GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0003676	nucleic acid binding	Gains
GO:0008270	zinc ion binding	Gains
GO:0003723	RNA binding	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0008527	taste receptor activity	Gains
GO:0046914	transition metal ion binding	Gains
GO:0005549	odorant binding	Gains
GO:0003677	DNA binding	Gains
GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
GO:0004175	endopeptidase activity	Gains
GO:0097159	organic cyclic compound binding	Gains
GO:1901363	heterocyclic compound binding	Gains
GO:0032450	maltose alpha-glucosidase activity	Gains
GO:0035064	methylated histone binding	Gains
GO:0140030	modification-dependent protein binding	Gains
GO:0140034	methylation-dependent protein binding	Gains
GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Gains
GO:0008233	peptidase activity	Gains
GO:0042393	histone binding	Gains
GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0015276	ligand-gated ion channel activity	Gains
GO:0022834	ligand-gated channel activity	Gains
GO:0036081	extracellular ammonia-gated ion channel activity	Gains
GO:0090599	alpha-glucosidase activity	Gains
GO:0005230	extracellular ligand-gated ion channel activity	Gains
GO:0004970	ionotropic glutamate receptor activity	Gains
GO:0022824	transmitter-gated ion channel activity	Gains
GO:0022835	transmitter-gated channel activity	Gains
GO:0008384	IkappaB kinase activity	Gains
GO:0016922	ligand-dependent nuclear receptor binding	Gains
GO:0004416	hydroxyacylglutathione hydrolase activity	Gains
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	Gains
GO:0004446	inositol-hexakisphosphate phosphatase activity	Gains
GO:0004731	purine-nucleoside phosphorylase activity	Gains
GO:0004705	JUN kinase activity	Gains
GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors	Gains
GO:0052826	inositol hexakisphosphate 2-phosphatase activity	Gains
GO:0016880	acid-ammonia (or amide) ligase activity	Gains
GO:0004645	phosphorylase activity	Gains
GO:0043958	acryloyl-CoA reductase activity	Gains
GO:0070548	L-glutamine aminotransferase activity	Gains
GO:0004519	endonuclease activity	Gains
GO:0005272	sodium channel activity	Gains
GO:0008307	structural constituent of muscle	Gains
GO:0016630	protochlorophyllide reductase activity	Gains
GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
GO:0030594	neurotransmitter receptor activity	Gains
GO:0008066	glutamate receptor activity	Gains
GO:0015926	glucosidase activity	Gains
GO:0001104	RNA polymerase II transcription cofactor activity	Gains
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Gains
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0004707	MAP kinase activity	Gains
GO:0031409	pigment binding	Gains
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
GO:0016790	thiolester hydrolase activity	Gains
GO:0016868	intramolecular transferase activity, phosphotransferases	Gains
GO:0004872	receptor activity	Losses
GO:0099600	transmembrane receptor activity	Losses
GO:0004930	G-protein coupled receptor activity	Losses
GO:0038023	signaling receptor activity	Losses
GO:0060089	molecular transducer activity	Losses
GO:0004888	transmembrane signaling receptor activity	Losses
GO:0004383	guanylate cyclase activity	Losses
GO:0004871	signal transducer activity	Losses
GO:0004713	protein tyrosine kinase activity	Losses
GO:0016849	phosphorus-oxygen lyase activity	Losses
GO:0004867	serine-type endopeptidase inhibitor activity	Losses
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Losses
GO:0004866	endopeptidase inhibitor activity	Losses
GO:0030414	peptidase inhibitor activity	Losses
GO:0050254	rhodopsin kinase activity	Losses
GO:0061135	endopeptidase regulator activity	Losses
GO:0004672	protein kinase activity	Losses
GO:0030246	carbohydrate binding	Losses
GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
GO:0005509	calcium ion binding	Losses
GO:0008484	sulfuric ester hydrolase activity	Losses
GO:0004197	cysteine-type endopeptidase activity	Losses
GO:0009975	cyclase activity	Losses
GO:0005085	guanyl-nucleotide exchange factor activity	Losses
GO:0015079	potassium ion transmembrane transporter activity	Losses
GO:0061134	peptidase regulator activity	Losses
GO:0016787	hydrolase activity	Losses
GO:0003960	NADPH:quinone reductase activity	Losses
GO:0004692	cGMP-dependent protein kinase activity	Losses
GO:0005267	potassium channel activity	Losses
GO:0008081	phosphoric diester hydrolase activity	Losses
GO:0017048	Rho GTPase binding	Losses
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Losses
GO:0140096	catalytic activity, acting on a protein	Losses
