:0004157	dihydropyrimidinase activity	Losses
GO:0072320	volume-sensitive chloride channel activity	Losses
GO:0004133	glycogen debranching enzyme activity	Losses
GO:0004134	4-alpha-glucanotransferase activity	Losses
GO:0004135	amylo-alpha-1,6-glucosidase activity	Losses
GO:0070735	protein-glycine ligase activity	Losses
GO:0070736	protein-glycine ligase activity, initiating	Losses
GO:0070737	protein-glycine ligase activity, elongating	Losses
GO:0047061	glucose-fructose oxidoreductase activity	Losses
GO:0070854	myosin VI heavy chain binding	Losses
GO:0070855	myosin VI head/neck binding	Losses
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
GO:0008066	glutamate receptor activity	Losses
GO:0030554	adenyl nucleotide binding	Losses
GO:0016791	phosphatase activity	Extinctions
GO:0004721	phosphoprotein phosphatase activity	Extinctions
GO:0016788	hydrolase activity, acting on ester bonds	Extinctions
GO:0042578	phosphoric ester hydrolase activity	Extinctions
GO:0005057	signal transducer activity, downstream of receptor	Extinctions
GO:0140096	catalytic activity, acting on a protein	Extinctions
GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity	Extinctions
GO:0004536	deoxyribonuclease activity	Extinctions
GO:0004520	endodeoxyribonuclease activity	Extinctions
GO:0004707	MAP kinase activity	Extinctions
GO:0008172	S-methyltransferase activity	Extinctions
GO:0003824	catalytic activity	Extinctions
GO:0016787	hydrolase activity	Extinctions
GO:0008484	sulfuric ester hydrolase activity	Extinctions
GO:0004620	phospholipase activity	Extinctions
GO:0052745	inositol phosphate phosphatase activity	Extinctions
GO:0004622	lysophospholipase activity	Extinctions
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	Extinctions
GO:0070888	E-box binding	Extinctions
GO:0047988	hydroxyacid-oxoacid transhydrogenase activity	Extinctions
GO:0004728	signal transducer, downstream of receptor, with protein tyrosine phosphatase activity	Extinctions
GO:0070513	death domain binding	Extinctions
GO:0016990	arginine deiminase activity	Extinctions
GO:0043914	NADPH:sulfur oxidoreductase activity	Extinctions
GO:0004824	lysine-tRNA ligase activity	Extinctions
GO:0004807	triose-phosphate isomerase activity	Extinctions
GO:0001760	aminocarboxymuconate-semialdehyde decarboxylase activity	Extinctions
GO:0001784	phosphotyrosine residue binding	Extinctions
GO:0050093	methanol dehydrogenase activity	Extinctions
GO:0047453	ATP-dependent NAD(P)H-hydrate dehydratase activity	Extinctions
GO:0003941	L-serine ammonia-lyase activity	Extinctions
GO:0018834	dichloromethane dehalogenase activity	Extinctions
GO:0016312	inositol bisphosphate phosphatase activity	Extinctions
GO:0047150	betaine-homocysteine S-methyltransferase activity	Extinctions
GO:0018580	nitronate monooxygenase activity	Extinctions
GO:0017020	myosin phosphatase regulator activity	Extinctions
GO:0070984	SET domain binding	Extinctions
GO:0046570	methylthioribulose 1-phosphate dehydratase activity	Extinctions
GO:0016403	dimethylargininase activity	Extinctions
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Extinctions
GO:0036401	pyrokinin receptor activity	Extinctions
GO:0005026	transforming growth factor beta receptor activity, type II	Extinctions
GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	Extinctions
GO:0045309	protein phosphorylated amino acid binding	Extinctions
GO:0043890	N-acetylgalactosamine-6-sulfatase activity	Extinctions
GO:0005368	taurine transmembrane transporter activity	Extinctions
GO:0005369	taurine:sodium symporter activity	Extinctions
GO:0047623	adenosine-phosphate deaminase activity	Extinctions
GO:0004423	iduronate-2-sulfatase activity	Extinctions
GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity	Extinctions
GO:0003876	AMP deaminase activity	Extinctions
GO:0004133	glycogen debranching enzyme activity	Extinctions
GO:0004134	4-alpha-glucanotransferase activity	Extinctions
GO:0004135	amylo-alpha-1,6-glucosidase activity	Extinctions
GO:0070735	protein-glycine ligase activity	Extinctions
GO:0070736	protein-glycine ligase activity, initiating	Extinctions
GO:0070737	protein-glycine ligase activity, elongating	Extinctions
GO:0047061	glucose-fructose oxidoreductase activity	Extinctions
GO:0030674	protein binding, bridging	Extinctions
GO:0004842	ubiquitin-protein transferase activity	Extinctions
GO:0019787	ubiquitin-like protein transferase activity	Extinctions
GO:0005509	calcium ion binding	Extinctions