GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0005549	odorant binding	Gains
GO:0008270	zinc ion binding	Gains
GO:0046914	transition metal ion binding	Gains
GO:0043169	cation binding	Gains
GO:0046872	metal ion binding	Gains
GO:0003676	nucleic acid binding	Gains
GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
GO:0004175	endopeptidase activity	Gains
GO:0004518	nuclease activity	Gains
GO:0004629	phospholipase C activity	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0004519	endonuclease activity	Gains
GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
GO:0004435	phosphatidylinositol phospholipase C activity	Gains
GO:0008233	peptidase activity	Gains
GO:0097159	organic cyclic compound binding	Gains
GO:1901363	heterocyclic compound binding	Gains
GO:0003697	single-stranded DNA binding	Gains
GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	Gains
GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Gains
GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Gains
GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Gains
GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Gains
GO:0004833	tryptophan 2,3-dioxygenase activity	Gains
GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	Gains
GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	Gains
GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	Gains
GO:0004503	monophenol monooxygenase activity	Gains
GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Gains
GO:0008241	peptidyl-dipeptidase activity	Gains
GO:0004784	superoxide dismutase activity	Gains
GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Gains
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
GO:0003678	DNA helicase activity	Gains
GO:0004869	cysteine-type endopeptidase inhibitor activity	Gains
GO:0017048	Rho GTPase binding	Gains
GO:0004888	transmembrane signaling receptor activity	Losses
GO:0038023	signaling receptor activity	Losses
GO:0060089	molecular transducer activity	Losses
GO:0099600	transmembrane receptor activity	Losses
GO:0004871	signal transducer activity	Losses
GO:0004872	receptor activity	Losses
GO:0016298	lipase activity	Losses
GO:0008066	glutamate receptor activity	Losses
GO:0052689	carboxylic ester hydrolase activity	Losses
GO:0008484	sulfuric ester hydrolase activity	Losses
GO:0004930	G-protein coupled receptor activity	Losses
GO:0004970	ionotropic glutamate receptor activity	Losses
GO:0022824	transmitter-gated ion channel activity	Losses
GO:0022835	transmitter-gated channel activity	Losses
GO:0004806	triglyceride lipase activity	Losses
GO:0036081	extracellular ammonia-gated ion channel activity	Losses
GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
GO:0140096	catalytic activity, acting on a protein	Losses
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
GO:0101005	ubiquitinyl hydrolase activity	Losses
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	Losses
GO:0004843	thiol-dependent ubiquitin-specific protease activity	Losses
GO:0035586	purinergic receptor activity	Losses
GO:0005216	ion channel activity	Losses
GO:0022838	substrate-specific channel activity	Losses
GO:0046873	metal ion transmembrane transporter activity	Losses
GO:0015081	sodium ion transmembrane transporter activity	Losses
GO:0022803	passive transmembrane transporter activity	Losses
GO:0015267	channel activity	Losses
GO:0016787	hydrolase activity	Losses
GO:0001653	peptide receptor activity	Losses
GO:0004500	dopamine beta-monooxygenase activity	Losses
GO:0030594	neurotransmitter receptor activity	Losses
GO:0008081	phosphoric diester hydrolase activity	Losses
GO:0005230	extracellular ligand-gated ion channel activity	Losses
GO:0019783	ubiquitin-like protein-specific protease activity	Losses
GO:0005272	sodium channel activity	Losses
GO:0016788	hydrolase activity, acting on ester bonds	Losses
GO:0008188	neuropeptide receptor activity	Losses
GO:0004713	protein tyrosine kinase activity	Losses
GO:0004383	guanylate cyclase activity	Losses
GO:0008233	peptidase activity	Losses
GO:0019001	guanyl nucleotide binding	Losses
GO:0009975	cyclase activity	Losses
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	Losses
GO:0017112	Rab guanyl-nucleotide exchange factor activity	Losses
GO:0003951	NAD+ kinase activity	Losses
GO:0004622	lysophospholipase activity	Losses
GO:0016849	phosphorus-oxygen lyase activity	Losses
GO:0004620	phospholipase activity	Losses
GO:0008528	G-protein coupled peptide receptor activity	Losses
GO:0036081	extracellular ammonia-gated ion channel activity	Extinctions
GO:0101005	ubiquitinyl hydrolase activity	Extinctions
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	Extinctions
GO:0004843	thiol-dependent ubiquitin-specific protease activity	Extinctions
GO:0004888	transmembrane signaling receptor activity	Extinctions
GO:0008066	glutamate receptor activity	Extinctions
GO:0019783	ubiquitin-like protein-specific protease activity	Extinctions
GO:0099600	transmembrane receptor activity	Extinctions
GO:0008484	sulfuric ester hydrolase activity	Extinctions
GO:0009975	cyclase activity	Extinctions
GO:0004383	guanylate cyclase activity	Extinctions
GO:0016849	phosphorus-oxygen lyase activity	Extinctions
GO:0038023	signaling receptor activity	Extinctions
GO:0004970	ionotropic glutamate receptor activity	Extinctions
GO:0022824	transmitter-gated ion channel activity	Extinctions
GO:0022835	transmitter-gated channel activity	Extinctions
GO:0004871	signal transducer activity	Extinctions
GO:0005234	extracellularly glutamate-gated ion channel activity	Extinctions
GO:0016298	lipase activity	Extinctions
GO:0005216	ion channel activity	Extinctions
GO:0004622	lysophospholipase activity	Extinctions
GO:0022838	substrate-specific channel activity	Extinctions
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Extinctions
GO:0004930	G-protein coupled receptor activity	Extinctions
GO:0022803	passive transmembrane transporter activity	Extinctions
GO:0015267	channel activity	Extinctions
GO:0016229	steroid dehydrogenase activity	Extinctions
GO:0032182	ubiquitin-like protein binding	Extinctions
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	Extinctions
GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Extinctions
GO:0005261	cation channel activity	Extinctions
GO:0008469	histone-arginine N-methyltransferase activity	Extinctions
GO:0008430	selenium binding	Extinctions
GO:0004303	estradiol 17-beta-dehydrogenase activity	Extinctions
GO:0016273	arginine N-methyltransferase activity	Extinctions
GO:0016274	protein-arginine N-methyltransferase activity	Extinctions
GO:0004872	receptor activity	Extinctions
GO:0030594	neurotransmitter receptor activity	Extinctions
GO:0046873	metal ion transmembrane transporter activity	Extinctions