GO:0016788	hydrolase activity, acting on ester bonds	Losses
GO:0008297	single-stranded DNA exodeoxyribonuclease activity	Losses
GO:0015269	calcium-activated potassium channel activity	Losses
GO:0005227	calcium activated cation channel activity	Losses
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Losses
GO:0003978	UDP-glucose 4-epimerase activity	Losses
GO:0033549	MAP kinase phosphatase activity	Losses
GO:0099106	ion channel regulator activity	Losses
GO:0005088	Ras guanyl-nucleotide exchange factor activity	Losses
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Losses
GO:0022836	gated channel activity	Losses
GO:0019199	transmembrane receptor protein kinase activity	Losses
GO:0038024	cargo receptor activity	Losses
GO:0098772	molecular function regulator	Losses
GO:0015459	potassium channel regulator activity	Losses
GO:0004372	glycine hydroxymethyltransferase activity	Losses
GO:0003834	beta-carotene 15,15'-monooxygenase activity	Losses
GO:0008890	glycine C-acetyltransferase activity	Losses
GO:0099095	ligand-gated anion channel activity	Losses
GO:0035312	5'-3' exodeoxyribonuclease activity	Losses
GO:0016286	small conductance calcium-activated potassium channel activity	Losses
GO:0031419	cobalamin binding	Losses
GO:0004806	triglyceride lipase activity	Losses
GO:0003951	NAD+ kinase activity	Losses
GO:0046906	tetrapyrrole binding	Losses
GO:0005215	transporter activity	Losses
GO:0005216	ion channel activity	Losses
GO:0004857	enzyme inhibitor activity	Losses
GO:0016301	kinase activity	Losses
GO:0005261	cation channel activity	Losses
GO:0022838	substrate-specific channel activity	Losses
GO:0008188	neuropeptide receptor activity	Losses
GO:0008171	O-methyltransferase activity	Losses
GO:0005044	scavenger receptor activity	Losses
GO:0043169	cation binding	Losses
GO:0016247	channel regulator activity	Losses
GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	Losses
GO:0022839	ion gated channel activity	Losses
GO:0046872	metal ion binding	Losses
GO:0008509	anion transmembrane transporter activity	Losses
GO:0015267	channel activity	Losses
GO:0022803	passive transmembrane transporter activity	Losses
GO:0004930	G-protein coupled receptor activity	Extinctions
GO:0008081	phosphoric diester hydrolase activity	Extinctions
GO:0008484	sulfuric ester hydrolase activity	Extinctions
GO:0004713	protein tyrosine kinase activity	Extinctions
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Extinctions
GO:0038023	signaling receptor activity	Extinctions
GO:0099600	transmembrane receptor activity	Extinctions
GO:0004888	transmembrane signaling receptor activity	Extinctions
GO:0015269	calcium-activated potassium channel activity	Extinctions
GO:0005227	calcium activated cation channel activity	Extinctions
GO:0003978	UDP-glucose 4-epimerase activity	Extinctions
GO:0099106	ion channel regulator activity	Extinctions
GO:0004872	receptor activity	Extinctions
GO:0004383	guanylate cyclase activity	Extinctions
GO:0015459	potassium channel regulator activity	Extinctions
GO:0003834	beta-carotene 15,15'-monooxygenase activity	Extinctions
GO:0008890	glycine C-acetyltransferase activity	Extinctions
GO:0016286	small conductance calcium-activated potassium channel activity	Extinctions
GO:0031419	cobalamin binding	Extinctions
GO:0016247	channel regulator activity	Extinctions
GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	Extinctions
GO:0022839	ion gated channel activity	Extinctions
GO:0004871	signal transducer activity	Extinctions
GO:0016788	hydrolase activity, acting on ester bonds	Extinctions
GO:0003960	NADPH:quinone reductase activity	Extinctions
GO:0060089	molecular transducer activity	Extinctions
GO:0005267	potassium channel activity	Extinctions
GO:0016849	phosphorus-oxygen lyase activity	Extinctions
GO:0003951	NAD+ kinase activity	Extinctions
GO:0004197	cysteine-type endopeptidase activity	Extinctions
GO:0009975	cyclase activity	Extinctions
GO:0008106	alcohol dehydrogenase (NADP+) activity	Extinctions
GO:0004447	iodide peroxidase activity	Extinctions
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Extinctions
GO:0017056	structural constituent of nuclear pore	Extinctions
GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Extinctions
GO:0016453	C-acetyltransferase activity	Extinctions
GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity	Extinctions
GO:0004657	proline dehydrogenase activity	Extinctions
GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	Extinctions
GO:0004064	arylesterase activity	Extinctions
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Extinctions
GO:0004033	aldo-keto reductase (NADP) activity	Extinctions