GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0003676	nucleic acid binding	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0004519	endonuclease activity	Gains
GO:0004435	phosphatidylinositol phospholipase C activity	Gains
GO:0004629	phospholipase C activity	Gains
GO:0097159	organic cyclic compound binding	Gains
GO:0004518	nuclease activity	Gains
GO:1901363	heterocyclic compound binding	Gains
GO:0030983	mismatched DNA binding	Gains
GO:0042393	histone binding	Gains
GO:0003723	RNA binding	Gains
GO:0004619	phosphoglycerate mutase activity	Gains
GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
GO:0051015	actin filament binding	Gains
GO:0003682	chromatin binding	Gains
GO:0016868	intramolecular transferase activity, phosphotransferases	Gains
GO:0033981	D-dopachrome decarboxylase activity	Gains
GO:0008470	isovaleryl-CoA dehydrogenase activity	Gains
GO:0033932	1,3-alpha-L-fucosidase activity	Gains
GO:0048495	Roundabout binding	Gains
GO:0070976	TIR domain binding	Gains
GO:0004122	cystathionine beta-synthase activity	Gains
GO:0004133	glycogen debranching enzyme activity	Gains
GO:0004134	4-alpha-glucanotransferase activity	Gains
GO:0004135	amylo-alpha-1,6-glucosidase activity	Gains
GO:0008511	sodium:potassium:chloride symporter activity	Gains
GO:0016287	glycerone-phosphate O-acyltransferase activity	Gains
GO:0004802	transketolase activity	Gains
GO:0034416	bisphosphoglycerate phosphatase activity	Gains
GO:0009014	succinyl-diaminopimelate desuccinylase activity	Gains
GO:0017172	cysteine dioxygenase activity	Gains
GO:0015026	coreceptor activity	Gains
GO:0047485	protein N-terminus binding	Gains
GO:0018392	glycoprotein 3-alpha-L-fucosyltransferase activity	Gains
GO:0034701	tripeptidase activity	Gains
GO:0004099	chitin deacetylase activity	Gains
GO:0004082	bisphosphoglycerate mutase activity	Gains
GO:0004083	bisphosphoglycerate 2-phosphatase activity	Gains
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0004521	endoribonuclease activity	Gains
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	Losses
GO:0043546	molybdopterin cofactor binding	Losses
GO:0051371	muscle alpha-actinin binding	Losses
GO:0008484	sulfuric ester hydrolase activity	Losses
GO:0042834	peptidoglycan binding	Losses
GO:0016878	acid-thiol ligase activity	Losses
GO:0017171	serine hydrolase activity	Losses
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
GO:0042805	actinin binding	Losses
GO:0051393	alpha-actinin binding	Losses
GO:0009378	four-way junction helicase activity	Losses
GO:0046592	polyamine oxidase activity	Losses
GO:0008289	lipid binding	Losses
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	Losses
GO:0008236	serine-type peptidase activity	Losses
GO:0004180	carboxypeptidase activity	Losses
GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Losses
GO:0008329	signaling pattern recognition receptor activity	Losses
GO:0008756	o-succinylbenzoate-CoA ligase activity	Losses
GO:0038187	pattern recognition receptor activity	Losses
GO:0001530	lipopolysaccharide binding	Losses
GO:0048038	quinone binding	Losses
GO:0030151	molybdenum ion binding	Losses
GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	Losses
GO:0016630	protochlorophyllide reductase activity	Losses
GO:0061783	peptidoglycan muralytic activity	Losses
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Losses
GO:0005539	glycosaminoglycan binding	Losses
GO:0016229	steroid dehydrogenase activity	Losses
GO:0019842	vitamin binding	Losses
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Losses
GO:0008519	ammonium transmembrane transporter activity	Losses
GO:0008238	exopeptidase activity	Losses
GO:0048037	cofactor binding	Losses
GO:0099589	serotonin receptor activity	Losses
GO:0004813	alanine-tRNA ligase activity	Losses
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	Losses
GO:0004993	G-protein coupled serotonin receptor activity	Losses
GO:0030145	manganese ion binding	Losses
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	Losses
GO:0008484	sulfuric ester hydrolase activity	Extinctions
GO:0042834	peptidoglycan binding	Extinctions
GO:0009378	four-way junction helicase activity	Extinctions
GO:0008329	signaling pattern recognition receptor activity	Extinctions
GO:0038187	pattern recognition receptor activity	Extinctions
GO:0001530	lipopolysaccharide binding	Extinctions
GO:0016630	protochlorophyllide reductase activity	Extinctions
GO:0008289	lipid binding	Extinctions
GO:0030145	manganese ion binding	Extinctions
GO:0019842	vitamin binding	Extinctions
GO:0004813	alanine-tRNA ligase activity	Extinctions
GO:0016805	dipeptidase activity	Extinctions
GO:0008496	mannan endo-1,6-alpha-mannosidase activity	Extinctions
GO:0008482	sulfite oxidase activity	Extinctions
GO:0016019	peptidoglycan receptor activity	Extinctions
GO:0015485	cholesterol binding	Extinctions
GO:0016936	galactoside binding	Extinctions
GO:0015145	monosaccharide transmembrane transporter activity	Extinctions
GO:0015149	hexose transmembrane transporter activity	Extinctions
GO:0004423	iduronate-2-sulfatase activity	Extinctions
GO:0004411	homogentisate 1,2-dioxygenase activity	Extinctions
GO:0003868	4-hydroxyphenylpyruvate dioxygenase activity	Extinctions
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	Extinctions
GO:0015248	sterol transporter activity	Extinctions
GO:0008760	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity	Extinctions
GO:0008743	L-threonine 3-dehydrogenase activity	Extinctions
GO:0008881	glutamate racemase activity	Extinctions
GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	Extinctions
GO:0016160	amylase activity	Extinctions
GO:0032500	muramyl dipeptide binding	Extinctions
GO:0004769	steroid delta-isomerase activity	Extinctions
GO:0015578	mannose transmembrane transporter activity	Extinctions
GO:0016250	N-sulfoglucosamine sulfohydrolase activity	Extinctions
GO:0000254	C-4 methylsterol oxidase activity	Extinctions
GO:0004844	uracil DNA N-glycosylase activity	Extinctions
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	Extinctions
GO:0005537	mannose binding	Extinctions
GO:0004556	alpha-amylase activity	Extinctions
GO:0045552	dihydrokaempferol 4-reductase activity	Extinctions
GO:0001875	lipopolysaccharide receptor activity	Extinctions
GO:0016826	hydrolase activity, acting on acid sulfur-nitrogen bonds	Extinctions
GO:0050080	malonyl-CoA decarboxylase activity	Extinctions
GO:0035237	corazonin receptor activity	Extinctions
GO:0017127	cholesterol transporter activity	Extinctions
GO:0005031	tumor necrosis factor-activated receptor activity	Extinctions
GO:0005035	death receptor activity	Extinctions
GO:0004092	carnitine O-acetyltransferase activity	Extinctions
GO:0004053	arginase activity	Extinctions
GO:0070547	L-tyrosine aminotransferase activity	Extinctions
GO:0097506	deaminated base DNA N-glycosylase activity	Extinctions
GO:0005539	glycosaminoglycan binding	Extinctions