EOG8SN434	GO:0030036	1/91	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8SN434	GO:0007413	1/91	axonal fasciculation	biological_process	"The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh]
EOG8SN434	GO:0030589	1/91	pseudocleavage involved in syncytial blastoderm formation	biological_process	"Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8SN434	GO:0005200	1/91	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8SN434	GO:0030713	1/91	ovarian follicle cell stalk formation	biological_process	"Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8SN434	GO:0010592	1/91	positive regulation of lamellipodium assembly	biological_process	"Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG8SN434	GO:0005737	1/91	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SN434	GO:0005884	1/91	actin filament	cellular_component	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]
EOG8SN434	GO:0005885	1/91	Arp2/3 protein complex	cellular_component	"A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments." [GOC:jl, GOC:vw, PMID:12479800]
EOG8SN434	GO:0051491	1/91	positive regulation of filopodium assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG8SN434	GO:0006886	1/91	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8SN434	GO:0097320	1/91	membrane tubulation	biological_process	"A modification in a plasma membrane resulting in formation of a tubular invagination." [GOC:BHF, PMID:15252009, PMID:20730103]
EOG8SN434	GO:0022416	1/91	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8SN434	GO:0006909	1/91	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8SN434	GO:0007010	1/91	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8SN434	GO:0005524	1/91	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8SN434	GO:0030037	1/91	actin filament reorganization involved in cell cycle	biological_process	"The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah]
EOG8SN434	GO:0030027	1/91	lamellipodium	cellular_component	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]
EOG8SN434	GO:0007520	1/91	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG8SN434	GO:0045747	1/91	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8SN434	GO:0000902	1/91	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG822CZH	GO:0005248	27/157	voltage-gated sodium channel activity	molecular_function	"Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG822CZH	GO:0001518	27/157	voltage-gated sodium channel complex	cellular_component	"A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732]
EOG822CZH	GO:0005509	20/157	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG822CZH	GO:0005216	8/157	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG822CZH	GO:0016021	8/157	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG822CZH	GO:0009987	1/157	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG822CZH	GO:0042493	1/157	response to drug	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl]
EOG822CZH	GO:0086010	1/157	membrane depolarization during action potential	biological_process	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
EOG822CZH	GO:0007638	1/157	mechanosensory behavior	biological_process	"Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators]
EOG822CZH	GO:0046684	1/157	response to pyrethroid	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage." [ISBN:0721662544]
EOG822CZH	GO:0046680	1/157	response to DDT	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544]
EOG822CZH	GO:0019228	1/157	neuronal action potential	biological_process	"An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb]
EOG822CZH	GO:0001666	1/157	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG822CZH	GO:0009612	1/157	response to mechanical stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]
EOG822CZH	GO:0005886	1/157	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG822CZH	GO:0006814	1/157	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG822CZH	GO:0035725	1/157	sodium ion transmembrane transport	biological_process	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
EOG822CZH	GO:0007268	1/157	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG822CZH	GO:0005887	1/157	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG822CZH	GO:0045433	1/157	male courtship behavior, veined wing generated song production	biological_process	"The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
EOG8NGK3K	GO:0003677	1/11	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8G7FFM	GO:0005634	384/651	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8G7FFM	GO:0000786	384/651	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8G7FFM	GO:0003677	384/651	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8G7FFM	GO:0006334	384/651	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8G7FFM	GO:0005811	50/651	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8G7FFM	GO:0051298	17/651	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8G7FFM	GO:0006281	1/651	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8G7FFM	GO:0005701	1/651	polytene chromosome chromocenter	cellular_component	"A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012]
EOG8G7FFM	GO:0071168	1/651	protein localization to chromatin	biological_process	"Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah]
EOG8G7FFM	GO:0005700	1/651	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8G7FFM	GO:0006974	1/651	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8G7FFM	GO:0005694	1/651	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8G7FFM	GO:0007275	1/651	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8CJXWX	GO:0008270	7/116	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CJXWX	GO:0005634	5/116	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CJXWX	GO:0003746	1/116	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG8CJXWX	GO:0004497	1/116	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8CJXWX	GO:0005506	1/116	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8CJXWX	GO:0020037	1/116	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8CJXWX	GO:0016705	1/116	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8CJXWX	GO:0046872	1/116	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG876NFT	GO:0003676	52/239	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG876NFT	GO:0046872	1/239	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG876NFT	GO:0005634	1/239	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG876NFT	GO:0003677	1/239	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XPSZV	GO:0003677	197/409	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XPSZV	GO:0000786	197/409	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8XPSZV	GO:0006334	197/409	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8XPSZV	GO:0005634	196/409	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XPSZV	GO:0032008	25/409	positive regulation of TOR signaling	biological_process	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8XPSZV	GO:0071230	25/409	cellular response to amino acid stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:mah]
EOG8XPSZV	GO:0032439	22/409	endosome localization	biological_process	"Any process in which endosomes are transported to, and/or maintained in, a specific location within the cell." [GOC:ecd]
EOG8XPSZV	GO:0007040	22/409	lysosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]
EOG8XPSZV	GO:0001919	22/409	regulation of receptor recycling	biological_process	"Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add]
EOG8XPSZV	GO:0071986	22/409	Ragulator complex	cellular_component	"A protein complex that contains MAPKSP1 (MP1, Map2k1ip1), ROBLD3 (p14, Mapbpip), C11orf59 (p18), LAMTOR4 and LAMTOR5. The complex is anchored to lipid rafts in late endosome membranes via C11orf59, recruits mTORC1 to lysosomal membranes in amino acid signaling to mTORC1, constitutes a guanine nucleotide exchange factor (GEF) for the Rag GTPases, and is also involved in ERK/MAPK signaling." [GOC:lb, PMID:19177150, PMID:20381137, PMID:22980980]
EOG8XPSZV	GO:0042632	22/409	cholesterol homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]
EOG8XPSZV	GO:0043410	22/409	positive regulation of MAPK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]
EOG8XPSZV	GO:0031902	3/409	late endosome membrane	cellular_component	"The lipid bilayer surrounding a late endosome." [GOC:pz]
EOG8XPSZV	GO:0003964	1/409	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8XPSZV	GO:0003723	1/409	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG87M4BX	GO:0007165	26/102	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG87M4BX	GO:0005622	26/102	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG87M4BX	GO:0035091	6/102	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG87M4BX	GO:0000723	2/102	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG87M4BX	GO:0006281	2/102	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG87M4BX	GO:0003678	2/102	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG87M4BX	GO:0005096	1/102	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG87M4BX	GO:0031290	1/102	retinal ganglion cell axon guidance	biological_process	"The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs]
EOG8V45Q1	GO:0031409	22/139	pigment binding	molecular_function	"Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah]
EOG8V45Q1	GO:0005576	19/139	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8V45Q1	GO:0036094	7/139	small molecule binding	molecular_function	"Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]
EOG8V45Q1	GO:0005215	5/139	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8V45Q1	GO:0008289	2/139	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG82VBZ9	GO:0015031	26/86	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG82VBZ9	GO:0032509	1/86	endosome transport via multivesicular body sorting pathway	biological_process	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]
EOG82VBZ9	GO:0030496	1/86	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG82VBZ9	GO:0044130	1/86	negative regulation of growth of symbiont in host	biological_process	"Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
EOG82VBZ9	GO:0042059	1/86	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG82VBZ9	GO:0008593	1/86	regulation of Notch signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG82VBZ9	GO:0043162	1/86	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]
EOG82VBZ9	GO:0006914	1/86	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG82VBZ9	GO:0005771	1/86	multivesicular body	cellular_component	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]
EOG82VBZ9	GO:0000815	1/86	ESCRT III complex	cellular_component	"An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
EOG82VBZ9	GO:0005515	1/86	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG82VBZ9	GO:0048813	1/86	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG82VBZ9	GO:0048812	1/86	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG82VBZ9	GO:0045746	1/86	negative regulation of Notch signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8WDGVH	GO:0035556	5/22	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8WDGVH	GO:0004629	1/22	phospholipase C activity	molecular_function	"Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]
EOG8WDGVH	GO:0007268	1/22	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8WDGVH	GO:0004871	1/22	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8DRCT9	GO:0003824	1/17	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG876NFH	GO:0004527	3/56	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG84BDH5	GO:0004407	18/102	histone deacetylase activity	molecular_function	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.98, PMID:9893272]
EOG84BDH5	GO:0000118	18/102	histone deacetylase complex	cellular_component	"A protein complex that possesses histone deacetylase activity." [GOC:mah]
EOG84BDH5	GO:0016787	6/102	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG84BDH5	GO:0006355	1/102	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG84BDH5	GO:0005634	1/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84BDH5	GO:0016575	1/102	histone deacetylation	biological_process	"The modification of histones by removal of acetyl groups." [GOC:ai]
EOG84BDH5	GO:0005737	1/102	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG815JT9	GO:0001104	29/106	RNA polymerase II transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG815JT9	GO:0016592	29/106	mediator complex	cellular_component	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
EOG815JT9	GO:0006366	2/106	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG815JT9	GO:0006367	1/106	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG815JT9	GO:0005515	1/106	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8DV82W	GO:0080019	172/601	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8DV82W	GO:0004043	6/601	L-aminoadipate-semialdehyde dehydrogenase activity	molecular_function	"Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31]
EOG8DV82W	GO:0010025	2/601	wax biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids." [ISBN:0943088399]
EOG8DV82W	GO:0006629	2/601	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8DV82W	GO:0016021	2/601	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DV82W	GO:0050062	2/601	long-chain-fatty-acyl-CoA reductase activity	molecular_function	"Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH." [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN]
EOG8DV82W	GO:0005777	2/601	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8DV82W	GO:0000166	1/601	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8DV82W	GO:0003676	1/601	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DV82W	GO:0005778	1/601	peroxisomal membrane	cellular_component	"The lipid bilayer surrounding a peroxisome." [GOC:mah]
EOG8DV82W	GO:0008340	1/601	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8DV82W	GO:0006909	1/601	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8DV82W	GO:0016746	1/601	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8GB9NN	GO:0008270	31/132	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GB9NN	GO:0006352	31/132	DNA-templated transcription, initiation	biological_process	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]
EOG8GB9NN	GO:0045893	23/132	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8GB9NN	GO:0005634	23/132	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GB9NN	GO:0006355	8/132	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8GB9NN	GO:0003743	2/132	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8GB9NN	GO:0005667	1/132	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8GB9NN	GO:0048812	1/132	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8GB9NN	GO:0008134	1/132	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8GB9NN	GO:0006359	1/132	regulation of transcription from RNA polymerase III promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter." [GOC:go_curators]
EOG8GB9NN	GO:0006383	1/132	transcription from RNA polymerase III promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH]
EOG8MWBKV	GO:0004725	22/93	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8MWBKV	GO:0007155	1/93	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8MWBKV	GO:0008045	1/93	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8MWBKV	GO:0007411	1/93	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8MWBKV	GO:0007414	1/93	axonal defasciculation	biological_process	"Separation of axons away from a bundle of axons known as a fascicle." [GOC:dgh, ISBN:039751820X]
EOG8MWBKV	GO:0046331	1/93	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8MWBKV	GO:0006470	1/93	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8MWBKV	GO:0007409	1/93	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8MWBKV	GO:0005001	1/93	transmembrane receptor protein tyrosine phosphatase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8MWBKV	GO:0048813	1/93	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8MWBKV	GO:0007415	1/93	defasciculation of motor neuron axon	biological_process	"Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh]
EOG8MWBKV	GO:0016021	1/93	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8MWBKV	GO:0035335	1/93	peptidyl-tyrosine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
EOG8MWBKV	GO:0050254	1/93	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8MWBKV	GO:0030424	1/93	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8MWBKV	GO:0005886	1/93	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8N06V0	GO:0016747	9/36	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8WWTZC	GO:0000166	6/79	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8WWTZC	GO:0003676	5/79	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WWTZC	GO:0046872	3/79	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WWTZC	GO:0003677	1/79	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81NX1D	GO:0003676	1/92	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG81NX1D	GO:0046872	1/92	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89627M	GO:0005737	26/78	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG89627M	GO:0019478	26/78	D-amino acid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg]
EOG89627M	GO:0016788	26/78	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG8WWTZG	GO:0006099	39/112	tricarboxylic acid cycle	biological_process	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]
EOG8WWTZG	GO:0004591	39/112	oxoglutarate dehydrogenase (succinyl-transferring) activity	molecular_function	"Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2]
EOG8WWTZG	GO:0030976	39/112	thiamine pyrophosphate binding	molecular_function	"Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [CHEBI:45931, GOC:mlg]
EOG8WWTZG	GO:0005875	1/112	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8WHC36	GO:0004601	1/27	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG879HP9	GO:0004035	127/508	alkaline phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1]
EOG879HP9	GO:0016791	75/508	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG879HP9	GO:0035094	1/508	response to nicotine	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [CHEBI:17688, GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089]
EOG879HP9	GO:0003824	1/508	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG879HP9	GO:0016021	1/508	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG879HP9	GO:0005576	1/508	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG879HP9	GO:0005615	1/508	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG879HP9	GO:0031225	1/508	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG879HP9	GO:0046872	1/508	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG879HP9	GO:0007399	1/508	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG879HP9	GO:0032504	1/508	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG879HP9	GO:0042045	1/508	epithelial fluid transport	biological_process	"The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830]
EOG879HP9	GO:0005886	1/508	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8Q2GX2	GO:0008146	19/45	sulfotransferase activity	molecular_function	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]
EOG8Q2GX2	GO:0016051	19/45	carbohydrate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]
EOG8Q2GX2	GO:0016021	19/45	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DRCV3	GO:0003676	3/252	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DRCV3	GO:0015074	3/252	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8DRCV3	GO:0003723	2/252	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8DRCV3	GO:0008270	2/252	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DRCV3	GO:0003964	2/252	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8DRCV3	GO:0004190	1/252	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8Q2GX1	GO:0005576	12/50	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Q2GX1	GO:0009755	1/50	hormone-mediated signaling pathway	biological_process	"A series of molecular signals mediated by the detection of a hormone." [GOC:sm]
EOG8Q2GX1	GO:0046982	1/50	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8Q2GX1	GO:0005615	1/50	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8J6V63	GO:0008234	42/98	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8J6V63	GO:0000338	1/98	protein deneddylation	biological_process	"The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]
EOG8J6V63	GO:0019784	1/98	NEDD8-specific protease activity	molecular_function	"Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates." [GOC:mah]
EOG8J6V63	GO:0043065	1/98	positive regulation of apoptotic process	biological_process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8WQ3HS	GO:0016773	31/111	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8WQ3HS	GO:0005524	31/111	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WQ3HS	GO:0006139	26/111	nucleobase-containing compound metabolic process	biological_process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
EOG8WQ3HS	GO:0019136	5/111	deoxynucleoside kinase activity	molecular_function	"Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145]
EOG8WQ3HS	GO:0016301	4/111	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8WQ3HS	GO:0006165	1/111	nucleoside diphosphate phosphorylation	biological_process	"The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]
EOG8WQ3HS	GO:0009157	1/111	deoxyribonucleoside monophosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
EOG8WQ3HS	GO:0006260	1/111	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8WQ3HS	GO:0005737	1/111	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WQ3HS	GO:0046939	1/111	nucleotide phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]
EOG8SXQSR	GO:0006355	25/100	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8SXQSR	GO:0005634	25/100	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SXQSR	GO:0003682	24/100	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8SXQSR	GO:0016568	22/100	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG8SXQSR	GO:0035041	1/100	sperm chromatin decondensation	biological_process	"Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus." [GOC:bf, PMID:11735001]
EOG8SXQSR	GO:0001673	1/100	male germ cell nucleus	cellular_component	"The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu]
EOG8SXQSR	GO:0006336	1/100	DNA replication-independent nucleosome assembly	biological_process	"The formation of nucleosomes outside the context of DNA replication." [GOC:mah]
EOG8SXQSR	GO:0006338	1/100	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG8SXQSR	GO:0042585	1/100	germinal vesicle	cellular_component	"The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, PMID:19019837]
EOG8SXQSR	GO:0004402	1/100	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8SXQSR	GO:0006351	1/100	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8SXQSR	GO:0035042	1/100	fertilization, exchange of chromosomal proteins	biological_process	"Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity." [GOC:bf, PMID:11735001]
EOG8F4VTV	GO:0042302	14/46	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8WQ3HX	GO:0006915	31/91	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8WQ3HX	GO:0004197	31/91	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8WQ3HX	GO:0005622	8/91	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8WQ3HX	GO:0042981	8/91	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8WQ3HX	GO:0008285	1/91	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8WQ3HX	GO:0031638	1/91	zymogen activation	biological_process	"The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd]
EOG8WQ3HX	GO:0010506	1/91	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8WQ3HX	GO:0005737	1/91	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WQ3HX	GO:0012501	1/91	programmed cell death	biological_process	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]
EOG8WQ3HX	GO:0042803	1/91	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8WQ3HX	GO:0016540	1/91	protein autoprocessing	biological_process	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]
EOG8WQ3HX	GO:0035234	1/91	ectopic germ cell programmed cell death	biological_process	"Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944]
EOG8WQ3HX	GO:0046668	1/91	regulation of retinal cell programmed cell death	biological_process	"Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
EOG8WQ3HX	GO:0007552	1/91	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG8WQ3HX	GO:0048813	1/91	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8WQ3HX	GO:0008258	1/91	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8WQ3HX	GO:0004175	1/91	endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8WQ3HX	GO:0046672	1/91	positive regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG8WQ3HX	GO:0007291	1/91	sperm individualization	biological_process	"The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
EOG8WQ3HX	GO:0006919	1/91	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
EOG8WQ3HX	GO:0010623	1/91	developmental programmed cell death	biological_process	"The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:tb]
EOG8WQ3HX	GO:0007516	1/91	hemocyte development	biological_process	"The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG8WQ3HX	GO:0007417	1/91	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8WQ3HX	GO:0007423	1/91	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8WQ3HX	GO:0016322	1/91	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG8WQ3HX	GO:0045476	1/91	nurse cell apoptotic process	biological_process	"Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306]
EOG8WQ3HX	GO:0048749	1/91	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8WQ3HX	GO:0035071	1/91	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8WQ3HX	GO:0005515	1/91	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8WQ3HX	GO:0035070	1/91	salivary gland histolysis	biological_process	"The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683]
EOG8WQ3HX	GO:0001700	1/91	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8WQ3HX	GO:0010941	1/91	regulation of cell death	biological_process	"Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]
EOG8WQ3HX	GO:0008340	1/91	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8WQ3HX	GO:0048102	1/91	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG88WFG9	GO:0009113	36/110	purine nucleobase biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [CHEBI:26386, GOC:go_curators, ISBN:0198506732]
EOG88WFG9	GO:0004044	36/110	amidophosphoribosyltransferase activity	molecular_function	"Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O." [EC:2.4.2.14, RHEA:14908]
EOG88WFG9	GO:0006189	35/110	'de novo' IMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]
EOG88WFG9	GO:0046872	35/110	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG88WFG9	GO:0009116	34/110	nucleoside metabolic process	biological_process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]
EOG88WFG9	GO:0051536	30/110	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG88WFG9	GO:0040016	1/110	embryonic cleavage	biological_process	"The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300]
EOG88WFG9	GO:0008340	1/110	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG88WFG9	GO:0048477	1/110	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG88WFG9	GO:0006541	1/110	glutamine metabolic process	biological_process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
EOG88WFG9	GO:0051539	1/110	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG88WFG9	GO:0006164	1/110	purine nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]
EOG80GG67	GO:0006950	2/58	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG80GG67	GO:0046872	1/58	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80GG67	GO:0020037	1/58	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG803085	GO:0003676	2/11	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG803085	GO:0046872	2/11	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG803085	GO:0008270	2/11	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8J3ZXD	GO:0003779	1/92	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8J3ZXD	GO:0009913	1/92	epidermal cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]
EOG8J3ZXD	GO:0035317	1/92	imaginal disc-derived wing hair organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853]
EOG8J3ZXD	GO:0051017	1/92	actin filament bundle assembly	biological_process	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
EOG8J3ZXD	GO:0035017	1/92	cuticle pattern formation	biological_process	"The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf]
EOG8J3ZXD	GO:0008407	1/92	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG8J3ZXD	GO:0007605	1/92	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8J3ZXD	GO:0048800	1/92	antennal morphogenesis	biological_process	"The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid]
EOG8HQH0B	GO:0003676	2/11	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HQH0B	GO:0046872	2/11	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QNQBW	GO:0007018	1/69	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8QNQBW	GO:0003777	1/69	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8DRCSQ	GO:0016021	19/71	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DRCSQ	GO:0005743	19/71	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8DRCSQ	GO:0005509	3/71	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8DRCSQ	GO:0005739	1/71	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8DRCSQ	GO:0022008	1/71	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG80GG68	GO:0008080	5/55	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG8F4VRB	GO:0004970	27/163	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8F4VRB	GO:0005234	27/163	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8F4VRB	GO:0016020	20/163	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8F4VRB	GO:0016021	9/163	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F4VRB	GO:0005215	8/163	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8F4VRB	GO:0015276	2/163	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8F4VRB	GO:0036081	2/163	extracellular ammonia-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
EOG8F4VRB	GO:0034220	2/163	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8F4VRB	GO:0009593	2/163	detection of chemical stimulus	biological_process	"The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
EOG8ZGRSF	GO:0004402	1/113	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8ZGRSF	GO:0042384	1/113	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8ZGRSF	GO:0005509	1/113	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8ZGRSF	GO:0031513	1/113	nonmotile primary cilium	cellular_component	"A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998]
EOG8ZGRSF	GO:0035058	1/113	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG8FN70X	GO:0008270	2/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FN70X	GO:0016568	2/4	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG8FN70X	GO:0005634	2/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8V45QH	GO:0000166	25/90	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8V45QH	GO:0003676	24/90	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V45QH	GO:0005634	1/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8V45QH	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8V45QH	GO:0003723	1/90	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8V45QH	GO:0048025	1/90	negative regulation of mRNA splicing, via spliceosome	biological_process	"Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]
EOG8V45QH	GO:0071011	1/90	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8V45QH	GO:0019013	1/90	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8V45QH	GO:0016607	1/90	nuclear speck	cellular_component	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]
EOG8V45QH	GO:0007052	1/90	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8V45QH	GO:0000398	1/90	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8V45QH	GO:0071013	1/90	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8V45QH	GO:0005685	1/90	U1 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U1." [GOC:krc, GOC:mah]
EOG8V45QH	GO:0005681	1/90	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8V45QH	GO:0003729	1/90	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8V45QH	GO:0022008	1/90	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8V45QH	GO:0000381	1/90	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8V45QH	GO:0030529	1/90	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8V45QH	GO:0043484	1/90	regulation of RNA splicing	biological_process	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]
EOG8QNQBK	GO:0016021	1/53	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QNQBK	GO:0055085	1/53	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8QNQBK	GO:0005576	1/53	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8QNQBK	GO:0007339	1/53	binding of sperm to zona pellucida	biological_process	"The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437]
EOG8Q2GXH	GO:0007229	4/8	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG8Q2GXH	GO:0007155	4/8	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8Q2GXH	GO:0008305	4/8	integrin complex	cellular_component	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]
EOG8DJN9T	GO:0005272	31/100	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8DJN9T	GO:0016021	27/100	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DJN9T	GO:0016020	4/100	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8DJN9T	GO:0008049	1/100	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8DJN9T	GO:0019236	1/100	response to pheromone	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl]
EOG8DJN9T	GO:0002121	1/100	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8Q5C3P	GO:0005525	26/93	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8Q5C3P	GO:0003924	2/93	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8Q5C3P	GO:0042273	1/93	ribosomal large subunit biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]
EOG8Q5C3P	GO:0006254	1/93	CTP catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]
EOG8Q5C3P	GO:0006200	1/93	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8Q5C3P	GO:0090070	1/93	positive regulation of ribosome biogenesis	biological_process	"Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]
EOG8Q5C3P	GO:0007431	1/93	salivary gland development	biological_process	"The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044]
EOG8Q5C3P	GO:0001652	1/93	granular component	cellular_component	"A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561]
EOG8Q5C3P	GO:0048588	1/93	developmental cell growth	biological_process	"The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete]
EOG8Q5C3P	GO:0042254	1/93	ribosome biogenesis	biological_process	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
EOG8Q5C3P	GO:0042127	1/93	regulation of cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
EOG8Q5C3P	GO:0005730	1/93	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8Q5C3P	GO:0016887	1/93	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8Q5C3P	GO:0006184	1/93	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8Q5C3P	GO:0046626	1/93	regulation of insulin receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8Q5C3P	GO:0043273	1/93	CTPase activity	molecular_function	"Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction." [GOC:go_curators]
EOG8Q5C3P	GO:0040014	1/93	regulation of multicellular organism growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG8Q5C3P	GO:0007494	1/93	midgut development	biological_process	"The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
EOG8Q5C3P	GO:0046052	1/93	UTP catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate." [GOC:go_curators]
EOG8SXQS9	GO:0004559	100/219	alpha-mannosidase activity	molecular_function	"Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24]
EOG8SXQS9	GO:0030246	96/219	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8SXQS9	GO:0006013	96/219	mannose metabolic process	biological_process	"The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732]
EOG8SXQS9	GO:0008270	92/219	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SXQS9	GO:0005975	8/219	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8SXQS9	GO:0015923	4/219	mannosidase activity	molecular_function	"Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai]
EOG8SXQS9	GO:0003723	1/219	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8SXQS9	GO:0001522	1/219	pseudouridine synthesis	biological_process	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]
EOG8SXQS9	GO:0009982	1/219	pseudouridine synthase activity	molecular_function	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]
EOG8SXQS9	GO:0005576	1/219	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8BVV7S	GO:0005525	28/94	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8BVV7S	GO:0003924	26/94	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8BVV7S	GO:0003746	1/94	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG8BVV7S	GO:0004222	1/94	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG81NX19	GO:0004743	2/4	pyruvate kinase activity	molecular_function	"Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40]
EOG81NX19	GO:0000287	2/4	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG81NX19	GO:0030955	2/4	potassium ion binding	molecular_function	"Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah]
EOG81NX19	GO:0006096	2/4	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8SN43V	GO:0016757	2/85	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8SN43V	GO:0004845	1/85	uracil phosphoribosyltransferase activity	molecular_function	"Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil." [EC:2.4.2.9, RHEA:13020]
EOG8GB9N1	GO:0071013	1/90	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8GB9N1	GO:0000398	1/90	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG86Q976	GO:0003700	74/252	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG86Q976	GO:0005634	74/252	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86Q976	GO:0043565	73/252	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG86Q976	GO:0001745	2/252	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG86Q976	GO:0048749	2/252	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG86Q976	GO:0045944	1/252	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG86Q976	GO:0007455	1/252	eye-antennal disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG86Q976	GO:0001744	1/252	optic lobe placode formation	biological_process	"Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833]
EOG86Q976	GO:0007623	1/252	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG86Q976	GO:0000976	1/252	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG86Q976	GO:0008406	1/252	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG86Q976	GO:0007503	1/252	fat body development	biological_process	"The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089]
EOG86Q976	GO:0048812	1/252	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG86Q976	GO:0007283	1/252	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG86Q976	GO:0001751	1/252	compound eye photoreceptor cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
EOG86Q976	GO:0001746	1/252	Bolwig's organ morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380]
EOG86Q976	GO:0008347	1/252	glial cell migration	biological_process	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
EOG86Q976	GO:0009649	1/252	entrainment of circadian clock	biological_process	"The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid]
EOG86Q976	GO:0006366	1/252	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG86Q976	GO:0003705	1/252	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG86Q976	GO:0007520	1/252	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG86Q976	GO:0035271	1/252	ring gland development	biological_process	"Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones." [GOC:bf, PMID:11223816, PMID:9584098]
EOG86Q976	GO:0007458	1/252	progression of morphogenetic furrow involved in compound eye morphogenesis	biological_process	"The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883]
EOG86Q976	GO:0008134	1/252	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG86Q976	GO:0007498	1/252	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG86Q976	GO:0048813	1/252	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG86Q976	GO:0005515	1/252	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG815JTF	GO:0016021	65/233	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG815JTF	GO:0006486	65/233	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG815JTF	GO:0005794	62/233	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG815JTF	GO:0046872	62/233	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG815JTF	GO:0016757	61/233	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG815JTF	GO:0004653	7/233	polypeptide N-acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595]
EOG815JTF	GO:0005795	3/233	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG815JTF	GO:0009312	3/233	oligosaccharide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]
EOG815JTF	GO:0000139	3/233	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG815JTF	GO:0008076	1/233	voltage-gated potassium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
EOG815JTF	GO:0005783	1/233	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG815JTF	GO:0051260	1/233	protein homooligomerization	biological_process	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
EOG815JTF	GO:0016740	1/233	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG815JTF	GO:0005249	1/233	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8B5RJV	GO:0016021	2/100	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8B5RJV	GO:0003944	2/100	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	molecular_function	"Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose." [EC:3.1.4.45]
EOG815JTD	GO:0004970	151/510	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG815JTD	GO:0005234	151/510	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG815JTD	GO:0030054	151/510	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG815JTD	GO:0045211	149/510	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG815JTD	GO:0016021	148/510	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG815JTD	GO:0035235	8/510	ionotropic glutamate receptor signaling pathway	biological_process	"A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732]
EOG815JTD	GO:0034220	8/510	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG815JTD	GO:0015277	7/510	kainate selective glutamate receptor activity	molecular_function	"An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist." [GOC:mah, PMID:10049997, PMID:8804111]
EOG815JTD	GO:0030425	6/510	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG815JTD	GO:0008328	6/510	ionotropic glutamate receptor complex	cellular_component	"A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
EOG815JTD	GO:0035249	5/510	synaptic transmission, glutamatergic	biological_process	"The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv]
EOG815JTD	GO:0005886	3/510	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG815JTD	GO:0031594	3/510	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG815JTD	GO:1900073	2/510	regulation of neuromuscular synaptic transmission	biological_process	"Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
EOG815JTD	GO:0045202	2/510	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG815JTD	GO:0036081	2/510	extracellular ammonia-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
EOG815JTD	GO:0007274	2/510	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG815JTD	GO:0008066	1/510	glutamate receptor activity	molecular_function	"Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]
EOG815JTD	GO:0005215	1/510	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG815JTD	GO:0043179	1/510	rhythmic excitation	biological_process	"Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit." [GOC:go_curators, ISBN:0195088433]
EOG815JTD	GO:0051968	1/510	positive regulation of synaptic transmission, glutamatergic	biological_process	"Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
EOG815JTD	GO:0048812	1/510	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG815JTD	GO:0007268	1/510	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG815JTD	GO:0005509	1/510	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG815JTD	GO:0046928	1/510	regulation of neurotransmitter secretion	biological_process	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
EOG815JTD	GO:0097482	1/510	muscle cell postsynaptic density	cellular_component	"A postsynaptic density that is part of a muscle cell." [GOC:pr]
EOG815JTD	GO:1900075	1/510	positive regulation of neuromuscular synaptic transmission	biological_process	"Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
EOG815JTD	GO:0016020	1/510	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG815JTD	GO:0060025	1/510	regulation of synaptic activity	biological_process	"Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell." [GOC:dph, GOC:tb]
EOG8DRCTG	GO:0022008	1/92	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8DRCTG	GO:0006909	1/92	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8WDGV7	GO:0042302	184/825	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8WDGV7	GO:0040003	5/825	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8WDGV7	GO:0031012	5/825	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8WDGV7	GO:0008010	5/825	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8WDGV7	GO:0022008	1/825	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8J9QFP	GO:0003676	15/55	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8J9QFP	GO:0006457	1/55	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8J9QFP	GO:0016272	1/55	prefoldin complex	cellular_component	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]
EOG876NF1	GO:0050897	18/56	cobalt ion binding	molecular_function	"Interacting selectively and non-covalently with a cobalt (Co) ion." [GOC:ai]
EOG876NF1	GO:0004038	18/56	allantoinase activity	molecular_function	"Catalysis of the reaction: allantoin + H2O = allantoate." [EC:3.5.2.5]
EOG876NF1	GO:0000256	18/56	allantoin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684]
EOG876NF1	GO:0008270	18/56	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG876NF1	GO:0016888	3/56	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	molecular_function	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
EOG876NF1	GO:0016812	1/56	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]
EOG876NF1	GO:0016810	1/56	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
EOG8JHFXM	GO:0016459	2/4	myosin complex	cellular_component	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
EOG8JHFXM	GO:0003774	2/4	motor activity	molecular_function	"Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
EOG83N9VJ	GO:0030150	25/83	protein import into mitochondrial matrix	biological_process	"The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]
EOG83N9VJ	GO:0005744	25/83	mitochondrial inner membrane presequence translocase complex	cellular_component	"The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659]
EOG83N9VJ	GO:0008566	2/83	mitochondrial protein-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex." [EC:3.6.3.51]
EOG8F7R11	GO:0016021	3/229	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F7R11	GO:0006909	3/229	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8F7R11	GO:0042742	2/229	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8F7R11	GO:0005886	1/229	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8F7R11	GO:0006910	1/229	phagocytosis, recognition	biological_process	"The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149]
EOG8F7R11	GO:0046331	1/229	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8F7R11	GO:0009986	1/229	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8F7R11	GO:0005615	1/229	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8F7R11	GO:0006898	1/229	receptor-mediated endocytosis	biological_process	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
EOG8F7R11	GO:0005044	1/229	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8F7R11	GO:0008233	1/229	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8F7R11	GO:0042834	1/229	peptidoglycan binding	molecular_function	"Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226]
EOG8JHFXX	GO:0008270	18/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8HMMSJ	GO:0000723	4/40	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8HMMSJ	GO:0003678	4/40	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8HMMSJ	GO:0006281	4/40	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8HMMSJ	GO:0030414	1/40	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8HMMSJ	GO:0016706	1/40	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG8HMMSJ	GO:0005576	1/40	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG83N9VG	GO:0019441	13/94	tryptophan catabolic process to kynurenine	biological_process	"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]
EOG83N9VG	GO:0004061	13/94	arylformamidase activity	molecular_function	"Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9]
EOG83N9VG	GO:0016787	10/94	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8FJBQF	GO:0007156	7/40	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8FJBQF	GO:0016021	7/40	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FJBQF	GO:0005509	7/40	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8FJBQF	GO:0005886	5/40	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG82VBX2	GO:0007264	37/113	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG82VBX2	GO:0005085	36/113	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG82VBX2	GO:0000166	1/113	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG82VBX2	GO:0046872	1/113	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82VBX2	GO:0003723	1/113	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG82VBX2	GO:0032319	1/113	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG82VBX2	GO:0035023	1/113	regulation of Rho protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]
EOG82VBX2	GO:0005634	1/113	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82VBX2	GO:0005089	1/113	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG82VBX2	GO:0003824	1/113	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8323FM	GO:0008270	27/78	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8323FM	GO:0005634	2/78	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8323FM	GO:0003676	2/78	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8323FM	GO:0030532	1/78	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8RV55P	GO:0055085	23/87	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8RV55P	GO:0016021	23/87	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HQGZV	GO:0005089	1/4	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG86Q99B	GO:0005576	3/19	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG82JR5W	GO:0070526	22/93	tRNA threonylcarbamoyladenosine modification	biological_process	"The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base)." [GO:0070526, GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706]
EOG82JR5W	GO:0016747	19/93	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG82JR5W	GO:0046872	19/93	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82JR5W	GO:0005739	19/93	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG82JR5W	GO:0004222	16/93	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG82JR5W	GO:0016787	1/93	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG81ZHQS	GO:0003677	29/98	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81ZHQS	GO:0005524	29/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG81ZHQS	GO:0004386	27/98	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG81ZHQS	GO:0005634	26/98	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81ZHQS	GO:0003682	26/98	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG81ZHQS	GO:0043044	25/98	ATP-dependent chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors." [GOC:jl, PMID:12042764]
EOG81ZHQS	GO:0016740	2/98	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG81ZHQS	GO:0006338	2/98	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG81ZHQS	GO:0035063	1/98	nuclear speck organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized." [GOC:bf, GOC:curators]
EOG81ZHQS	GO:0006355	1/98	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG81ZHQS	GO:0016818	1/98	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	molecular_function	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]
EOG81ZHQS	GO:0016590	1/98	ACF complex	cellular_component	"An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and generally no other subunits, though Xenopus is an exception with a third non-conserved subunit. ACF plays roles in regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:12192034, PMID:15284901, PMID:16568949, PMID:21810179]
EOG81ZHQS	GO:0008134	1/98	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG81ZHQS	GO:0032508	1/98	DNA duplex unwinding	biological_process	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]
EOG81ZHQS	GO:0048813	1/98	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG81ZHQS	GO:0045892	1/98	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG81ZHQS	GO:0016584	1/98	nucleosome positioning	biological_process	"Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GOC:bf, PMID:11447119, PMID:8676389]
EOG81ZHQS	GO:0005667	1/98	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG81ZHQS	GO:0006325	1/98	chromatin organization	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
EOG81ZHQS	GO:0042766	1/98	nucleosome mobilization	biological_process	"The movement of nucleosomes along a DNA fragment." [PMID:12006495]
EOG81ZHQS	GO:0016589	1/98	NURF complex	cellular_component	"An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters." [GOC:bf, GOC:krc, PMID:10779516, PMID:11279013, PMID:15284901, PMID:16568949, PMID:21810179]
EOG81ZHQS	GO:0008094	1/98	DNA-dependent ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl]
EOG81ZHQS	GO:0006351	1/98	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG81ZHQS	GO:0006200	1/98	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG81ZHQS	GO:0008623	1/98	CHRAC	cellular_component	"An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179, PMID:9252192]
EOG81ZHQS	GO:0035076	1/98	ecdysone receptor-mediated signaling pathway	biological_process	"The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf]
EOG81ZHQS	GO:0006357	1/98	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG81ZHQS	GO:0000166	1/98	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG81ZHQS	GO:0031213	1/98	RSF complex	cellular_component	"An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters)." [GOC:krc, PMID:12972596, PMID:15284901, PMID:16568949, PMID:21810179]
EOG81ZHQS	GO:0007517	1/98	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG81ZHQS	GO:0005515	1/98	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG81ZHQS	GO:0070615	1/98	nucleosome-dependent ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of one or more nucleosomes." [GOC:mah, PMID:19165147]
EOG81ZHQS	GO:0003678	1/98	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG81ZHQS	GO:0006334	1/98	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG81ZHQS	GO:0045944	1/98	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG81ZHQS	GO:0042752	1/98	regulation of circadian rhythm	biological_process	"Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]
EOG81ZHQS	GO:0045893	1/98	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG81ZHQS	GO:0005700	1/98	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG81ZHQS	GO:0006333	1/98	chromatin assembly or disassembly	biological_process	"The formation or destruction of chromatin structures." [GOC:mah]
EOG81ZHQP	GO:0005524	25/111	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG81ZHQP	GO:0004714	22/111	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG81ZHQP	GO:0016020	21/111	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG81ZHQP	GO:0007169	21/111	transmembrane receptor protein tyrosine kinase signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
EOG81ZHQP	GO:0016021	8/111	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81ZHQP	GO:0004713	3/111	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG81ZHQP	GO:0043410	1/111	positive regulation of MAPK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]
EOG81ZHQP	GO:0042051	1/111	compound eye photoreceptor development	biological_process	"The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
EOG81ZHQP	GO:0045610	1/111	regulation of hemocyte differentiation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG81ZHQP	GO:0090328	1/111	regulation of olfactory learning	biological_process	"Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb]
EOG81ZHQP	GO:0004716	1/111	receptor signaling protein tyrosine kinase activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.2]
EOG81ZHQP	GO:1900074	1/111	negative regulation of neuromuscular synaptic transmission	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
EOG81ZHQP	GO:0007498	1/111	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG81ZHQP	GO:0006468	1/111	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG81ZHQP	GO:0080019	1/111	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG81ZHQP	GO:0071212	1/111	subsynaptic reticulum	cellular_component	"An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:1460464, PMID:18171947, PMID:19244343, PMID:7946331]
EOG81ZHQP	GO:0023014	1/111	signal transduction by protein phosphorylation	biological_process	"A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling]
EOG81ZHQP	GO:0048565	1/111	digestive tract development	biological_process	"The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators]
EOG81ZHQP	GO:0040008	1/111	regulation of growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]
EOG81ZHQP	GO:0007522	1/111	visceral muscle development	biological_process	"The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators]
EOG81ZHQP	GO:0018108	1/111	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG81ZHQP	GO:0070374	1/111	positive regulation of ERK1 and ERK2 cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]
EOG81ZHQP	GO:0004672	1/111	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG81ZHQP	GO:0061177	1/111	type Is terminal bouton	cellular_component	"Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons." [GOC:dph, GOC:mc]
EOG81ZHQP	GO:0007411	1/111	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG81ZHQP	GO:0061176	1/111	type Ib terminal bouton	cellular_component	"Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons." [GOC:dph, GOC:mc]
EOG81ZHQP	GO:0000186	1/111	activation of MAPKK activity	biological_process	"The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK)." [PMID:9561267]
EOG81ZHQP	GO:0045792	1/111	negative regulation of cell size	biological_process	"Any process that reduces cell size." [GOC:go_curators]
EOG818F3C	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG818F3C	GO:0022857	2/5	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8C5FZR	GO:0016021	59/197	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C5FZR	GO:0022857	55/197	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8C5FZR	GO:0055085	4/197	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8C5FZR	GO:0008643	1/197	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG81RS9W	GO:0003700	3/37	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG81RS9W	GO:0003677	3/37	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8642ST	GO:0005634	2/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8642ST	GO:0004842	2/4	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8642ST	GO:0006511	2/4	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8642ST	GO:0007275	2/4	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8642ST	GO:0008270	2/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8KM1GR	GO:0005506	1/100	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8KM1GR	GO:0022008	1/100	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8KM1GR	GO:0016705	1/100	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8KM1GR	GO:0020037	1/100	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG81ZHQN	GO:0003777	54/190	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG81ZHQN	GO:0007018	54/190	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG81ZHQN	GO:0030286	48/190	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG81ZHQN	GO:0005524	48/190	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG81ZHQN	GO:0016887	45/190	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG81ZHQN	GO:0005875	2/190	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG81ZHQN	GO:0006200	2/190	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG81ZHQN	GO:0042623	2/190	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG81ZHQN	GO:0007605	1/190	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8N06V9	GO:0016747	176/428	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8N06V9	GO:0022416	1/428	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8N06V9	GO:0035220	1/428	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8D55DJ	GO:0007010	1/7	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG837TTP	GO:0005622	25/119	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG837TTP	GO:0005525	21/119	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG837TTP	GO:0007264	20/119	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG837TTP	GO:0007165	7/119	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG837TTP	GO:0032321	1/119	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG837TTP	GO:0005100	1/119	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG837TTP	GO:0007415	1/119	defasciculation of motor neuron axon	biological_process	"Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh]
EOG837TTP	GO:0016319	1/119	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG837TTP	GO:0007266	1/119	Rho protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf]
EOG837TTP	GO:0050770	1/119	regulation of axonogenesis	biological_process	"Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]
EOG837TTP	GO:0045792	1/119	negative regulation of cell size	biological_process	"Any process that reduces cell size." [GOC:go_curators]
EOG837TTP	GO:0030215	1/119	semaphorin receptor binding	molecular_function	"Interacting selectively and non-covalently with semaphorin receptors." [GOC:ceb, PMID:12001990]
EOG818F3Q	GO:0008080	33/135	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG818F3Q	GO:0016740	3/135	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG818F3Q	GO:0030431	1/135	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG818F3Q	GO:0048066	1/135	developmental pigmentation	biological_process	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
EOG818F3Q	GO:0004060	1/135	arylamine N-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine." [EC:2.3.1.5]
EOG818F3Q	GO:0045187	1/135	regulation of circadian sleep/wake cycle, sleep	biological_process	"Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981]
EOG818F3Q	GO:0042420	1/135	dopamine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
EOG818F3Q	GO:0006584	1/135	catecholamine metabolic process	biological_process	"The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
EOG818F3Q	GO:0042429	1/135	serotonin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
EOG818F3Q	GO:0046334	1/135	octopamine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732]
EOG818F3Q	GO:0004059	1/135	aralkylamine N-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87]
EOG818F3Q	GO:0030187	1/135	melatonin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732]
EOG818F3Q	GO:0005737	1/135	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8C5FZD	GO:0016491	67/285	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8C5FZD	GO:0004503	7/285	monophenol monooxygenase activity	molecular_function	"Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1, GOC:bf, GOC:sart, PMID:4965136]
EOG8C5FZD	GO:0005576	5/285	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8C5FZD	GO:0046872	4/285	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8C5FZD	GO:0042438	3/285	melanin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [CHEBI:25179, GOC:curators]
EOG8C5FZD	GO:0036264	3/285	dopamine monooxygenase activity	molecular_function	"Catalysis of the reaction: dopamine + O2 = ? + H2O. This reaction catalyzes the oxygenation of dopamine to the corresponding o-quinone." [GOC:sart, PMID:22120533]
EOG8C5FZD	GO:0042417	3/285	dopamine metabolic process	biological_process	"The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
EOG8C5FZD	GO:0036263	3/285	L-DOPA monooxygenase activity	molecular_function	"Catalysis of the reaction: L-DOPA + O2 = ? + H2O. This reaction catalyzes the oxygenation of the dopamine precursor L-DOPA, to the corresponding o-quinone." [GOC:sart, PMID:22120533]
EOG8C5FZD	GO:0004097	2/285	catechol oxidase activity	molecular_function	"Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O." [EC:1.10.3.1]
EOG8C5FZD	GO:0006952	1/285	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8C5FZD	GO:0005615	1/285	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8C5FZD	GO:0006583	1/285	melanin biosynthetic process from tyrosine	biological_process	"The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators]
EOG81RS9B	GO:0016787	10/56	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG808QPR	GO:0007165	23/117	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG808QPR	GO:0005622	20/117	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG808QPR	GO:0005096	20/117	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG808QPR	GO:0005737	3/117	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG808QPR	GO:0003964	3/117	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG808QPR	GO:0007229	1/117	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG808QPR	GO:0003723	1/117	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG808QPR	GO:0035058	1/117	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG808QPR	GO:0034464	1/117	BBSome	cellular_component	"A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [GOC:BHF, PMID:17574030]
EOG8RFPB1	GO:0007017	1/5	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8RFPB1	GO:0051258	1/5	protein polymerization	biological_process	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
EOG8RFPB1	GO:0005200	1/5	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8RFPB1	GO:0003924	1/5	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8RFPB1	GO:0005525	1/5	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8RFPB1	GO:0005874	1/5	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG870WZW	GO:0006950	6/101	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG870WZW	GO:0030018	1/101	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8S4RW6	GO:0008270	23/96	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8S4RW6	GO:0016021	13/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S4RW6	GO:0019706	13/96	protein-cysteine S-palmitoyltransferase activity	molecular_function	"Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule." [EC:2.3.1.225, GOC:ai, GOC:pr]
EOG8S4RW6	GO:0016740	10/96	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8S4RW6	GO:0016491	2/96	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8SR09K	GO:0016301	3/106	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8SR09K	GO:0005737	1/106	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SR09K	GO:0017112	1/106	Rab guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8SR09K	GO:0016192	1/106	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8SR09K	GO:1902041	1/106	regulation of extrinsic apoptotic signaling pathway via death domain receptors	biological_process	"Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429]
EOG8SR09K	GO:0004819	1/106	glutamine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18]
EOG8SR09K	GO:0016021	1/106	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SR09K	GO:0006425	1/106	glutaminyl-tRNA aminoacylation	biological_process	"The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8SR09K	GO:0006915	1/106	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8SR09K	GO:0032313	1/106	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8SR09K	GO:0051726	1/106	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8SR09K	GO:0008021	1/106	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8SR09K	GO:0000187	1/106	activation of MAPK activity	biological_process	"The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267]
EOG8SR09K	GO:0007269	1/106	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8SR09K	GO:0005524	1/106	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG879HMZ	GO:0016772	69/190	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG879HMZ	GO:0016301	11/190	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG879HMZ	GO:0017022	1/190	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG879HMZ	GO:0022008	1/190	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8S7N4R	GO:0004190	11/76	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8S7N4R	GO:0005737	1/76	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8S7N4R	GO:0043130	1/76	ubiquitin binding	molecular_function	"Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]
EOG8S7N4R	GO:0007301	1/76	female germline ring canal formation	biological_process	"Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238]
EOG8S7N4R	GO:0005634	1/76	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8S7N4R	GO:0070628	1/76	proteasome binding	molecular_function	"Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]
EOG8H48JC	GO:0051539	25/90	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8H48JC	GO:0016992	25/90	lipoate synthase activity	molecular_function	"Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl." [EC:2.8.1.8, PMID:18307109]
EOG8H48JC	GO:0009249	24/90	protein lipoylation	biological_process	"The addition of a lipoyl group to an amino acid residue in a protein." [GOC:mah]
EOG8H48JC	GO:0005739	24/90	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8H48JC	GO:0046872	24/90	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG87DCWC	GO:0005524	24/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87DCWC	GO:0004674	23/98	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG87DCWC	GO:0004712	10/98	protein serine/threonine/tyrosine kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]
EOG87DCWC	GO:0046777	8/98	protein autophosphorylation	biological_process	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
EOG87DCWC	GO:0008355	1/98	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG87DCWC	GO:0006468	1/98	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG87DCWC	GO:2000253	1/98	positive regulation of feeding behavior	biological_process	"Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol]
EOG87DCWC	GO:0007632	1/98	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG87DCWC	GO:0005634	1/98	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87DCWC	GO:0007399	1/98	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG87DCWC	GO:0030154	1/98	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG87DCWC	GO:0004672	1/98	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG87DCWC	GO:0045927	1/98	positive regulation of growth	biological_process	"Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
EOG87DCWC	GO:0035332	1/98	positive regulation of hippo signaling	biological_process	"Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf]
EOG87DCWC	GO:0007623	1/98	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG87DCWC	GO:0007611	1/98	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG85TG2S	GO:0005634	2/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85TG2S	GO:0003676	2/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85TG2S	GO:0008270	2/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG812PM6	GO:0004222	25/103	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG812PM6	GO:0008270	25/103	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG812PM6	GO:0031012	24/103	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG812PM6	GO:0005509	22/103	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG812PM6	GO:0007155	1/103	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG812PM6	GO:0042060	1/103	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG812PM6	GO:0005578	1/103	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG812PM6	GO:0006629	1/103	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG812PM6	GO:0002168	1/103	instar larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG812PM6	GO:0071711	1/103	basement membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah]
EOG812PM6	GO:0030425	1/103	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG812PM6	GO:0035159	1/103	regulation of tube length, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
EOG812PM6	GO:0035001	1/103	dorsal trunk growth, open tracheal system	biological_process	"Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system." [GOC:mtg_sensu, ISBN:0879694238]
EOG812PM6	GO:0030198	1/103	extracellular matrix organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]
EOG812PM6	GO:0007424	1/103	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG812PM6	GO:0034769	1/103	basement membrane disassembly	biological_process	"The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221]
EOG812PM6	GO:0016020	1/103	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG812PM6	GO:0048102	1/103	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG812PM6	GO:0042246	1/103	tissue regeneration	biological_process	"The regrowth of lost or destroyed tissues." [GOC:curators]
EOG812PM6	GO:0007561	1/103	imaginal disc eversion	biological_process	"The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317]
EOG812PM6	GO:0007591	1/103	molting cycle, chitin-based cuticle	biological_process	"The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu]
EOG812PM6	GO:0035071	1/103	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8Q87GW	GO:0004252	2/3	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8PRW77	GO:0003796	126/416	lysozyme activity	molecular_function	"Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17]
EOG8PRW77	GO:0016998	121/416	cell wall macromolecule catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators]
EOG8PRW77	GO:0016021	20/416	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PRW77	GO:0005886	10/416	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8PRW77	GO:0006811	10/416	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8PRW77	GO:0005230	10/416	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8PRW77	GO:0019835	9/416	cytolysis	biological_process	"The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204]
EOG8PRW77	GO:0042742	8/416	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8PRW77	GO:0030054	8/416	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8PRW77	GO:0045202	8/416	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8PRW77	GO:0048102	1/416	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8PRW77	GO:0035071	1/416	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8PRW77	GO:0050829	1/416	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8PRW77	GO:0032504	1/416	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8PRW77	GO:0004568	1/416	chitinase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
EOG8PRW77	GO:0005615	1/416	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8PRW77	GO:0045824	1/416	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG8GTNT0	GO:0003676	5/105	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GTNT0	GO:0015074	4/105	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8GTNT0	GO:0008270	2/105	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XD66J	GO:0016021	27/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XD66J	GO:0055085	26/91	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8XD66J	GO:0005743	6/91	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8XD66J	GO:0006810	1/91	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8XD66J	GO:0050829	1/91	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8XD66J	GO:0045089	1/91	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG812PMJ	GO:0016491	24/91	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG812PMJ	GO:0046872	21/91	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG812PMJ	GO:0051537	21/91	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG812PMJ	GO:0008137	2/91	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG812PMJ	GO:0009055	1/91	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG812PMJ	GO:0006120	1/91	mitochondrial electron transport, NADH to ubiquinone	biological_process	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363]
EOG812PMJ	GO:0005739	1/91	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG812PMJ	GO:0005747	1/91	mitochondrial respiratory chain complex I	cellular_component	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]
EOG870WZ1	GO:0016021	2/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG870WZ1	GO:0022857	1/6	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG870WZ1	GO:0055085	1/6	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8N06V1	GO:0020037	1/69	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8N06V1	GO:0019825	1/69	oxygen binding	molecular_function	"Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl]
EOG85HVB3	GO:0007050	22/139	cell cycle arrest	biological_process	"A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]
EOG85HVB3	GO:0005509	22/139	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG85HVB3	GO:0005856	19/139	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG85HVB3	GO:0016204	1/139	determination of muscle attachment site	biological_process	"The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete]
EOG85HVB3	GO:0051491	1/139	positive regulation of filopodium assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG85HVB3	GO:0035149	1/139	lumen formation, open tracheal system	biological_process	"Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
EOG85HVB3	GO:0000226	1/139	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG85HVB3	GO:0035147	1/139	branch fusion, open tracheal system	biological_process	"Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584]
EOG85HVB3	GO:0016203	1/139	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG85HVB3	GO:0007475	1/139	apposition of dorsal and ventral imaginal disc-derived wing surfaces	biological_process	"The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu]
EOG85HVB3	GO:0048813	1/139	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG85HVB3	GO:0005912	1/139	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG85HVB3	GO:0045169	1/139	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG85HVB3	GO:0030716	1/139	oocyte fate determination	biological_process	"The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
EOG85HVB3	GO:0045773	1/139	positive regulation of axon extension	biological_process	"Any process that activates or increases the frequency, rate or extent of axon extension." [GOC:go_curators]
EOG85HVB3	GO:0030175	1/139	filopodium	cellular_component	"Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194]
EOG85HVB3	GO:0008017	1/139	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG85HVB3	GO:0000235	1/139	astral microtubule	cellular_component	"Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194]
EOG85HVB3	GO:0003779	1/139	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG85HVB3	GO:0030036	1/139	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG85HVB3	GO:0007423	1/139	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG85HVB3	GO:0007017	1/139	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG85HVB3	GO:0004725	1/139	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG85HVB3	GO:0007424	1/139	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG85HVB3	GO:0007409	1/139	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG85HVB3	GO:0005874	1/139	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG85HVB3	GO:0044295	1/139	axonal growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954]
EOG85HVB3	GO:0016199	1/139	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG85HVB3	GO:0007026	1/139	negative regulation of microtubule depolymerization	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]
EOG85HVB3	GO:0030426	1/139	growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194]
EOG85HVB3	GO:0008092	1/139	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG85HVB3	GO:0005515	1/139	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG85HVB3	GO:0016319	1/139	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG85HVB3	GO:0030516	1/139	regulation of axon extension	biological_process	"Any process that modulates the rate, direction or extent of axon extension." [GOC:go_curators]
EOG85HVB3	GO:0035371	1/139	microtubule plus-end	cellular_component	"The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]
EOG85HVB3	GO:0001578	1/139	microtubule bundle formation	biological_process	"A process that results in a parallel arrangement of microtubules." [GOC:dph]
EOG812PMD	GO:0008360	1/61	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG812PMD	GO:0070864	1/61	sperm individualization complex	cellular_component	"A macromolecular complex that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst." [GOC:sart, PMID:10588662, PMID:9550716]
EOG812PMD	GO:0048260	1/61	positive regulation of receptor-mediated endocytosis	biological_process	"Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb]
EOG812PMD	GO:0007298	1/61	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG812PMD	GO:0043234	1/61	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG812PMD	GO:0030145	1/61	manganese ion binding	molecular_function	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
EOG812PMD	GO:0007301	1/61	female germline ring canal formation	biological_process	"Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238]
EOG812PMD	GO:0070064	1/61	proline-rich region binding	molecular_function	"Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein." [GOC:mah]
EOG812PMD	GO:0004177	1/61	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG8BP3RX	GO:0016020	2/6	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8W9MK0	GO:0005525	26/97	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8W9MK0	GO:0007264	26/97	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8W9MK0	GO:0015031	23/97	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8W9MK0	GO:0004767	1/97	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8W9MK0	GO:0001738	1/97	morphogenesis of a polarized epithelium	biological_process	"The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]
EOG8W9MK0	GO:0055037	1/97	recycling endosome	cellular_component	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]
EOG8W9MK0	GO:0005737	1/97	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8W9MK0	GO:0043025	1/97	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8W9MK0	GO:0045202	1/97	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8CNT5N	GO:0016773	22/99	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8CNT5N	GO:0016301	3/99	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8CNT5N	GO:0005524	2/99	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CNT5N	GO:0005802	1/99	trans-Golgi network	cellular_component	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]
EOG8CNT5N	GO:0032252	1/99	secretory granule localization	biological_process	"Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah]
EOG8CNT5N	GO:0005770	1/99	late endosome	cellular_component	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
EOG8CNT5N	GO:0046854	1/99	phosphatidylinositol phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]
EOG8CNT5N	GO:0004430	1/99	1-phosphatidylinositol 4-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.67, RHEA:19880]
EOG8CNT5N	GO:0007030	1/99	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8VMHWZ	GO:0005524	37/96	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VMHWZ	GO:0004674	30/96	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8VMHWZ	GO:0051301	6/96	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8VMHWZ	GO:0004672	3/96	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8VMHWZ	GO:0004693	2/96	cyclin-dependent protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]
EOG8VMHWZ	GO:0004702	2/96	receptor signaling protein serine/threonine kinase activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah]
EOG8VMHWZ	GO:0023014	2/96	signal transduction by protein phosphorylation	biological_process	"A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling]
EOG8VMHWZ	GO:0006468	2/96	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8VMHWZ	GO:0035071	1/96	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8VMHWZ	GO:0008360	1/96	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8VMHWZ	GO:0004707	1/96	MAP kinase activity	molecular_function	"Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]
EOG8VMHWZ	GO:0006909	1/96	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8VMHWZ	GO:0004697	1/96	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG8VMHWZ	GO:0048102	1/96	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG86X1QR	GO:0006954	3/25	inflammatory response	biological_process	"The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, GOC:mtg_15nov05, ISBN:0198506732]
EOG86X1QR	GO:0005576	3/25	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8NKF9Q	GO:0016020	55/747	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NKF9Q	GO:0007157	8/747	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]
EOG8NKF9Q	GO:0005887	3/747	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NKF9Q	GO:0007415	2/747	defasciculation of motor neuron axon	biological_process	"Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh]
EOG8NKF9Q	GO:0007411	2/747	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8NKF9Q	GO:0004252	2/747	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8NKF9Q	GO:0005576	1/747	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8NKF9Q	GO:0005515	1/747	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8NKF9Q	GO:0001746	1/747	Bolwig's organ morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380]
EOG8NKF9Q	GO:0016198	1/747	axon choice point recognition	biological_process	"The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152]
EOG8NKF9Q	GO:0008045	1/747	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8NKF9Q	GO:0016201	1/747	synaptic target inhibition	biological_process	"The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]
EOG8NKF9Q	GO:0031225	1/747	anchored component of membrane	cellular_component	"The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG83XXJ8	GO:0016787	29/77	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG83XXJ8	GO:0004067	5/77	asparaginase activity	molecular_function	"Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]
EOG83XXJ8	GO:0033345	2/77	asparagine catabolic process via L-aspartate	biological_process	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]
EOG83XXJ8	GO:0008798	2/77	beta-aspartyl-peptidase activity	molecular_function	"Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide." [EC:3.4.19.5]
EOG83XXJ8	GO:0005737	2/77	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83XXJ8	GO:0003948	2/77	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	molecular_function	"Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)." [EC:3.5.1.26, RHEA:11547]
EOG83XXJ8	GO:0035071	1/77	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG83XXJ8	GO:0048102	1/77	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8RJJG5	GO:0005886	49/215	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8RJJG5	GO:0016021	49/215	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RJJG5	GO:0050909	49/215	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8RJJG5	GO:0003031	2/215	detection of carbon dioxide	biological_process	"The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
EOG8RJJG5	GO:0007608	2/215	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8RJJG5	GO:0050912	2/215	detection of chemical stimulus involved in sensory perception of taste	biological_process	"The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8RJJG5	GO:0010037	2/215	response to carbon dioxide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:sm]
EOG8RJJG5	GO:0008527	2/215	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8RJJG5	GO:0007610	2/215	behavior	biological_process	"The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
EOG8RJJG5	GO:0043025	1/215	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8RJJG5	GO:0030425	1/215	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8RJJG5	GO:0008340	1/215	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8T4G95	GO:0035091	23/82	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG8T4G95	GO:0007165	1/82	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8GTNTX	GO:0004298	40/99	threonine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8GTNTX	GO:0005839	40/99	proteasome core complex	cellular_component	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]
EOG8GTNTX	GO:0051603	39/99	proteolysis involved in cellular protein catabolic process	biological_process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]
EOG8GTNTX	GO:0005634	39/99	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GTNTX	GO:0005737	39/99	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8GTNTX	GO:0051297	1/99	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8GTNTX	GO:0022008	1/99	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8GTNTX	GO:0000022	1/99	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8GTNTX	GO:0008283	1/99	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8GTNTX	GO:0007052	1/99	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8GTNTX	GO:0043161	1/99	proteasome-mediated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
EOG86T5FC	GO:0007156	24/88	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG86T5FC	GO:0005509	24/88	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG86T5FC	GO:0005886	23/88	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG86T5FC	GO:0016021	23/88	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86T5FC	GO:0046843	1/88	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG86T5FC	GO:0005887	1/88	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86T5FC	GO:0016339	1/88	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
EOG86T5FC	GO:0042803	1/88	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG86T5FC	GO:0016324	1/88	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG86T5FC	GO:0005902	1/88	microvillus	cellular_component	"Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194]
EOG86T5FC	GO:0044331	1/88	cell-cell adhesion mediated by cadherin	biological_process	"The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains." [GOC:ha, GOC:hjd, GOC:jl, PMID:10923970]
EOG8N5ZBP	GO:0050661	42/135	NADP binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]
EOG8N5ZBP	GO:0006006	42/135	glucose metabolic process	biological_process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]
EOG8N5ZBP	GO:0051287	42/135	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8N5ZBP	GO:0004365	32/135	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	molecular_function	"Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12]
EOG8N5ZBP	GO:0016620	14/135	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG8N5ZBP	GO:0006096	3/135	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8N5ZBP	GO:0005737	2/135	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8N5ZBP	GO:0005811	2/135	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8N5ZBP	GO:0030018	1/135	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8N5ZBP	GO:0005875	1/135	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8N5ZBP	GO:0031430	1/135	M band	cellular_component	"The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194]
EOG8VMHWV	GO:0005576	7/70	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8XD66T	GO:0016020	1/3	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8S4RWM	GO:0005634	28/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8S4RWM	GO:0003684	28/103	damaged DNA binding	molecular_function	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
EOG8S4RWM	GO:0000012	28/103	single strand break repair	biological_process	"The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html]
EOG8S4RWM	GO:0006285	1/103	base-excision repair, AP site formation	biological_process	"The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired." [ISBN:0815316194]
EOG8S4RWM	GO:0046331	1/103	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8S4RWM	GO:0006974	1/103	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8S4RWM	GO:0046872	1/103	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8S4RWM	GO:0003676	1/103	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V9X6G	GO:0006562	1/37	proline catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
EOG8V9X6G	GO:0004657	1/37	proline dehydrogenase activity	molecular_function	"Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8]
EOG8ZKN1W	GO:0008448	22/95	N-acetylglucosamine-6-phosphate deacetylase activity	molecular_function	"Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate." [EC:3.5.1.25]
EOG8ZKN1W	GO:0006044	22/95	N-acetylglucosamine metabolic process	biological_process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
EOG8ZKN1W	GO:0005975	21/95	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8ZKN1W	GO:0016021	1/95	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZKN1W	GO:0046872	1/95	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZKN1W	GO:0016810	1/95	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
EOG8ZKN1W	GO:0008270	1/95	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZKN1W	GO:0005622	1/95	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8ZKN1W	GO:0005215	1/95	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8ZKN1W	GO:0004342	1/95	glucosamine-6-phosphate deaminase activity	molecular_function	"Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+)." [EC:3.5.99.6, RHEA:12175]
EOG8ZKN1W	GO:0055085	1/95	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8C5FZ9	GO:0050909	13/77	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8C5FZ9	GO:0005886	13/77	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8C5FZ9	GO:0016021	13/77	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZKN1X	GO:0006807	72/199	nitrogen compound metabolic process	biological_process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
EOG8ZKN1X	GO:0016811	72/199	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]
EOG8ZKN1X	GO:0004435	2/199	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8ZKN1X	GO:0035556	2/199	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8ZKN1X	GO:0006629	2/199	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8ZKN1X	GO:0071110	1/199	histone biotinylation	biological_process	"The modification of a histone by the addition of a biotinyl group." [GOC:rph, PMID:14613969, PMID:19019041]
EOG8ZKN1X	GO:0019898	1/199	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8ZKN1X	GO:0016787	1/199	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8ZKN1X	GO:0009408	1/199	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8ZKN1X	GO:0017159	1/199	pantetheine hydrolase activity	molecular_function	"Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine." [EC:3.5.1.92, RHEA:13448]
EOG8ZKN1X	GO:0018054	1/199	peptidyl-lysine biotinylation	biological_process	"The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117]
EOG8642S4	GO:0003824	64/235	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8642S4	GO:0047747	4/235	cholate-CoA ligase activity	molecular_function	"Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA." [EC:6.2.1.7, MetaCyc:CHOLATE--COA-LIGASE-RXN]
EOG8642S4	GO:0016874	1/235	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8642S4	GO:0005886	1/235	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8642S4	GO:0015909	1/235	long-chain fatty acid transport	biological_process	"The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ai]
EOG8642S4	GO:0070328	1/235	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG8642S4	GO:0005324	1/235	long-chain fatty acid transporter activity	molecular_function	"Enables the directed movement of long-chain fatty acids into, out of or within a cell, or between cells. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, ISBN:0198506732]
EOG8BVV87	GO:0004842	25/91	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8BVV87	GO:0008270	25/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FJBQ2	GO:0005524	54/181	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8FJBQ2	GO:0003676	53/181	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FJBQ2	GO:0008026	49/181	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8FJBQ2	GO:0008270	5/181	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FJBQ2	GO:0004386	4/181	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8FJBQ2	GO:0002168	1/181	instar larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8FJBQ2	GO:0007283	1/181	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8FJBQ2	GO:0043186	1/181	P granule	cellular_component	"A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
EOG8FJBQ2	GO:0005811	1/181	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8FJBQ2	GO:0006200	1/181	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8FJBQ2	GO:0005737	1/181	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8FJBQ2	GO:0007286	1/181	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG8FJBQ2	GO:0016246	1/181	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG8FJBQ2	GO:0005875	1/181	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8FJBQ2	GO:0016442	1/181	RISC complex	cellular_component	"A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]
EOG8FJBQ2	GO:0010468	1/181	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8FJBQ2	GO:0000070	1/181	mitotic sister chromatid segregation	biological_process	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
EOG8FJBQ2	GO:0048477	1/181	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8FJBQ2	GO:0004004	1/181	ATP-dependent RNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8FJBQ2	GO:0043025	1/181	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8FJBQ2	GO:0003723	1/181	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG89628N	GO:0016055	2/10	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG89628N	GO:0007275	2/10	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8CC6FJ	GO:0030659	2/135	cytoplasmic vesicle membrane	cellular_component	"The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]
EOG8CC6FJ	GO:0005856	2/135	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8CC6FJ	GO:0005886	2/135	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8CC6FJ	GO:0048471	2/135	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8CC6FJ	GO:0015031	2/135	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8CC6FJ	GO:0030029	1/135	actin filament-based process	biological_process	"Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah]
EOG8CC6FJ	GO:0045010	1/135	actin nucleation	biological_process	"The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194]
EOG8CC6FJ	GO:0005515	1/135	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8CC6FJ	GO:0045451	1/135	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8CC6FJ	GO:0007315	1/135	pole plasm assembly	biological_process	"Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8CC6FJ	GO:0008017	1/135	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8CC6FJ	GO:0007304	1/135	chorion-containing eggshell formation	biological_process	"The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8CC6FJ	GO:0051639	1/135	actin filament network formation	biological_process	"The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]
EOG8CC6FJ	GO:0005938	1/135	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8CC6FJ	GO:0048477	1/135	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8CC6FJ	GO:0007015	1/135	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8CC6FJ	GO:0005737	1/135	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CC6FJ	GO:0030717	1/135	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG8CC6FJ	GO:0051493	1/135	regulation of cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
EOG8CC6FJ	GO:0003779	1/135	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8CC6FJ	GO:0016192	1/135	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8CC6FJ	GO:0030036	1/135	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8CC6FJ	GO:0007275	1/135	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8CC6FJ	GO:0007316	1/135	pole plasm RNA localization	biological_process	"Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
EOG8QZB24	GO:0005272	158/406	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8QZB24	GO:0016021	144/406	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QZB24	GO:0016020	15/406	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QZB24	GO:0003964	2/406	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8QZB24	GO:0003723	2/406	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8QZB24	GO:0007638	1/406	mechanosensory behavior	biological_process	"Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators]
EOG8QZB24	GO:0043022	1/406	ribosome binding	molecular_function	"Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators]
EOG8QZB24	GO:0050975	1/406	sensory perception of touch	biological_process	"The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]
EOG8QZB24	GO:0050966	1/406	detection of mechanical stimulus involved in sensory perception of pain	biological_process	"The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
EOG8QZB24	GO:0044736	1/406	acid-sensing ion channel activity	molecular_function	"Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when a an extracellular proton has been bound by the channel complex." [GOC:jl]
EOG8QZB24	GO:0030425	1/406	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8QZB24	GO:0048266	1/406	behavioral response to pain	biological_process	"Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid]
EOG8QZB24	GO:0008345	1/406	larval locomotory behavior	biological_process	"Locomotory behavior in a larval (immature) organism." [GOC:ai]
EOG8QZB24	GO:0043025	1/406	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8QZB24	GO:0042256	1/406	mature ribosome assembly	biological_process	"The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome." [GOC:ma]
EOG8QZB24	GO:0035725	1/406	sodium ion transmembrane transport	biological_process	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
EOG8QZB24	GO:0030424	1/406	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG808QP2	GO:0020037	41/103	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG808QP2	GO:0004383	41/103	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG808QP2	GO:0035556	37/103	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG808QP2	GO:0000166	26/103	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG808QP2	GO:0008074	2/103	guanylate cyclase complex, soluble	cellular_component	"Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah]
EOG808QP2	GO:0046982	2/103	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG808QP2	GO:0046872	2/103	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG808QP2	GO:0001666	2/103	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG808QP2	GO:0005525	2/103	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG808QP2	GO:0006184	2/103	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG808QP2	GO:0000302	2/103	response to reactive oxygen species	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc]
EOG808QP2	GO:0006182	2/103	cGMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]
EOG808QP2	GO:0055093	1/103	response to hyperoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:kmv]
EOG8TTK1H	GO:0006457	19/41	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8TTK1H	GO:0016272	19/41	prefoldin complex	cellular_component	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]
EOG8TTK1H	GO:0008796	1/41	bis(5'-nucleosyl)-tetraphosphatase activity	molecular_function	"Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai]
EOG8DRCS3	GO:0004842	25/124	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8DRCS3	GO:0046872	23/124	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DRCS3	GO:0008234	1/124	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8DRCS3	GO:0005737	1/124	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8DRCS3	GO:0004869	1/124	cysteine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb]
EOG8DRCS3	GO:0042787	1/124	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological_process	"The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]
EOG8DRCS3	GO:0005634	1/124	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GQSKH	GO:0016787	53/131	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8GQSKH	GO:0006909	1/131	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG89KJ5X	GO:0000502	6/81	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG89KJ5X	GO:0003677	1/81	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG89KJ5X	GO:0006974	1/81	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG89KJ5X	GO:0005515	1/81	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8DNHKX	GO:0008745	2/3	N-acetylmuramoyl-L-alanine amidase activity	molecular_function	"Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]
EOG8DNHKX	GO:0009253	2/3	peptidoglycan catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
EOG8DNHKX	GO:0008270	1/3	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84J4Z8	GO:0016746	22/107	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG84J4Z8	GO:0005509	18/107	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG84J4Z8	GO:0005789	1/107	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG84J4Z8	GO:0000139	1/107	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG84J4Z8	GO:0047184	1/107	1-acylglycerophosphocholine O-acyltransferase activity	molecular_function	"Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN]
EOG84J4Z8	GO:0005794	1/107	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG84J4Z8	GO:0005783	1/107	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG84J4Z8	GO:0008654	1/107	phospholipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG84J4Z8	GO:0016021	1/107	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z0DKF	GO:0005634	22/93	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z0DKF	GO:0003677	22/93	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Z0DKF	GO:0005700	1/93	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8Z0DKF	GO:0035098	1/93	ESC/E(Z) complex	cellular_component	"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]
EOG8Z0DKF	GO:0061085	1/93	regulation of histone H3-K27 methylation	biological_process	"Any process that modulates the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb]
EOG8Z0DKF	GO:0005719	1/93	nuclear euchromatin	cellular_component	"The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732]
EOG8JT2PV	GO:0030145	1/3	manganese ion binding	molecular_function	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
EOG8JT2PV	GO:0000287	1/3	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8JT2PV	GO:0004721	1/3	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG88GZH9	GO:0003700	29/122	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG88GZH9	GO:0004871	29/122	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG88GZH9	GO:0005634	29/122	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88GZH9	GO:0005509	28/122	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG88GZH9	GO:0005737	24/122	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG88GZH9	GO:0003677	24/122	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG88GZH9	GO:0006351	23/122	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG88GZH9	GO:0030097	1/122	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG88GZH9	GO:0007530	1/122	sex determination	biological_process	"Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732]
EOG88GZH9	GO:0006952	1/122	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG88GZH9	GO:0048749	1/122	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG88GZH9	GO:0001077	1/122	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG88GZH9	GO:0002230	1/122	positive regulation of defense response to virus by host	biological_process	"Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
EOG88GZH9	GO:0005515	1/122	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG88GZH9	GO:0071481	1/122	cellular response to X-ray	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:mah]
EOG88GZH9	GO:0045944	1/122	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG88GZH9	GO:0048103	1/122	somatic stem cell division	biological_process	"The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089]
EOG88GZH9	GO:0008284	1/122	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG88GZH9	GO:0035019	1/122	somatic stem cell population maintenance	biological_process	"Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089]
EOG88GZH9	GO:0007476	1/122	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG88GZH9	GO:0007424	1/122	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG88GZH9	GO:0007538	1/122	primary sex determination	biological_process	"The sex determination process that results in the initial specification of sexual status of an individual organism." [GOC:mah]
EOG88GZH9	GO:0035167	1/122	larval lymph gland hemopoiesis	biological_process	"The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385]
EOG88GZH9	GO:0019827	1/122	stem cell population maintenance	biological_process	"The process by which an organism or tissue maintains a population of stem cells of a single type.  This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437]
EOG88GZH9	GO:0035172	1/122	hemocyte proliferation	biological_process	"The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG88GZH9	GO:0007399	1/122	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG88GZH9	GO:0043697	1/122	cell dedifferentiation	biological_process	"The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:dph, GOC:pg]
EOG88GZH9	GO:0007259	1/122	JAK-STAT cascade	biological_process	"Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028]
EOG88GZH9	GO:0017145	1/122	stem cell division	biological_process	"The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089]
EOG88GZH9	GO:0046425	1/122	regulation of JAK-STAT cascade	biological_process	"Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf]
EOG88GZH9	GO:0007526	1/122	larval somatic muscle development	biological_process	"The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG88GZH9	GO:0030178	1/122	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG88GZH9	GO:0048477	1/122	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG88GZH9	GO:0071222	1/122	cellular response to lipopolysaccharide	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]
EOG88GZH9	GO:0007616	1/122	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG88GZH9	GO:0007379	1/122	segment specification	biological_process	"The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG88GZH9	GO:0035171	1/122	lamellocyte differentiation	biological_process	"The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104]
EOG88GZH9	GO:0007442	1/122	hindgut morphogenesis	biological_process	"The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
EOG88GZH9	GO:0007350	1/122	blastoderm segmentation	biological_process	"The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG88GZH9	GO:0008348	1/122	negative regulation of antimicrobial humoral response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." [GOC:go_curators]
EOG88GZH9	GO:0042078	1/122	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG88GZH9	GO:0006959	1/122	humoral immune response	biological_process	"An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]
EOG88GZH9	GO:0007455	1/122	eye-antennal disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG88GZH9	GO:0007425	1/122	epithelial cell fate determination, open tracheal system	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940]
EOG88GZH9	GO:0007298	1/122	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG88GZH9	GO:0030720	1/122	oocyte localization involved in germarium-derived egg chamber formation	biological_process	"Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356]
EOG88GZH9	GO:0030713	1/122	ovarian follicle cell stalk formation	biological_process	"Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG88GZH9	GO:0030718	1/122	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8V45NN	GO:0005089	20/92	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8V45NN	GO:0005096	19/92	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8V45NN	GO:0005622	19/92	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8V45NN	GO:0007165	13/92	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8V45NN	GO:0035556	7/92	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8V45NN	GO:0004674	4/92	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8V45NN	GO:0016740	2/92	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8V45NN	GO:0045792	1/92	negative regulation of cell size	biological_process	"Any process that reduces cell size." [GOC:go_curators]
EOG8V45NN	GO:0007030	1/92	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8XPSVX	GO:0042578	23/95	phosphoric ester hydrolase activity	molecular_function	"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]
EOG8XPSVX	GO:0008270	1/95	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XPSVX	GO:0005634	1/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85XBB7	GO:0003676	2/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85XBB7	GO:0046872	2/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8N5ZBG	GO:0003824	13/77	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8N5ZBG	GO:0006470	10/77	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8N5ZBG	GO:0004722	10/77	protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
EOG8N5ZBG	GO:0046872	9/77	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8N5ZBG	GO:0016301	2/77	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8N5ZBG	GO:0004721	1/77	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8JQ6F4	GO:0007186	1/58	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8JQ6F4	GO:0005615	1/58	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8JQ6F4	GO:0001664	1/58	G-protein coupled receptor binding	molecular_function	"Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph]
EOG84TRQ7	GO:0048812	1/94	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG85XB9K	GO:0005578	143/527	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG85XB9K	GO:0016055	142/527	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG85XB9K	GO:0007275	138/527	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG85XB9K	GO:0005109	5/527	frizzled binding	molecular_function	"Interacting selectively and non-covalently with the frizzled (fz) receptor." [GOC:ceb, PR:000001315]
EOG85XB9K	GO:0005615	5/527	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG85XB9K	GO:0045165	4/527	cell fate commitment	biological_process	"The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
EOG85XB9K	GO:0030182	3/527	neuron differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
EOG85XB9K	GO:0007367	2/527	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG85XB9K	GO:0005576	2/527	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG85XB9K	GO:0048675	2/527	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG85XB9K	GO:0044719	2/527	regulation of imaginal disc-derived wing size	biological_process	"Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
EOG85XB9K	GO:0005515	2/527	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG85XB9K	GO:0008544	1/527	epidermis development	biological_process	"The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]
EOG85XB9K	GO:0048728	1/527	proboscis development	biological_process	"The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure." [GOC:rc]
EOG85XB9K	GO:0060914	1/527	heart formation	biological_process	"The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart]
EOG85XB9K	GO:0001745	1/527	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG85XB9K	GO:0050919	1/527	negative chemotaxis	biological_process	"The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete]
EOG85XB9K	GO:0035147	1/527	branch fusion, open tracheal system	biological_process	"Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584]
EOG85XB9K	GO:0007411	1/527	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG85XB9K	GO:0061332	1/527	Malpighian tubule bud morphogenesis	biological_process	"The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG85XB9K	GO:0002168	1/527	instar larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG85XB9K	GO:0035290	1/527	trunk segmentation	biological_process	"Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402]
EOG85XB9K	GO:0048190	1/527	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG85XB9K	GO:0006355	1/527	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85XB9K	GO:0005112	1/527	Notch binding	molecular_function	"Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb]
EOG85XB9K	GO:0005539	1/527	glycosaminoglycan binding	molecular_function	"Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732]
EOG85XB9K	GO:0035225	1/527	determination of genital disc primordium	biological_process	"Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318]
EOG85XB9K	GO:0061328	1/527	posterior Malpighian tubule development	biological_process	"The process whose specific outcome is the progression of the posterior Malpighian tubule over time, from its formation to the mature structure. The pair of posterior tubules arise from a ventrolateral region of the embryonic hindgut and project backwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10]
EOG85XB9K	GO:0007398	1/527	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG85XB9K	GO:0007419	1/527	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG85XB9K	GO:0030054	1/527	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG85XB9K	GO:0005783	1/527	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG85XB9K	GO:0072091	1/527	regulation of stem cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
EOG85XB9K	GO:0048076	1/527	regulation of compound eye pigmentation	biological_process	"Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid]
EOG85XB9K	GO:0007476	1/527	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG85XB9K	GO:0007507	1/527	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG85XB9K	GO:0048754	1/527	branching morphogenesis of an epithelial tube	biological_process	"The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid]
EOG85XB9K	GO:0046672	1/527	positive regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG85XB9K	GO:0007424	1/527	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG85XB9K	GO:0035277	1/527	spiracle morphogenesis, open tracheal system	biological_process	"The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268]
EOG85XB9K	GO:0005102	1/527	receptor binding	molecular_function	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]
EOG85XB9K	GO:0060061	1/527	Spemann organizer formation	biological_process	"Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:bf, GOC:dph]
EOG85XB9K	GO:0007523	1/527	larval visceral muscle development	biological_process	"The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid]
EOG85XB9K	GO:0035167	1/527	larval lymph gland hemopoiesis	biological_process	"The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385]
EOG85XB9K	GO:0035289	1/527	posterior head segmentation	biological_process	"Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136]
EOG85XB9K	GO:0005771	1/527	multivesicular body	cellular_component	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]
EOG85XB9K	GO:0035017	1/527	cuticle pattern formation	biological_process	"The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf]
EOG85XB9K	GO:0005886	1/527	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG85XB9K	GO:0051017	1/527	actin filament bundle assembly	biological_process	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
EOG85XB9K	GO:0050840	1/527	extracellular matrix binding	molecular_function	"Interacting selectively and non-covalently with a component of the extracellular matrix." [GOC:ai]
EOG85XB9K	GO:0007394	1/527	dorsal closure, elongation of leading edge cells	biological_process	"The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138]
EOG85XB9K	GO:0007444	1/527	imaginal disc development	biological_process	"The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238]
EOG85XB9K	GO:0060070	1/527	canonical Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488]
EOG85XB9K	GO:0014019	1/527	neuroblast development	biological_process	"The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585]
EOG85XB9K	GO:0016015	1/527	morphogen activity	molecular_function	"Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient." [GOC:go_curators]
EOG85XB9K	GO:0007446	1/527	imaginal disc growth	biological_process	"The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387]
EOG85XB9K	GO:0003136	1/527	negative regulation of heart induction by canonical Wnt signaling pathway	biological_process	"Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329]
EOG85XB9K	GO:0035224	1/527	genital disc anterior/posterior pattern formation	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318]
EOG85XB9K	GO:0035217	1/527	labial disc development	biological_process	"Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238]
EOG85XB9K	GO:0030139	1/527	endocytic vesicle	cellular_component	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]
EOG85XB9K	GO:0009996	1/527	negative regulation of cell fate specification	biological_process	"Any process that restricts, stops or prevents a cell from adopting a specific cell fate." [GOC:go_curators]
EOG85XB9K	GO:0016204	1/527	determination of muscle attachment site	biological_process	"The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete]
EOG85XB9K	GO:0007448	1/527	anterior/posterior pattern specification, imaginal disc	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238]
EOG85XB9K	GO:0032876	1/527	negative regulation of DNA endoreduplication	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication." [GOC:mah]
EOG85XB9K	GO:0007391	1/527	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG85XB9K	GO:0007435	1/527	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG85XB9K	GO:0046847	1/527	filopodium assembly	biological_process	"The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790]
EOG85XB9K	GO:0008595	1/527	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG85XB9K	GO:0010002	1/527	cardioblast differentiation	biological_process	"The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG85XB9K	GO:0043066	1/527	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG85XB9K	GO:0035311	1/527	wing cell fate specification	biological_process	"The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment." [PMID:10860999]
EOG85XB9K	GO:0016318	1/527	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG85XB9K	GO:0045202	1/527	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG85XB9K	GO:0007418	1/527	ventral midline development	biological_process	"The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342]
EOG85XB9K	GO:0045892	1/527	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85XB9K	GO:0048542	1/527	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG85XB9K	GO:0007442	1/527	hindgut morphogenesis	biological_process	"The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
EOG85XB9K	GO:0007616	1/527	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG85XB9K	GO:0061382	1/527	Malpighian tubule tip cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells." [GOC:dph, GOC:mtg_kidney_jan10, PMID:7821213]
EOG85XB9K	GO:0042127	1/527	regulation of cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
EOG85XB9K	GO:0035215	1/527	genital disc development	biological_process	"Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318]
EOG85XB9K	GO:0007479	1/527	leg disc proximal/distal pattern formation	biological_process	"The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf]
EOG85XB9K	GO:0016023	1/527	cytoplasmic membrane-bounded vesicle	cellular_component	"A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
EOG85XB9K	GO:0005110	1/527	frizzled-2 binding	molecular_function	"Interacting selectively and non-covalently with frizzled-2 (fz2)." [GOC:ceb, PR:000007719]
EOG85XB9K	GO:0035220	1/527	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG85XB9K	GO:0030707	1/527	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG85XB9K	GO:0009986	1/527	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG85XB9K	GO:0008284	1/527	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG85XB9K	GO:0007423	1/527	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG85XB9K	GO:0007346	1/527	regulation of mitotic cell cycle	biological_process	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG85XB9K	GO:0007447	1/527	imaginal disc pattern formation	biological_process	"The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid]
EOG85XB9K	GO:0042691	1/527	positive regulation of crystal cell differentiation	biological_process	"Any process that activates or increases the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]
EOG85XB9K	GO:0007223	1/527	Wnt signaling pathway, calcium modulating pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:bf, GOC:dph, GOC:go_curators, PMID:11532397]
EOG85XB9K	GO:0035170	1/527	lymph gland crystal cell differentiation	biological_process	"The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
EOG85XB9K	GO:0048749	1/527	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG85XB9K	GO:0035153	1/527	epithelial cell type specification, open tracheal system	biological_process	"Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940]
EOG85XB9K	GO:0007517	1/527	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG85XB9K	GO:0007450	1/527	dorsal/ventral pattern formation, imaginal disc	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238]
EOG85XB9K	GO:0061331	1/527	epithelial cell proliferation involved in Malpighian tubule morphogenesis	biological_process	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG85XB9K	GO:0035263	1/527	genital disc sexually dimorphic development	biological_process	"The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781]
EOG85XB9K	GO:0030032	1/527	lamellipodium assembly	biological_process	"Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194]
EOG85XB9K	GO:0035288	1/527	anterior head segmentation	biological_process	"Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136]
EOG85XB9K	GO:0007498	1/527	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG85XB9K	GO:0061320	1/527	pericardial nephrocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]
EOG85XB9K	GO:0045121	1/527	membrane raft	cellular_component	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198]
EOG85XB9K	GO:0045611	1/527	negative regulation of hemocyte differentiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG85XB9K	GO:0048332	1/527	mesoderm morphogenesis	biological_process	"The process in which the anatomical structures of the mesoderm are generated and organized." [GOC:go_curators]
EOG86HJSV	GO:0034498	1/3	early endosome to Golgi transport	biological_process	"The directed movement of substances from early endosomes to the Golgi." [GOC:rb]
EOG86HJSV	GO:0006886	1/3	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG86HJSV	GO:0031901	1/3	early endosome membrane	cellular_component	"The lipid bilayer surrounding an early endosome." [GOC:pz]
EOG86HJSV	GO:0035091	1/3	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG8JT2M4	GO:0050660	28/94	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8JT2M4	GO:0003995	26/94	acyl-CoA dehydrogenase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]
EOG8JT2M4	GO:0008470	2/94	isovaleryl-CoA dehydrogenase activity	molecular_function	"Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF." [EC:1.3.99.10]
EOG86MDZS	GO:0003824	24/102	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG86MDZS	GO:0009116	24/102	nucleoside metabolic process	biological_process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]
EOG86MDZS	GO:0046331	1/102	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8JT2M3	GO:0000166	71/254	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8JT2M3	GO:0003676	65/254	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JT2M3	GO:0030529	4/254	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8JT2M3	GO:0019013	3/254	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8JT2M3	GO:0005737	2/254	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8JT2M3	GO:0003729	2/254	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8JT2M3	GO:0042078	1/254	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG8JT2M3	GO:0017148	1/254	negative regulation of translation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8JT2M3	GO:0048024	1/254	regulation of mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]
EOG8JT2M3	GO:0003697	1/254	single-stranded DNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174]
EOG8JT2M3	GO:0003727	1/254	single-stranded RNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl]
EOG8JT2M3	GO:0046331	1/254	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8JT2M3	GO:0007298	1/254	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8JT2M3	GO:0000900	1/254	translation repressor activity, nucleic acid binding	molecular_function	"Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw]
EOG8JT2M3	GO:0007411	1/254	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8JT2M3	GO:0003723	1/254	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8JT2M3	GO:0048864	1/254	stem cell development	biological_process	"The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete]
EOG8JT2M3	GO:0045182	1/254	translation regulator activity	molecular_function	"Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai]
EOG8JT2M3	GO:0043234	1/254	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8JT2M3	GO:0022416	1/254	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8JT2M3	GO:0005844	1/254	polysome	cellular_component	"A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]
EOG8JT2M3	GO:0005634	1/254	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8JT2M3	GO:0045727	1/254	positive regulation of translation	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8JT2M3	GO:0008266	1/254	poly(U) RNA binding	molecular_function	"Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule." [GOC:mah]
EOG8JT2M3	GO:0003730	1/254	mRNA 3'-UTR binding	molecular_function	"Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah]
EOG8JT2M3	GO:0071456	1/254	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG8JT2M3	GO:0006417	1/254	regulation of translation	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8JT2M3	GO:0019827	1/254	stem cell population maintenance	biological_process	"The process by which an organism or tissue maintains a population of stem cells of a single type.  This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437]
EOG8JT2M3	GO:0005654	1/254	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG8JT2M3	GO:0048027	1/254	mRNA 5'-UTR binding	molecular_function	"Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule." [GOC:jid]
EOG8JT2M3	GO:0007319	1/254	negative regulation of oskar mRNA translation	biological_process	"Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems]
EOG8JT2M3	GO:0001709	1/254	cell fate determination	biological_process	"A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
EOG8JT2M3	GO:0045451	1/254	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8JT2M3	GO:0005515	1/254	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8W9MJT	GO:0008299	27/163	isoprenoid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
EOG8W9MJT	GO:0016740	24/163	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8W9MJT	GO:0004161	3/163	dimethylallyltranstransferase activity	molecular_function	"Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate." [EC:2.5.1.1]
EOG8W9MJT	GO:0008354	1/163	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8W9MJT	GO:0035220	1/163	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8W9MJT	GO:0004337	1/163	geranyltranstransferase activity	molecular_function	"Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate." [EC:2.5.1.10, RHEA:19364]
EOG8VHNN3	GO:0016905	2/90	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG8VHNN3	GO:0071013	1/90	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8VHNN3	GO:0000398	1/90	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8VHNN3	GO:0005682	1/90	U5 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U5." [GOC:krc, GOC:mah]
EOG8VHNN3	GO:0030532	1/90	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8VHNN3	GO:0007067	1/90	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8VHNN3	GO:0071011	1/90	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8HX7GQ	GO:0016311	1/208	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG8HX7GQ	GO:0005515	1/208	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8HX7GQ	GO:0005634	1/208	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HX7GQ	GO:0008195	1/208	phosphatidate phosphatase activity	molecular_function	"Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [EC:3.1.3.4, GOC:pr]
EOG8HX7GQ	GO:0003682	1/208	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8HX7GQ	GO:0001672	1/208	regulation of chromatin assembly or disassembly	biological_process	"Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators]
EOG8HX7GQ	GO:0042803	1/208	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8HX7GQ	GO:0048477	1/208	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8HX7GQ	GO:0005704	1/208	polytene chromosome band	cellular_component	"A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342]
EOG8HX7GQ	GO:0006355	1/208	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8HX7GQ	GO:0005886	1/208	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8HX7GQ	GO:0010032	1/208	meiotic chromosome condensation	biological_process	"Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401]
EOG8HX7GQ	GO:0000785	1/208	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG8HX7GQ	GO:0006915	1/208	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8HX7GQ	GO:0003677	1/208	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8HX7GQ	GO:0007141	1/208	male meiosis I	biological_process	"A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah]
EOG8HX7GQ	GO:0006351	1/208	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8HX7GQ	GO:0005700	1/208	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8HX7GQ	GO:0016568	1/208	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG8HX7GQ	GO:0003676	1/208	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HX7GQ	GO:0007060	1/208	male meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai]
EOG8HX7GQ	GO:0008354	1/208	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8HX7GQ	GO:0031208	1/208	POZ domain binding	molecular_function	"Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847]
EOG8HX7GQ	GO:0046872	1/208	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89KJ5B	GO:0035556	19/128	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG89KJ5B	GO:0046872	17/128	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG88PQ18	GO:0005846	5/37	nuclear cap binding complex	cellular_component	"A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export." [PMID:16043498]
EOG88PQ18	GO:0000339	5/37	RNA cap binding	molecular_function	"Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule." [GOC:krc]
EOG88PQ18	GO:0045292	5/37	mRNA cis splicing, via spliceosome	biological_process	"The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, http://calspace.ucsd.edu/origins/Glossary/C.htm, ISBN:0879695897]
EOG88PQ18	GO:0051028	5/37	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8W6RC2	GO:0005622	2/21	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8W6RC2	GO:0005085	2/21	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8W6RC2	GO:0007264	2/21	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG86DPJ8	GO:0004252	2/4	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG86DPJ9	GO:0016021	7/45	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84N16G	GO:0005328	263/840	neurotransmitter:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
