EOG876NFT	GO:0003676	52/239	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG876NFT	GO:0046872	1/239	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG876NFT	GO:0005634	1/239	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG876NFT	GO:0003677	1/239	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8M3CPP	GO:0004066	31/97	asparagine synthase (glutamine-hydrolyzing) activity	molecular_function	"Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4]
EOG8M3CPP	GO:0070981	27/97	L-asparagine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [CHEBI:17196, GOC:mah]
EOG8M3CPP	GO:0005524	27/97	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8M3CPP	GO:0006529	4/97	asparagine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]
EOG8M3CPP	GO:0008152	1/97	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8XKXMT	GO:0004222	23/97	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8XKXMT	GO:0008270	16/97	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XKXMT	GO:0008237	1/97	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8XKXMT	GO:0008593	1/97	regulation of Notch signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8XKXMT	GO:0006509	1/97	membrane protein ectodomain proteolysis	biological_process	"The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/]
EOG8PG8JC	GO:0003676	3/19	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8PG8JC	GO:0004523	3/19	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG822CZV	GO:0016021	46/145	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG822CZV	GO:0055085	39/145	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG822CZV	GO:0022857	7/145	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG822CZV	GO:0046331	1/145	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG822CZV	GO:0003676	1/145	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG822CZV	GO:0016298	1/145	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG822CZV	GO:0008270	1/145	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG822CZV	GO:0006629	1/145	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8XSP5F	GO:0016780	18/41	phosphotransferase activity, for other substituted phosphate groups	molecular_function	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]
EOG8XSP5F	GO:0008654	18/41	phospholipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8XSP5F	GO:0016020	17/41	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XSP5F	GO:0005886	1/41	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8XSP5F	GO:0000139	1/41	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8XSP5F	GO:0006665	1/41	sphingolipid metabolic process	biological_process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]
EOG8XSP5F	GO:0016021	1/41	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG841SSX	GO:0009055	1/59	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG841SSX	GO:0051536	1/59	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG81RS7Z	GO:0016740	46/887	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG81RS7Z	GO:0004364	41/887	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG81RS7Z	GO:0006749	24/887	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG81RS7Z	GO:0018833	4/887	DDT-dehydrochlorinase activity	molecular_function	"Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)." [EC:4.5.1.1, RHEA:19220]
EOG81RS7Z	GO:0005515	2/887	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG81RS7Z	GO:0005576	2/887	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG81RS7Z	GO:0004602	2/887	glutathione peroxidase activity	molecular_function	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9]
EOG81RS7Z	GO:0009408	1/887	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG81RS7Z	GO:0055114	1/887	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG81RS7Z	GO:0022008	1/887	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG81RS7Z	GO:0008152	1/887	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8Q2GX1	GO:0005576	12/50	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Q2GX1	GO:0009755	1/50	hormone-mediated signaling pathway	biological_process	"A series of molecular signals mediated by the detection of a hormone." [GOC:sm]
EOG8Q2GX1	GO:0046982	1/50	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8Q2GX1	GO:0005615	1/50	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8KSS1K	GO:0003676	2/189	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8KSS1K	GO:0015074	1/189	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG88WFGK	GO:0004056	22/73	argininosuccinate lyase activity	molecular_function	"Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine." [EC:4.3.2.1]
EOG88WFGK	GO:0042450	22/73	arginine biosynthetic process via ornithine	biological_process	"The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine." [GOC:jl]
EOG88WFGK	GO:0005524	2/73	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88WFGK	GO:0016887	2/73	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG88WFGK	GO:0016020	1/73	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG88WFGK	GO:0005215	1/73	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8R267T	GO:0003676	3/40	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8R267T	GO:0008270	2/40	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8R267T	GO:0005634	2/40	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8R267T	GO:0046872	1/40	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8X3KGV	GO:0005509	8/38	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8X3KGV	GO:0007229	1/38	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG893624	GO:0008023	3/22	transcription elongation factor complex	cellular_component	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]
EOG893624	GO:0006368	3/22	transcription elongation from RNA polymerase II promoter	biological_process	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
EOG8DRCTF	GO:0050353	18/85	trimethyllysine dioxygenase activity	molecular_function	"Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate." [EC:1.14.11.8, RHEA:14184]
EOG8DRCTF	GO:0045329	18/85	carnitine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]
EOG8DRCTF	GO:0031418	18/85	L-ascorbic acid binding	molecular_function	"Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]
EOG8DRCTF	GO:0005506	18/85	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8DRCTF	GO:0003676	6/85	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DRCTF	GO:0016491	2/85	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8DRCTF	GO:0051213	2/85	dioxygenase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf, http://www.onelook.com/]
EOG8DRCTF	GO:0008336	1/85	gamma-butyrobetaine dioxygenase activity	molecular_function	"Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate." [EC:1.14.11.1, RHEA:24031]
EOG8NGK30	GO:0016491	28/91	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8NGK30	GO:0050221	1/91	prostaglandin-E2 9-reductase activity	molecular_function	"Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH." [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN]
EOG818F3J	GO:0004252	11/36	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG82VBX8	GO:0005215	5/52	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG82VBX8	GO:0005622	5/52	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8XPSZV	GO:0003677	197/409	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XPSZV	GO:0000786	197/409	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8XPSZV	GO:0006334	197/409	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8XPSZV	GO:0005634	196/409	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XPSZV	GO:0032008	25/409	positive regulation of TOR signaling	biological_process	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8XPSZV	GO:0071230	25/409	cellular response to amino acid stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:mah]
EOG8XPSZV	GO:0032439	22/409	endosome localization	biological_process	"Any process in which endosomes are transported to, and/or maintained in, a specific location within the cell." [GOC:ecd]
EOG8XPSZV	GO:0007040	22/409	lysosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]
EOG8XPSZV	GO:0001919	22/409	regulation of receptor recycling	biological_process	"Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add]
EOG8XPSZV	GO:0071986	22/409	Ragulator complex	cellular_component	"A protein complex that contains MAPKSP1 (MP1, Map2k1ip1), ROBLD3 (p14, Mapbpip), C11orf59 (p18), LAMTOR4 and LAMTOR5. The complex is anchored to lipid rafts in late endosome membranes via C11orf59, recruits mTORC1 to lysosomal membranes in amino acid signaling to mTORC1, constitutes a guanine nucleotide exchange factor (GEF) for the Rag GTPases, and is also involved in ERK/MAPK signaling." [GOC:lb, PMID:19177150, PMID:20381137, PMID:22980980]
EOG8XPSZV	GO:0042632	22/409	cholesterol homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]
EOG8XPSZV	GO:0043410	22/409	positive regulation of MAPK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]
EOG8XPSZV	GO:0031902	3/409	late endosome membrane	cellular_component	"The lipid bilayer surrounding a late endosome." [GOC:pz]
EOG8XPSZV	GO:0003964	1/409	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8XPSZV	GO:0003723	1/409	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8FJBQJ	GO:0004064	2/99	arylesterase activity	molecular_function	"Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2]
EOG8FJBQJ	GO:0016021	1/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FJBQJ	GO:1901739	1/99	regulation of myoblast fusion	biological_process	"Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]
EOG86HJRS	GO:0019318	76/195	hexose metabolic process	biological_process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
EOG86HJRS	GO:0030246	76/195	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG86HJRS	GO:0004034	60/195	aldose 1-epimerase activity	molecular_function	"Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3]
EOG86HJRS	GO:0016853	16/195	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG86HJRS	GO:0005576	1/195	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8W3W1S	GO:0007156	53/168	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8W3W1S	GO:0005509	53/168	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8W3W1S	GO:0005886	52/168	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8W3W1S	GO:0016021	52/168	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W3W1S	GO:0030286	3/168	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8W3W1S	GO:0003777	3/168	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8W3W1S	GO:0007018	3/168	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8W3W1S	GO:0001539	3/168	cilium or flagellum-dependent cell motility	biological_process	"Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc]
EOG8W3W1S	GO:0030031	3/168	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG8W3W1S	GO:0050839	2/168	cell adhesion molecule binding	molecular_function	"Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai]
EOG8W3W1S	GO:0016339	2/168	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
EOG8W3W1S	GO:0004872	2/168	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8W3W1S	GO:0048846	2/168	axon extension involved in axon guidance	biological_process	"The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jid]
EOG8W3W1S	GO:0005887	2/168	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W3W1S	GO:0004022	2/168	alcohol dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
EOG8W3W1S	GO:0045463	2/168	R8 cell development	biological_process	"The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium." [PMID:11880339]
EOG8W3W1S	GO:0045467	2/168	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8W3W1S	GO:0016318	2/168	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG8W3W1S	GO:0030425	1/168	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8W3W1S	GO:0004725	1/168	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8W3W1S	GO:0007413	1/168	axonal fasciculation	biological_process	"The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh]
EOG8W3W1S	GO:0008013	1/168	beta-catenin binding	molecular_function	"Interacting selectively and non-covalently with the beta subunit of the catenin complex." [GOC:bf]
EOG8W3W1S	GO:0030424	1/168	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8W3W1S	GO:0045296	1/168	cadherin binding	molecular_function	"Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]
EOG8W3W1S	GO:0005515	1/168	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8W3W1S	GO:0050774	1/168	negative regulation of dendrite morphogenesis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG8W3W1S	GO:0007412	1/168	axon target recognition	biological_process	"The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437]
EOG8W3W1S	GO:0005911	1/168	cell-cell junction	cellular_component	"A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah]
EOG8W3W1S	GO:0031290	1/168	retinal ganglion cell axon guidance	biological_process	"The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs]
EOG8W3W1S	GO:0048814	1/168	regulation of dendrite morphogenesis	biological_process	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG8W3W1S	GO:0007411	1/168	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8W3W1S	GO:0048841	1/168	regulation of axon extension involved in axon guidance	biological_process	"Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]
EOG8W3W1S	GO:0042803	1/168	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8W3W1S	GO:0048675	1/168	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG8W3W1S	GO:0044331	1/168	cell-cell adhesion mediated by cadherin	biological_process	"The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains." [GOC:ha, GOC:hjd, GOC:jl, PMID:10923970]
EOG83XXJF	GO:0016021	8/30	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83XXJF	GO:0005506	8/30	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG83XXJF	GO:0006633	8/30	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG83XXJF	GO:0016491	8/30	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG87DCWX	GO:0016787	125/753	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG87DCWX	GO:0003990	29/753	acetylcholinesterase activity	molecular_function	"Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
EOG87DCWX	GO:0052689	10/753	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG87DCWX	GO:0004104	5/753	cholinesterase activity	molecular_function	"Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8]
EOG87DCWX	GO:0005576	3/753	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG87DCWX	GO:0005524	1/753	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87DCWX	GO:0006730	1/753	one-carbon metabolic process	biological_process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
EOG87DCWX	GO:0004013	1/753	adenosylhomocysteinase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1]
EOG87DCWX	GO:0003677	1/753	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG87DCWX	GO:0016021	1/753	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87DCWX	GO:0006260	1/753	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8ZPHCG	GO:0015074	1/9	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8ZPHCG	GO:0003676	1/9	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QRKHT	GO:0005524	22/59	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QRKHT	GO:0016021	22/59	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QRKHT	GO:0004672	21/59	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8QRKHT	GO:0035556	21/59	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8QRKHT	GO:0004383	20/59	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG8QRKHT	GO:0000226	1/59	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8QRKHT	GO:0016849	1/59	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG8QRKHT	GO:0005525	1/59	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8QRKHT	GO:0005815	1/59	microtubule organizing center	cellular_component	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416]
EOG8QRKHT	GO:0004872	1/59	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8QRKHT	GO:0005887	1/59	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QRKHT	GO:0009190	1/59	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG8QRKHT	GO:0016772	1/59	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8QRKHT	GO:0004930	1/59	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8QRKHT	GO:0000922	1/59	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8QRKHT	GO:0006182	1/59	cGMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]
EOG8VX4NB	GO:0043565	25/89	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8VX4NB	GO:0005634	25/89	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VX4NB	GO:0003700	25/89	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8VX4NB	GO:0035071	1/89	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8VX4NB	GO:0060322	1/89	head development	biological_process	"The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph]
EOG8VX4NB	GO:0042803	1/89	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8VX4NB	GO:0046982	1/89	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8VX4NB	GO:0045944	1/89	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8VX4NB	GO:0048102	1/89	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG87DCWN	GO:0016772	137/261	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8PRW77	GO:0003796	126/416	lysozyme activity	molecular_function	"Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17]
EOG8PRW77	GO:0016998	121/416	cell wall macromolecule catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators]
EOG8PRW77	GO:0016021	20/416	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PRW77	GO:0005886	10/416	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8PRW77	GO:0006811	10/416	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8PRW77	GO:0005230	10/416	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8PRW77	GO:0019835	9/416	cytolysis	biological_process	"The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204]
EOG8PRW77	GO:0042742	8/416	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8PRW77	GO:0030054	8/416	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8PRW77	GO:0045202	8/416	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8PRW77	GO:0048102	1/416	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8PRW77	GO:0035071	1/416	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8PRW77	GO:0050829	1/416	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8PRW77	GO:0032504	1/416	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8PRW77	GO:0004568	1/416	chitinase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
EOG8PRW77	GO:0005615	1/416	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8PRW77	GO:0045824	1/416	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG83FKCS	GO:0006813	1/15	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG83FKCS	GO:0005890	1/15	sodium:potassium-exchanging ATPase complex	cellular_component	"Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732]
EOG83FKCS	GO:0006814	1/15	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG83FKCS	GO:0005509	1/15	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG870WZ4	GO:0005634	4/18	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG870WZ4	GO:0006351	4/18	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG870WZ4	GO:0003677	4/18	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG870WZ4	GO:0005667	4/18	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG870WZ4	GO:0003700	4/18	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG87H867	GO:0003723	6/322	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG87H867	GO:0003964	6/322	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8CNT5M	GO:0007165	8/439	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8CNT5M	GO:0016021	1/439	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CNT5M	GO:0022891	1/439	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8CNT5M	GO:0006909	1/439	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8CNT5M	GO:0035330	1/439	regulation of hippo signaling	biological_process	"Any process that modulates the frequency, rate or extent of hippo signaling." [GOC:bf]
EOG8CNT5M	GO:0031410	1/439	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG8RJJG5	GO:0005886	49/215	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8RJJG5	GO:0016021	49/215	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RJJG5	GO:0050909	49/215	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8RJJG5	GO:0003031	2/215	detection of carbon dioxide	biological_process	"The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
EOG8RJJG5	GO:0007608	2/215	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8RJJG5	GO:0050912	2/215	detection of chemical stimulus involved in sensory perception of taste	biological_process	"The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8RJJG5	GO:0010037	2/215	response to carbon dioxide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:sm]
EOG8RJJG5	GO:0008527	2/215	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8RJJG5	GO:0007610	2/215	behavior	biological_process	"The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
EOG8RJJG5	GO:0043025	1/215	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8RJJG5	GO:0030425	1/215	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8RJJG5	GO:0008340	1/215	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8VMHWR	GO:0003884	17/86	D-amino-acid oxidase activity	molecular_function	"Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.3]
EOG8VMHWR	GO:0016641	7/86	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]
EOG8VMHWR	GO:0008445	4/86	D-aspartate oxidase activity	molecular_function	"Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide." [EC:1.4.3.1]
EOG8VMHWR	GO:0005777	1/86	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8S4RWK	GO:0016798	25/117	hydrolase activity, acting on glycosyl bonds	molecular_function	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]
EOG8S4RWK	GO:0016020	25/117	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8S4RWK	GO:0005975	4/117	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8S4RWK	GO:0015991	2/117	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8S4RWK	GO:0015078	2/117	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG8S4RWK	GO:0033179	2/117	proton-transporting V-type ATPase, V0 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG8S4RWK	GO:0005811	1/117	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8CC6JD	GO:0008270	4/52	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CC6JD	GO:0005634	4/52	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CC6JD	GO:0046872	1/52	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CC6JD	GO:0016568	1/52	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG8X99XM	GO:0016021	24/72	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZKN1X	GO:0006807	72/199	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG8ZKN1X	GO:0016811	72/199	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]
EOG8ZKN1X	GO:0004435	2/199	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8ZKN1X	GO:0035556	2/199	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8ZKN1X	GO:0006629	2/199	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8ZKN1X	GO:0071110	1/199	histone biotinylation	biological_process	"The modification of a histone by the addition of a biotinyl group." [GOC:rph, PMID:14613969, PMID:19019041]
EOG8ZKN1X	GO:0019898	1/199	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8ZKN1X	GO:0016787	1/199	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8ZKN1X	GO:0009408	1/199	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8ZKN1X	GO:0017159	1/199	pantetheine hydrolase activity	molecular_function	"Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine." [EC:3.5.1.92, RHEA:13448]
EOG8ZKN1X	GO:0018054	1/199	peptidyl-lysine biotinylation	biological_process	"The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117]
EOG8323D9	GO:0016021	19/98	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8323D9	GO:0004930	19/98	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8323D9	GO:0009881	8/98	photoreceptor activity	molecular_function	"The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators]
EOG8323D9	GO:0018298	8/98	protein-chromophore linkage	biological_process	"The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma]
EOG8323D9	GO:0007601	1/98	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8QFZZ1	GO:0003824	1/4	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG87SVX7	GO:0005549	9/26	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8BVV80	GO:0005509	1/68	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG86Q96V	GO:0016772	12/72	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8T1M3R	GO:0004521	39/92	endoribonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8T1M3R	GO:0009303	39/92	rRNA transcription	biological_process	"The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732]
EOG8T1M3R	GO:0016021	1/92	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8T1M3R	GO:0090502	1/92	RNA phosphodiester bond hydrolysis, endonucleolytic	biological_process	"The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
EOG8JQ6F4	GO:0007186	1/58	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8JQ6F4	GO:0005615	1/58	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8JQ6F4	GO:0001664	1/58	G-protein coupled receptor binding	molecular_function	"Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph]
EOG84N16G	GO:0005328	263/840	neurotransmitter:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
EOG84N16G	GO:0016021	251/840	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84N16G	GO:0003333	12/840	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG84N16G	GO:0005887	12/840	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84N16G	GO:0042940	11/840	D-amino acid transport	biological_process	"The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
EOG84N16G	GO:0042943	11/840	D-amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
EOG84N16G	GO:0005283	11/840	sodium:amino acid symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai]
EOG84N16G	GO:0015804	11/840	neutral amino acid transport	biological_process	"The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84N16G	GO:0015175	11/840	neutral amino acid transmembrane transporter activity	molecular_function	"Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG84N16G	GO:0006814	11/840	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84N16G	GO:0005326	7/840	neurotransmitter transporter activity	molecular_function	"Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732]
EOG84N16G	GO:0006836	7/840	neurotransmitter transport	biological_process	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]
EOG84N16G	GO:0005886	2/840	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG84N16G	GO:0019811	1/840	cocaine binding	molecular_function	"Interacting selectively and non-covalently with cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis." [GOC:jl, ISBN:0198506732]
EOG84N16G	GO:0015872	1/840	dopamine transport	biological_process	"The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
EOG84N16G	GO:0015222	1/840	serotonin transmembrane transporter activity	molecular_function	"Enables the transfer of serotonin from one side of the membrane to the other. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
EOG84N16G	GO:0004181	1/840	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG84N16G	GO:0015179	1/840	L-amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
EOG84N16G	GO:0030431	1/840	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG84N16G	GO:0042745	1/840	circadian sleep/wake cycle	biological_process	"The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com]
EOG84N16G	GO:0043679	1/840	axon terminus	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl]
EOG84N16G	GO:0015807	1/840	L-amino acid transport	biological_process	"The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah]
EOG84N16G	GO:0006909	1/840	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG84N16G	GO:0010226	1/840	response to lithium ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:tb]
EOG84N16G	GO:1902475	1/840	L-alpha-amino acid transmembrane transport	biological_process	"The directed movement of L-alpha-amino acid across a membrane." [GOC:kmv, GOC:TermGenie, PMID:14668347]
EOG84N16G	GO:0005416	1/840	cation:amino acid symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai]
