GO:0008235	metalloexopeptidase activity	Gains
GO:0003954	NADH dehydrogenase activity	Gains
GO:0016651	oxidoreductase activity, acting on NAD(P)H	Gains
GO:0001637	G-protein coupled chemoattractant receptor activity	Gains
GO:0004950	chemokine receptor activity	Gains
GO:0050136	NADH dehydrogenase (quinone) activity	Gains
GO:0008137	NADH dehydrogenase (ubiquinone) activity	Gains
GO:0004896	cytokine receptor activity	Gains
GO:0016491	oxidoreductase activity	Gains
GO:0019104	DNA N-glycosylase activity	Gains
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Gains
GO:0020037	heme binding	Gains
GO:0046906	tetrapyrrole binding	Gains
GO:0071855	neuropeptide receptor binding	Gains
GO:0016209	antioxidant activity	Gains
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Gains
GO:0016615	malate dehydrogenase activity	Gains
GO:0004722	protein serine/threonine phosphatase activity	Gains
GO:0016831	carboxy-lyase activity	Gains
GO:0015081	sodium ion transmembrane transporter activity	Gains
GO:0015296	anion:cation symporter activity	Gains
GO:0005272	sodium channel activity	Gains
GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	Gains
GO:0004351	glutamate decarboxylase activity	Gains
GO:0043733	DNA-3-methylbase glycosylase activity	Gains
GO:0050080	malonyl-CoA decarboxylase activity	Gains
GO:0008725	DNA-3-methyladenine glycosylase activity	Gains
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Gains
GO:0004157	dihydropyrimidinase activity	Gains
GO:0008836	diaminopimelate decarboxylase activity	Gains
GO:0004149	dihydrolipoyllysine-residue succinyltransferase activity	Gains
GO:0008511	sodium:potassium:chloride symporter activity	Gains
GO:0008515	sucrose transmembrane transporter activity	Gains
GO:0004782	sulfinoalanine decarboxylase activity	Gains
GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity	Gains
GO:0016751	S-succinyltransferase activity	Gains
GO:0004586	ornithine decarboxylase activity	Gains
GO:0043916	DNA-7-methylguanine glycosylase activity	Gains
GO:0003943	N-acetylgalactosamine-4-sulfatase activity	Gains
GO:0004507	steroid 11-beta-monooxygenase activity	Gains
GO:0003905	alkylbase DNA N-glycosylase activity	Gains
GO:0004642	phosphoribosylformylglycinamidine synthase activity	Gains
GO:0000700	mismatch base pair DNA N-glycosylase activity	Gains
GO:0030586	[methionine synthase] reductase activity	Gains
GO:0004096	catalase activity	Gains
GO:0004068	aspartate 1-decarboxylase activity	Gains
GO:0047749	cholestanetriol 26-monooxygenase activity	Gains
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	Gains
GO:0052821	DNA-7-methyladenine glycosylase activity	Gains
GO:0052822	DNA-3-methylguanine glycosylase activity	Gains
GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Gains
GO:0005415	nucleoside:sodium symporter activity	Gains
GO:0004397	histidine ammonia-lyase activity	Gains
GO:0004601	peroxidase activity	Gains
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Gains
GO:0008237	metallopeptidase activity	Gains
GO:0015294	solute:cation symporter activity	Gains
GO:0004866	endopeptidase inhibitor activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0140097	catalytic activity, acting on DNA	Losses
GO:0046914	transition metal ion binding	Losses
GO:0003676	nucleic acid binding	Losses
GO:0008270	zinc ion binding	Losses
GO:0003677	DNA binding	Losses
GO:0004519	endonuclease activity	Losses
GO:0046872	metal ion binding	Losses
GO:0043169	cation binding	Losses
GO:0031267	small GTPase binding	Losses
GO:0004518	nuclease activity	Losses
GO:0017016	Ras GTPase binding	Losses
GO:0017137	Rab GTPase binding	Losses
GO:0051020	GTPase binding	Losses
GO:0043015	gamma-tubulin binding	Losses
GO:0004435	phosphatidylinositol phospholipase C activity	Losses
GO:0004629	phospholipase C activity	Losses
GO:1901363	heterocyclic compound binding	Losses