EOG84N16G	GO:0016021	251/840	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84N16G	GO:0003333	12/840	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG84N16G	GO:0005887	12/840	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84N16G	GO:0042940	11/840	D-amino acid transport	biological_process	"The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
EOG84N16G	GO:0042943	11/840	D-amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
EOG84N16G	GO:0005283	11/840	sodium:amino acid symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai]
EOG84N16G	GO:0015804	11/840	neutral amino acid transport	biological_process	"The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84N16G	GO:0015175	11/840	neutral amino acid transmembrane transporter activity	molecular_function	"Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG84N16G	GO:0006814	11/840	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG84N16G	GO:0005326	7/840	neurotransmitter transporter activity	molecular_function	"Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732]
EOG84N16G	GO:0006836	7/840	neurotransmitter transport	biological_process	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]
EOG84N16G	GO:0005886	2/840	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG84N16G	GO:0019811	1/840	cocaine binding	molecular_function	"Interacting selectively and non-covalently with cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis." [GOC:jl, ISBN:0198506732]
EOG84N16G	GO:0015872	1/840	dopamine transport	biological_process	"The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
EOG84N16G	GO:0015222	1/840	serotonin transmembrane transporter activity	molecular_function	"Enables the transfer of serotonin from one side of the membrane to the other. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
EOG84N16G	GO:0004181	1/840	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG84N16G	GO:0015179	1/840	L-amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
EOG84N16G	GO:0030431	1/840	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG84N16G	GO:0042745	1/840	circadian sleep/wake cycle	biological_process	"The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com]
EOG84N16G	GO:0043679	1/840	axon terminus	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl]
EOG84N16G	GO:0015807	1/840	L-amino acid transport	biological_process	"The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah]
EOG84N16G	GO:0006909	1/840	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG84N16G	GO:0010226	1/840	response to lithium ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:tb]
EOG84N16G	GO:1902475	1/840	L-alpha-amino acid transmembrane transport	biological_process	"The directed movement of L-alpha-amino acid across a membrane." [GOC:kmv, GOC:TermGenie, PMID:14668347]
EOG84N16G	GO:0005416	1/840	cation:amino acid symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai]
EOG84N16G	GO:0046872	1/840	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84N16G	GO:0005261	1/840	cation channel activity	molecular_function	"Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG84N16G	GO:0030424	1/840	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG84N16G	GO:0008270	1/840	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84N16G	GO:0015844	1/840	monoamine transport	biological_process	"The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:25375, GOC:mah]
EOG84N16G	GO:0051610	1/840	serotonin uptake	biological_process	"The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
EOG84N16G	GO:0006837	1/840	serotonin transport	biological_process	"The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
EOG84N16G	GO:0008504	1/840	monoamine transmembrane transporter activity	molecular_function	"Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other." [CHEBI:25375, GOC:mah]
EOG84N16G	GO:0005329	1/840	dopamine transmembrane transporter activity	molecular_function	"Enables the transfer of dopamine from one side of the membrane to the other. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
EOG84N16G	GO:0007632	1/840	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG8JQ6CG	GO:0005634	32/109	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8JQ6CG	GO:0003676	32/109	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8JQ6CG	GO:0004535	5/109	poly(A)-specific ribonuclease activity	molecular_function	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]
EOG8JQ6CG	GO:0090503	1/109	RNA phosphodiester bond hydrolysis, exonucleolytic	biological_process	"The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
EOG8JQ6CG	GO:0005737	1/109	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8JQ6CG	GO:0048666	1/109	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8JQ6CG	GO:0007095	1/109	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8JQ6CG	GO:0006402	1/109	mRNA catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]
EOG8JQ6CG	GO:0005515	1/109	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8JQ6CG	GO:0030014	1/109	CCR4-NOT complex	cellular_component	"The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins." [GOC:sart, PMID:11113136]
EOG8JQ6CG	GO:0017148	1/109	negative regulation of translation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8JQ6CG	GO:0007517	1/109	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8JQ6CG	GO:0022008	1/109	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8JQ6CG	GO:0000289	1/109	nuclear-transcribed mRNA poly(A) tail shortening	biological_process	"Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc]
EOG8616HW	GO:0007165	19/111	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8616HW	GO:0048730	1/111	epidermis morphogenesis	biological_process	"The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:jid, UBERON:0001003]
EOG8616HW	GO:0032880	1/111	regulation of protein localization	biological_process	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]
EOG8616HW	GO:0016330	1/111	second mitotic wave involved in compound eye morphogenesis	biological_process	"A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224]
EOG8616HW	GO:0019904	1/111	protein domain specific binding	molecular_function	"Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators]
EOG8616HW	GO:0007219	1/111	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8616HW	GO:0007391	1/111	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8616HW	GO:0014009	1/111	glial cell proliferation	biological_process	"The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585]
EOG8616HW	GO:0048749	1/111	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8616HW	GO:0007265	1/111	Ras protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf]
EOG8616HW	GO:0005938	1/111	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8616HW	GO:0005926	1/111	connecting hemi-adherens junction	cellular_component	"A cell-substrate adherens junction, also known as a hemiadherens junction (HAJ) that forms one of a pair of junctions in opposing cells that are separated by only 30-40nm, with a thin line of extracellular electron-dense material in between; found where muscles attach to epidermal cells directly (in insects)." [http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm]
EOG8616HW	GO:0016318	1/111	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG8616HW	GO:0007394	1/111	dorsal closure, elongation of leading edge cells	biological_process	"The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138]
EOG8616HW	GO:0005915	1/111	zonula adherens	cellular_component	"A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208]
EOG8616HW	GO:0007254	1/111	JNK cascade	biological_process	"An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974]
EOG8616HW	GO:0007163	1/111	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8616HW	GO:0046328	1/111	regulation of JNK cascade	biological_process	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8616HW	GO:0048598	1/111	embryonic morphogenesis	biological_process	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]
EOG8616HW	GO:0005515	1/111	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8616HW	GO:0017016	1/111	Ras GTPase binding	molecular_function	"Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG8616HW	GO:0005912	1/111	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8616HW	GO:0000132	1/111	establishment of mitotic spindle orientation	biological_process	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
EOG81G5M7	GO:0005509	31/95	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG81G5M7	GO:0032440	2/95	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG81G5M7	GO:0016459	1/95	myosin complex	cellular_component	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
EOG81G5M7	GO:0060361	1/95	flight	biological_process	"Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph]
EOG81G5M7	GO:0003012	1/95	muscle system process	biological_process	"A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio]
EOG81G5M7	GO:0030239	1/95	myofibril assembly	biological_process	"Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]
EOG81G5M7	GO:0030016	1/95	myofibril	cellular_component	"The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194]
EOG8ZSCJH	GO:0004984	1/11	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8ZSCJH	GO:0016020	1/11	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8ZSCJH	GO:0005549	1/11	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8SR0C4	GO:0046872	59/198	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8SR0C4	GO:0004784	57/198	superoxide dismutase activity	molecular_function	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]
EOG8SR0C4	GO:0005737	11/198	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SR0C4	GO:0006801	4/198	superoxide metabolic process	biological_process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl]
EOG8SR0C4	GO:0055114	4/198	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8SR0C4	GO:0005507	2/198	copper ion binding	molecular_function	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]
EOG8SR0C4	GO:0008270	2/198	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SR0C4	GO:0019430	2/198	removal of superoxide radicals	biological_process	"Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [CHEBI:18421, GOC:jl]
EOG8SR0C4	GO:0006979	2/198	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8SR0C4	GO:0005615	1/198	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8SR0C4	GO:0016209	1/198	antioxidant activity	molecular_function	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
EOG8SR0C4	GO:0005777	1/198	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8SR0C4	GO:0007568	1/198	aging	biological_process	"A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death (GO:0016265) and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators]
EOG8SR0C4	GO:0042803	1/198	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8SR0C4	GO:0008340	1/198	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8SR0C4	GO:0009650	1/198	UV protection	biological_process	"Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml]
EOG8PK4RN	GO:0000062	2/6	fatty-acyl-CoA binding	molecular_function	"Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732]
EOG8K6JM0	GO:0016020	24/154	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8K6JM0	GO:0004872	23/154	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8K6JM0	GO:0007275	22/154	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8K6JM0	GO:0070983	2/154	dendrite guidance	biological_process	"The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
EOG8K6JM0	GO:0071678	2/154	olfactory bulb axon guidance	biological_process	"The process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]
EOG8K6JM0	GO:0005576	1/154	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8K6JM0	GO:0005515	1/154	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8K6JM0	GO:0007632	1/154	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG8K6JM0	GO:0007411	1/154	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8K6JM0	GO:2001020	1/154	regulation of response to DNA damage stimulus	biological_process	"Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
EOG8K6JM0	GO:0016200	1/154	synaptic target attraction	biological_process	"The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437]
EOG8K6JM0	GO:0042756	1/154	drinking behavior	biological_process	"The specific behavior of an organism relating to the intake of liquids, especially water." [GOC:curators, GOC:pr]
EOG8K6JM0	GO:0016201	1/154	synaptic target inhibition	biological_process	"The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]
EOG8K6JM0	GO:0007629	1/154	flight behavior	biological_process	"The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]
EOG8K6JM0	GO:0030534	1/154	adult behavior	biological_process	"Behavior in a fully developed and mature organism." [GOC:mah, ISBN:0877797099]
EOG8SR0C1	GO:0005525	27/168	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8SR0C1	GO:0007264	27/168	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8SR0C1	GO:0015031	24/168	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8SR0C1	GO:0008168	4/168	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8SR0C1	GO:0030798	3/168	trans-aconitate 2-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972]
EOG8SR0C1	GO:0016740	2/168	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8SR0C1	GO:0006184	1/168	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8SR0C1	GO:0006887	1/168	exocytosis	biological_process	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
EOG8SR0C1	GO:0019010	1/168	farnesoic acid O-methyltransferase activity	molecular_function	"Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine." [PMID:12135499]
EOG8SR0C1	GO:0048786	1/168	presynaptic active zone	cellular_component	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]
EOG8SR0C1	GO:0045202	1/168	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8SR0C1	GO:0030054	1/168	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8SR0C1	GO:0006718	1/168	juvenile hormone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684]
EOG8SR0C1	GO:0035049	1/168	juvenile hormone acid methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to juvenile hormone acid." [GOC:bf]
EOG8SR0C1	GO:0007186	1/168	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8SR0C1	GO:0008021	1/168	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8SR0C1	GO:0004871	1/168	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8SR0C1	GO:0007269	1/168	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8SR0C1	GO:0005834	1/168	heterotrimeric G-protein complex	cellular_component	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684]
EOG8SR0C1	GO:0048790	1/168	maintenance of presynaptic active zone structure	biological_process	"The process in which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr]
EOG8SR0C1	GO:0004767	1/168	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8SR0C1	GO:0016192	1/168	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8284FG	GO:0046872	3/99	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8284FG	GO:0016477	1/99	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG8284FG	GO:0031012	1/99	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8284FG	GO:0070831	1/99	basement membrane assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue." [GOC:mah]
EOG8284FG	GO:0003944	1/99	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	molecular_function	"Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose." [EC:3.1.4.45]
EOG8284FG	GO:0005604	1/99	basement membrane	cellular_component	"A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]
EOG8284FG	GO:0007155	1/99	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8284FG	GO:0008406	1/99	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG8284FG	GO:0045089	1/99	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8284FG	GO:0050829	1/99	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8284FG	GO:0048513	1/99	organ development	biological_process	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]
EOG8284FG	GO:0005605	1/99	basal lamina	cellular_component	"A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix." [ISBN:0198547684]
EOG8284FG	GO:0004714	1/99	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8D55CJ	GO:0008532	5/138	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149]
EOG8D55CJ	GO:0016740	3/138	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8D55CJ	GO:0005506	1/138	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8D55CJ	GO:0007218	1/138	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8D55CJ	GO:0002121	1/138	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8D55CJ	GO:0008109	1/138	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.150]
EOG8D55CJ	GO:0020037	1/138	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8D55CJ	GO:0016705	1/138	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG88PQ1T	GO:0016021	23/51	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D81KK	GO:0005643	25/86	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG8D81KK	GO:0006810	24/86	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8D81KK	GO:0007184	1/86	SMAD protein import into nucleus	biological_process	"The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph]
EOG8D81KK	GO:0005635	1/86	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG85XB9M	GO:0005634	50/177	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85XB9M	GO:0003707	49/177	steroid hormone receptor activity	molecular_function	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
EOG85XB9M	GO:0008270	44/177	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG85XB9M	GO:0043565	42/177	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG85XB9M	GO:0006351	26/177	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG85XB9M	GO:0003700	26/177	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG85XB9M	GO:0004879	24/177	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	molecular_function	"Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH]
EOG85XB9M	GO:0003677	8/177	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG85XB9M	GO:0042803	2/177	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG85XB9M	GO:0030522	2/177	intracellular receptor signaling pathway	biological_process	"Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah]
EOG85XB9M	GO:0046982	2/177	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG85XB9M	GO:0005515	2/177	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG85XB9M	GO:0008289	1/177	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG85XB9M	GO:0007465	1/177	R7 cell fate commitment	biological_process	"The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883]
EOG85XB9M	GO:0048813	1/177	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG85XB9M	GO:0045892	1/177	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85XB9M	GO:0007419	1/177	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG85XB9M	GO:0071390	1/177	cellular response to ecdysone	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah]
EOG85XB9M	GO:0007510	1/177	cardioblast cell fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG85XB9M	GO:0042331	1/177	phototaxis	biological_process	"The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981]
EOG85XB9M	GO:0005500	1/177	juvenile hormone binding	molecular_function	"Interacting selectively and non-covalently with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732]
EOG85XB9M	GO:0045596	1/177	negative regulation of cell differentiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]
EOG85XB9M	GO:0001078	1/177	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
EOG85XB9M	GO:0048666	1/177	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG85XB9M	GO:0007601	1/177	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG85XB9M	GO:0035076	1/177	ecdysone receptor-mediated signaling pathway	biological_process	"The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf]
EOG85XB9M	GO:0007503	1/177	fat body development	biological_process	"The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089]
EOG85XB9M	GO:0005737	1/177	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG85XB9M	GO:0004884	1/177	ecdysteroid hormone receptor activity	molecular_function	"Combining with an ecdysteroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:1653701]
EOG85XB9M	GO:0007298	1/177	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG85XB9M	GO:0007281	1/177	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG85XB9M	GO:0040034	1/177	regulation of development, heterochronic	biological_process	"Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909]
EOG85XB9M	GO:0007464	1/177	R3/R4 cell fate commitment	biological_process	"The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
EOG85XB9M	GO:0000166	1/177	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG85XB9M	GO:0007517	1/177	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG85XB9M	GO:0061331	1/177	epithelial cell proliferation involved in Malpighian tubule morphogenesis	biological_process	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG85XB9M	GO:0008230	1/177	ecdysone receptor holocomplex	cellular_component	"A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980]
EOG85XB9M	GO:0042562	1/177	hormone binding	molecular_function	"Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
EOG85XB9M	GO:0000122	1/177	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG85XB9M	GO:0016319	1/177	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG85XB9M	GO:0007270	1/177	neuron-neuron synaptic transmission	biological_process	"The process of communication from a neuron to another neuron across a synapse." [GOC:add, GOC:jl, MeSH:D009435]
EOG85XB9M	GO:0035075	1/177	response to ecdysone	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf]
EOG85XB9M	GO:0035073	1/177	pupariation	biological_process	"The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
EOG85XB9M	GO:0007462	1/177	R1/R6 cell fate commitment	biological_process	"The process in which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
EOG85XB9M	GO:0007507	1/177	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG85XB9M	GO:0021782	1/177	glial cell development	biological_process	"The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG85XB9M	GO:0045944	1/177	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG85XB9M	GO:0046530	1/177	photoreceptor cell differentiation	biological_process	"The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732]
EOG85XB9M	GO:0030425	1/177	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG85XB9M	GO:0008232	1/177	activator ecdysone receptor complex	cellular_component	"A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes." [PMID:10488333]
EOG85XB9M	GO:0045893	1/177	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85XB9M	GO:0004872	1/177	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG85XB9M	GO:0016322	1/177	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG85XB9M	GO:0001752	1/177	compound eye photoreceptor fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
EOG85XB9M	GO:0005700	1/177	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG85XB9M	GO:0000976	1/177	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG85XB9B	GO:0004114	11/77	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular_function	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]
EOG85XB9B	GO:0007165	11/77	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG85XB9B	GO:0046872	7/77	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8FBM6V	GO:0004519	14/108	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8FBM6V	GO:0003964	14/108	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8FBM6V	GO:0006629	14/108	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8FBM6V	GO:0004435	13/108	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8FBM6V	GO:0004871	11/108	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8FBM6V	GO:0035556	9/108	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8FBM6V	GO:0005509	9/108	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8FBM6V	GO:0007264	8/108	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8FBM6V	GO:0005622	8/108	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8FBM6V	GO:0005085	8/108	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8FBM6V	GO:0003723	2/108	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8FBM6V	GO:0008081	1/108	phosphoric diester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]
EOG8284FH	GO:0007165	43/170	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8284FH	GO:0000159	43/170	protein phosphatase type 2A complex	cellular_component	"A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]
EOG8284FH	GO:0008601	43/170	protein phosphatase type 2A regulator activity	molecular_function	"Modulation of the activity of the enzyme protein phosphatase type 2A." [GOC:ai]
EOG8284FH	GO:0008270	3/170	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8284FH	GO:0005634	3/170	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8284FH	GO:0003676	3/170	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8284FH	GO:0006914	2/170	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG8284FH	GO:0043066	1/170	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8284FH	GO:0051726	1/170	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8284FH	GO:0051225	1/170	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG8284FH	GO:0070328	1/170	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG8284FH	GO:0007059	1/170	chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
EOG8284FH	GO:0007528	1/170	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8284FH	GO:0008340	1/170	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8284FH	GO:0007274	1/170	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8284FH	GO:0006470	1/170	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8284FH	GO:0046872	1/170	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8284FH	GO:0050790	1/170	regulation of catalytic activity	biological_process	"Any process that modulates the activity of an enzyme." [GOC:ai]
EOG8GB9MH	GO:0005975	26/97	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8GB9MH	GO:0000287	25/97	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8GB9MH	GO:0016868	24/97	intramolecular transferase activity, phosphotransferases	molecular_function	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]
EOG8GB9MH	GO:0004614	3/97	phosphoglucomutase activity	molecular_function	"Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [EC:5.4.2.2]
EOG8GB9MH	GO:0005829	1/97	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8GB9MH	GO:0006006	1/97	glucose metabolic process	biological_process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]
EOG8GB9MH	GO:0005992	1/97	trehalose biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]
EOG8GB9MH	GO:0004619	1/97	phosphoglycerate mutase activity	molecular_function	"Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1]
EOG8GB9MH	GO:0060361	1/97	flight	biological_process	"Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph]
EOG8GB9MH	GO:0019388	1/97	galactose catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose." [ISBN:0198506732]
EOG8GB9MH	GO:0005978	1/97	glycogen biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]
EOG8GB9MH	GO:0046331	1/97	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG89627C	GO:0022008	1/85	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG89627C	GO:0000022	1/85	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8284FP	GO:0005328	49/189	neurotransmitter:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
EOG8284FP	GO:0016021	45/189	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8284FP	GO:0005887	4/189	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8284FP	GO:0006836	2/189	neurotransmitter transport	biological_process	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]
EOG8284FP	GO:0005326	2/189	neurotransmitter transporter activity	molecular_function	"Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732]
EOG8284FP	GO:0005886	1/189	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8P5NRZ	GO:0006457	1/3	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG82RGPB	GO:0016020	1/4	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82RGPB	GO:0005234	1/4	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG82RGPB	GO:0004970	1/4	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG82RGPD	GO:0005840	4/79	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG82RGPD	GO:0006412	3/79	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG82RGPD	GO:0003735	3/79	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG82RGPD	GO:0015074	1/79	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG82RGPD	GO:0003677	1/79	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG82RGPD	GO:0006310	1/79	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8FR372	GO:0005509	61/185	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8FR372	GO:0007268	2/185	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8FR372	GO:0007269	2/185	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8FR372	GO:0007528	2/185	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8FR372	GO:0046928	2/185	regulation of neurotransmitter secretion	biological_process	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
EOG8FR372	GO:0016174	2/185	NAD(P)H oxidase activity	molecular_function	"Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide." [EC:1.6.3.1]
EOG8FR372	GO:0031284	1/185	positive regulation of guanylate cyclase activity	biological_process	"Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity." [GOC:mah]
EOG8FR372	GO:0008021	1/185	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8FR372	GO:0008048	1/185	calcium sensitive guanylate cyclase activator activity	molecular_function	"Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration." [GOC:mah]
EOG8FR372	GO:0016020	1/185	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8FR372	GO:0016192	1/185	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG84QWH7	GO:0005634	35/133	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84QWH7	GO:0003700	35/133	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG84QWH7	GO:0006351	34/133	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG84QWH7	GO:0044212	34/133	transcription regulatory region DNA binding	molecular_function	"Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836]
EOG84QWH7	GO:0006915	33/133	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG84QWH7	GO:0006282	1/133	regulation of DNA repair	biological_process	"Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators]
EOG84QWH7	GO:0010332	1/133	response to gamma radiation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators, Wikipedia:Gamma_ray]
EOG84QWH7	GO:0008630	1/133	intrinsic apoptotic signaling pathway in response to DNA damage	biological_process	"A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]
EOG84QWH7	GO:0007131	1/133	reciprocal meiotic recombination	biological_process	"The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]
EOG84QWH7	GO:1990248	1/133	regulation of transcription from RNA polymerase II promoter in response to DNA damage	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:15660129]
EOG84QWH7	GO:0010165	1/133	response to X-ray	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray]
EOG84QWH7	GO:0031571	1/133	mitotic G1 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG84QWH7	GO:0034644	1/133	cellular response to UV	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah]
EOG84QWH7	GO:0008134	1/133	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG84QWH7	GO:0045787	1/133	positive regulation of cell cycle	biological_process	"Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators]
EOG84QWH7	GO:0005667	1/133	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG84QWH7	GO:0042127	1/133	regulation of cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
EOG84QWH7	GO:0035234	1/133	ectopic germ cell programmed cell death	biological_process	"Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944]
EOG84QWH7	GO:0009314	1/133	response to radiation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation]
EOG84QWH7	GO:2000685	1/133	positive regulation of cellular response to X-ray	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular response to X-ray." [GOC:obol]
EOG84QWH7	GO:0030330	1/133	DNA damage response, signal transduction by p53 class mediator	biological_process	"A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators]
EOG84QWH7	GO:0009411	1/133	response to UV	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]
EOG84QWH7	GO:0048477	1/133	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG84QWH7	GO:0006978	1/133	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	biological_process	"A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage." [PMID:10967424]
EOG84QWH7	GO:0002039	1/133	p53 binding	molecular_function	"Interacting selectively and non-covalently with one of the p53 family of proteins." [GOC:hjd]
EOG84QWH7	GO:0071480	1/133	cellular response to gamma radiation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah]
EOG84QWH7	GO:0042771	1/133	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological_process	"A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]
EOG84QWH7	GO:0008219	1/133	cell death	biological_process	"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as \"apoptotic bodies\"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo." [GOC:mah, GOC:mtg_apoptosis]
EOG84QWH7	GO:0045893	1/133	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG84QWH7	GO:0005829	1/133	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG84QWH7	GO:0003684	1/133	damaged DNA binding	molecular_function	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
EOG84QWH7	GO:0014016	1/133	neuroblast differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585]
EOG84QWH7	GO:0003690	1/133	double-stranded DNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh]
EOG84QWH7	GO:0009267	1/133	cellular response to starvation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]
EOG84QWH7	GO:0006919	1/133	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
EOG84QWH7	GO:0006974	1/133	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG84QWH7	GO:0010212	1/133	response to ionizing radiation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526]
EOG84QWH7	GO:0005515	1/133	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG84QWH7	GO:0007405	1/133	neuroblast proliferation	biological_process	"The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart]
EOG84QWH7	GO:0000122	1/133	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG84QWH7	GO:0046620	1/133	regulation of organ growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
EOG84QWH7	GO:0042246	1/133	tissue regeneration	biological_process	"The regrowth of lost or destroyed tissues." [GOC:curators]
EOG84QWH7	GO:0008340	1/133	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG84QWH7	GO:0046533	1/133	negative regulation of photoreceptor cell differentiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
EOG84QWH7	GO:0003682	1/133	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG84QWH7	GO:0016239	1/133	positive regulation of macroautophagy	biological_process	"Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464]
EOG84QWH7	GO:0043565	1/133	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG84QWH7	GO:0031625	1/133	ubiquitin protein ligase binding	molecular_function	"Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]
EOG84QWH7	GO:0043523	1/133	regulation of neuron apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
EOG84QWH7	GO:0001047	1/133	core promoter binding	molecular_function	"Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH]
EOG84QWH7	GO:0000785	1/133	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG85XBBB	GO:0008236	2/3	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG84J4ZX	GO:0046872	52/224	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84J4ZX	GO:0016787	45/224	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG84J4ZX	GO:0004177	13/224	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG84J4ZX	GO:0005829	1/224	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG84J4ZX	GO:0006508	1/224	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG84J4ZX	GO:0022008	1/224	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84J4ZX	GO:0070006	1/224	metalloaminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG87DCX7	GO:0008061	105/374	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG87DCX7	GO:0006030	105/374	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG87DCX7	GO:0005576	103/374	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG87DCX7	GO:0005615	2/374	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG87DCX7	GO:0010716	1/374	negative regulation of extracellular matrix disassembly	biological_process	"Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
EOG87DCX7	GO:0032504	1/374	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG87DCX7	GO:0040003	1/374	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG86X1QB	GO:0042438	3/94	melanin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [CHEBI:25179, GOC:curators]
EOG86X1QB	GO:0005576	3/94	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG86X1QB	GO:0048067	3/94	cuticle pigmentation	biological_process	"Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
EOG86X1QB	GO:0004167	3/94	dopachrome isomerase activity	molecular_function	"Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12, RHEA:13044]
EOG86X1QB	GO:0042435	2/94	indole-containing compound biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." [CHEBI:24828, GOC:jl]
EOG86X1QB	GO:0006583	2/94	melanin biosynthetic process from tyrosine	biological_process	"The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators]
EOG86X1QB	GO:0048066	2/94	developmental pigmentation	biological_process	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
EOG84J4ZT	GO:0006909	1/84	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG84J4ZT	GO:0005884	1/84	actin filament	cellular_component	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]
EOG84J4ZT	GO:0005737	1/84	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84J4ZT	GO:0016021	1/84	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84J4ZT	GO:0003779	1/84	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG84J4ZT	GO:0005829	1/84	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG84J4ZT	GO:0030041	1/84	actin filament polymerization	biological_process	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG84J4ZT	GO:0005576	1/84	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG84J4ZT	GO:0046872	1/84	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84J4ZT	GO:0005215	1/84	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8HX7DZ	GO:0016592	24/105	mediator complex	cellular_component	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
EOG8HX7DZ	GO:0001104	24/105	RNA polymerase II transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8HX7DZ	GO:0045498	1/105	sex comb development	biological_process	"The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk]
EOG8HX7DZ	GO:0045165	1/105	cell fate commitment	biological_process	"The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
EOG8HX7DZ	GO:0048749	1/105	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8HX7DZ	GO:0030177	1/105	positive regulation of Wnt signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8HX7DZ	GO:0006366	1/105	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8HX7DZ	GO:0006357	1/105	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8HX7DZ	GO:0048190	1/105	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8HX7DZ	GO:0022416	1/105	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8HX7DZ	GO:0036011	1/105	imaginal disc-derived leg segmentation	biological_process	"Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf]
EOG8HX7DZ	GO:0005634	1/105	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HX7DZ	GO:0005515	1/105	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG88GZHG	GO:0005856	1/86	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG88GZHG	GO:0005739	1/86	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG88GZHG	GO:0000070	1/86	mitotic sister chromatid segregation	biological_process	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
EOG88GZHG	GO:0090307	1/86	mitotic spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis." [GOC:tb, GOC:vw]
EOG88GZHG	GO:0005737	1/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84XMWJ	GO:0032258	25/117	CVT pathway	biological_process	"A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast." [PMID:12865942, PMID:15659643]
EOG84XMWJ	GO:0030242	25/117	pexophagy	biological_process	"The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions." [GOC:autophagy, PMID:10547367, PMID:20083110]
EOG84XMWJ	GO:0006914	8/117	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG84XMWJ	GO:0016236	1/117	macroautophagy	biological_process	"The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure.  Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464]
EOG84XMWJ	GO:0010506	1/117	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG84XMWJ	GO:0014067	1/117	negative regulation of phosphatidylinositol 3-kinase signaling	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef]
EOG84XMWJ	GO:0042060	1/117	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG84XMWJ	GO:0035069	1/117	larval midgut histolysis	biological_process	"The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683]
EOG8CRPD9	GO:0016059	1/103	deactivation of rhodopsin mediated signaling	biological_process	"The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831]
EOG88GZHM	GO:0003676	8/57	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88GZHM	GO:0005524	1/57	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88GZHM	GO:0004386	1/57	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8H74RD	GO:0016021	26/103	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8H74RD	GO:0016758	1/103	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8H74RD	GO:0031227	1/103	intrinsic component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
EOG8FFGH2	GO:0005524	27/85	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8FFGH2	GO:0051085	27/85	chaperone mediated protein folding requiring cofactor	biological_process	"The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb]
EOG8FFGH2	GO:0017111	7/85	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8FFGH2	GO:0043104	1/85	positive regulation of GTP cyclohydrolase I activity	biological_process	"Any process that activates or increases the activity of the enzyme GTP cyclohydrolase I." [GOC:jl]
EOG8FFGH2	GO:0040011	1/85	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG8FFGH2	GO:0048085	1/85	adult chitin-containing cuticle pigmentation	biological_process	"Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
EOG8FFGH2	GO:0005783	1/85	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8FFGH2	GO:0042053	1/85	regulation of dopamine metabolic process	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]
EOG8FFGH2	GO:0005788	1/85	endoplasmic reticulum lumen	cellular_component	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]
EOG86X1Q7	GO:0046872	68/241	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG86X1Q7	GO:0003676	66/241	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG86X1Q7	GO:0007366	3/241	periodic partitioning by pair rule gene	biological_process	"Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG86X1Q7	GO:0045893	3/241	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG86X1Q7	GO:0045944	3/241	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG86X1Q7	GO:0016348	3/241	imaginal disc-derived leg joint morphogenesis	biological_process	"The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG86X1Q7	GO:0000122	3/241	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG86X1Q7	GO:0005634	3/241	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86X1Q7	GO:0045892	3/241	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG86X1Q7	GO:0003677	2/241	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86X1Q7	GO:0007350	2/241	blastoderm segmentation	biological_process	"The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG86X1Q7	GO:0000981	2/241	RNA polymerase II transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
EOG86X1Q7	GO:0006366	2/241	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG86X1Q7	GO:0009880	1/241	embryonic pattern specification	biological_process	"The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
EOG86X1Q7	GO:0006351	1/241	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG86X1Q7	GO:0007480	1/241	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG86X1Q7	GO:0007443	1/241	Malpighian tubule morphogenesis	biological_process	"The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089]
EOG86X1Q7	GO:0046331	1/241	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG86X1Q7	GO:0035220	1/241	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG86X1Q7	GO:0048619	1/241	embryonic hindgut morphogenesis	biological_process	"The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc]
EOG86X1Q7	GO:0007442	1/241	hindgut morphogenesis	biological_process	"The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
EOG86X1Q7	GO:0006909	1/241	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG86X1Q7	GO:0003700	1/241	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG86X1Q7	GO:0048617	1/241	embryonic foregut morphogenesis	biological_process	"The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc]
EOG86X1Q7	GO:0007362	1/241	terminal region determination	biological_process	"Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG86X1Q7	GO:0006357	1/241	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG86X1Q7	GO:0006355	1/241	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8577PM	GO:0035091	23/57	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG87SVTS	GO:0005524	25/88	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87SVTS	GO:0008026	23/88	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG87SVTS	GO:0003723	22/88	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG87SVTS	GO:0003676	3/88	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG87SVTS	GO:0004386	1/88	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG87SVTS	GO:0006200	1/88	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG87SVTS	GO:0004004	1/88	ATP-dependent RNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]
EOG805VGT	GO:0031047	1/262	gene silencing by RNA	biological_process	"Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054]
EOG805VGT	GO:0048477	1/262	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG805VGT	GO:0045892	1/262	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG805VGT	GO:0005634	1/262	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87SVTQ	GO:0004519	1/49	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG85HVCP	GO:0005576	2/4	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG85HVCP	GO:0006629	2/4	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG85HVCP	GO:0016787	2/4	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8CNT6C	GO:0003964	574/3445	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8CNT6C	GO:0003723	549/3445	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CNT6C	GO:0008270	159/3445	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CNT6C	GO:0003676	89/3445	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CNT6C	GO:0004523	26/3445	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8CNT6C	GO:0005198	8/3445	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8CNT6C	GO:0005882	8/3445	intermediate filament	cellular_component	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
EOG8CNT6C	GO:0004519	5/3445	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8CNT6C	GO:0003677	5/3445	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CNT6C	GO:0046872	4/3445	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CNT6C	GO:0015074	4/3445	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8CNT6C	GO:0016021	3/3445	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CNT6C	GO:0004871	2/3445	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8CNT6C	GO:0000166	1/3445	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8CNT6C	GO:0006310	1/3445	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8CNT6C	GO:0004555	1/3445	alpha,alpha-trehalase activity	molecular_function	"Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28]
EOG8CNT6C	GO:0016874	1/3445	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8CNT6C	GO:0005991	1/3445	trehalose metabolic process	biological_process	"The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]
EOG8CNT6C	GO:0016881	1/3445	acid-amino acid ligase activity	molecular_function	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
EOG8CNT6C	GO:0016020	1/3445	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CNT6C	GO:0005549	1/3445	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8CNT6C	GO:0005622	1/3445	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8CNT6C	GO:0005215	1/3445	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8CNT6C	GO:0080019	1/3445	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8CNT6C	GO:0003887	1/3445	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG8CNT6C	GO:0016787	1/3445	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8CNT6C	GO:0022857	1/3445	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8CNT6C	GO:0004984	1/3445	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8PCD80	GO:0003964	2/12	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8PCD80	GO:0003723	1/12	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG883GKQ	GO:0008270	24/85	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG883GKQ	GO:0003676	2/85	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG883GKQ	GO:0046872	1/85	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GQSKX	GO:0008474	30/97	palmitoyl-(protein) hydrolase activity	molecular_function	"Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22]
EOG8GQSKX	GO:0006464	29/97	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG8GQSKX	GO:0005764	1/97	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8GQSKX	GO:0002084	1/97	protein depalmitoylation	biological_process	"The removal of palymitoyl groups from a lipoprotein." [GOC:hjd]
EOG8FTZDW	GO:0003677	21/92	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FTZDW	GO:0009880	1/92	embryonic pattern specification	biological_process	"The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
EOG8FTZDW	GO:0007315	1/92	pole plasm assembly	biological_process	"Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8FTZDW	GO:0031519	1/92	PcG protein complex	cellular_component	"A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908]
EOG8FTZDW	GO:0042048	1/92	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG8FTZDW	GO:0006342	1/92	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG8FTZDW	GO:0005634	1/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FTZDW	GO:0008595	1/92	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8FTZDW	GO:0016458	1/92	gene silencing	biological_process	"Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb]
EOG8FTZDW	GO:0042803	1/92	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8FTZDW	GO:0043565	1/92	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8FTZDW	GO:0031935	1/92	regulation of chromatin silencing	biological_process	"Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah]
EOG8FTZDW	GO:0007476	1/92	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8FTZDW	GO:0031208	1/92	POZ domain binding	molecular_function	"Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847]
EOG8SXQV3	GO:0016787	4/102	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8SXQV3	GO:0008477	2/102	purine nucleosidase activity	molecular_function	"Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose." [EC:3.2.2.1]
EOG8QC3K7	GO:0003676	24/98	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QC3K7	GO:0005524	24/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QC3K7	GO:0008026	19/98	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8QC3K7	GO:0004386	4/98	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8QC3K7	GO:0006200	1/98	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8QC3K7	GO:0000398	1/98	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8QC3K7	GO:0002121	1/98	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8QC3K7	GO:0005681	1/98	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8QC3K7	GO:0000381	1/98	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8QC3K7	GO:0004004	1/98	ATP-dependent RNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8QC3K7	GO:0006810	1/98	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8QC3K7	GO:0007476	1/98	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8PRW6R	GO:0016491	44/293	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8PRW6R	GO:0004022	8/293	alcohol dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
EOG8PRW6R	GO:0016404	4/293	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	molecular_function	"Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141]
EOG8PRW6R	GO:0003939	1/293	L-iditol 2-dehydrogenase activity	molecular_function	"Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14]
EOG8PRW6R	GO:0006066	1/293	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG8ZCWMM	GO:0005272	2/5	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8ZCWMM	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZCWMM	GO:0016020	1/5	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QNQCF	GO:0016021	3/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85MQNG	GO:0016301	8/464	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG85MQNG	GO:0005576	3/464	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG85MQNG	GO:0004672	1/464	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG85MQNG	GO:0045297	1/464	post-mating behavior	biological_process	"The specific behavior of an organism following mating." [GOC:bf, GOC:pr]
EOG85MQNG	GO:0006468	1/464	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG85MQNG	GO:0004674	1/464	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8P2SHP	GO:0016491	3/4	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG88GZKC	GO:0005576	69/178	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG88GZKC	GO:0005615	10/178	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG88GZKC	GO:0008286	3/178	insulin receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]
EOG88GZKC	GO:0005158	3/178	insulin receptor binding	molecular_function	"Interacting selectively and non-covalently with the insulin receptor." [GOC:ai]
EOG88GZKC	GO:0060180	2/178	female mating behavior	biological_process	"The specific behavior of a female organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb]