EOG84N16G	GO:0046872	1/840	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84N16G	GO:0005261	1/840	cation channel activity	molecular_function	"Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG84N16G	GO:0030424	1/840	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG84N16G	GO:0008270	1/840	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84N16G	GO:0015844	1/840	monoamine transport	biological_process	"The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:25375, GOC:mah]
EOG84N16G	GO:0051610	1/840	serotonin uptake	biological_process	"The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
EOG84N16G	GO:0006837	1/840	serotonin transport	biological_process	"The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
EOG84N16G	GO:0008504	1/840	monoamine transmembrane transporter activity	molecular_function	"Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other." [CHEBI:25375, GOC:mah]
EOG84N16G	GO:0005329	1/840	dopamine transmembrane transporter activity	molecular_function	"Enables the transfer of dopamine from one side of the membrane to the other. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
EOG84N16G	GO:0007632	1/840	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG8RBT19	GO:0006479	4/48	protein methylation	biological_process	"The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai]
EOG8RBT19	GO:0008168	4/48	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8RBT19	GO:0005737	2/48	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RBT19	GO:0008276	2/48	protein methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732]
EOG8JHFWR	GO:0005615	2/9	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG83JFN4	GO:0008270	14/61	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83JFN4	GO:0005680	13/61	anaphase-promoting complex	cellular_component	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]
EOG83JFN4	GO:0004842	12/61	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG83JFN4	GO:0031145	1/61	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [PMID:15380083]
EOG83JFN4	GO:0045842	1/61	positive regulation of mitotic metaphase/anaphase transition	biological_process	"Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
EOG83JFN4	GO:0000151	1/61	ubiquitin ligase complex	cellular_component	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
EOG83JFN4	GO:0090302	1/61	APC-Cdc20 complex activity	molecular_function	"A ubiquitin-protein ligase activity that increases the rate or extent of the metaphase to anaphase transition of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
EOG8PG8G2	GO:0016021	3/24	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8284FJ	GO:0016020	22/160	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8284FJ	GO:0015269	22/160	calcium-activated potassium channel activity	molecular_function	"Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]
EOG8284FJ	GO:0006813	2/160	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8284FJ	GO:0005515	1/160	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8284FJ	GO:0071805	1/160	potassium ion transmembrane transport	biological_process	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
EOG8284FJ	GO:0008076	1/160	voltage-gated potassium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
EOG8284FJ	GO:0043005	1/160	neuron projection	cellular_component	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
EOG8284FJ	GO:0060072	1/160	large conductance calcium-activated potassium channel activity	molecular_function	"Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729, PMID:17115074]
EOG8284FJ	GO:0045433	1/160	male courtship behavior, veined wing generated song production	biological_process	"The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
EOG8284FJ	GO:0048512	1/160	circadian behavior	biological_process	"The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr]
EOG8284FJ	GO:0043025	1/160	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8284FJ	GO:0005249	1/160	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8284FJ	GO:0007623	1/160	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG8284FJ	GO:0005886	1/160	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8284FJ	GO:0042493	1/160	response to drug	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl]
EOG8VHNNB	GO:0005319	1/21	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG8VHNNB	GO:0045735	1/21	nutrient reservoir activity	molecular_function	"Functions in the storage of nutritious substrates." [GOC:ai]
EOG8CNT86	GO:0016829	1/45	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8CNT86	GO:0046872	1/45	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CNT86	GO:0030170	1/45	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8CNT86	GO:0004252	1/45	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8CNT86	GO:0006520	1/45	cellular amino acid metabolic process	biological_process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]
EOG84J4ZX	GO:0046872	52/224	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84J4ZX	GO:0016787	45/224	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG84J4ZX	GO:0004177	13/224	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG84J4ZX	GO:0005829	1/224	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG84J4ZX	GO:0006508	1/224	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG84J4ZX	GO:0022008	1/224	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84J4ZX	GO:0070006	1/224	metalloaminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8H74RQ	GO:0016021	20/85	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8H74RQ	GO:0022857	19/85	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8H74RQ	GO:0008643	2/85	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8H74RQ	GO:0055085	1/85	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8H74RQ	GO:0005215	1/85	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG87M4F6	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87M4F6	GO:0007275	2/5	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG87M4F6	GO:0006511	2/5	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG87M4F6	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG847J8V	GO:0044237	22/163	cellular metabolic process	biological_process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
EOG847J8V	GO:0006412	16/163	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG847J8V	GO:0005840	16/163	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG847J8V	GO:0003735	16/163	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG847J8V	GO:0003743	3/163	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG847J8V	GO:0005829	1/163	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG847J8V	GO:0045947	1/163	negative regulation of translational initiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG847J8V	GO:0005737	1/163	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG847J8V	GO:0005085	1/163	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG847J8V	GO:0006413	1/163	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG847J8V	GO:0005851	1/163	eukaryotic translation initiation factor 2B complex	cellular_component	"A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375]
EOG847J8V	GO:0022008	1/163	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG847J8V	GO:0006446	1/163	regulation of translational initiation	biological_process	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG847J8V	GO:0043087	1/163	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG86X1QR	GO:0006954	3/25	inflammatory response	biological_process	"The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, GOC:mtg_15nov05, ISBN:0198506732]
EOG86X1QR	GO:0005576	3/25	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8VHNQ4	GO:0005509	4/15	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8JT2MP	GO:0008324	2/9	cation transmembrane transporter activity	molecular_function	"Enables the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
EOG8JT2MP	GO:0016021	2/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83R638	GO:0004930	5/30	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG83R638	GO:0016021	5/30	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V71XM	GO:0016491	1/39	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8CNT6C	GO:0003964	574/3445	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8CNT6C	GO:0003723	549/3445	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CNT6C	GO:0008270	159/3445	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CNT6C	GO:0003676	89/3445	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CNT6C	GO:0004523	26/3445	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8CNT6C	GO:0005198	8/3445	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8CNT6C	GO:0005882	8/3445	intermediate filament	cellular_component	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
EOG8CNT6C	GO:0004519	5/3445	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8CNT6C	GO:0003677	5/3445	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CNT6C	GO:0046872	4/3445	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CNT6C	GO:0015074	4/3445	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8CNT6C	GO:0016021	3/3445	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CNT6C	GO:0004871	2/3445	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8CNT6C	GO:0000166	1/3445	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8CNT6C	GO:0006310	1/3445	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8CNT6C	GO:0004555	1/3445	alpha,alpha-trehalase activity	molecular_function	"Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28]
EOG8CNT6C	GO:0016874	1/3445	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8CNT6C	GO:0005991	1/3445	trehalose metabolic process	biological_process	"The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]
EOG8CNT6C	GO:0016881	1/3445	acid-amino acid ligase activity	molecular_function	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
EOG8CNT6C	GO:0016020	1/3445	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CNT6C	GO:0005549	1/3445	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8CNT6C	GO:0005622	1/3445	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8CNT6C	GO:0005215	1/3445	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8CNT6C	GO:0080019	1/3445	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8CNT6C	GO:0003887	1/3445	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8CNT6C	GO:0016787	1/3445	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8CNT6C	GO:0022857	1/3445	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8CNT6C	GO:0004984	1/3445	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG88974K	GO:0003676	1/30	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG800405	GO:0005509	6/42	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8V71XT	GO:0003755	65/213	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8V71XT	GO:0006457	65/213	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8V71XT	GO:0000166	26/213	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8V71XT	GO:0003723	21/213	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8V71XT	GO:0003676	4/213	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V71XT	GO:0003729	1/213	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8V71XT	GO:0042277	1/213	peptide binding	molecular_function	"Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds." [GOC:jl]
EOG8V71XT	GO:0071013	1/213	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8V71XT	GO:0000398	1/213	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8V71XT	GO:0005829	1/213	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8V71XT	GO:0016853	1/213	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8V71XT	GO:0000413	1/213	protein peptidyl-prolyl isomerization	biological_process	"The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570]
EOG8V71XT	GO:0071011	1/213	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8V71XT	GO:0035071	1/213	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8V71XT	GO:0048102	1/213	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8V71XT	GO:0006909	1/213	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8V71XT	GO:0005515	1/213	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8V71XT	GO:0005875	1/213	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8FTZDZ	GO:0003677	24/147	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FTZDZ	GO:0005634	2/147	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FTZDZ	GO:0045197	1/147	establishment or maintenance of epithelial cell apical/basal polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]
EOG8FTZDZ	GO:0007427	1/147	epithelial cell migration, open tracheal system	biological_process	"The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8FTZDZ	GO:0007428	1/147	primary branching, open tracheal system	biological_process	"Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG8FTZDZ	GO:0006355	1/147	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8FTZDZ	GO:0035297	1/147	regulation of Malpighian tubule diameter	biological_process	"Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells." [PMID:9286684]
EOG8FTZDZ	GO:0007442	1/147	hindgut morphogenesis	biological_process	"The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
EOG8FTZDZ	GO:0016477	1/147	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG8FTZDZ	GO:0008258	1/147	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8FTZDZ	GO:0007426	1/147	tracheal outgrowth, open tracheal system	biological_process	"The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8FTZDZ	GO:0003700	1/147	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8FTZDZ	GO:0007010	1/147	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8FTZDZ	GO:0007424	1/147	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8FTZDZ	GO:0007431	1/147	salivary gland development	biological_process	"The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044]
EOG8FTZDZ	GO:0007443	1/147	Malpighian tubule morphogenesis	biological_process	"The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089]
EOG8FTZDZ	GO:0035149	1/147	lumen formation, open tracheal system	biological_process	"Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
EOG8FTZDZ	GO:0008360	1/147	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8FTZDZ	GO:0003676	1/147	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FTZDZ	GO:0046872	1/147	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8FTZDZ	GO:0007417	1/147	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8FTZDZ	GO:0007391	1/147	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8FTZDZ	GO:0061024	1/147	membrane organization	biological_process	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]
EOG8FTZDZ	GO:0008104	1/147	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8FTZDZ	GO:0007435	1/147	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8FTZDZ	GO:0008406	1/147	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG8GQSKT	GO:0003676	25/84	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GQSKT	GO:0046872	23/84	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GQSKT	GO:0008270	2/84	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GQSKT	GO:0005634	2/84	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8KSRZV	GO:0000502	4/102	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG8KSRZV	GO:0009987	1/102	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8KSRZV	GO:0006508	1/102	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8KSRZV	GO:0005838	1/102	proteasome regulatory particle	cellular_component	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]
EOG8KSRZV	GO:0008541	1/102	proteasome regulatory particle, lid subcomplex	cellular_component	"The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb]
EOG8KSRZV	GO:0022008	1/102	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8KSRZV	GO:0043161	1/102	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG85MQNG	GO:0016301	8/464	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG85MQNG	GO:0005576	3/464	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG85MQNG	GO:0004672	1/464	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG85MQNG	GO:0045297	1/464	post-mating behavior	biological_process	"The specific behavior of an organism following mating." [GOC:bf, GOC:pr]
EOG85MQNG	GO:0006468	1/464	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG85MQNG	GO:0004674	1/464	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8V19FS	GO:0016787	15/283	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8V19FS	GO:0050357	6/283	tropinesterase activity	molecular_function	"Catalysis of the reaction: atropine + H(2)O = H(+) + tropate + tropine." [EC:3.1.1.10, RHEA:23307]
EOG8V19FS	GO:0007275	1/283	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8V19FS	GO:0003676	1/283	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V19FS	GO:0017171	1/283	serine hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [Wikipedia:Serine_hydrolase]
EOG8V19FS	GO:0000166	1/283	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8V19FS	GO:0007586	1/283	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG8V19FS	GO:0008152	1/283	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8V19FS	GO:0009636	1/283	response to toxic substance	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr]
EOG8XSP61	GO:0003676	3/275	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XSP61	GO:0003677	2/275	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XSP61	GO:0015074	2/275	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8XSP61	GO:0003887	1/275	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8XSP61	GO:0000166	1/275	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG837TWK	GO:0004725	39/155	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG837TWK	GO:0003993	32/155	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG837TWK	GO:0005737	31/155	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG837TWK	GO:0004726	30/155	non-membrane spanning protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate." [EC:3.1.3.48]
EOG837TWK	GO:0006470	3/155	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG837TWK	GO:0035335	3/155	peptidyl-tyrosine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
EOG837TWK	GO:0003963	1/155	RNA-3'-phosphate cyclase activity	molecular_function	"Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4]
EOG8R2697	GO:0003723	1/31	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8R2697	GO:0003964	1/31	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8XSP6B	GO:0003676	57/550	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XSP6B	GO:0008270	55/550	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XSP6B	GO:0003723	11/550	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8XSP6B	GO:0003964	11/550	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8XSP6B	GO:0004190	5/550	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8XSP6B	GO:0005882	4/550	intermediate filament	cellular_component	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
EOG8XSP6B	GO:0005198	4/550	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8XSP6B	GO:0006355	1/550	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8XSP6B	GO:0016787	1/550	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8XSP6B	GO:0015074	1/550	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8XSP6B	GO:0005634	1/550	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TXF6D	GO:0006807	29/98	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG8TXF6D	GO:0016810	27/98	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
EOG8TXF6D	GO:0003837	3/98	beta-ureidopropionase activity	molecular_function	"Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6]
EOG8TXF6D	GO:0006208	1/98	pyrimidine nucleobase catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [CHEBI:26432, GOC:go_curators]
EOG8TXF6D	GO:0006207	1/98	'de novo' pyrimidine nucleobase biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]
EOG82NMF1	GO:0006457	36/136	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG82NMF1	GO:0046872	34/136	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82NMF1	GO:0009408	31/136	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG82NMF1	GO:0005524	31/136	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82NMF1	GO:0022008	1/136	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8CJXX9	GO:0003676	2/47	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QVFS2	GO:0050909	5/32	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8QVFS2	GO:0016021	5/32	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QVFS2	GO:0005886	5/32	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8M945K	GO:0050660	36/104	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8M945K	GO:0008812	33/104	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG8M945K	GO:0006066	33/104	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG8M945K	GO:0016614	4/104	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8M945K	GO:0004344	3/104	glucose dehydrogenase activity	molecular_function	"Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10]
EOG8M945K	GO:0016491	2/104	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8M945K	GO:0045455	2/104	ecdysteroid metabolic process	biological_process	"The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732]
EOG8M945K	GO:0007498	1/104	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8X0Q8B	GO:0003676	11/65	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X0Q8B	GO:0000166	11/65	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8X0Q8B	GO:0030529	2/65	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8X0Q8B	GO:0019013	2/65	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8T7BJ8	GO:0003676	10/33	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CJZ0X	GO:0016021	24/70	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CJZ0X	GO:0042246	24/70	tissue regeneration	biological_process	"The regrowth of lost or destroyed tissues." [GOC:curators]
EOG8CJZ0X	GO:0007155	24/70	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8WQ3H2	GO:0003951	25/110	NAD+ kinase activity	molecular_function	"Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632]
EOG8WQ3H2	GO:0019674	25/110	NAD metabolic process	biological_process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]
EOG8WQ3H2	GO:0006741	25/110	NADP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]
EOG8WQ3H2	GO:0042736	1/110	NADH kinase activity	molecular_function	"Catalysis of the reaction: ATP + NADH = ADP + 2 H(+) + NADPH." [EC:2.7.1.86, RHEA:12263]
EOG81G5NH	GO:0003723	2/18	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG81G5NH	GO:0003964	2/18	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG81G5NH	GO:0004519	1/18	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8909S1	GO:0007173	1/74	epidermal growth factor receptor signaling pathway	biological_process	"A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933]
EOG8909S1	GO:0005154	1/74	epidermal growth factor receptor binding	molecular_function	"Interacting selectively and non-covalently with the epidermal growth factor receptor." [GOC:ai]
EOG8909S1	GO:0007298	1/74	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8909S1	GO:0008586	1/74	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG8909S1	GO:0005576	1/74	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8909S1	GO:0007267	1/74	cell-cell signaling	biological_process	"Any process that mediates the transfer of information from one cell to another." [GOC:mah]
EOG8909S1	GO:0007477	1/74	notum development	biological_process	"The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jid]
EOG8909S1	GO:0008284	1/74	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG8909S1	GO:0016203	1/74	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8909S1	GO:0007476	1/74	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8909S1	GO:0007479	1/74	leg disc proximal/distal pattern formation	biological_process	"The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf]
EOG8909S1	GO:0030031	1/74	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG8909S1	GO:0045742	1/74	positive regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8909S1	GO:0008355	1/74	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8909S1	GO:0005515	1/74	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8909S1	GO:0035310	1/74	notum cell fate specification	biological_process	"The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment." [PMID:10860999]
EOG8909S1	GO:0008201	1/74	heparin binding	molecular_function	"Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]
EOG8909S1	GO:0007420	1/74	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG8909S1	GO:0007494	1/74	midgut development	biological_process	"The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
EOG8909S1	GO:0007482	1/74	haltere development	biological_process	"The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net]
EOG8909S1	GO:0007474	1/74	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG8909S1	GO:0007422	1/74	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8909S1	GO:0043066	1/74	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8HQH1K	GO:0006412	27/88	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8HQH1K	GO:0003735	27/88	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8HQH1K	GO:0005840	27/88	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8HQH1K	GO:0005730	1/88	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8HQH1K	GO:0000228	1/88	nuclear chromosome	cellular_component	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
EOG8HQH1K	GO:0005737	1/88	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8W10W2	GO:0016021	2/10	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W10W2	GO:0004930	2/10	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8VHNMB	GO:0016021	3/11	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VHNMB	GO:0005216	3/11	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG87WR3Z	GO:0004364	77/178	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG87WR3Z	GO:0005737	76/178	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87WR3Z	GO:0016782	4/178	transferase activity, transferring sulfur-containing groups	molecular_function	"Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG87WR3Z	GO:0045174	4/178	glutathione dehydrogenase (ascorbate) activity	molecular_function	"Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [EC:1.8.5.1, RHEA:24427]
EOG87WR3Z	GO:0006749	4/178	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG87WR3Z	GO:0042803	1/178	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG87WR3Z	GO:0055114	1/178	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG87WR3Z	GO:0045454	1/178	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG87WR3Z	GO:0050829	1/178	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG87WR3Z	GO:0009055	1/178	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG87WR3Z	GO:0006726	1/178	eye pigment biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
EOG87WR3Z	GO:0045824	1/178	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG87WR3Z	GO:0004734	1/178	pyrimidodiazepine synthase activity	molecular_function	"Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1]
EOG87WR3Z	GO:0006728	1/178	pteridine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732]
EOG8JWXVJ	GO:0005525	1/46	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8JWXVJ	GO:0003924	1/46	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8642V3	GO:0005634	11/33	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8642V3	GO:0043565	11/33	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8642V3	GO:0008270	11/33	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8642V3	GO:0003700	11/33	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8642V3	GO:0006351	7/33	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8642V3	GO:0003707	1/33	steroid hormone receptor activity	molecular_function	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
EOG81K1SX	GO:0005886	4/13	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG81K1SX	GO:0004930	4/13	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG81K1SX	GO:0004984	4/13	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG81K1SX	GO:0016021	4/13	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81K1SX	GO:0005549	4/13	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8WM7BG	GO:0007165	2/23	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8CVJMZ	GO:0005524	25/86	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CVJMZ	GO:0016021	25/86	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CVJMZ	GO:0042626	23/86	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8CVJMZ	GO:0008559	2/86	xenobiotic-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44]
EOG8CVJMZ	GO:0055085	1/86	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8RFP7N	GO:0030246	26/95	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8JWXV5	GO:0004930	1/20	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8JWXV5	GO:0016021	1/20	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8909SP	GO:0008237	1/5	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8909SP	GO:0031225	1/5	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG8909SP	GO:0046872	1/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8909SP	GO:0016805	1/5	dipeptidase activity	molecular_function	"Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com]
EOG8NP9K1	GO:0008137	9/57	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8NP9K1	GO:0042773	6/57	ATP synthesis coupled electron transport	biological_process	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363]
EOG8NP9K1	GO:0006120	1/57	mitochondrial electron transport, NADH to ubiquinone	biological_process	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363]
EOG8NP9K1	GO:0031966	1/57	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG8NP9K1	GO:0016021	1/57	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NP9K1	GO:0070469	1/57	respiratory chain	cellular_component	"The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684]
EOG8JQ6BG	GO:0016021	23/284	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JQ6BG	GO:0005216	21/284	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8JQ6BG	GO:0005249	4/284	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8JQ6BG	GO:0006812	2/284	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8JQ6BG	GO:0004692	2/284	cGMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
EOG8JQ6BG	GO:0005887	2/284	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JQ6BG	GO:0019935	2/284	cyclic-nucleotide-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
EOG8JQ6BG	GO:0042391	2/284	regulation of membrane potential	biological_process	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
EOG8JQ6BG	GO:0005221	2/284	intracellular cyclic nucleotide activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG8JQ6BG	GO:0071805	2/284	potassium ion transmembrane transport	biological_process	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
EOG8JQ6BG	GO:0017071	2/284	intracellular cyclic nucleotide activated cation channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah]
EOG8JQ6BG	GO:0005223	1/284	intracellular cGMP activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG8JQ6BG	GO:0005222	1/284	intracellular cAMP activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG8JQ6BG	GO:0030553	1/284	cGMP binding	molecular_function	"Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai]
EOG8JQ6BG	GO:0007603	1/284	phototransduction, visible light	biological_process	"The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
EOG8JQ6BK	GO:0003824	242/458	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8JQ6BK	GO:0032504	4/458	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8JQ6BK	GO:0005615	3/458	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8JQ6BK	GO:0055085	2/458	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8JQ6BK	GO:0016021	2/458	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FXTNC	GO:0004222	24/67	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8FXTNC	GO:0008270	11/67	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FXTNC	GO:0030713	1/67	ovarian follicle cell stalk formation	biological_process	"Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8FXTNC	GO:0001541	1/67	ovarian follicle development	biological_process	"The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:go_curators]
EOG8FXTNC	GO:0048477	1/67	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG80CKZW	GO:0035295	1/53	tube development	biological_process	"The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]
EOG8FR363	GO:0016758	2/28	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG893614	GO:0003676	17/107	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG893614	GO:0004523	17/107	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG893614	GO:0003723	1/107	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG893614	GO:0003964	1/107	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8DV813	GO:0005509	1/31	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8DV813	GO:0007156	1/31	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8DV813	GO:0016021	1/31	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M3CQ4	GO:0003964	10/341	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8M3CQ4	GO:0003723	9/341	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8M3CQ4	GO:0005198	3/341	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8M3CQ4	GO:0005882	3/341	intermediate filament	cellular_component	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
EOG8M3CQ4	GO:0015074	2/341	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8M3CQ4	GO:0003677	2/341	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8M3CQ4	GO:0003676	2/341	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M3CQ4	GO:0007155	1/341	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8M3CQ4	GO:0009007	1/341	site-specific DNA-methyltransferase (adenine-specific) activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72]
EOG8M3CQ4	GO:0046872	1/341	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8M3CQ4	GO:0006310	1/341	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8M3CQ4	GO:0008168	1/341	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG81VNJP	GO:0008061	4/17	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG81VNJP	GO:0005576	4/17	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG81VNJP	GO:0006030	4/17	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG81VNJN	GO:0008270	3/26	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DV81S	GO:0003676	6/1523	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DV81S	GO:0015074	4/1523	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8DV81S	GO:0003677	3/1523	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DV81S	GO:0008270	2/1523	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DV81S	GO:0003723	2/1523	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8DV81S	GO:0003964	2/1523	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8DV81S	GO:0005524	1/1523	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8DV81S	GO:0008234	1/1523	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8DV81S	GO:0004518	1/1523	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8GF5XM	GO:0003700	50/194	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8GF5XM	GO:0043565	49/194	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8GF5XM	GO:0005634	49/194	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GF5XM	GO:0007275	20/194	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8GF5XM	GO:0009952	4/194	anterior/posterior pattern specification	biological_process	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8GF5XM	GO:0006355	4/194	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8GF5XM	GO:0003677	3/194	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GF5XM	GO:0007507	2/194	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8GF5XM	GO:0045944	2/194	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8GF5XM	GO:0014019	2/194	neuroblast development	biological_process	"The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585]
EOG8GF5XM	GO:0004000	2/194	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8GF5XM	GO:0006366	2/194	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8GF5XM	GO:0003705	2/194	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG8GF5XM	GO:0042694	2/194	muscle cell fate specification	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators]
EOG8GF5XM	GO:0007494	2/194	midgut development	biological_process	"The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
EOG8GF5XM	GO:0035053	1/194	dorsal vessel heart proper cell fate commitment	biological_process	"The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110]
EOG8GF5XM	GO:0009987	1/194	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8GF5XM	GO:0007383	1/194	specification of segmental identity, antennal segment	biological_process	"The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
EOG8GF5XM	GO:0009948	1/194	anterior/posterior axis specification	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8GF5XM	GO:0048636	1/194	positive regulation of muscle organ development	biological_process	"Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators]
EOG8GF5XM	GO:0048738	1/194	cardiac muscle tissue development	biological_process	"The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]
EOG8GF5XM	GO:0007384	1/194	specification of segmental identity, thorax	biological_process	"The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
EOG8GF5XM	GO:0007422	1/194	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8GF5XM	GO:0048806	1/194	genitalia development	biological_process	"The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid]
EOG8GF5XM	GO:0007280	1/194	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG8GF5XM	GO:0007506	1/194	gonadal mesoderm development	biological_process	"The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai]
EOG8GF5XM	GO:0007400	1/194	neuroblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
EOG8GF5XM	GO:0007501	1/194	mesodermal cell fate specification	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
EOG8GF5XM	GO:0005737	1/194	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8GF5XM	GO:0008406	1/194	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG8GF5XM	GO:0010002	1/194	cardioblast differentiation	biological_process	"The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG8GF5XM	GO:0035224	1/194	genital disc anterior/posterior pattern formation	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318]
EOG8GF5XM	GO:0008354	1/194	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8GF5XM	GO:0048542	1/194	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG8GF5XM	GO:0005667	1/194	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8GF5XM	GO:0035225	1/194	determination of genital disc primordium	biological_process	"Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318]
EOG8GF5XM	GO:0006915	1/194	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8GF5XM	GO:0007399	1/194	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8GF5XM	GO:0007438	1/194	oenocyte development	biological_process	"The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397]
EOG8V9X72	GO:0008270	41/538	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V9X72	GO:0003676	38/538	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V9X72	GO:0003964	3/538	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8V9X72	GO:0003723	3/538	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8V9X72	GO:0006811	1/538	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8V9X72	GO:0005921	1/538	gap junction	cellular_component	"A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181]
EOG80308T	GO:0017022	1/119	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG80308T	GO:0043565	1/119	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG80308T	GO:0005634	1/119	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8M3CQD	GO:0046331	1/79	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8VQD3S	GO:0005871	3/26	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8VQD3S	GO:0007018	3/26	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8VQD3S	GO:0003777	3/26	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8VQD3S	GO:0005874	3/26	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8VQD3S	GO:0005524	3/26	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8XWJFG	GO:0031966	22/70	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG8J3ZZX	GO:0048102	1/92	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8J3ZZX	GO:0046692	1/92	sperm competition	biological_process	"Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514]
EOG8J3ZZX	GO:0035071	1/92	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8FN6ZB	GO:0008270	33/186	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FN6ZB	GO:0003700	32/186	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8FN6ZB	GO:0005634	32/186	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FN6ZB	GO:0043565	31/186	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8FN6ZB	GO:0016740	2/186	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8FN6ZB	GO:0003677	2/186	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FN6ZB	GO:0000977	1/186	RNA polymerase II regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
EOG8FN6ZB	GO:0035218	1/186	leg disc development	biological_process	"Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
EOG8FN6ZB	GO:0007517	1/186	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8FN6ZB	GO:0007450	1/186	dorsal/ventral pattern formation, imaginal disc	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238]
EOG8FN6ZB	GO:0007399	1/186	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8FN6ZB	GO:0045165	1/186	cell fate commitment	biological_process	"The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
EOG8FN6ZB	GO:0007526	1/186	larval somatic muscle development	biological_process	"The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG8FN6ZB	GO:0007559	1/186	histolysis	biological_process	"The breakdown of tissues; usually, if not always, accompanied by cell death, followed by the complete dissolution of dead tissue." [GOC:dph, GOC:ma]
EOG8FN6ZB	GO:0045944	1/186	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8FN6ZB	GO:0007476	1/186	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8FN6ZB	GO:0007479	1/186	leg disc proximal/distal pattern formation	biological_process	"The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf]
EOG8FN6ZB	GO:0048190	1/186	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8FN6ZB	GO:0006351	1/186	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8FN6ZB	GO:0007411	1/186	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8FN6ZB	GO:0036011	1/186	imaginal disc-derived leg segmentation	biological_process	"Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf]
EOG8FN6ZB	GO:0007451	1/186	dorsal/ventral lineage restriction, imaginal disc	biological_process	"Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402]
EOG8BCH3D	GO:0030246	25/87	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG88KTTR	GO:0006334	177/356	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG88KTTR	GO:0003677	177/356	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG88KTTR	GO:0000786	177/356	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG88KTTR	GO:0005634	177/356	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WM77P	GO:0004222	3/62	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8WM77P	GO:0008270	2/62	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WM77P	GO:0005578	2/62	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG8WM77P	GO:0008233	1/62	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8WM77P	GO:0031012	1/62	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG841SRM	GO:0005216	25/73	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG841SRM	GO:0016021	25/73	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG841SRM	GO:0019934	1/73	cGMP-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
EOG841SRM	GO:0071805	1/73	potassium ion transmembrane transport	biological_process	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
EOG841SRM	GO:0005249	1/73	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG841SRM	GO:0005223	1/73	intracellular cGMP activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG841SRM	GO:0017071	1/73	intracellular cyclic nucleotide activated cation channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah]
EOG841SRM	GO:0007603	1/73	phototransduction, visible light	biological_process	"The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
EOG841SRM	GO:0005221	1/73	intracellular cyclic nucleotide activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG841SRM	GO:0042391	1/73	regulation of membrane potential	biological_process	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
EOG841SRM	GO:0030553	1/73	cGMP binding	molecular_function	"Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai]
EOG841SRM	GO:0001666	1/73	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG841SRM	GO:0005222	1/73	intracellular cAMP activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG841SRM	GO:0004692	1/73	cGMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
EOG841SRM	GO:0005887	1/73	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG841SRM	GO:0006812	1/73	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8Q5C4Z	GO:0008270	29/245	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q5C4Z	GO:0003676	26/245	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q5C4Z	GO:0003964	4/245	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8Q5C4Z	GO:0003723	4/245	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8Q5C4R	GO:0005506	36/89	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8Q5C4R	GO:0042586	36/89	peptide deformylase activity	molecular_function	"Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide." [EC:3.5.1.88, GOC:jl]
EOG8N3333	GO:0046872	1/24	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QC3MN	GO:0030246	46/187	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8QC3MN	GO:0006810	2/187	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8QC3MN	GO:0016021	2/187	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QC3MN	GO:0016020	1/187	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QC3MN	GO:0008233	1/187	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG80P6ND	GO:0016021	230/726	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6ND	GO:0022891	177/726	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG80P6ND	GO:0022857	38/726	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG80P6ND	GO:0008643	18/726	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG80P6ND	GO:0005886	18/726	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80P6ND	GO:0015771	15/726	trehalose transport	biological_process	"The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai]
EOG80P6ND	GO:0015574	15/726	trehalose transmembrane transporter activity	molecular_function	"Enables the transfer of trehalose from one side of the membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
EOG80P6ND	GO:0032440	8/726	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG80P6ND	GO:0016020	2/726	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG80P6ND	GO:0046427	1/726	positive regulation of JAK-STAT cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG86MF03	GO:0016324	1/64	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG86MF03	GO:0007370	1/64	ventral furrow formation	biological_process	"Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238]
EOG8WSZR6	GO:0004055	20/77	argininosuccinate synthase activity	molecular_function	"Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5]
EOG8WSZR6	GO:0005524	20/77	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WSZR6	GO:0006526	20/77	arginine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, ISBN:0198506732]
EOG8WSZR6	GO:0000050	3/77	urea cycle	biological_process	"The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate." [GOC:pde, GOC:vw, ISBN:0198506732]
EOG8RZ1D6	GO:0016021	14/44	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RZ1D6	GO:0050909	12/44	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8RZ1D6	GO:0005886	12/44	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8RZ1D6	GO:0008527	2/44	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8PK4P0	GO:0004348	23/61	glucosylceramidase activity	molecular_function	"Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45]
EOG8PK4P0	GO:0016021	23/61	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PK4P0	GO:0006680	18/61	glucosylceramide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai]
EOG8PK4P0	GO:0005886	18/61	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8PK4P0	GO:0006665	5/61	sphingolipid metabolic process	biological_process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]
EOG8PK4P0	GO:0016139	1/61	glycoside catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]
EOG8PK4P0	GO:0008206	1/61	bile acid metabolic process	biological_process	"The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:go_curators]
EOG8PK4P0	GO:0008422	1/61	beta-glucosidase activity	molecular_function	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21]
EOG8B2WBF	GO:0006281	2/52	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8B2WBF	GO:0003678	2/52	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8B2WBF	GO:0000723	2/52	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8B2WBF	GO:0005524	2/52	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8B2WBF	GO:0007018	1/52	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8B2WBF	GO:0006511	1/52	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8B2WBF	GO:0003777	1/52	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG85XBCR	GO:0007018	1/69	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG85XBCR	GO:0006200	1/69	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG85XBCR	GO:0005875	1/69	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG85XBCR	GO:0042623	1/69	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG85XBCR	GO:0030286	1/69	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8RZ1D8	GO:0003676	55/523	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RZ1D8	GO:0016301	3/523	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8RZ1D8	GO:0046872	2/523	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RZ1D8	GO:0005524	1/523	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8RZ1D8	GO:0004743	1/523	pyruvate kinase activity	molecular_function	"Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40]
EOG8RZ1D8	GO:0000287	1/523	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8RZ1D8	GO:0003723	1/523	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RZ1D8	GO:0008270	1/523	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RZ1D8	GO:0006096	1/523	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8RZ1D8	GO:0030955	1/523	potassium ion binding	molecular_function	"Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah]
EOG8RZ1D8	GO:0004672	1/523	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8RZ1D8	GO:0003964	1/523	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG86Q985	GO:0003677	10/105	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86Q985	GO:0003676	3/105	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG86Q985	GO:0005622	1/105	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG84TRPP	GO:0005622	8/20	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG84TRPP	GO:0007165	8/20	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG84TRPP	GO:0005096	6/20	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8ZW7RZ	GO:0016021	25/103	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZW7RZ	GO:0006839	19/103	mitochondrial transport	biological_process	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]
EOG8ZW7RZ	GO:0031966	19/103	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG8ZW7RZ	GO:0055085	4/103	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8ZW7RZ	GO:0006810	2/103	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8ZW7RZ	GO:0005739	1/103	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8ZW7RZ	GO:0030302	1/103	deoxynucleotide transport	biological_process	"The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell." [GOC:mah, ISBN:0198506732]
EOG8ZW7RZ	GO:0045333	1/103	cellular respiration	biological_process	"The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732]
EOG8ZW7RZ	GO:0006390	1/103	transcription from mitochondrial promoter	biological_process	"The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl]
EOG8ZW7RZ	GO:0040011	1/103	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG8ZW7RZ	GO:0048311	1/103	mitochondrion distribution	biological_process	"Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid]
EOG8ZW7RZ	GO:0007005	1/103	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8RV58H	GO:0003723	2/31	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RV58H	GO:0003964	2/31	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8H74SF	GO:0004930	7/74	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8H74SF	GO:0016021	7/74	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8H74SF	GO:0005886	5/74	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8ZPH98	GO:0016772	6/12	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8H74SB	GO:0016772	19/55	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8H74SB	GO:0004672	1/55	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8H74SB	GO:0016301	1/55	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8H74SB	GO:0005524	1/55	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG81ZHRZ	GO:0008270	15/49	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81ZHRZ	GO:0005622	14/49	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8FJBPP	GO:0016021	24/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FJBPP	GO:0005216	23/99	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8FJBPP	GO:0005262	1/99	calcium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8FJBPP	GO:0034605	1/99	cellular response to heat	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]
EOG8FJBPP	GO:0006812	1/99	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8FJBPP	GO:0007602	1/99	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG8FJBPP	GO:0034765	1/99	regulation of ion transmembrane transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
EOG8FJBPP	GO:0070588	1/99	calcium ion transmembrane transport	biological_process	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8FJBPP	GO:0001580	1/99	detection of chemical stimulus involved in sensory perception of bitter taste	biological_process	"The series of events required for a bitter taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
EOG8FJBPP	GO:0009408	1/99	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8FJBPP	GO:0046957	1/99	negative phototaxis	biological_process	"The directed movement of a cell or organism away from a source of light." [GOC:ai]
EOG8FJBPP	GO:0006816	1/99	calcium ion transport	biological_process	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8FJBPP	GO:0032440	1/99	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8FJBPP	GO:0043052	1/99	thermotaxis	biological_process	"The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
EOG8FJBPP	GO:0022843	1/99	voltage-gated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8FJBPP	GO:0040040	1/99	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG8FJBPP	GO:0005261	1/99	cation channel activity	molecular_function	"Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8FJBPP	GO:0007638	1/99	mechanosensory behavior	biological_process	"Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators]
EOG8FJBPP	GO:0034703	1/99	cation channel complex	cellular_component	"An ion channel complex through which cations pass." [GOC:mah]
EOG8FJBPP	GO:0010378	1/99	temperature compensation of the circadian clock	biological_process	"The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099]
EOG8FJBPP	GO:0050960	1/99	detection of temperature stimulus involved in thermoception	biological_process	"The series of events in which a temperature stimulus is received and converted into a molecular signal as part of thermoception." [GOC:ai, GOC:dos]
EOG86X1RX	GO:0042981	1/29	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG86X1RX	GO:0005622	1/29	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8RV581	GO:0016021	6/66	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RV581	GO:0005789	6/66	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8RV581	GO:0033116	6/66	endoplasmic reticulum-Golgi intermediate compartment membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system." [GOC:mah, GOC:pr, PMID:16723730]
EOG8RV581	GO:0012507	6/66	ER to Golgi transport vesicle membrane	cellular_component	"The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8N333Z	GO:0016740	3/78	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8N333Z	GO:0004364	3/78	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG8N333Z	GO:0005737	1/78	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8N333Z	GO:0043295	1/78	glutathione binding	molecular_function	"Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732]