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
GO:0097159	organic cyclic compound binding	Losses
GO:0015085	calcium ion transmembrane transporter activity	Losses
GO:0070001	aspartic-type peptidase activity	Losses
GO:0004190	aspartic-type endopeptidase activity	Losses
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
GO:0072509	divalent inorganic cation transmembrane transporter activity	Losses
GO:0005262	calcium channel activity	Losses
GO:0008172	S-methyltransferase activity	Losses
GO:0034062	5'-3' RNA polymerase activity	Losses
GO:0097747	RNA polymerase activity	Losses
GO:0004984	olfactory receptor activity	Losses
GO:0005488	binding	Losses
GO:0005549	odorant binding	Losses
GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
GO:0005088	Ras guanyl-nucleotide exchange factor activity	Losses
GO:0005245	voltage-gated calcium channel activity	Losses
GO:0004521	endoribonuclease activity	Losses
GO:0004185	serine-type carboxypeptidase activity	Losses
GO:0017034	Rap guanyl-nucleotide exchange factor activity	Losses
GO:0008525	phosphatidylcholine transporter activity	Losses
GO:0004809	tRNA (guanine-N2-)-methyltransferase activity	Losses
GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	Losses
GO:0050824	water binding	Losses
GO:0050825	ice binding	Losses
GO:0016906	sterol 3-beta-glucosyltransferase activity	Losses
GO:0048365	Rac GTPase binding	Losses
GO:0030676	Rac guanyl-nucleotide exchange factor activity	Losses
GO:0016769	transferase activity, transferring nitrogenous groups	Losses
GO:0008483	transaminase activity	Losses
GO:0004857	enzyme inhibitor activity	Losses
GO:0019899	enzyme binding	Losses
GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
GO:0046906	tetrapyrrole binding	Losses
GO:0005506	iron ion binding	Losses
GO:0015631	tubulin binding	Losses
GO:0042302	structural constituent of cuticle	Losses
GO:0004497	monooxygenase activity	Losses
GO:0019842	vitamin binding	Losses
GO:0030414	peptidase inhibitor activity	Losses
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Losses
GO:0061134	peptidase regulator activity	Losses
GO:0003678	DNA helicase activity	Losses
GO:0005085	guanyl-nucleotide exchange factor activity	Losses
GO:0020037	heme binding	Losses
GO:0003676	nucleic acid binding	Extinctions
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0016779	nucleotidyltransferase activity	Extinctions
GO:0034061	DNA polymerase activity	Extinctions
GO:0003677	DNA binding	Extinctions
GO:0008270	zinc ion binding	Extinctions
GO:0046914	transition metal ion binding	Extinctions
GO:1901363	heterocyclic compound binding	Extinctions
GO:0097159	organic cyclic compound binding	Extinctions
GO:0140097	catalytic activity, acting on DNA	Extinctions
GO:0004984	olfactory receptor activity	Extinctions
GO:0004519	endonuclease activity	Extinctions
GO:0004518	nuclease activity	Extinctions
GO:0004857	enzyme inhibitor activity	Extinctions
GO:0034062	5'-3' RNA polymerase activity	Extinctions
GO:0097747	RNA polymerase activity	Extinctions
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Extinctions
GO:0008527	taste receptor activity	Extinctions
GO:0043015	gamma-tubulin binding	Extinctions
GO:0005184	neuropeptide hormone activity	Extinctions
GO:0004549	tRNA-specific ribonuclease activity	Extinctions
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Extinctions
GO:0005549	odorant binding	Extinctions
GO:0017137	Rab GTPase binding	Extinctions
GO:0070001	aspartic-type peptidase activity	Extinctions
GO:0004190	aspartic-type endopeptidase activity	Extinctions
GO:0051427	hormone receptor binding	Extinctions
GO:0005179	hormone activity	Extinctions
GO:0030291	protein serine/threonine kinase inhibitor activity	Extinctions
GO:0061134	peptidase regulator activity	Extinctions
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions