GO:0016783	sulfurtransferase activity	Gains
GO:0005215	transporter activity	Gains
GO:0022892	substrate-specific transporter activity	Gains
GO:0022891	substrate-specific transmembrane transporter activity	Gains
GO:0022857	transmembrane transporter activity	Gains
GO:0016782	transferase activity, transferring sulfur-containing groups	Gains
GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	Gains
GO:0008603	cAMP-dependent protein kinase regulator activity	Gains
GO:0004690	cyclic nucleotide-dependent protein kinase activity	Gains
GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	Gains
GO:0004837	tyrosine decarboxylase activity	Gains
GO:0004808	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	Gains
GO:0015075	ion transmembrane transporter activity	Gains
GO:0016615	malate dehydrogenase activity	Gains
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Gains
GO:0051540	metal cluster binding	Gains
GO:0051536	iron-sulfur cluster binding	Gains
GO:0048037	cofactor binding	Gains
GO:0008233	peptidase activity	Gains
GO:0004692	cGMP-dependent protein kinase activity	Gains
GO:0030594	neurotransmitter receptor activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0061783	peptidoglycan muralytic activity	Gains
GO:0015291	secondary active transmembrane transporter activity	Gains
GO:0046592	polyamine oxidase activity	Gains
GO:0008177	succinate dehydrogenase (ubiquinone) activity	Gains
GO:0004185	serine-type carboxypeptidase activity	Gains
GO:0030060	L-malate dehydrogenase activity	Gains
GO:0046872	metal ion binding	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Gains
GO:0010181	FMN binding	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
GO:0043169	cation binding	Gains
GO:0042302	structural constituent of cuticle	Gains
GO:0015293	symporter activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0016307	phosphatidylinositol phosphate kinase activity	Gains
GO:0015267	channel activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	Gains
GO:0051287	NAD binding	Gains
GO:0048038	quinone binding	Gains
GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	Gains
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	Gains
GO:0070008	serine-type exopeptidase activity	Gains
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	Gains
GO:0003810	protein-glutamine gamma-glutamyltransferase activity	Gains
GO:0004792	thiosulfate sulfurtransferase activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0005216	ion channel activity	Gains
GO:0005085	guanyl-nucleotide exchange factor activity	Gains
GO:0017112	Rab guanyl-nucleotide exchange factor activity	Gains
GO:0005328	neurotransmitter:sodium symporter activity	Gains
GO:0005088	Ras guanyl-nucleotide exchange factor activity	Gains
GO:0004970	ionotropic glutamate receptor activity	Gains
GO:0022824	transmitter-gated ion channel activity	Gains
GO:0022835	transmitter-gated channel activity	Gains
GO:0004180	carboxypeptidase activity	Losses
GO:0030594	neurotransmitter receptor activity	Losses
GO:0004181	metallocarboxypeptidase activity	Losses
GO:0008238	exopeptidase activity	Losses
GO:0008270	zinc ion binding	Losses
GO:0003676	nucleic acid binding	Losses
GO:0061542	3-demethylubiquinone-n 3-O-methyltransferase activity	Losses
GO:0033971	hydroxyisourate hydrolase activity	Losses
GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity	Losses
GO:0010420	polyprenyldihydroxybenzoate methyltransferase activity	Losses
GO:0004747	ribokinase activity	Losses
GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity	Losses
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Losses
GO:0047936	glucose 1-dehydrogenase [NAD(P)] activity	Losses
GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	Losses
GO:0050038	L-xylulose reductase (NADP+) activity	Losses
GO:0070011	peptidase activity, acting on L-amino acid peptides	Losses
GO:0004386	helicase activity	Losses
GO:0003678	DNA helicase activity	Losses
GO:0043958	acryloyl-CoA reductase activity	Losses
GO:0004971	AMPA glutamate receptor activity	Losses
GO:0008425	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	Losses
GO:0008169	C-methyltransferase activity	Losses
GO:0016084	myostimulatory hormone activity	Losses
GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Losses
GO:0019788	NEDD8 transferase activity	Losses
GO:0030580	quinone cofactor methyltransferase activity	Losses
GO:0000403	Y-form DNA binding	Losses
GO:0003933	GTP cyclohydrolase activity	Losses
GO:0003934	GTP cyclohydrolase I activity	Losses
GO:0033814	propanoyl-CoA C-acyltransferase activity	Losses
GO:0004197	cysteine-type endopeptidase activity	Losses
GO:0046914	transition metal ion binding	Losses
GO:0008235	metalloexopeptidase activity	Losses
GO:0004970	ionotropic glutamate receptor activity	Losses
GO:0022824	transmitter-gated ion channel activity	Losses
GO:0022835	transmitter-gated channel activity	Losses
GO:0005234	extracellularly glutamate-gated ion channel activity	Losses
GO:0004972	NMDA glutamate receptor activity	Losses
GO:0030798	trans-aconitate 2-methyltransferase activity	Losses
GO:0004185	serine-type carboxypeptidase activity	Losses
GO:0003681	bent DNA binding	Losses
GO:0008613	diuretic hormone activity	Losses
GO:0009922	fatty acid elongase activity	Losses
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Losses
GO:0008066	glutamate receptor activity	Losses
GO:0008233	peptidase activity	Losses
GO:0033549	MAP kinase phosphatase activity	Losses
GO:0070008	serine-type exopeptidase activity	Losses
GO:0099528	G-protein coupled neurotransmitter receptor activity	Losses
GO:0015464	acetylcholine receptor activity	Losses
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	Losses
GO:0019238	cyclohydrolase activity	Losses
GO:0043138	3'-5' DNA helicase activity	Losses
GO:0016907	G-protein coupled acetylcholine receptor activity	Losses
GO:0005154	epidermal growth factor receptor binding	Losses
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Losses
GO:0000217	DNA secondary structure binding	Losses
GO:0033971	hydroxyisourate hydrolase activity	Extinctions
GO:0004971	AMPA glutamate receptor activity	Extinctions
GO:0016084	myostimulatory hormone activity	Extinctions
GO:0003933	GTP cyclohydrolase activity	Extinctions
GO:0003934	GTP cyclohydrolase I activity	Extinctions
GO:0004180	carboxypeptidase activity	Extinctions
GO:0004386	helicase activity	Extinctions
GO:0004972	NMDA glutamate receptor activity	Extinctions
GO:0004185	serine-type carboxypeptidase activity	Extinctions
GO:0003681	bent DNA binding	Extinctions
GO:0008613	diuretic hormone activity	Extinctions
GO:0005261	cation channel activity	Extinctions
GO:0070008	serine-type exopeptidase activity	Extinctions
GO:0019238	cyclohydrolase activity	Extinctions
GO:0005244	voltage-gated ion channel activity	Extinctions
GO:0022832	voltage-gated channel activity	Extinctions
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	Extinctions
GO:0071855	neuropeptide receptor binding	Extinctions
GO:0003676	nucleic acid binding	Extinctions
GO:0003678	DNA helicase activity	Extinctions