EOG8N333Z	GO:0007095	1/78	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8N333Z	GO:0008152	1/78	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8N333Z	GO:0022008	1/78	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8N333Z	GO:0003676	1/78	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZPHBQ	GO:0046872	1/17	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZPHBQ	GO:0003676	1/17	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG818F41	GO:0005509	8/88	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8Q87FD	GO:0055114	2/35	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8Q5C47	GO:0003964	34/377	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8Q5C47	GO:0003723	27/377	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8Q5C47	GO:0046872	14/377	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Q5C47	GO:0003677	7/377	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Q5C47	GO:0008270	3/377	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Q5C47	GO:0003676	2/377	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Q5C47	GO:0006355	2/377	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Q5C47	GO:0004519	1/377	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8RNDQD	GO:0016021	3/27	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RNDQD	GO:0005216	3/27	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8RJJFP	GO:0005234	64/194	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8RJJFP	GO:0016020	63/194	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RJJFP	GO:0004970	63/194	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8RJJFP	GO:0034220	3/194	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8RJJFP	GO:0036081	3/194	extracellular ammonia-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
EOG8RJJFP	GO:0016021	3/194	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RJJFP	GO:0015276	2/194	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8RJJFP	GO:0050907	1/194	detection of chemical stimulus involved in sensory perception	biological_process	"The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
EOG8RJJFP	GO:0005215	1/194	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8RJJFP	GO:0009593	1/194	detection of chemical stimulus	biological_process	"The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
EOG8RJJFP	GO:0050911	1/194	detection of chemical stimulus involved in sensory perception of smell	biological_process	"The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8RBT06	GO:0009890	2/79	negative regulation of biosynthetic process	biological_process	"Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
EOG8RBT06	GO:0016787	1/79	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8RBT06	GO:0003676	1/79	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RJJFT	GO:0016021	16/63	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RJJFT	GO:0022891	15/63	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8RJJFT	GO:0008643	5/63	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8RJJFT	GO:0003964	1/63	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8RJJFT	GO:0046872	1/63	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RJJFT	GO:0003723	1/63	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RJJFT	GO:0022857	1/63	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG85MQKW	GO:0016757	28/90	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8SN453	GO:0003677	1/51	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG883GNT	GO:0003964	338/1363	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG883GNT	GO:0003723	333/1363	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG883GNT	GO:0008270	44/1363	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG883GNT	GO:0003676	19/1363	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG883GNT	GO:0004519	4/1363	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG883GNT	GO:0004523	3/1363	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG883GNT	GO:0006511	2/1363	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG883GNT	GO:0046872	2/1363	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG883GNT	GO:0005634	1/1363	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG883GNT	GO:0016020	1/1363	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG883GNT	GO:0034450	1/1363	ubiquitin-ubiquitin ligase activity	molecular_function	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]
EOG883GNT	GO:0005524	1/1363	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG883GNT	GO:0004674	1/1363	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG883GNT	GO:0015074	1/1363	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG883GNT	GO:0006281	1/1363	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG883GNT	GO:0000723	1/1363	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG883GNT	GO:0003677	1/1363	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG883GNT	GO:0000786	1/1363	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG883GNT	GO:0003678	1/1363	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG883GNT	GO:0016758	1/1363	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG883GNT	GO:0006334	1/1363	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG883GNT	GO:0000151	1/1363	ubiquitin ligase complex	cellular_component	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
EOG8NGK1D	GO:0008270	118/444	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NGK1D	GO:0008237	118/444	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8NGK1D	GO:0004177	19/444	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG8NGK1D	GO:0033227	1/444	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8NGK1D	GO:0004463	1/444	leukotriene-A4 hydrolase activity	molecular_function	"Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4)." [EC:3.3.2.6, RHEA:22327]
EOG8NGK1D	GO:0006508	1/444	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG876NDT	GO:0003677	8/55	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG876NDT	GO:0006310	2/55	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG876NDT	GO:0015074	2/55	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG876NDT	GO:0003676	1/55	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NGK1T	GO:0016021	35/159	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NGK1T	GO:0055085	35/159	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8DRCV3	GO:0003676	3/252	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DRCV3	GO:0015074	3/252	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8DRCV3	GO:0003723	2/252	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8DRCV3	GO:0008270	2/252	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DRCV3	GO:0003964	2/252	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8DRCV3	GO:0004190	1/252	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8RZ1DV	GO:0003677	10/252	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RZ1DV	GO:0015074	5/252	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8RZ1DV	GO:0006310	5/252	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8RZ1DV	GO:0003676	1/252	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RZ1DV	GO:0003723	1/252	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RZ1DV	GO:0003964	1/252	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8GF5VB	GO:0000226	28/99	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8GF5VB	GO:0005874	28/99	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8GF5VB	GO:0007017	1/99	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8GF5VB	GO:0008017	1/99	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8GF5VB	GO:0005875	1/99	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8BP3TH	GO:0004190	2/20	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8QNQD0	GO:0003677	21/117	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8QNQD0	GO:0003676	2/117	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QNQD0	GO:0003964	1/117	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8QNQD0	GO:0003723	1/117	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8F4VRB	GO:0004970	27/163	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8F4VRB	GO:0005234	27/163	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8F4VRB	GO:0016020	20/163	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8F4VRB	GO:0016021	9/163	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F4VRB	GO:0005215	8/163	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8F4VRB	GO:0015276	2/163	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8F4VRB	GO:0036081	2/163	extracellular ammonia-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
EOG8F4VRB	GO:0034220	2/163	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8F4VRB	GO:0009593	2/163	detection of chemical stimulus	biological_process	"The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
EOG8QNQD6	GO:0004190	4/578	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8QNQD6	GO:0003676	3/578	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QNQD6	GO:0003964	1/578	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8QNQD6	GO:0008270	1/578	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8QNQD6	GO:0003723	1/578	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8QNQD6	GO:0015074	1/578	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG80ZTCT	GO:0016787	26/181	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG80ZTCT	GO:0052689	3/181	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG80ZTCT	GO:0008152	1/181	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG80ZTCT	GO:0005737	1/181	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8V9X55	GO:0008236	34/100	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8V9X55	GO:0004180	11/100	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8CJZ12	GO:0015074	3/41	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8CJZ12	GO:0003676	3/41	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CJZ12	GO:0003964	2/41	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8CJZ12	GO:0004190	1/41	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8CJZ12	GO:0003723	1/41	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG81K1TV	GO:0015918	4/343	sterol transport	biological_process	"The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]
EOG81K1TV	GO:0001530	1/343	lipopolysaccharide binding	molecular_function	"Interacting selectively and non-covalently with lipopolysaccharide." [PMID:11079463]
EOG81K1TV	GO:0030882	1/343	lipid antigen binding	molecular_function	"Interacting selectively and non-covalently with a lipid antigen." [PMID:14500461]
EOG81K1TV	GO:0008270	1/343	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81K1TV	GO:0022008	1/343	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG81K1TV	GO:0005615	1/343	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG81K1TV	GO:0070891	1/343	lipoteichoic acid binding	molecular_function	"Interacting selectively and non-covalently with lipoteichoic acid." [GOC:add, PMID:14665680]
EOG81K1TV	GO:0061057	1/343	peptidoglycan recognition protein signaling pathway	biological_process	"A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280]
EOG81K1TV	GO:0042834	1/343	peptidoglycan binding	molecular_function	"Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226]
EOG8DNHJZ	GO:0031012	8/43	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8DNHJZ	GO:0008270	8/43	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DNHJZ	GO:0004222	8/43	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8DNHJZ	GO:0005509	3/43	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8CJZ17	GO:0016192	1/8	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8CJZ17	GO:0016020	1/8	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Z919V	GO:0008241	93/395	peptidyl-dipeptidase activity	molecular_function	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]
EOG8Z919V	GO:0016020	92/395	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Z919V	GO:0008237	91/395	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8Z919V	GO:0004180	14/395	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8Z919V	GO:0005615	2/395	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8Z919V	GO:0016491	2/395	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8Z919V	GO:0006508	2/395	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8Z919V	GO:0045938	1/395	positive regulation of circadian sleep/wake cycle, sleep	biological_process	"Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators]
EOG8Z919V	GO:0007289	1/395	spermatid nucleus differentiation	biological_process	"The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah]
EOG8Z919V	GO:0009609	1/395	response to symbiotic bacterium	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism." [GOC:hb, ISBN:0198506732]
EOG8Z919V	GO:0005576	1/395	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Z919V	GO:0046872	1/395	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z919V	GO:0004222	1/395	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8Z919V	GO:0007291	1/395	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8Z919V	GO:0007507	1/395	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8Z919V	GO:0003700	1/395	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z919V	GO:0016021	1/395	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z919V	GO:0005634	1/395	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z919V	GO:0005515	1/395	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8Z919V	GO:0030431	1/395	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8Z919V	GO:0007552	1/395	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG8Z919V	GO:0008270	1/395	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Z919V	GO:0043565	1/395	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG880MB1	GO:0003677	1/142	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG880MB1	GO:0003678	1/142	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG880MB1	GO:0000723	1/142	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG880MB1	GO:0006281	1/142	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8WHC1J	GO:0005524	8/22	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WHC1J	GO:0006950	3/22	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8WHC1J	GO:0032440	2/22	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8X9B03	GO:0016020	3/24	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8X9B03	GO:0051781	2/24	positive regulation of cell division	biological_process	"Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai]
EOG8DNHJD	GO:0005507	33/127	copper ion binding	molecular_function	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]
EOG8DNHJD	GO:0016491	31/127	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8DNHJD	GO:0004322	1/127	ferroxidase activity	molecular_function	"Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1]
EOG8DNHJD	GO:0008447	1/127	L-ascorbate oxidase activity	molecular_function	"Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O." [EC:1.10.3.3]
EOG8DNHJD	GO:0031233	1/127	intrinsic component of external side of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah]
EOG8DNHJD	GO:0055072	1/127	iron ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
EOG8DNHJD	GO:0045178	1/127	basal part of cell	cellular_component	"The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194]
EOG8DNHJD	GO:0009986	1/127	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8JHFVN	GO:0007229	20/67	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG8JHFVN	GO:0007155	19/67	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8JHFVN	GO:0016021	19/67	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JHFVN	GO:0004872	14/67	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8JHFVN	GO:0007275	13/67	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8JHFVN	GO:0035011	1/67	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG8JHFVN	GO:0045886	1/67	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8JHFVN	GO:0007476	1/67	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8JHFVN	GO:0050839	1/67	cell adhesion molecule binding	molecular_function	"Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai]
EOG8JHFVN	GO:0043277	1/67	apoptotic cell clearance	biological_process	"The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684]
EOG8JHFVN	GO:0007160	1/67	cell-matrix adhesion	biological_process	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]
EOG8JHFVN	GO:0046716	1/67	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG8JHFVN	GO:0008305	1/67	integrin complex	cellular_component	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]
EOG8JHFVN	GO:0007157	1/67	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]
EOG8JHFVN	GO:0042048	1/67	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG8JHFVN	GO:0006909	1/67	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8JHFVN	GO:0016772	1/67	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG83BQ5X	GO:0006836	19/49	neurotransmitter transport	biological_process	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]
EOG83BQ5X	GO:0005326	1/49	neurotransmitter transporter activity	molecular_function	"Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732]
EOG83BQ5X	GO:0048786	1/49	presynaptic active zone	cellular_component	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
EOG83BQ5X	GO:0050804	1/49	modulation of synaptic transmission	biological_process	"Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
EOG83BQ5X	GO:0051124	1/49	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG83BQ5X	GO:0043195	1/49	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG83BQ5X	GO:0046928	1/49	regulation of neurotransmitter secretion	biological_process	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
EOG83BQ5X	GO:0016079	1/49	synaptic vesicle exocytosis	biological_process	"Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
EOG83BQ5X	GO:0007274	1/49	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG83BQ5X	GO:0016020	1/49	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG83N9TS	GO:0016021	1/63	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83N9TS	GO:0017080	1/63	sodium channel regulator activity	molecular_function	"Modulates the activity of a sodium channel." [GOC:mah]
EOG83N9TS	GO:0002028	1/63	regulation of sodium ion transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph]
EOG8SN45G	GO:0003682	14/229	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8SN45G	GO:0006915	3/229	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8SN45G	GO:0005634	3/229	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SN45G	GO:0003677	3/229	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8SN45G	GO:0008270	1/229	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NKFBP	GO:0019239	29/80	deaminase activity	molecular_function	"Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl]
EOG8NKFBP	GO:0006457	1/80	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG83N9TX	GO:0016905	1/15	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG8D55FF	GO:0005578	1/13	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG8D55FF	GO:0016055	1/13	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG8D55FF	GO:0007275	1/13	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8DBWWW	GO:0004930	5/50	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8DBWWW	GO:0016021	5/50	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DBWWW	GO:0016301	4/50	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8DBWWW	GO:0005524	3/50	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8DBWWW	GO:0046872	1/50	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DBWWW	GO:0003676	1/50	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DBWWW	GO:0005525	1/50	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG82NMG9	GO:0005509	105/381	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG82NMG9	GO:0043565	1/381	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG82NMG9	GO:0032440	1/381	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG82NMG9	GO:0003700	1/381	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG83JFKT	GO:0006139	19/56	nucleobase-containing compound metabolic process	biological_process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
EOG83JFKT	GO:0019205	19/56	nucleobase-containing compound kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]
EOG83JFKT	GO:0005524	19/56	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8D55FK	GO:0005615	3/466	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8D55FK	GO:0032504	3/466	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8D55FK	GO:0008233	2/466	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8D55FK	GO:0046692	1/466	sperm competition	biological_process	"Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514]
EOG8D55FK	GO:0030414	1/466	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8D55FK	GO:0030162	1/466	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8D55FK	GO:0010951	1/466	negative regulation of endopeptidase activity	biological_process	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG8D55FK	GO:0010466	1/466	negative regulation of peptidase activity	biological_process	"Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG8D55FK	GO:0004867	1/466	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG8D55FK	GO:0007610	1/466	behavior	biological_process	"The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
EOG8D55FK	GO:0045861	1/466	negative regulation of proteolysis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
EOG879HMZ	GO:0016772	69/190	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG879HMZ	GO:0016301	11/190	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG879HMZ	GO:0017022	1/190	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG879HMZ	GO:0022008	1/190	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG89KJ5X	GO:0000502	6/81	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG89KJ5X	GO:0003677	1/81	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG89KJ5X	GO:0006974	1/81	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG89KJ5X	GO:0005515	1/81	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG870WXS	GO:0016491	43/81	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG870WXS	GO:0008336	4/81	gamma-butyrobetaine dioxygenase activity	molecular_function	"Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate." [EC:1.14.11.1, RHEA:24031]
EOG870WXS	GO:0051213	1/81	dioxygenase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf, http://www.onelook.com/]
EOG8GTNV3	GO:0004017	27/91	adenylate kinase activity	molecular_function	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]
EOG8GTNV3	GO:0005524	27/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8GTNV3	GO:0005739	23/91	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8GTNV3	GO:0046899	3/91	nucleoside triphosphate adenylate kinase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP." [EC:2.7.4.10]
EOG8GTNV3	GO:0046939	1/91	nucleotide phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]
EOG81C9BP	GO:0003824	14/79	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8W10VZ	GO:0046872	1/19	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89KJ52	GO:0004984	4/23	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG89KJ52	GO:0005549	4/23	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG89KJ52	GO:0004930	3/23	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG89KJ52	GO:0016021	3/23	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89KJ52	GO:0005886	2/23	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG89KJ52	GO:0016020	1/23	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG869T8S	GO:0008270	5/25	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CRPDN	GO:0004984	2/18	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8CRPDN	GO:0016020	2/18	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CRPDN	GO:0005549	2/18	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8M0HH2	GO:0003676	7/156	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WWV1R	GO:0003676	182/2316	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WWV1R	GO:0008270	149/2316	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WWV1R	GO:0003677	110/2316	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8WWV1R	GO:0005634	107/2316	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WWV1R	GO:0015074	83/2316	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8WWV1R	GO:0003964	8/2316	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8WWV1R	GO:0003723	4/2316	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8WWV1R	GO:0004519	4/2316	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8WWV1R	GO:0046872	2/2316	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WWV1R	GO:0004190	1/2316	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8WWV1R	GO:0005524	1/2316	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WWV1R	GO:0008762	1/2316	UDP-N-acetylmuramate dehydrogenase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158]
EOG8WWV1R	GO:0006351	1/2316	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8WWV1R	GO:0050660	1/2316	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8WWV1R	GO:0016043	1/2316	cellular component organization	biological_process	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]
EOG8WWV1R	GO:0016787	1/2316	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8WWV1R	GO:0016491	1/2316	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8M0HH7	GO:0003677	18/140	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8M0HH7	GO:0015074	16/140	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8M0HH7	GO:0006310	16/140	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8M0HH7	GO:0008270	3/140	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8M0HH7	GO:0005634	2/140	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8M0HH7	GO:0003964	2/140	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8M0HH7	GO:0051607	2/140	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG8M0HH7	GO:0005739	2/140	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8M0HH7	GO:0004871	2/140	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8M0HH7	GO:0003723	2/140	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8M0HH7	GO:0005975	1/140	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8M0HH7	GO:0016616	1/140	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8M0HH7	GO:0003676	1/140	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG81RSB0	GO:0003968	1/78	RNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah]
EOG8GTNVW	GO:0005615	233/444	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8GTNVW	GO:0010951	13/444	negative regulation of endopeptidase activity	biological_process	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0004867	13/444	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG8GTNVW	GO:0016740	13/444	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8GTNVW	GO:0030162	12/444	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8GTNVW	GO:0045861	10/444	negative regulation of proteolysis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
EOG8GTNVW	GO:0008233	8/444	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8GTNVW	GO:0032504	7/444	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8GTNVW	GO:0000155	6/444	phosphorelay sensor kinase activity	molecular_function	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
EOG8GTNVW	GO:0016020	6/444	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8GTNVW	GO:0019732	1/444	antifungal humoral response	biological_process	"An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8GTNVW	GO:0008063	1/444	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8GTNVW	GO:0002784	1/444	regulation of antimicrobial peptide production	biological_process	"Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
EOG8GTNVW	GO:0003677	1/444	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GTNVW	GO:0005576	1/444	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8GTNVW	GO:0006281	1/444	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8GTNVW	GO:0050829	1/444	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GTNVW	GO:0060570	1/444	negative regulation of peptide hormone processing	biological_process	"Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0006955	1/444	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8GTNVW	GO:0004869	1/444	cysteine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0010955	1/444	negative regulation of protein processing	biological_process	"Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]
EOG8GTNVW	GO:0042562	1/444	hormone binding	molecular_function	"Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
EOG8GTNVW	GO:0045751	1/444	negative regulation of Toll signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8GTNVW	GO:0050832	1/444	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG82VBZX	GO:0004930	3/34	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG82VBZX	GO:0016021	3/34	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W3W3W	GO:0046080	31/74	dUTP metabolic process	biological_process	"The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators]
EOG8W3W3W	GO:0004170	30/74	dUTP diphosphatase activity	molecular_function	"Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [EC:3.6.1.23]
EOG8W3W3W	GO:0005634	1/74	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8W3W3W	GO:0016787	1/74	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8W3W3W	GO:0005737	1/74	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8MGVP3	GO:0008270	14/476	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MGVP3	GO:0003676	4/476	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FJBS3	GO:0003676	72/1100	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FJBS3	GO:0003964	71/1100	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8FJBS3	GO:0004523	69/1100	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8FJBS3	GO:0003723	34/1100	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8FJBS3	GO:0008270	8/1100	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FJBS3	GO:0004519	1/1100	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8FJBS3	GO:0004842	1/1100	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8G7FCH	GO:0016021	12/69	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G7FCH	GO:0004984	11/69	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8G7FCH	GO:0005549	11/69	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8G7FCH	GO:0004930	10/69	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8G7FCH	GO:0005886	6/69	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8G7FCH	GO:0050909	2/69	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8G7FCH	GO:0016020	1/69	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8616M6	GO:0008270	4/65	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8616M6	GO:0003676	3/65	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8616M6	GO:0003723	1/65	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8616M6	GO:0003964	1/65	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8DNHMM	GO:0016705	2/63	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8DNHMM	GO:0020037	2/63	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8DNHMM	GO:0005506	2/63	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8DNHMM	GO:0004497	1/63	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8VQD44	GO:0020037	27/145	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8VQD44	GO:0005506	27/145	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8VQD44	GO:0016705	25/145	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8VQD44	GO:0051205	23/145	protein insertion into membrane	biological_process	"The process that results in the incorporation of a protein into a biological membrane.  Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]
EOG8VQD44	GO:0016021	23/145	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VQD44	GO:0004497	22/145	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8VQD44	GO:0005576	2/145	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8VQD44	GO:0008061	2/145	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8VQD44	GO:0006030	2/145	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8VQD44	GO:0008386	2/145	cholesterol monooxygenase (side-chain-cleaving) activity	molecular_function	"Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6]
EOG8VQD44	GO:0005272	1/145	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8VQD44	GO:0042768	1/145	ecdysteroid 2-hydroxylase activity	molecular_function	"Catalysis of the hydroxylation of an ecdysteroid at carbon position 2." [PMID:12177427]
EOG8VQD44	GO:0031966	1/145	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG8VQD44	GO:0007391	1/145	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8VQD44	GO:0007417	1/145	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8VQD44	GO:0008045	1/145	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8VQD44	GO:0006697	1/145	ecdysone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732]
EOG8VQD44	GO:0007494	1/145	midgut development	biological_process	"The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
EOG8VQD44	GO:0008258	1/145	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8VQD44	GO:0005739	1/145	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8R52K5	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8R52K5	GO:0005272	2/5	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8R52K3	GO:0008233	1/74	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8R52K3	GO:0042832	1/74	defense response to protozoan	biological_process	"Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism." [GOC:jl]
EOG8R52K3	GO:0045087	1/74	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8R52K3	GO:0005576	1/74	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8R52K3	GO:0042742	1/74	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8PZMQ0	GO:0003676	4/17	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8PZMQ0	GO:0008270	4/17	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FR36D	GO:0042302	96/271	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8FR36D	GO:0040003	4/271	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8FR36D	GO:0008010	4/271	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8FR36D	GO:0031012	4/271	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8FR36D	GO:0004252	3/271	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8FR36D	GO:0008270	1/271	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PRW6R	GO:0016491	44/293	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8PRW6R	GO:0004022	8/293	alcohol dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
EOG8PRW6R	GO:0016404	4/293	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	molecular_function	"Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141]
EOG8PRW6R	GO:0003939	1/293	L-iditol 2-dehydrogenase activity	molecular_function	"Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14]
EOG8PRW6R	GO:0006066	1/293	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG8NZX8V	GO:0016021	9/66	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NZX8V	GO:0003954	1/66	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8KH5BP	GO:0032259	19/59	methylation	biological_process	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]
EOG8KH5BP	GO:0005845	19/59	mRNA cap binding complex	cellular_component	"Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA." [GOC:jid]
EOG8KH5BP	GO:0003723	19/59	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8KH5BP	GO:0046331	1/59	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG886BTB	GO:0004144	12/86	diacylglycerol O-acyltransferase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20]
EOG886BTB	GO:0045017	10/86	glycerolipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]
EOG89360S	GO:0008270	3/41	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG89360S	GO:0003676	3/41	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8G7FC6	GO:0008076	33/158	voltage-gated potassium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
EOG8G7FC6	GO:0005249	32/158	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8G7FC6	GO:0006813	1/158	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8G7FC6	GO:0034765	1/158	regulation of ion transmembrane transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
EOG8G7FC6	GO:0005251	1/158	delayed rectifier potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]
EOG8G7FC6	GO:0060048	1/158	cardiac muscle contraction	biological_process	"Muscle contraction of cardiac muscle tissue." [GOC:dph]
EOG8G7FC6	GO:0016021	1/158	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G7FC6	GO:0002027	1/158	regulation of heart rate	biological_process	"Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008]
EOG8G7FC6	GO:0022843	1/158	voltage-gated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8G7FC6	GO:0001700	1/158	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8TQPQ5	GO:0016772	2/16	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8TQPQ5	GO:0016310	2/16	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG886BT3	GO:0016021	44/166	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG886BT3	GO:0004930	37/166	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG886BT3	GO:0050254	5/166	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG886BT3	GO:0005000	4/166	vasopressin receptor activity	molecular_function	"Combining with vasopressin to initiate a change in cell activity." [GOC:ai]
EOG886BT3	GO:0016500	3/166	protein-hormone receptor activity	molecular_function	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]
EOG886BT3	GO:0055088	1/166	lipid homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]
EOG886BT3	GO:0070328	1/166	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG886BT3	GO:0016042	1/166	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG886BT3	GO:0097004	1/166	adipokinetic hormone binding	molecular_function	"Interacting selectively and non-covalently with an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407]
EOG886BT3	GO:0097003	1/166	adipokinetic hormone receptor activity	molecular_function	"Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407]
EOG886BT3	GO:0033500	1/166	carbohydrate homeostasis	biological_process	"A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah]
EOG886BT3	GO:0005887	1/166	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG886BT3	GO:0007218	1/166	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG886BT3	GO:0008188	1/166	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG886BT3	GO:0007186	1/166	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8JT2KX	GO:0007017	1/22	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8JT2KX	GO:0005737	1/22	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8JT2KX	GO:0003924	1/22	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8JT2KX	GO:0005525	1/22	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8JT2KX	GO:0005874	1/22	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8JT2KX	GO:0051258	1/22	protein polymerization	biological_process	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
EOG8JT2KX	GO:0005200	1/22	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8Z0DNN	GO:0003676	5/34	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VT8B9	GO:0016021	63/217	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VT8B9	GO:0004930	44/217	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8VT8B9	GO:0001607	19/217	neuromedin U receptor activity	molecular_function	"Combining with neuromedin U to initiate a change in cell activity." [GOC:ai]
EOG8VT8B9	GO:0036401	3/217	pyrokinin receptor activity	molecular_function	"Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation." [GOC:ha, PMID:12951076, PMID:19186060]
EOG8VT8B9	GO:0050254	3/217	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8VT8B9	GO:0007218	3/217	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8VT8B9	GO:0005887	3/217	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VT8B9	GO:0007186	3/217	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8VT8B9	GO:0008188	3/217	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8VT8B9	GO:0001653	1/217	peptide receptor activity	molecular_function	"Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl]
EOG83BQ3C	GO:0003676	2/14	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83BQ3C	GO:0046872	2/14	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83BQ3C	GO:0016887	1/14	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG83BQ3C	GO:0005524	1/14	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8JQ6DN	GO:0003964	6/36	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8JQ6DN	GO:0003723	6/36	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8JQ6DS	GO:0006351	5/21	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8JQ6DS	GO:0005634	5/21	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8JQ6DS	GO:0007179	5/21	transforming growth factor beta receptor signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
EOG8JQ6DS	GO:0003700	5/21	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8JQ6DS	GO:0005667	5/21	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG86HJTB	GO:0006450	28/52	regulation of translational fidelity	biological_process	"Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]
EOG86HJTB	GO:0032543	24/52	mitochondrial translation	biological_process	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]
EOG86HJTB	GO:0070681	24/52	glutaminyl-tRNAGln biosynthesis via transamidation	biological_process	"A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921]
EOG86HJTB	GO:0005739	24/52	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG86HJTB	GO:0050567	24/52	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	molecular_function	"Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN]
EOG86HJTB	GO:0005524	24/52	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG86HJTB	GO:0030956	24/52	glutamyl-tRNA(Gln) amidotransferase complex	cellular_component	"A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg]
EOG83V28B	GO:0003677	19/90	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG83V28B	GO:0003886	16/90	DNA (cytosine-5-)-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37]
EOG83V28B	GO:0003682	14/90	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG83V28B	GO:0005634	12/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83V28B	GO:0008270	8/90	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83V28B	GO:0006306	3/90	DNA methylation	biological_process	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]
EOG83V28B	GO:0008168	3/90	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG83V28B	GO:0016746	3/90	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG83V28B	GO:0031461	1/90	cullin-RING ubiquitin ligase complex	cellular_component	"Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063]
EOG83V28B	GO:0006511	1/90	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG83V28B	GO:0004379	1/90	glycylpeptide N-tetradecanoyltransferase activity	molecular_function	"Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97]
EOG8RJJG8	GO:0046872	5/16	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RJJG8	GO:0003676	4/16	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RJJG8	GO:0015074	1/16	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8RJJG8	GO:0003677	1/16	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RJJG8	GO:0006310	1/16	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8XKXPH	GO:0016020	142/797	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XKXPH	GO:0005515	4/797	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8XKXPH	GO:0015031	1/797	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8XKXPH	GO:0046331	1/797	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8XKXPH	GO:0005789	1/797	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8XKXPH	GO:0016021	1/797	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZCWKH	GO:0008270	23/79	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZCWKH	GO:0004089	23/79	carbonate dehydratase activity	molecular_function	"Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1]
EOG8ZCWKH	GO:0006730	1/79	one-carbon metabolic process	biological_process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
EOG8ZCWKH	GO:0005739	1/79	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG88D389	GO:0007165	19/141	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG88D389	GO:0007432	1/141	salivary gland boundary specification	biological_process	"Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957]
EOG88D389	GO:0008347	1/141	glial cell migration	biological_process	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
EOG88D389	GO:0050919	1/141	negative chemotaxis	biological_process	"The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete]
EOG88D389	GO:0008045	1/141	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG88D389	GO:0007411	1/141	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG88D389	GO:0005515	1/141	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG88D389	GO:0005043	1/141	netrin receptor activity involved in chemorepulsion	molecular_function	"Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin." [GOC:dph, GOC:signaling]
EOG88D389	GO:0016021	1/141	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CJXZ4	GO:0005874	23/71	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8CJXZ4	GO:0005524	23/71	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CJXZ4	GO:0007018	23/71	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8CJXZ4	GO:0005871	23/71	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8CJXZ4	GO:0003777	23/71	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8CJXZ4	GO:0004871	7/71	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8CJXZ4	GO:0007186	7/71	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8CJXZ4	GO:0005834	7/71	heterotrimeric G-protein complex	cellular_component	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684]
EOG8CJXZ4	GO:0050113	1/71	inositol oxygenase activity	molecular_function	"Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+)." [EC:1.13.99.1, RHEA:23699]
EOG8CJXZ4	GO:0003676	1/71	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CJXZ4	GO:0008152	1/71	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8CJXZ4	GO:0005737	1/71	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CJXZ4	GO:0005506	1/71	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8CJXZ4	GO:0019310	1/71	inositol catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, GOC:go_curators]
EOG854CD2	GO:0016021	27/75	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG854CD2	GO:0016500	27/75	protein-hormone receptor activity	molecular_function	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]
EOG854CD2	GO:0004930	1/75	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG854CD2	GO:0042562	1/75	hormone binding	molecular_function	"Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
EOG854CD2	GO:0005840	1/75	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG854CD2	GO:0008188	1/75	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG854CD2	GO:0007186	1/75	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG854CD2	GO:0007218	1/75	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG854CD2	GO:0005887	1/75	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG854CD2	GO:0004715	1/75	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG854CD2	GO:0009755	1/75	hormone-mediated signaling pathway	biological_process	"A series of molecular signals mediated by the detection of a hormone." [GOC:sm]
EOG8CJXZ8	GO:0005515	1/80	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8CJXZ8	GO:0016021	1/80	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CJXZ8	GO:0019005	1/80	SCF ubiquitin ligase complex	cellular_component	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
EOG8CJXZ8	GO:0031647	1/80	regulation of protein stability	biological_process	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]
EOG8CJXZ8	GO:0009952	1/80	anterior/posterior pattern specification	biological_process	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8CJXZG	GO:0003899	2/211	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8CJXZG	GO:0003677	2/211	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CJXZG	GO:0006351	2/211	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8CJXZG	GO:0003676	1/211	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8P2SJ2	GO:0015074	13/185	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8P2SJ2	GO:0003677	13/185	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8P2SJ2	GO:0006310	13/185	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8P2SJ2	GO:0003964	2/185	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8P2SJ2	GO:0003723	2/185	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG84BDGW	GO:0005874	22/56	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG84BDGW	GO:0005524	22/56	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG84BDGW	GO:0005871	22/56	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG84BDGW	GO:0007018	22/56	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG84BDGW	GO:0003777	22/56	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG84BDGW	GO:0008152	1/56	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8PCD6R	GO:0020037	19/73	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8PCD6R	GO:0005506	17/73	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8PCD6R	GO:0006633	17/73	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8PCD6R	GO:0016491	15/73	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8PCD6R	GO:0005783	13/73	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8PCD6R	GO:0006665	13/73	sphingolipid metabolic process	biological_process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]
EOG8PCD6R	GO:0016021	2/73	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PCD6R	GO:0046872	2/73	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8PCD6R	GO:0006979	1/73	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8PCD6R	GO:0052722	1/73	fatty acid in-chain hydroxylase activity	molecular_function	"Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O." [MetaCyc:RXN-12186]
EOG8PCD6R	GO:0004601	1/73	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG8PCD6R	GO:0003676	1/73	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QRKJ0	GO:0008270	49/217	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8QRKJ0	GO:0016740	1/217	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG854CDF	GO:0016021	24/82	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG854CDF	GO:0006810	17/82	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG854CDF	GO:0055085	4/82	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG854CDF	GO:0006839	3/82	mitochondrial transport	biological_process	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]
EOG854CDF	GO:0031966	3/82	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG8HDW80	GO:0005634	9/49	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HDW80	GO:0003676	8/49	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HDW80	GO:0004535	1/49	poly(A)-specific ribonuclease activity	molecular_function	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]
EOG8ZKN41	GO:0005388	3/38	calcium-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8]
EOG80GG4P	GO:0005234	33/99	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG80GG4P	GO:0004970	32/99	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG80GG4P	GO:0016021	31/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80GG4P	GO:0030054	26/99	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG80GG4P	GO:0045211	26/99	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG80GG4P	GO:0016020	2/99	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG80GG4P	GO:0072375	1/99	medium-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster)." [GOC:sart, PMID:14659098, PMID:7923375]
EOG80GG4P	GO:0007616	1/99	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG80GG4P	GO:0035249	1/99	synaptic transmission, glutamatergic	biological_process	"The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv]
EOG80GG4P	GO:0004972	1/99	NMDA glutamate receptor activity	molecular_function	"An ionotropic glutamate receptor activity that exhibits slow gating by glutamate, acts by opening a nonselective cation channel, and can be activated by L-aspartate." [GOC:mah, PMID:10049997]
EOG80GG4P	GO:0003723	1/99	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG80GG4P	GO:0017146	1/99	NMDA selective glutamate receptor complex	cellular_component	"An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
EOG80GG4P	GO:0003964	1/99	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG80GG4P	GO:0008328	1/99	ionotropic glutamate receptor complex	cellular_component	"A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
EOG80GG4P	GO:0050975	1/99	sensory perception of touch	biological_process	"The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]
EOG80GG4P	GO:0034220	1/99	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG80GG4P	GO:0030425	1/99	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG80GG4P	GO:0035235	1/99	ionotropic glutamate receptor signaling pathway	biological_process	"A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732]
EOG8F7R11	GO:0016021	3/229	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F7R11	GO:0006909	3/229	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8F7R11	GO:0042742	2/229	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8F7R11	GO:0005886	1/229	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8F7R11	GO:0006910	1/229	phagocytosis, recognition	biological_process	"The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149]
EOG8F7R11	GO:0046331	1/229	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8F7R11	GO:0009986	1/229	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8F7R11	GO:0005615	1/229	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8F7R11	GO:0006898	1/229	receptor-mediated endocytosis	biological_process	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
EOG8F7R11	GO:0005044	1/229	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8F7R11	GO:0008233	1/229	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8F7R11	GO:0042834	1/229	peptidoglycan binding	molecular_function	"Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226]
EOG8C5G08	GO:0009058	19/71	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG8C5G08	GO:0030170	19/71	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG8C5G08	GO:0008890	18/71	glycine C-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+)." [EC:2.3.1.29, RHEA:20739]
EOG8C5G08	GO:0016874	2/71	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8C5G08	GO:0003824	1/71	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8S4RZ6	GO:0005634	38/129	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8S4RZ6	GO:0006352	36/129	DNA-templated transcription, initiation	biological_process	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]
EOG8S4RZ6	GO:0003743	4/129	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8S4RZ6	GO:0005669	2/129	transcription factor TFIID complex	cellular_component	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]
EOG8S4RZ6	GO:0005737	2/129	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8S4RZ6	GO:0051123	2/129	RNA polymerase II transcriptional preinitiation complex assembly	biological_process	"The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:10882737, PMID:15020047]
EOG8S4RZ6	GO:0006367	2/129	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG8S4RZ6	GO:0000124	2/129	SAGA complex	cellular_component	"A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012]
EOG8S4RZ6	GO:0006355	2/129	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8S4RZ6	GO:0005515	1/129	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8S4RZ6	GO:0000123	1/129	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG8N8TJK	GO:0016021	1/16	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8N8TJK	GO:0005524	1/16	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8N8TJK	GO:0046872	1/16	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8N8TJK	GO:0006754	1/16	ATP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]
EOG8N8TJK	GO:0019829	1/16	cation-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]
EOG8N8TJK	GO:0015077	1/16	monovalent inorganic cation transmembrane transporter activity	molecular_function	"Enables the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8B8MW9	GO:0050905	2/62	neuromuscular process	biological_process	"Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai]
EOG88GZJM	GO:0015074	16/52	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG88GZJM	GO:0003676	16/52	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88GZJM	GO:0005634	2/52	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88GZJG	GO:0008270	1/14	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG88GZJG	GO:0005634	1/14	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FFGH6	GO:0007067	1/75	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG88WFFS	GO:0003735	1/49	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG88WFFS	GO:0015934	1/49	large ribosomal subunit	cellular_component	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]
EOG88WFFS	GO:0035091	1/49	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG88WFFS	GO:0006412	1/49	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8MWBQ0	GO:0006511	3/21	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8NKFCJ	GO:0015074	4/97	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8NKFCJ	GO:0003676	4/97	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NKFCJ	GO:0003723	2/97	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8NKFCJ	GO:0008270	2/97	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NKFCJ	GO:0004190	2/97	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8NKFCJ	GO:0003964	2/97	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8HHRKM	GO:0016021	6/37	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HHRKM	GO:0004935	4/37	adrenergic receptor activity	molecular_function	"Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274]
EOG8HHRKM	GO:0004930	2/37	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8HHRKM	GO:0004715	1/37	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8KPWR7	GO:0005524	26/100	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8KPWR7	GO:0004674	25/100	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8KPWR7	GO:0007165	16/100	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8KPWR7	GO:0005840	3/100	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8KPWR7	GO:0040018	1/100	positive regulation of multicellular organism growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8KPWR7	GO:0007584	1/100	response to nutrient	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators]
EOG8KPWR7	GO:0005874	1/100	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8KPWR7	GO:0006974	1/100	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8KPWR7	GO:0045927	1/100	positive regulation of growth	biological_process	"Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
EOG8KPWR7	GO:0005829	1/100	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8KPWR7	GO:0051124	1/100	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8KPWR7	GO:0008361	1/100	regulation of cell size	biological_process	"Any process that modulates the size of a cell." [GOC:go_curators]
EOG8KPWR7	GO:0048786	1/100	presynaptic active zone	cellular_component	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
EOG8KPWR7	GO:0046622	1/100	positive regulation of organ growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
EOG8KPWR7	GO:0016239	1/100	positive regulation of macroautophagy	biological_process	"Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464]
EOG8KPWR7	GO:0008340	1/100	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8KPWR7	GO:0004711	1/100	ribosomal protein S6 kinase activity	molecular_function	"Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608]
EOG8KPWR7	GO:0005515	1/100	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KPWR7	GO:0030307	1/100	positive regulation of cell growth	biological_process	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8KPWR7	GO:0030536	1/100	larval feeding behavior	biological_process	"Feeding behavior in a larval (immature) organism." [GOC:mah]
EOG8KPWR7	GO:0006468	1/100	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8KPWR7	GO:0000226	1/100	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8KPWR7	GO:0045793	1/100	positive regulation of cell size	biological_process	"Any process that increases cell size." [GOC:go_curators]
EOG8KPWR7	GO:0007411	1/100	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8KPWR7	GO:0040007	1/100	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG8KPWR7	GO:0010508	1/100	positive regulation of autophagy	biological_process	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8KPWR7	GO:0048477	1/100	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8KPWR7	GO:0007015	1/100	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8KPWR7	GO:0004697	1/100	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG8KPWR7	GO:0006909	1/100	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8KPWR7	GO:2001023	1/100	regulation of response to drug	biological_process	"Any process that modulates the frequency, rate or extent of response to drug." [GOC:obol]
EOG8KPWR7	GO:0048813	1/100	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8G4K72	GO:0042302	1/5	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8BP3S3	GO:0016301	5/104	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8BP3S3	GO:0016618	2/104	hydroxypyruvate reductase activity	molecular_function	"Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+." [EC:1.1.1.81]
EOG8BP3S3	GO:0008887	1/104	glycerate kinase activity	molecular_function	"Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H(+)." [EC:2.7.1.31, RHEA:23519]
EOG8BP3S3	GO:0005737	1/104	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8BP3S3	GO:0006468	1/104	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8BP3S3	GO:0005524	1/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8J9QGG	GO:0016021	3/30	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J9QGG	GO:0005230	3/30	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8PP0XV	GO:0005524	21/86	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8PP0XV	GO:0004674	20/86	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8PP0XV	GO:0004672	1/86	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8PP0XV	GO:0004709	1/86	MAP kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
EOG8PP0XV	GO:0006468	1/86	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8PP0XV	GO:0032008	1/86	positive regulation of TOR signaling	biological_process	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8F4VRJ	GO:0016772	1/27	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8Z91BB	GO:0015074	44/793	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8Z91BB	GO:0003676	43/793	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Z91BB	GO:0003964	17/793	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8Z91BB	GO:0003723	15/793	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8Z91BB	GO:0003677	6/793	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Z91BB	GO:0008270	4/793	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Z91BB	GO:0004523	2/793	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8Z91BB	GO:0005622	1/793	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8Z91BB	GO:0019028	1/793	viral capsid	cellular_component	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
EOG8Z91BB	GO:0046718	1/793	viral entry into host cell	biological_process	"The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm." [GOC:jl]
EOG8Z91BB	GO:0019076	1/793	viral release from host cell	biological_process	"The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane." [GOC:jl]
EOG8Z91BB	GO:0006351	1/793	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8Z91BB	GO:0003899	1/793	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8Z91BB	GO:0044163	1/793	host cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of host cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the host cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the host cell. The various elements of the host cytoskeleton not only serve in the maintenance of host cellular shape but also have roles in other host cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:rph]
EOG8Z91BB	GO:0075521	1/793	microtubule-dependent intracellular transport of viral material towards nucleus	biological_process	"The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules." [UniProtKB-KW:KW-1177, VZ:983]
EOG8Z91BB	GO:0042025	1/793	host cell nucleus	cellular_component	"A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
EOG8Z91BB	GO:0030430	1/793	host cell cytoplasm	cellular_component	"The cytoplasm of a host cell." [GOC:mah]
EOG8Z91BB	GO:0004190	1/793	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8KD932	GO:0006030	20/42	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8KD932	GO:0008061	20/42	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8KD932	GO:0005576	20/42	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG80KBCM	GO:0035556	30/108	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG80KBCM	GO:0004435	25/108	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG80KBCM	GO:0004871	24/108	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG80KBCM	GO:0005509	20/108	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG80KBCM	GO:0006629	18/108	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG80KBCM	GO:0009395	11/108	phospholipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG80KBCM	GO:0008081	4/108	phosphoric diester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]
EOG80KBCM	GO:0030307	1/108	positive regulation of cell growth	biological_process	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG80KBCM	GO:0007298	1/108	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG80KBCM	GO:0032868	1/108	response to insulin	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]
EOG80KBCM	GO:0032065	1/108	cortical protein anchoring	biological_process	"A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw]
EOG80KBCM	GO:0005938	1/108	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG80KBCM	GO:0045596	1/108	negative regulation of cell differentiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]
EOG80KBCM	GO:0042059	1/108	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG80KBCM	GO:0005543	1/108	phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8PVRGB	GO:0005524	1/5	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8PVRGB	GO:0003723	1/5	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8PVRGB	GO:0006418	1/5	tRNA aminoacylation for protein translation	biological_process	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]
EOG8PVRGB	GO:0004822	1/5	isoleucine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.5, RHEA:11063]
EOG8JWXT7	GO:0007519	1/166	skeletal muscle tissue development	biological_process	"The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
EOG8JWXT7	GO:0008307	1/166	structural constituent of muscle	molecular_function	"The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah]
EOG8JWXT7	GO:0016203	1/166	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8JWXT7	GO:0000794	1/166	condensed nuclear chromosome	cellular_component	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh]
EOG8JWXT7	GO:0007062	1/166	sister chromatid cohesion	biological_process	"The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other." [GOC:jh, GOC:mah, ISBN:0815316194]
EOG8JWXT7	GO:0035206	1/166	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8JWXT7	GO:0007522	1/166	visceral muscle development	biological_process	"The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators]
EOG8JWXT7	GO:0007525	1/166	somatic muscle development	biological_process	"The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
EOG8JWXT7	GO:0030018	1/166	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8JWXT7	GO:0003779	1/166	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8JWXT7	GO:0007076	1/166	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8JWXT7	GO:0040011	1/166	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG8JWXT7	GO:0007517	1/166	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8JWXT7	GO:0007520	1/166	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG8JWXT7	GO:0030017	1/166	sarcomere	cellular_component	"The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]
EOG8JWXT7	GO:0045214	1/166	sarcomere organization	biological_process	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
EOG8JWXT7	GO:0007498	1/166	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8JWXT7	GO:0005875	1/166	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8JWXT7	GO:0016301	1/166	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8V720H	GO:0003677	17/146	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8V720H	GO:0006313	14/146	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG8V720H	GO:0015074	14/146	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8V720H	GO:0004803	14/146	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG8V720H	GO:0007476	1/146	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8V720H	GO:0002121	1/146	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG89KJ7B	GO:0004129	35/91	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG89KJ7B	GO:0016887	1/91	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG89KJ7B	GO:0005524	1/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8N06W3	GO:0003723	6/119	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8RV56H	GO:0005215	33/156	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8RV56H	GO:0016021	31/156	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RV56H	GO:0016020	3/156	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RV56H	GO:0005886	1/156	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8RV56H	GO:0055085	1/156	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8RV56H	GO:0007399	1/156	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8RV56H	GO:0006812	1/156	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8RV56H	GO:0007398	1/156	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG8RV56H	GO:0016337	1/156	single organismal cell-cell adhesion	biological_process	"The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb]
EOG8RV56H	GO:0007498	1/156	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8RV56H	GO:0015267	1/156	channel activity	molecular_function	"Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-]
EOG8RV56H	GO:0031410	1/156	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG8RV56H	GO:0005912	1/156	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8RV56H	GO:0046331	1/156	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8RV56H	GO:0044719	1/156	regulation of imaginal disc-derived wing size	biological_process	"Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
EOG8RV56H	GO:0030707	1/156	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8RV56H	GO:0007219	1/156	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8RV56H	GO:0005261	1/156	cation channel activity	molecular_function	"Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8B013N	GO:0000226	20/106	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8B013N	GO:0005874	20/106	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG80GG71	GO:0003676	20/947	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80GG71	GO:0008270	20/947	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80GG71	GO:0003677	3/947	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80GG71	GO:0005634	3/947	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80GG71	GO:0004190	2/947	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG80GG71	GO:0003964	2/947	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG80GG71	GO:0003723	2/947	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG80GG71	GO:0000786	1/947	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG80GG71	GO:0015074	1/947	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG80GG71	GO:0004812	1/947	aminoacyl-tRNA ligase activity	molecular_function	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
EOG80GG71	GO:0006334	1/947	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8GQSMF	GO:0008270	22/97	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GQSMF	GO:0016740	1/97	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG880MC4	GO:0007156	1/33	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG880MC4	GO:0016021	1/33	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG880MC4	GO:0005509	1/33	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8NZX77	GO:0015074	206/1674	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8NZX77	GO:0003964	173/1674	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8NZX77	GO:0003723	170/1674	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8NZX77	GO:0003676	151/1674	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NZX77	GO:0008270	67/1674	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NZX77	GO:0004190	64/1674	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8NZX77	GO:0004523	2/1674	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8NZX77	GO:0003677	2/1674	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NZX77	GO:0003899	1/1674	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8NZX77	GO:0043565	1/1674	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NZX77	GO:0005634	1/1674	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NZX77	GO:0003700	1/1674	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NZX77	GO:0004519	1/1674	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8NZX77	GO:0046872	1/1674	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NZX77	GO:0019048	1/1674	modulation by virus of host morphology or physiology	biological_process	"The process in which a virus effects a change in the structure or processes of its host organism." [GOC:bf, GOC:jl, ISBN:0781718325, UniProtKB-KW:KW-0945]
EOG8NZX77	GO:0019031	1/1674	viral envelope	cellular_component	"The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope]
EOG8NZX77	GO:0006351	1/1674	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8NZX77	GO:0008233	1/1674	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8MSGC0	GO:0004601	52/183	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG8MSGC0	GO:0006979	52/183	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8MSGC0	GO:0020037	52/183	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8MSGC0	GO:0060967	1/183	negative regulation of gene silencing by RNA	biological_process	"Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb]
EOG8MSGC0	GO:0016758	1/183	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8MSGC0	GO:0070189	1/183	kynurenine metabolic process	biological_process	"The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph]
EOG8MSGC0	GO:0005764	1/183	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8MSGC0	GO:1901216	1/183	positive regulation of neuron death	biological_process	"Any process that activates or increases the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]
EOG8MSGC0	GO:0006727	1/183	ommochrome biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
EOG8MSGC2	GO:0005089	21/80	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8MSGC2	GO:0035556	5/80	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8MSGC2	GO:0016740	2/80	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8FTZFK	GO:0003676	18/140	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FTZFK	GO:0046872	18/140	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DFS2D	GO:0005216	18/68	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8DFS2D	GO:0016021	18/68	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DFS2D	GO:0006812	1/68	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8DFS2D	GO:0004692	1/68	cGMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
EOG8DFS2D	GO:0005221	1/68	intracellular cyclic nucleotide activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG8DFS2D	GO:0017071	1/68	intracellular cyclic nucleotide activated cation channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah]
EOG8DFS2D	GO:0019935	1/68	cyclic-nucleotide-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
EOG8CZDZF	GO:0043565	33/120	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8CZDZF	GO:0005634	33/120	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CZDZF	GO:0006351	32/120	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8CZDZF	GO:0003700	32/120	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8CZDZF	GO:0008301	1/120	DNA binding, bending	molecular_function	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]
EOG8CZDZF	GO:0006366	1/120	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8CZDZF	GO:0003705	1/120	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG8CZDZF	GO:0007389	1/120	pattern specification process	biological_process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
EOG8CZDZF	GO:0048806	1/120	genitalia development	biological_process	"The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid]
EOG8CZDZF	GO:0000122	1/120	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8CZDZF	GO:0008134	1/120	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8CZDZF	GO:0009888	1/120	tissue development	biological_process	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]
EOG8CZDZF	GO:0005667	1/120	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8CZDZF	GO:0051090	1/120	regulation of sequence-specific DNA binding transcription factor activity	biological_process	"Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]
EOG8CZDZF	GO:0003690	1/120	double-stranded DNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh]
EOG8DFS2J	GO:0005509	4/17	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8DFS2J	GO:0005886	4/17	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8DFS2J	GO:0007156	4/17	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8DFS2J	GO:0016021	3/17	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG883GM6	GO:0000166	27/120	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG883GM6	GO:0003676	20/120	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG883GM6	GO:0022008	1/120	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG883GM6	GO:0030182	1/120	neuron differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
EOG883GM6	GO:0003729	1/120	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG883GM6	GO:0005634	1/120	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG89W4VV	GO:0030554	2/15	adenyl nucleotide binding	molecular_function	"Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732]
EOG89W4VV	GO:0003938	2/15	IMP dehydrogenase activity	molecular_function	"Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205]
EOG89W4VV	GO:0005737	1/15	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG89W4VV	GO:0046872	1/15	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89W4VV	GO:0006164	1/15	purine nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
EOG89W4VV	GO:0006177	1/15	GMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732]
EOG89W4VX	GO:0004984	10/20	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG89W4VX	GO:0016021	10/20	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89W4VX	GO:0004930	10/20	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG89W4VX	GO:0005549	10/20	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG89W4VX	GO:0005886	8/20	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG89W4VX	GO:0050911	1/20	detection of chemical stimulus involved in sensory perception of smell	biological_process	"The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8QJV3F	GO:0004252	41/104	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8QJV3F	GO:0006508	3/104	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8B0146	GO:0005524	53/172	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8B0146	GO:0004674	48/172	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8B0146	GO:0004672	4/172	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8B0146	GO:0004683	3/172	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG8B0146	GO:0006468	2/172	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8B0146	GO:0000780	1/172	condensed nuclear chromosome, centromeric region	cellular_component	"The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
EOG8B0146	GO:0005813	1/172	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8B0146	GO:0007076	1/172	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8B0146	GO:0000281	1/172	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8B0146	GO:0000070	1/172	mitotic sister chromatid segregation	biological_process	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
EOG8B0146	GO:0051233	1/172	spindle midzone	cellular_component	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
EOG8B0146	GO:0006325	1/172	chromatin organization	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
EOG8B0146	GO:0008608	1/172	attachment of spindle microtubules to kinetochore	biological_process	"The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137]
EOG8B0146	GO:0051298	1/172	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8B0146	GO:0051297	1/172	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8B0146	GO:0051299	1/172	centrosome separation	biological_process	"The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai]
EOG8B0146	GO:0000775	1/172	chromosome, centromeric region	cellular_component	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]
EOG8B0146	GO:0016572	1/172	histone phosphorylation	biological_process	"The modification of histones by addition of phosphate groups." [GOC:ai]
EOG8B0146	GO:0007100	1/172	mitotic centrosome separation	biological_process	"Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194]
EOG8B0146	GO:0007052	1/172	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8B0146	GO:0000776	1/172	kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG8B0146	GO:0007126	1/172	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8B0146	GO:0005737	1/172	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8B0146	GO:0030496	1/172	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG8B0146	GO:0007279	1/172	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8B0146	GO:0007098	1/172	centrosome cycle	biological_process	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]
EOG8B0146	GO:0005819	1/172	spindle	cellular_component	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
EOG8B0146	GO:0032133	1/172	chromosome passenger complex	cellular_component	"A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910]
EOG8B0146	GO:0008105	1/172	asymmetric protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma]
EOG8B0146	GO:0022008	1/172	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8B0146	GO:0050767	1/172	regulation of neurogenesis	biological_process	"Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]
EOG8B0146	GO:0046872	1/172	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8B0146	GO:0051294	1/172	establishment of spindle orientation	biological_process	"Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai]
EOG8B0146	GO:0045167	1/172	asymmetric protein localization involved in cell fate determination	biological_process	"Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai]
EOG8B0146	GO:0007017	1/172	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG82JR8P	GO:0006302	4/34	double-strand break repair	biological_process	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]
EOG82JR8P	GO:0003677	4/34	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG82JR8P	GO:0006310	4/34	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG82JR8P	GO:0005634	3/34	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82Z774	GO:0048047	1/66	mating behavior, sex discrimination	biological_process	"The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700]
EOG82Z774	GO:0005179	1/66	hormone activity	molecular_function	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]
EOG82Z774	GO:0048018	1/66	receptor agonist activity	molecular_function	"Interacts with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb, ISBN:0198506732]
EOG82Z774	GO:0005615	1/66	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG82Z774	GO:0007218	1/66	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG82Z774	GO:0007621	1/66	negative regulation of female receptivity	biological_process	"Any process that stops, prevents or reduces the receptiveness of a female to male advances." [GOC:bf, PMID:11092827]
EOG82Z774	GO:0071855	1/66	neuropeptide receptor binding	molecular_function	"Interacting selectively and non-covalently with a neuropeptide receptor." [GOC:kmv, GOC:mah]
EOG82Z774	GO:0005184	1/66	neuropeptide hormone activity	molecular_function	"The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]
EOG85B3ZM	GO:0008121	12/49	ubiquinol-cytochrome-c reductase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]
EOG85B3ZM	GO:0009055	12/49	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8XWJDB	GO:0051726	1/89	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG80ZTBF	GO:0008270	19/87	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80ZTBF	GO:0016874	3/87	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG854CGX	GO:0004519	1/18	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG854CGX	GO:0003964	1/18	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG854CGX	GO:0003723	1/18	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG880MCS	GO:0003676	1/74	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG880MCS	GO:0033209	1/74	tumor necrosis factor-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG880MCS	GO:0070050	1/74	neuron cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah]
EOG880MCS	GO:0005031	1/74	tumor necrosis factor-activated receptor activity	molecular_function	"Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function." [GOC:jl, http://lookwayup.com/]
EOG880MCS	GO:0003677	1/74	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG880MCS	GO:0006281	1/74	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG880MCS	GO:0003910	1/74	DNA ligase (ATP) activity	molecular_function	"Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]
EOG880MCS	GO:0005887	1/74	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG880MCS	GO:0006310	1/74	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG880MCS	GO:0007166	1/74	cell surface receptor signaling pathway	biological_process	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
EOG880MCS	GO:0008270	1/74	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG880MCS	GO:0006915	1/74	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG880MCS	GO:0072499	1/74	photoreceptor cell axon guidance	biological_process	"The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
EOG880MCS	GO:0005515	1/74	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG880MCS	GO:0005634	1/74	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG880MCS	GO:1900074	1/74	negative regulation of neuromuscular synaptic transmission	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
EOG8NZX7J	GO:0016021	15/49	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NZX7J	GO:0055085	15/49	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8WWV00	GO:0005524	3/11	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WWV00	GO:0003677	2/11	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8WWV00	GO:0008270	2/11	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WWV00	GO:0017111	2/11	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8WQ3GZ	GO:0006099	48/110	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8WQ3GZ	GO:0045239	43/110	tricarboxylic acid cycle enzyme complex	cellular_component	"Any of the heteromeric enzymes that act in the TCA cycle." [GOC:mah]
EOG8WQ3GZ	GO:0006106	43/110	fumarate metabolic process	biological_process	"The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [ISBN:0198506732]
EOG8WQ3GZ	GO:0004333	43/110	fumarate hydratase activity	molecular_function	"Catalysis of the reaction: (S)-malate = fumarate + H(2)O." [EC:4.2.1.2, RHEA:12463]
EOG8WQ3GZ	GO:0016829	5/110	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8WQ3GZ	GO:0003824	2/110	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8WQ3GZ	GO:0005739	1/110	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8NZX7C	GO:0045480	1/47	galactose oxidase activity	molecular_function	"Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide." [EC:1.1.3.9]
EOG80S2WC	GO:0006629	148/439	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG80S2WC	GO:0005576	148/439	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG80S2WC	GO:0008970	88/439	phosphatidylcholine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32]
EOG80S2WC	GO:0016787	52/439	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG80S2WC	GO:0052739	12/439	phosphatidylserine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG:R04034]
EOG80S2WC	GO:0052740	12/439	1-acyl-2-lysophosphatidylserine acylhydrolase activity	molecular_function	"Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32]
EOG80S2WC	GO:0004806	11/439	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG80S2WC	GO:0003824	3/439	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG80S2WC	GO:0003676	1/439	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80S2WC	GO:0008270	1/439	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80S2WC	GO:0022008	1/439	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8GTNW6	GO:0006810	42/118	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8GTNW6	GO:0005622	42/118	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8GTNW6	GO:0050829	1/118	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GTNW6	GO:0003676	1/118	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GTNW6	GO:0045824	1/118	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG8GTNW6	GO:0003723	1/118	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8GTNW6	GO:0005635	1/118	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG8GTNW6	GO:0005654	1/118	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG8GTNW6	GO:0015031	1/118	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8GTNW6	GO:0005737	1/118	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8GTNW6	GO:0016973	1/118	poly(A)+ mRNA export from nucleus	biological_process	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]
EOG8GTNW6	GO:0003964	1/118	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8WQ3GQ	GO:0004619	4/17	phosphoglycerate mutase activity	molecular_function	"Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1]
EOG8WQ3GQ	GO:0030145	4/17	manganese ion binding	molecular_function	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
EOG8WQ3GQ	GO:0006007	4/17	glucose catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai]
EOG8WQ3GQ	GO:0005737	4/17	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8GQSM0	GO:0016021	8/37	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GQSM0	GO:0035556	8/37	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8GQSM0	GO:0000166	6/37	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8GQSM0	GO:0009190	4/37	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG8GQSM0	GO:0004383	4/37	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG8GQSM0	GO:0016849	4/37	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG8GQSM0	GO:0004672	2/37	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8GQSM0	GO:0005524	2/37	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8N06X6	GO:0008270	7/79	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8284GK	GO:0016757	5/23	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8284GK	GO:0050510	1/23	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	molecular_function	"Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.226, MetaCyc:2.4.1.226-RXN]
EOG8NW22Z	GO:0016021	69/289	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NW22Z	GO:0004930	45/289	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8NW22Z	GO:0004935	13/289	adrenergic receptor activity	molecular_function	"Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274]
EOG8NW22Z	GO:0005886	11/289	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8NW22Z	GO:0004993	7/289	serotonin receptor activity	molecular_function	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai]
EOG8NW22Z	GO:0043565	4/289	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NW22Z	GO:0004715	4/289	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8NW22Z	GO:0003700	4/289	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NW22Z	GO:0007186	3/289	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8NW22Z	GO:0010579	3/289	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	biological_process	"Any process that increases the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G-protein coupled receptor signaling pathway." [GOC:dph, GOC:signaling, GOC:tb]
EOG8NW22Z	GO:0008227	3/289	G-protein coupled amine receptor activity	molecular_function	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
EOG8NW22Z	GO:0004989	3/289	octopamine receptor activity	molecular_function	"Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [CHEBI:17134, GOC:ai]
EOG8NW22Z	GO:0005887	3/289	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NW22Z	GO:0007189	3/289	adenylate cyclase-activating G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
EOG8NW22Z	GO:0004977	2/289	melanocortin receptor activity	molecular_function	"Combining with melanocortin to initiate a change in cell activity." [GOC:ai]
EOG8NW22Z	GO:0045886	1/289	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8NW22Z	GO:0007188	1/289	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194]
EOG8NW22Z	GO:0045887	1/289	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8S7N56	GO:0000287	26/87	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8S7N56	GO:0008253	26/87	5'-nucleotidase activity	molecular_function	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]
EOG8S7N56	GO:0005737	25/87	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8S7N56	GO:0016298	3/87	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG8S7N56	GO:0006629	3/87	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8S7N56	GO:0008252	1/87	nucleotidase activity	molecular_function	"Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [EC:3.1.3.31]
EOG8S7N56	GO:0000166	1/87	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8S7N56	GO:0009158	1/87	ribonucleoside monophosphate catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
EOG8S7N56	GO:0009117	1/87	nucleotide metabolic process	biological_process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]
EOG8S7N56	GO:1901069	1/87	guanosine-containing compound catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of guanosine-containing compounds (guanosines)." [GOC:TermGenie]
EOG8S7N56	GO:0005829	1/87	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8S7N56	GO:0016311	1/87	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG86T5G8	GO:0006260	9/99	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG86T5G8	GO:0003677	9/99	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86T5G8	GO:0005524	4/99	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG86T5G8	GO:0009378	3/99	four-way junction helicase activity	molecular_function	"Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [GOC:jl, PMID:9442895]
EOG86T5G8	GO:0006281	3/99	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG86T5G8	GO:0006310	3/99	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG86T5G8	GO:0000166	3/99	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG86T5G8	GO:0004386	2/99	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG86T5G8	GO:0017111	2/99	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8284H5	GO:0016021	71/178	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8284H7	GO:0006412	21/70	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8284H7	GO:0005840	21/70	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8284H7	GO:0003735	21/70	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG844P06	GO:0016021	81/188	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG844P06	GO:0005524	81/188	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG844P06	GO:0042626	77/188	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG844P06	GO:0008559	6/188	xenobiotic-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44]
EOG844P06	GO:0031427	4/188	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG844P06	GO:0005886	4/188	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG844P06	GO:0055085	4/188	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG844P06	GO:0015440	2/188	peptide-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [EC:3.6.3.43]
EOG844P06	GO:0006855	2/188	drug transmembrane transport	biological_process	"The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:ai, GOC:bf]
EOG844P06	GO:0015238	1/188	drug transmembrane transporter activity	molecular_function	"Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [ISBN:0198506732]
EOG844P06	GO:0060857	1/188	establishment of glial blood-brain barrier	biological_process	"Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
EOG844P06	GO:0008354	1/188	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG844P06	GO:0042908	1/188	xenobiotic transport	biological_process	"The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
EOG844P06	GO:0001666	1/188	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG844P06	GO:0005919	1/188	pleated septate junction	cellular_component	"A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298]
EOG844P06	GO:0015562	1/188	efflux transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG844P06	GO:0043190	1/188	ATP-binding cassette (ABC) transporter complex	cellular_component	"A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107]
EOG844P06	GO:0005887	1/188	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CG2R8	GO:0003676	293/3952	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CG2R8	GO:0015074	167/3952	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8CG2R8	GO:0008270	165/3952	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CG2R8	GO:0003723	66/3952	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CG2R8	GO:0003964	66/3952	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8CG2R8	GO:0004190	48/3952	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8CG2R8	GO:0005634	3/3952	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CG2R8	GO:0005509	3/3952	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8CG2R8	GO:0003677	3/3952	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CG2R8	GO:0016021	2/3952	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CG2R8	GO:0007166	2/3952	cell surface receptor signaling pathway	biological_process	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
EOG8CG2R8	GO:0004842	2/3952	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8CG2R8	GO:0023051	2/3952	regulation of signaling	biological_process	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
EOG8CG2R8	GO:0046872	2/3952	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CG2R8	GO:0004871	2/3952	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8CG2R8	GO:0003700	1/3952	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8CG2R8	GO:0016620	1/3952	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG8CG2R8	GO:0004527	1/3952	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8CG2R8	GO:0005524	1/3952	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CG2R8	GO:0055085	1/3952	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8CG2R8	GO:0043565	1/3952	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8CG2R8	GO:0004518	1/3952	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8CG2R8	GO:0004672	1/3952	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8CG2R8	GO:0004725	1/3952	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8CG2R8	GO:0005840	1/3952	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8CG2R8	GO:0006412	1/3952	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8CG2R8	GO:0022857	1/3952	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8CG2R8	GO:0019031	1/3952	viral envelope	cellular_component	"The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope]
EOG8CG2R8	GO:0003735	1/3952	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8CG2R8	GO:0016491	1/3952	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8CG2R8	GO:0005975	1/3952	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG88971H	GO:0005524	2/21	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88971H	GO:0005874	2/21	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG88971H	GO:0003777	2/21	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG88971H	GO:0007018	2/21	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG88971H	GO:0005871	2/21	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8S1WPB	GO:0007156	2/24	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8S1WPB	GO:0016021	2/24	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S1WPB	GO:0005886	2/24	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8S1WPB	GO:0005509	2/24	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8R26BJ	GO:0015991	65/111	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8R26BJ	GO:0015078	65/111	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG8R26BJ	GO:0033179	63/111	proton-transporting V-type ATPase, V0 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG8R26BJ	GO:0016787	5/111	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8R26BJ	GO:0000220	2/111	vacuolar proton-transporting V-type ATPase, V0 domain	cellular_component	"The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG8R26BJ	GO:0033181	1/111	plasma membrane proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
EOG8R26BJ	GO:0005886	1/111	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8FJBRW	GO:0016021	1/55	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FJBRW	GO:0004579	1/55	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	molecular_function	"Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119]
EOG8FJBRW	GO:0006486	1/55	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8FJBRW	GO:0005783	1/55	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8FJBRW	GO:0005739	1/55	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG86HJSW	GO:0016740	1/28	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8FXTPM	GO:0003824	23/90	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8FXTPM	GO:0004300	3/90	enoyl-CoA hydratase activity	molecular_function	"Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.17]
EOG8FXTPM	GO:0005811	1/90	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8FXTPM	GO:0005875	1/90	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8P5NQ5	GO:0006097	1/99	glyoxylate cycle	biological_process	"A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732]
EOG8P5NQ5	GO:0004474	1/99	malate synthase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+)." [EC:2.3.3.9, RHEA:18184]
EOG82JR6D	GO:0003824	21/67	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG886BSZ	GO:0016021	26/104	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG886BSZ	GO:0004930	25/104	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG886BSZ	GO:0001587	1/104	Gq/11-coupled serotonin receptor activity	molecular_function	"Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels." [GOC:bf, GOC:mah, PMID:18571247, PMID:18703043]
EOG886BSZ	GO:0004993	1/104	serotonin receptor activity	molecular_function	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai]
EOG886BSZ	GO:0007210	1/104	serotonin receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah]
EOG886BSZ	GO:2000253	1/104	positive regulation of feeding behavior	biological_process	"Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol]
EOG886BSZ	GO:0008227	1/104	G-protein coupled amine receptor activity	molecular_function	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
EOG886BSZ	GO:0005886	1/104	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG886BSZ	GO:0007377	1/104	germ-band extension	biological_process	"Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:08795694238]
EOG8TB6V3	GO:0030695	14/52	GTPase regulator activity	molecular_function	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
EOG8HTC6V	GO:0016021	121/277	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HTC6V	GO:0032580	121/277	Golgi cisterna membrane	cellular_component	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]
EOG8HTC6V	GO:0006486	121/277	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8HTC6V	GO:0008417	116/277	fucosyltransferase activity	molecular_function	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
EOG8HTC6V	GO:0017060	3/277	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	molecular_function	"Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.65]
EOG8HTC6V	GO:0018392	3/277	glycoprotein 3-alpha-L-fucosyltransferase activity	molecular_function	"Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H(+)." [EC:2.4.1.214, RHEA:24447]
EOG8HTC6V	GO:0005797	1/277	Golgi medial cisterna	cellular_component	"The middle Golgi cisterna (or cisternae)." [ISBN:0815316194]
EOG8HTC6V	GO:0033932	1/277	1,3-alpha-L-fucosidase activity	molecular_function	"Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins." [EC:3.2.1.111]
EOG8HTC6V	GO:0046920	1/277	alpha-(1->3)-fucosyltransferase activity	molecular_function	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]
EOG8HTC6V	GO:0007399	1/277	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8HTC6V	GO:0036071	1/277	N-glycan fucosylation	biological_process	"The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains." [CHEBI:59520, GOC:sart, PMID:19948734]
EOG8XH2GQ	GO:0042302	1098/2997	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8XH2GQ	GO:0031012	32/2997	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8XH2GQ	GO:0040003	31/2997	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8XH2GQ	GO:0008010	31/2997	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8XH2GQ	GO:0022008	2/2997	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8XH2GQ	GO:0008011	2/2997	structural constituent of pupal chitin-based cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8XH2GQ	GO:0032504	1/2997	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8XH2GQ	GO:0048058	1/2997	compound eye corneal lens development	biological_process	"The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells." [GOC:jid]
EOG8XH2GQ	GO:0005615	1/2997	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8XH2GQ	GO:0005212	1/2997	structural constituent of eye lens	molecular_function	"The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah]
EOG8XH2GQ	GO:0005576	1/2997	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8XH2GQ	GO:0005509	1/2997	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8XH2GQ	GO:0007601	1/2997	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8XH2GQ	GO:0003824	1/2997	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8XH2GQ	GO:0005811	1/2997	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8H48KB	GO:0016021	9/61	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8H48KB	GO:0005375	9/61	copper ion transmembrane transporter activity	molecular_function	"Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai]
EOG8GTNSR	GO:0007165	95/374	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8GTNSR	GO:0016021	55/374	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GTNSR	GO:0004721	6/374	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8GTNSR	GO:0046790	1/374	virion binding	molecular_function	"Interacting selectively and non-covalently with a virion, either by binding to components of the capsid or the viral envelope." [GOC:ai]
EOG8GTNSR	GO:0002227	1/374	innate immune response in mucosa	biological_process	"Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105]
EOG8GTNSR	GO:0006952	1/374	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8GTNSR	GO:0005886	1/374	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8GTNSR	GO:0006955	1/374	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8GTNSR	GO:0002752	1/374	cell surface pattern recognition receptor signaling pathway	biological_process	"Any series of molecular signals generated as a consequence of a cell surface pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
EOG8GTNSR	GO:0010508	1/374	positive regulation of autophagy	biological_process	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8GTNSR	GO:0019731	1/374	antibacterial humoral response	biological_process	"An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8GTNSR	GO:0048598	1/374	embryonic morphogenesis	biological_process	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]
EOG8GTNSR	GO:0009653	1/374	anatomical structure morphogenesis	biological_process	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]
EOG8GTNSR	GO:0004888	1/374	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8GTNSR	GO:0008329	1/374	signaling pattern recognition receptor activity	molecular_function	"Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity." [GOC:ar, PMID:12507420, PMID:12925128, PMID:14523544, Wikipedia:Pattern_recognition_receptor]
EOG8GTNSR	GO:0009897	1/374	external side of plasma membrane	cellular_component	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]
EOG8GTNSR	GO:0060049	1/374	regulation of protein glycosylation	biological_process	"Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr]
EOG8GTNSR	GO:0048935	1/374	peripheral nervous system neuron development	biological_process	"The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh]
EOG8GTNSR	GO:0007275	1/374	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8GTNSR	GO:0050688	1/374	regulation of defense response to virus	biological_process	"Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai]
EOG8GTNSR	GO:0051607	1/374	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG8GTNSR	GO:0007155	1/374	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8GTNSR	GO:0005737	1/374	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8M67Z3	GO:0003682	11/17	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8577NG	GO:0004012	3/29	phospholipid-translocating ATPase activity	molecular_function	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684]
EOG8577NG	GO:0005524	3/29	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8577NG	GO:0000287	3/29	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8577NG	GO:0016021	3/29	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FN6XQ	GO:0016491	9/70	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8FN6XQ	GO:0005507	9/70	copper ion binding	molecular_function	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]
EOG83R62S	GO:0003896	3/35	DNA primase activity	molecular_function	"Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases." [GOC:mah, GOC:mcc, ISBN:0716720094, PMID:26184436]
EOG83R62S	GO:0020037	1/35	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG83R62S	GO:0046872	1/35	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8BCH3F	GO:0003700	27/104	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8BCH3F	GO:0005634	26/104	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BCH3F	GO:0000976	19/104	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8BCH3F	GO:0043565	8/104	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8BCH3F	GO:0007411	1/104	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8BCH3F	GO:0004000	1/104	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8BCH3F	GO:0048663	1/104	neuron fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph]
EOG8HHRHG	GO:0016021	111/321	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HHRHG	GO:0055085	111/321	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8HHRHG	GO:0008260	2/321	3-oxoacid CoA-transferase activity	molecular_function	"Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [EC:2.8.3.5]
EOG8HHRHG	GO:0005886	1/321	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8HHRHG	GO:0005215	1/321	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8HHRHG	GO:0006171	1/321	cAMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]
EOG8HHRHG	GO:0004016	1/321	adenylate cyclase activity	molecular_function	"Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]
EOG81NX22	GO:0016021	20/83	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81NX22	GO:0005267	20/83	potassium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8D2979	GO:0032504	3/136	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8D2979	GO:0005615	3/136	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8D2979	GO:0004857	1/136	enzyme inhibitor activity	molecular_function	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai]
EOG8D2979	GO:0043086	1/136	negative regulation of catalytic activity	biological_process	"Any process that stops or reduces the activity of an enzyme." [GOC:jl, GOC:tb]
EOG8M0HGC	GO:0016021	35/133	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M0HGC	GO:0005000	29/133	vasopressin receptor activity	molecular_function	"Combining with vasopressin to initiate a change in cell activity." [GOC:ai]
EOG8M0HGC	GO:0004930	6/133	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8M0HGC	GO:0018990	1/133	ecdysis, chitin-based cuticle	biological_process	"The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8M0HGC	GO:0007186	1/133	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8M0HGC	GO:0008188	1/133	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8M0HGC	GO:0007218	1/133	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8M0HGC	GO:0005887	1/133	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M3CSC	GO:0005811	1/109	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8BZQHV	GO:0016491	14/46	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8BZQHV	GO:0016630	1/46	protochlorophyllide reductase activity	molecular_function	"Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33]
EOG87Q0MP	GO:0016787	1/35	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8RNDPK	GO:0016021	1/108	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RNDPK	GO:0055085	1/108	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG83V29G	GO:0042384	1/79	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8MSGGG	GO:0003676	2/235	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MSGGG	GO:0005524	2/235	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8MSGGG	GO:0006094	1/235	gluconeogenesis	biological_process	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]
EOG8MSGGG	GO:0003968	1/235	RNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah]
EOG8MSGGG	GO:0004736	1/235	pyruvate carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847]
EOG8MSGGG	GO:0004075	1/235	biotin carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]
EOG8MSGGG	GO:0003964	1/235	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8MSGGG	GO:0008026	1/235	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8MSGGG	GO:0019079	1/235	viral genome replication	biological_process	"Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534]
EOG8K9DV8	GO:0015074	1/50	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8K9DV8	GO:0003676	1/50	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88D3BT	GO:0005750	33/98	mitochondrial respiratory chain complex III	cellular_component	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684]
EOG88D3BT	GO:0006122	33/98	mitochondrial electron transport, ubiquinol to cytochrome c	biological_process	"The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]
EOG88D3BT	GO:0016491	3/98	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG88D3BT	GO:0008340	1/98	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG88D3BT	GO:0000302	1/98	response to reactive oxygen species	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc]
EOG88D3BT	GO:0008121	1/98	ubiquinol-cytochrome-c reductase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]
EOG88D3BT	GO:0034551	1/98	mitochondrial respiratory chain complex III assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc]
EOG8QFZV3	GO:0005975	201/525	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8QFZV3	GO:0043169	199/525	cation binding	molecular_function	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]
EOG8QFZV3	GO:0003824	188/525	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8QFZV3	GO:0032450	12/525	maltose alpha-glucosidase activity	molecular_function	"Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141]
EOG8QFZV3	GO:0016740	1/525	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8QFZV3	GO:0003677	1/525	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8PVRFT	GO:0005507	27/100	copper ion binding	molecular_function	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]
EOG8PVRFT	GO:0055070	27/100	copper ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
EOG8JMB6B	GO:0003676	2/20	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JMB6B	GO:0015074	2/20	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG854CDK	GO:0005024	3/40	transforming growth factor beta-activated receptor activity	molecular_function	"Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]
EOG854CDK	GO:0016020	3/40	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Q87CD	GO:0016021	42/106	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Q87CD	GO:0045747	2/106	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8Q87CD	GO:0007298	2/106	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8Q87CD	GO:0006909	1/106	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8Q87CD	GO:0007399	1/106	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8S7N58	GO:0008270	8/24	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8S7N58	GO:0004518	7/24	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8S7N58	GO:0003677	7/24	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8MPM5T	GO:0016021	2/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8MPM5T	GO:0004937	1/9	alpha1-adrenergic receptor activity	molecular_function	"Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]
EOG8MPM5T	GO:0005886	1/9	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8MPM5T	GO:0004935	1/9	adrenergic receptor activity	molecular_function	"Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274]
EOG8MPM5T	GO:0055117	1/9	regulation of cardiac muscle contraction	biological_process	"Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd]
EOG8MPM5T	GO:0019229	1/9	regulation of vasoconstriction	biological_process	"Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels." [GOC:jl]
EOG8PG8DR	GO:0009253	3/17	peptidoglycan catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
EOG8PG8DR	GO:0008745	3/17	N-acetylmuramoyl-L-alanine amidase activity	molecular_function	"Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]
EOG8PG8DR	GO:0004252	1/17	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8X3KHJ	GO:0008270	126/815	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X3KHJ	GO:0003676	118/815	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X3KHJ	GO:0003964	12/815	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8X3KHJ	GO:0003723	12/815	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8X3KHJ	GO:0003677	1/815	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X3KHJ	GO:0016192	1/815	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8X3KHJ	GO:0015074	1/815	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8X3KHJ	GO:0016020	1/815	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8VDSFF	GO:0016020	35/2018	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8VDSFF	GO:0051781	22/2018	positive regulation of cell division	biological_process	"Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai]
EOG8VDSFF	GO:0007435	2/2018	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8VDSFF	GO:0035099	2/2018	hemocyte migration	biological_process	"The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551]
EOG8VDSFF	GO:0003964	1/2018	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8VDSFF	GO:0008039	1/2018	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8VDSFF	GO:0035172	1/2018	hemocyte proliferation	biological_process	"The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG8ZSCHB	GO:0016757	23/78	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8ZSCHB	GO:0006486	23/78	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8ZSCHB	GO:0016021	23/78	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZSCHB	GO:0005794	22/78	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8ZSCHB	GO:0046872	8/78	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZSCHB	GO:0004653	4/78	polypeptide N-acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595]
EOG8ZSCHB	GO:0009312	1/78	oligosaccharide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]
EOG8ZSCHB	GO:0000139	1/78	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8ZSCHB	GO:0005795	1/78	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG805VF0	GO:0016021	70/329	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG805VF0	GO:0022857	41/329	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG805VF0	GO:0055085	29/329	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG805VF0	GO:0005215	13/329	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG805VF0	GO:0008643	1/329	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8FFGG3	GO:0007165	110/271	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8FFGG3	GO:0016021	58/271	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FFGG3	GO:0000281	2/271	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8FFGG3	GO:0045087	2/271	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8FFGG3	GO:0006967	2/271	positive regulation of antifungal peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah]
EOG8FFGG3	GO:0008063	2/271	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8FFGG3	GO:0004721	2/271	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8FFGG3	GO:0009620	1/271	response to fungus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
EOG8FFGG3	GO:0009880	1/271	embryonic pattern specification	biological_process	"The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
EOG8FFGG3	GO:0007352	1/271	zygotic specification of dorsal/ventral axis	biological_process	"The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf]
EOG8FFGG3	GO:0005737	1/271	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8FFGG3	GO:0016201	1/271	synaptic target inhibition	biological_process	"The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]
EOG8FFGG3	GO:0019732	1/271	antifungal humoral response	biological_process	"An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8FFGG3	GO:0019730	1/271	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG8FFGG3	GO:0015026	1/271	coreceptor activity	molecular_function	"Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators]
EOG8FFGG3	GO:0019901	1/271	protein kinase binding	molecular_function	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]
EOG8FFGG3	GO:0003676	1/271	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FFGG3	GO:0051536	1/271	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8FFGG3	GO:0050832	1/271	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8FFGG3	GO:0004888	1/271	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8FFGG3	GO:0043234	1/271	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8FFGG3	GO:0045610	1/271	regulation of hemocyte differentiation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG8FFGG3	GO:0070976	1/271	TIR domain binding	molecular_function	"Interacting selectively and non-covalently with a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]
EOG8FFGG3	GO:0009950	1/271	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8FFGG3	GO:0007416	1/271	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG8FFGG3	GO:0035172	1/271	hemocyte proliferation	biological_process	"The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG8FFGG3	GO:0019955	1/271	cytokine binding	molecular_function	"Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471]
EOG8FFGG3	GO:0007155	1/271	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8FFGG3	GO:0007507	1/271	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8FFGG3	GO:0005769	1/271	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG8FFGG3	GO:0006963	1/271	positive regulation of antibacterial peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475]
EOG8FFGG3	GO:0005515	1/271	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FFGG3	GO:0002807	1/271	positive regulation of antimicrobial peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
EOG8FFGG3	GO:0009897	1/271	external side of plasma membrane	cellular_component	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]
EOG8FFGG3	GO:0042802	1/271	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG8FFGG3	GO:0005121	1/271	Toll binding	molecular_function	"Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb]
EOG8FFGG3	GO:0050830	1/271	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG8FFGG3	GO:0006952	1/271	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8FFGG3	GO:0030097	1/271	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG8FFGG3	GO:0005886	1/271	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8FFGG3	GO:0009617	1/271	response to bacterium	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]
EOG8FFGG3	GO:0008270	1/271	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FFGG3	GO:0002121	1/271	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8FFGG3	GO:0006955	1/271	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8W10TF	GO:0004930	4/57	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8W10TF	GO:0004984	4/57	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8W10TF	GO:0016021	4/57	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W10TF	GO:0005549	4/57	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8W10TF	GO:0050911	1/57	detection of chemical stimulus involved in sensory perception of smell	biological_process	"The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8W10TF	GO:0004888	1/57	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8W10TF	GO:0007186	1/57	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8W10TF	GO:0005886	1/57	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8W10TF	GO:0007608	1/57	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8W10TF	GO:0032590	1/57	dendrite membrane	cellular_component	"The portion of the plasma membrane surrounding a dendrite." [GOC:mah]
EOG8W10TF	GO:0030425	1/57	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8X3KHC	GO:0016021	6/14	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X3KHC	GO:0006810	5/14	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8X3KHC	GO:0055085	1/14	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8CZDW0	GO:0003676	9/35	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CZDW0	GO:0003677	2/35	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8W10TT	GO:0016021	26/124	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W10TT	GO:0004930	25/124	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8W10TT	GO:0004993	3/124	serotonin receptor activity	molecular_function	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai]
EOG8W10TT	GO:0007626	2/124	locomotory behavior	biological_process	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
EOG8W10TT	GO:0005887	2/124	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W10TT	GO:0007631	2/124	feeding behavior	biological_process	"Behavior associated with the intake of food." [GOC:mah]
EOG8W10TT	GO:0007210	1/124	serotonin receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah]
EOG8HMMQ4	GO:0007156	6/39	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8HMMQ4	GO:0016021	6/39	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HMMQ4	GO:0005886	6/39	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8HMMQ4	GO:0005509	6/39	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8HB12X	GO:0007052	1/87	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8HB12X	GO:0000398	1/87	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8HB12X	GO:0071011	1/87	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8GMXB0	GO:0008233	12/66	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG805VFS	GO:0016021	217/605	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG805VFS	GO:0005886	209/605	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG805VFS	GO:0050909	202/605	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG805VFS	GO:0008527	21/605	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG805VFS	GO:0050912	8/605	detection of chemical stimulus involved in sensory perception of taste	biological_process	"The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG805VFS	GO:0004930	3/605	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG805VFS	GO:0030425	2/605	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG805VFS	GO:0004984	2/605	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG805VFS	GO:0017085	2/605	response to insecticide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]
EOG805VFS	GO:0030424	2/605	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG805VFS	GO:0007635	2/605	chemosensory behavior	biological_process	"Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators]
EOG805VFS	GO:0005549	2/605	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG805VFS	GO:0046957	1/605	negative phototaxis	biological_process	"The directed movement of a cell or organism away from a source of light." [GOC:ai]
EOG805VFS	GO:0007631	1/605	feeding behavior	biological_process	"Behavior associated with the intake of food." [GOC:mah]
EOG805VFS	GO:0040040	1/605	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG805VFS	GO:0031000	1/605	response to caffeine	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah]
EOG805VFS	GO:0006955	1/605	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG805VFS	GO:0007602	1/605	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG805VFS	GO:0046982	1/605	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG805VFS	GO:0008049	1/605	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG805VFS	GO:0035006	1/605	melanization defense response	biological_process	"The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809]
EOG805VFS	GO:0042742	1/605	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG805VFS	GO:0044297	1/605	cell body	cellular_component	"The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]
EOG8NKF9Q	GO:0016020	55/747	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NKF9Q	GO:0007157	8/747	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]
EOG8NKF9Q	GO:0005887	3/747	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NKF9Q	GO:0007415	2/747	defasciculation of motor neuron axon	biological_process	"Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh]
EOG8NKF9Q	GO:0007411	2/747	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8NKF9Q	GO:0004252	2/747	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8NKF9Q	GO:0005576	1/747	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8NKF9Q	GO:0005515	1/747	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8NKF9Q	GO:0001746	1/747	Bolwig's organ morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380]
EOG8NKF9Q	GO:0016198	1/747	axon choice point recognition	biological_process	"The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152]
EOG8NKF9Q	GO:0008045	1/747	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8NKF9Q	GO:0016201	1/747	synaptic target inhibition	biological_process	"The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]
EOG8NKF9Q	GO:0031225	1/747	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG8RZ1H0	GO:0003677	5/88	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RZ1H0	GO:0008234	1/88	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8RZ1H0	GO:0003682	1/88	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8NKF9K	GO:0003700	20/48	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NKF9K	GO:0005634	20/48	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NKF9K	GO:0043565	20/48	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NKF9K	GO:0022008	1/48	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8NKF9K	GO:0009744	1/48	response to sucrose	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl]
EOG8NKF9K	GO:0048813	1/48	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8NKF9K	GO:0006006	1/48	glucose metabolic process	biological_process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]
EOG88D38W	GO:0016788	294/950	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG88D38W	GO:0016042	262/950	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG88D38W	GO:0006629	148/950	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG88D38W	GO:0004806	8/950	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG88D38W	GO:0005615	5/950	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG88D38W	GO:0032504	5/950	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG88D38W	GO:0016298	4/950	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG88D38W	GO:0030246	1/950	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG88D38W	GO:0016787	1/950	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG88D38W	GO:0003676	1/950	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88D38W	GO:0007586	1/950	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG88D38W	GO:0042632	1/950	cholesterol homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]
EOG88D38W	GO:0006886	1/950	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG88D38W	GO:0048812	1/950	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG88D38W	GO:0016192	1/950	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG88D38W	GO:0005576	1/950	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG88D38W	GO:0030132	1/950	clathrin coat of coated pit	cellular_component	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]
EOG88D38W	GO:0030130	1/950	clathrin coat of trans-Golgi network vesicle	cellular_component	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]
EOG88D38W	GO:0005198	1/950	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG88D38W	GO:0031410	1/950	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG88D38W	GO:0070328	1/950	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG88D38W	GO:0004771	1/950	sterol esterase activity	molecular_function	"Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13]
EOG8T4G8V	GO:0018095	38/135	protein polyglutamylation	biological_process	"The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid." [RESID:AA0202]
EOG8T4G8V	GO:0004835	3/135	tubulin-tyrosine ligase activity	molecular_function	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]
EOG8T4G8V	GO:0042060	1/135	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8T4G8V	GO:0022008	1/135	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8W10T3	GO:0004222	1/49	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8QZB1Z	GO:0042302	27/131	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG847JB4	GO:0004867	79/126	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG847JB4	GO:0008233	4/126	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG847JB4	GO:0032504	1/126	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG847JB4	GO:0005615	1/126	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8V19GB	GO:0008270	5/50	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V19GB	GO:0005524	2/50	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VX4KS	GO:0046872	11/348	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8VX4KS	GO:0005737	1/348	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8VX4KS	GO:0010629	1/348	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8VX4KS	GO:0042826	1/348	histone deacetylase binding	molecular_function	"Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl]
EOG8VX4KS	GO:0005634	1/348	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80KBD0	GO:0050660	5/37	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG80KBD0	GO:0006066	4/37	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG80KBD0	GO:0008812	4/37	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG80KBD0	GO:0016614	1/37	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8ZCWJG	GO:0005509	23/74	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8ZCWJG	GO:0006511	23/74	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8ZCWJG	GO:0004843	22/74	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG8ZCWJG	GO:0008233	1/74	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8ZCWJG	GO:0008234	1/74	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8ZCWJG	GO:0004221	1/74	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG8VX4KB	GO:0016324	1/216	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8VX4KB	GO:0005080	1/216	protein kinase C binding	molecular_function	"Interacting selectively and non-covalently with protein kinase C." [GOC:jl]
EOG8VX4KB	GO:0008594	1/216	photoreceptor cell morphogenesis	biological_process	"The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
EOG8VX4KB	GO:0002009	1/216	morphogenesis of an epithelium	biological_process	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
EOG8VX4KB	GO:0035088	1/216	establishment or maintenance of apical/basal cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483]
EOG8VX4KB	GO:0016333	1/216	morphogenesis of follicular epithelium	biological_process	"The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl]
EOG8VX4KB	GO:0016334	1/216	establishment or maintenance of polarity of follicular epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah]
EOG8VX4KB	GO:0035509	1/216	negative regulation of myosin-light-chain-phosphatase activity	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators]
EOG8VX4KB	GO:0005737	1/216	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8VX4KB	GO:0032033	1/216	myosin II light chain binding	molecular_function	"Interacting selectively and non-covalently with a light chain of a myosin II complex." [GOC:mah]
EOG8VX4KB	GO:0005886	1/216	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8VX4KB	GO:0045176	1/216	apical protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf]
EOG8VX4KB	GO:0005918	1/216	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG8VX4KB	GO:0034332	1/216	adherens junction organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah]
EOG8VX4KB	GO:0001736	1/216	establishment of planar polarity	biological_process	"Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
EOG8VX4KB	GO:0016332	1/216	establishment or maintenance of polarity of embryonic epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah]
EOG8VX4KB	GO:0045494	1/216	photoreceptor cell maintenance	biological_process	"Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]
EOG8VX4KB	GO:0005635	1/216	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG8VX4KB	GO:0007163	1/216	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8VX4KB	GO:0035209	1/216	pupal development	biological_process	"The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis." [GOC:bf, GOC:mtg_sensu]
EOG8VX4KB	GO:0005515	1/216	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VX4KB	GO:0016327	1/216	apicolateral plasma membrane	cellular_component	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
EOG8VX4KB	GO:0035003	1/216	subapical complex	cellular_component	"The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938]
EOG8VX4KB	GO:0005875	1/216	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8VX4KB	GO:0007043	1/216	cell-cell junction assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai]
EOG8VX4KB	GO:0005912	1/216	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8VX4KB	GO:0045179	1/216	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8VX4KB	GO:0034334	1/216	adherens junction maintenance	biological_process	"The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah]
EOG8VX4KB	GO:0045186	1/216	zonula adherens assembly	biological_process	"Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf]
EOG8HDW8F	GO:0006886	37/164	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8HDW8F	GO:0048193	24/164	Golgi vesicle transport	biological_process	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG8HDW8F	GO:0016020	23/164	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8HDW8F	GO:0007269	2/164	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8HDW8F	GO:0042147	1/164	retrograde transport, endosome to Golgi	biological_process	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]
EOG8HDW8F	GO:0005886	1/164	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8HDW8F	GO:0016081	1/164	synaptic vesicle docking	biological_process	"The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342]
EOG8HDW8F	GO:0051726	1/164	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8HDW8F	GO:0016021	1/164	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HDW8F	GO:0006906	1/164	vesicle fusion	biological_process	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]
EOG8HDW8F	GO:0016082	1/164	synaptic vesicle priming	biological_process	"The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342]
EOG8HDW8F	GO:0005483	1/164	soluble NSF attachment protein activity	molecular_function	"Interacting selectively and non-covalently with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857]
EOG8HDW8F	GO:0016192	1/164	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8HDW8F	GO:0005737	1/164	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HDW8F	GO:0048190	1/164	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8HDW8F	GO:0005484	1/164	SNAP receptor activity	molecular_function	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
EOG879HN0	GO:0008270	7/90	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG879HN0	GO:0003677	3/90	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG879HN0	GO:0006355	1/90	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG879HN0	GO:0046872	1/90	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG87Q0MH	GO:0005524	37/124	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87Q0MH	GO:0004674	33/124	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG87Q0MH	GO:0004683	3/124	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG87Q0MH	GO:0004672	2/124	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG87Q0MH	GO:0006468	1/124	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8N335J	GO:0008234	7/37	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8N335J	GO:0008270	2/37	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]