EOG88GZKC	GO:0040007	1/178	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG88GZKC	GO:0040009	1/178	regulation of growth rate	biological_process	"Any process that modulates the rate of growth of all or part of an organism." [GOC:mah]
EOG88GZKC	GO:0040014	1/178	regulation of multicellular organism growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG88GZKC	GO:0008340	1/178	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG88GZKC	GO:0060250	1/178	germ-line stem-cell niche homeostasis	biological_process	"A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion." [GOC:dph]
EOG88GZKC	GO:0046620	1/178	regulation of organ growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
EOG88GZKC	GO:0009758	1/178	carbohydrate utilization	biological_process	"A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mcc2, GOC:mlg]
EOG88GZKC	GO:0070328	1/178	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG88GZKC	GO:0030536	1/178	larval feeding behavior	biological_process	"Feeding behavior in a larval (immature) organism." [GOC:mah]
EOG88GZKC	GO:0030307	1/178	positive regulation of cell growth	biological_process	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG88GZKC	GO:0008284	1/178	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG88GZKC	GO:0040018	1/178	positive regulation of multicellular organism growth	biological_process	"Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
EOG88GZKC	GO:0008361	1/178	regulation of cell size	biological_process	"Any process that modulates the size of a cell." [GOC:go_curators]
EOG88GZKC	GO:2000252	1/178	negative regulation of feeding behavior	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." [GOC:obol]
EOG8ZKN2V	GO:0035091	2/15	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG8ZKN2V	GO:0016301	1/15	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8S7N5S	GO:0030234	16/259	enzyme regulator activity	molecular_function	"Binds to and modulates the activity of an enzyme." [GOC:mah]
EOG8S7N5S	GO:0005509	16/259	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8S7N5S	GO:0090256	1/259	regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis	biological_process	"Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8S7N5S	GO:0005615	1/259	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8S7N5S	GO:0032504	1/259	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8S7N5S	GO:0042302	1/259	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8S7N5S	GO:0005811	1/259	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8S7N5S	GO:0005576	1/259	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8S7N5S	GO:0005829	1/259	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8S7N5S	GO:0009631	1/259	cold acclimation	biological_process	"Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr]
EOG8S7N5S	GO:0044720	1/259	negative regulation of imaginal disc-derived wing size	biological_process	"Any process that reduces the size of an imaginal disc-derived wing." [PMID:21393605]
EOG8XKXN8	GO:0030726	1/139	male germline ring canal formation	biological_process	"Formation of the intercellular bridges that connect the germ-line cells of a male cyst." [ISBN:0879694238]
EOG8XKXN8	GO:0007112	1/139	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG8XKXN8	GO:0008017	1/139	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8XKXN8	GO:0007067	1/139	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8XKXN8	GO:0048477	1/139	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8XKXN8	GO:0070938	1/139	contractile ring	cellular_component	"A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles." [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889]
EOG8XKXN8	GO:0031106	1/139	septin ring organization	biological_process	"Control of the formation, spatial distribution, and breakdown of the septin ring." [GOC:mah]
EOG8XKXN8	GO:0008356	1/139	asymmetric cell division	biological_process	"The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
EOG8XKXN8	GO:0007349	1/139	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG8XKXN8	GO:0000281	1/139	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8XKXN8	GO:0005634	1/139	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XKXN8	GO:0003676	1/139	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8XKXN8	GO:0005826	1/139	actomyosin contractile ring	cellular_component	"A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, ISBN:0805319409, ISBN:0815316194]
EOG8XKXN8	GO:0017022	1/139	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8XKXN8	GO:0051297	1/139	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8XKXN8	GO:0000915	1/139	actomyosin contractile ring assembly	biological_process	"The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
EOG8XKXN8	GO:0005737	1/139	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XKXN8	GO:0007126	1/139	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8XKXN8	GO:0051533	1/139	positive regulation of NFAT protein import into nucleus	biological_process	"Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai]
EOG8XKXN8	GO:0007279	1/139	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8XKXN8	GO:0000910	1/139	cytokinesis	biological_process	"The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle]
EOG8XKXN8	GO:0043063	1/139	intercellular bridge organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another." [GOC:jid]
EOG8XKXN8	GO:0007009	1/139	plasma membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8XKXN8	GO:0045172	1/139	germline ring canal	cellular_component	"Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801]
EOG8XKXN8	GO:0005515	1/139	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8XKXN8	GO:0035323	1/139	male germline ring canal	cellular_component	"An intercellular bridge that connects the germline cells of a male cyst." [PMID:9635420]
EOG8XKXN8	GO:0045035	1/139	sensory organ precursor cell division	biological_process	"The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597]
EOG8XKXN8	GO:0022008	1/139	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8XKXN8	GO:0046872	1/139	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XKXN8	GO:0032189	1/139	maintenance of actomyosin contractile ring localization	biological_process	"Any process in which an actomyosin contractile ring is maintained in a location and prevented from moving elsewhere." [GOC:mah]
EOG8XKXN8	GO:0008104	1/139	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8XKXN8	GO:0003779	1/139	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8XKXN8	GO:0007423	1/139	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG85MQNP	GO:0032981	25/83	mitochondrial respiratory chain complex I assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]
EOG82NMFH	GO:0016740	26/202	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG82NMFH	GO:0016491	24/202	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG82NMFH	GO:0004766	2/202	spermidine synthase activity	molecular_function	"Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine." [EC:2.5.1.16]
EOG8STVJG	GO:0071203	28/94	WASH complex	cellular_component	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]
EOG870WX7	GO:0005634	28/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG870WX7	GO:0003677	28/103	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG870WX7	GO:0006355	3/103	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG870WX7	GO:0008587	3/103	imaginal disc-derived wing margin morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG870WX7	GO:0007379	3/103	segment specification	biological_process	"The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG870WX7	GO:0016055	3/103	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG870WX7	GO:0046530	3/103	photoreceptor cell differentiation	biological_process	"The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732]
EOG870WX7	GO:0016568	3/103	chromatin modification	biological_process	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]
EOG870WX7	GO:0006351	3/103	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG870WX7	GO:0042058	1/103	regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG870WX7	GO:0005515	1/103	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG870WX7	GO:0014017	1/103	neuroblast fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585]
EOG870WX7	GO:0022008	1/103	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG870WX7	GO:0007476	1/103	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG870WX7	GO:0007480	1/103	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG870WX7	GO:0008586	1/103	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG870WX7	GO:0035060	1/103	brahma complex	cellular_component	"A SWI/SNF-type complex that contains the ATPase product of the Drosophila brahma gene, or an ortholog thereof." [GOC:bf, PMID:10809665, PMID:12482982]
EOG870WX7	GO:0048190	1/103	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG870WX7	GO:0045893	1/103	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG84QWF0	GO:0007010	23/89	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG84QWF0	GO:0051693	1/89	actin filament capping	biological_process	"The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]
EOG84QWF0	GO:0003746	1/89	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG84QWF0	GO:0003779	1/89	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG84QWF0	GO:0005737	1/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84QWF0	GO:0007300	1/89	ovarian nurse cell to oocyte transport	biological_process	"Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG84QWF0	GO:0005739	1/89	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG84QWF0	GO:0035317	1/89	imaginal disc-derived wing hair organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853]
EOG84QWF0	GO:0007015	1/89	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8HDW9G	GO:0005741	2/4	mitochondrial outer membrane	cellular_component	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
EOG8HDW9G	GO:0033554	2/4	cellular response to stress	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8Z655V	GO:0043565	4/23	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8Z655V	GO:0003700	4/23	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z655V	GO:0005634	1/23	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GF5W0	GO:0004332	37/105	fructose-bisphosphate aldolase activity	molecular_function	"Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate." [EC:4.1.2.13]
EOG8GF5W0	GO:0006096	37/105	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8GF5W0	GO:0007498	1/105	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8GF5W0	GO:0007095	1/105	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8GF5W0	GO:0030018	1/105	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8GF5W0	GO:0031430	1/105	M band	cellular_component	"The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194]
EOG8ZSCJ6	GO:0006869	23/125	lipid transport	biological_process	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
EOG8ZSCJ6	GO:0033868	1/125	Goodpasture-antigen-binding protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein." [EC:2.7.11.9]
EOG8ZCWMS	GO:0030529	1/84	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8ZCWMS	GO:0005515	1/84	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8ZCWMS	GO:0019013	1/84	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8XKXN6	GO:0033961	66/183	cis-stilbene-oxide hydrolase activity	molecular_function	"Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9]
EOG8XKXN6	GO:0004301	3/183	epoxide hydrolase activity	molecular_function	"Catalysis of the reaction: an epoxide + H2O = a glycol." [EC:3.3.2.10]
EOG8XKXN6	GO:0004602	2/183	glutathione peroxidase activity	molecular_function	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9]
EOG8XKXN6	GO:0006979	2/183	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8XKXN6	GO:0016787	1/183	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8XKXN6	GO:0003824	1/183	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8F4VSW	GO:0016021	252/803	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F4VSW	GO:0006633	246/803	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8F4VSW	GO:0016740	246/803	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8F4VSW	GO:0009922	7/803	fatty acid elongase activity	molecular_function	"Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb]
EOG8F4VSW	GO:0030497	7/803	fatty acid elongation	biological_process	"The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094]
EOG8F4VSW	GO:0022008	1/803	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8F4VSW	GO:0051225	1/803	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG8F4VSW	GO:0007112	1/803	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG8F4VSW	GO:0042761	1/803	very long-chain fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:go_curators]
EOG8F4VSW	GO:0007110	1/803	meiosis I cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8F4VSW	GO:0000915	1/803	actomyosin contractile ring assembly	biological_process	"The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
EOG8F4VSW	GO:0007111	1/803	meiosis II cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8F4VSW	GO:0030176	1/803	integral component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
EOG8F4VSW	GO:0000212	1/803	meiotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah]
EOG87M4CW	GO:0008270	37/166	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87M4CW	GO:0016491	33/166	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG87M4CW	GO:0003960	3/166	NADPH:quinone reductase activity	molecular_function	"Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5]
EOG87M4CW	GO:0047522	1/166	15-oxoprostaglandin 13-oxidase activity	molecular_function	"Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, KEGG:R04556, KEGG:R04557, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN]
EOG87M4CW	GO:0036132	1/166	13-prostaglandin reductase activity	molecular_function	"Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin." [EC:1.3.1.48, GOC:mw, KEGG:R04556, KEGG:R04557, PMID:17449869]
EOG8C2KSK	GO:0008270	2/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8C2KSK	GO:0003676	2/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8C2KSK	GO:0005634	2/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG837TW2	GO:0003677	1/7	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8616JD	GO:0005524	29/133	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8616JD	GO:0004713	25/133	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8616JD	GO:0005509	19/133	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8616JD	GO:0007156	19/133	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8616JD	GO:0016021	18/133	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8616JD	GO:0004715	2/133	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8616JD	GO:0004714	2/133	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8616JD	GO:0004672	2/133	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8616JD	GO:0006468	1/133	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8616JD	GO:0090303	1/133	positive regulation of wound healing	biological_process	"Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF]
EOG8616JD	GO:0007030	1/133	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8616JD	GO:0016020	1/133	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8616JD	GO:0016772	1/133	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8616JD	GO:0045177	1/133	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8616JD	GO:0005887	1/133	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8616JD	GO:0045792	1/133	negative regulation of cell size	biological_process	"Any process that reduces cell size." [GOC:go_curators]
EOG8616JD	GO:0042060	1/133	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8616JD	GO:0018108	1/133	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG8616JD	GO:0016339	1/133	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
EOG8CG2P8	GO:0008270	21/112	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CG2P8	GO:0005622	20/112	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8CG2P8	GO:0007276	1/112	gamete generation	biological_process	"The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu]
EOG8CG2P8	GO:0007281	1/112	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8CG2P8	GO:0007126	1/112	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8GTNVG	GO:0016740	1/37	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG82NMF0	GO:0046872	1/76	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XKXNG	GO:0050660	5/13	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8XKXNG	GO:0008812	5/13	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG8XKXNG	GO:0006066	5/13	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG8F4VSG	GO:0016491	199/611	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8F4VSG	GO:0047886	2/611	farnesol dehydrogenase activity	molecular_function	"Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH." [EC:1.1.1.216, RHEA:14700]
EOG8F4VSG	GO:0004316	1/611	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
EOG8F4VSG	GO:0016063	1/611	rhodopsin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732]
EOG8F4VSG	GO:0022008	1/611	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8XH2GQ	GO:0042302	1098/2997	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8XH2GQ	GO:0031012	32/2997	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8XH2GQ	GO:0040003	31/2997	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8XH2GQ	GO:0008010	31/2997	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8XH2GQ	GO:0022008	2/2997	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8XH2GQ	GO:0008011	2/2997	structural constituent of pupal chitin-based cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8XH2GQ	GO:0032504	1/2997	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8XH2GQ	GO:0048058	1/2997	compound eye corneal lens development	biological_process	"The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells." [GOC:jid]
EOG8XH2GQ	GO:0005615	1/2997	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8XH2GQ	GO:0005212	1/2997	structural constituent of eye lens	molecular_function	"The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah]
EOG8XH2GQ	GO:0005576	1/2997	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8XH2GQ	GO:0005509	1/2997	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8XH2GQ	GO:0007601	1/2997	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8XH2GQ	GO:0003824	1/2997	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8XH2GQ	GO:0005811	1/2997	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8GB9MK	GO:0006355	25/90	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8GB9MK	GO:0097372	25/90	NAD-dependent histone deacetylase activity (H3-K18 specific)	molecular_function	"Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein." [EC:3.5.1.17, GOC:sp, PMID:22722849, RHEA:24551]
EOG8GB9MK	GO:0032041	25/90	NAD-dependent histone deacetylase activity (H3-K14 specific)	molecular_function	"Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [EC:3.5.1.17, RHEA:24551]
EOG8GB9MK	GO:0006351	25/90	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8GB9MK	GO:0005634	25/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GB9MK	GO:0046969	25/90	NAD-dependent histone deacetylase activity (H3-K9 specific)	molecular_function	"Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [EC:3.5.1.17, RHEA:24551]
EOG8GB9MK	GO:0046970	25/90	NAD-dependent histone deacetylase activity (H4-K16 specific)	molecular_function	"Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [EC:3.5.1.17, GOC:vw, RHEA:24551]
EOG8GB9MK	GO:0043066	1/90	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8GB9MK	GO:0016049	1/90	cell growth	biological_process	"The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]
EOG8GB9MK	GO:0043984	1/90	histone H4-K16 acetylation	biological_process	"The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone." [GOC:jl]
EOG8GB9MK	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8GB9MK	GO:0006342	1/90	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG8GB9MK	GO:0004407	1/90	histone deacetylase activity	molecular_function	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.98, PMID:9893272]
EOG8GB9MK	GO:0005737	1/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG85MQN0	GO:0003964	1/38	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG85MQN0	GO:0046872	1/38	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TF33V	GO:0020037	2/3	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8TF33V	GO:0016705	2/3	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8TF33V	GO:0005506	2/3	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8TF33V	GO:0004497	1/3	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8BS00S	GO:0006281	28/109	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8BS00S	GO:0006629	1/109	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8BS00S	GO:0007095	1/109	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG89PDDS	GO:0046872	23/80	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89PDDS	GO:0007275	1/80	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8XKXNR	GO:0005524	1/71	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8XKXNR	GO:0032039	1/71	integrator complex	cellular_component	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]
EOG8XKXNR	GO:0005634	1/71	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XKXNR	GO:0034472	1/71	snRNA 3'-end processing	biological_process	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]
EOG8XKXNR	GO:0017111	1/71	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8THZ7P	GO:0003677	8/30	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8THZ7P	GO:0006281	8/30	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8THZ7P	GO:0000910	1/30	cytokinesis	biological_process	"The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle]
EOG8THZ7P	GO:0000226	1/30	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8GB9MG	GO:0004725	20/72	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8GB9MG	GO:0046872	15/72	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GB9MG	GO:0008138	1/72	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG8GB9MG	GO:0006470	1/72	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8GB9MG	GO:0000285	1/72	1-phosphatidylinositol-3-phosphate 5-kinase activity	molecular_function	"Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13612]
EOG8CJXXD	GO:0005634	28/85	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CJXXD	GO:0006355	28/85	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8CJXXD	GO:0003677	28/85	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CJXXD	GO:0007275	27/85	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8CJXXD	GO:0007405	1/85	neuroblast proliferation	biological_process	"The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart]
EOG8CJXXD	GO:0000122	1/85	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8CJXXD	GO:0010001	1/85	glial cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]
EOG8CJXXD	GO:0045179	1/85	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8CJXXD	GO:0003700	1/85	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8CJXXD	GO:0045178	1/85	basal part of cell	cellular_component	"The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194]
EOG8CJXXD	GO:0005886	1/85	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8CJXXD	GO:0005938	1/85	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8CJXXD	GO:0010628	1/85	positive regulation of gene expression	biological_process	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8CJXXD	GO:0007422	1/85	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8CJXXD	GO:0045165	1/85	cell fate commitment	biological_process	"The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
EOG8CJXXD	GO:0042676	1/85	compound eye cone cell fate commitment	biological_process	"The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu]
EOG8CJXXD	GO:0007402	1/85	ganglion mother cell fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
EOG8CJXXD	GO:0010629	1/85	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8CJXXD	GO:0007423	1/85	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8CJXXD	GO:0007416	1/85	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG8CJXXD	GO:0001754	1/85	eye photoreceptor cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators]
EOG8CJXXD	GO:0007619	1/85	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG8CJXXD	GO:0050771	1/85	negative regulation of axonogenesis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis." [GOC:ai]
EOG8CJXXD	GO:0007417	1/85	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8CJXXD	GO:0008104	1/85	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG8CJXXD	GO:0007409	1/85	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8CJXXD	GO:0045664	1/85	regulation of neuron differentiation	biological_process	"Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
EOG8CJXXD	GO:0042673	1/85	regulation of retinal cone cell fate specification	biological_process	"Any process that mediates the specification of a cell into a retinal cone cell." [GOC:go_curators]
EOG8CJXXD	GO:0048813	1/85	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8CJXXD	GO:0008049	1/85	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8CJXXD	GO:0007420	1/85	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG8CJXXD	GO:0007406	1/85	negative regulation of neuroblast proliferation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai]
EOG8CJXXD	GO:0005875	1/85	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8CJXXD	GO:0007419	1/85	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8CJXXD	GO:0001708	1/85	cell fate specification	biological_process	"The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators]
EOG8CJXXD	GO:0045676	1/85	regulation of R7 cell differentiation	biological_process	"Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators]
EOG8CJXXD	GO:0008356	1/85	asymmetric cell division	biological_process	"The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
EOG8CJXXD	GO:0006909	1/85	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8CJXXD	GO:0055059	1/85	asymmetric neuroblast division	biological_process	"The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
EOG8CJXXD	GO:0045180	1/85	basal cortex	cellular_component	"The region that lies just beneath the plasma membrane on the basal edge of a cell." [GOC:bf]
EOG8CJXXD	GO:0007399	1/85	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8CJXXD	GO:0007465	1/85	R7 cell fate commitment	biological_process	"The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883]
EOG8CJXXD	GO:0007411	1/85	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8CJXXD	GO:0006351	1/85	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8CJXXD	GO:0007400	1/85	neuroblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
EOG8CJXXD	GO:0055060	1/85	asymmetric neuroblast division resulting in ganglion mother cell formation	biological_process	"Any process resulting in the physical partitioning and separation of a neuroblast into a neuroblast and a ganglion mother cell." [GOC:dph]
EOG8CJXXD	GO:0050909	1/85	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8CJXXD	GO:0060385	1/85	axonogenesis involved in innervation	biological_process	"The neurite development process that generates a long process of a neuron, as it invades a target tissue." [GOC:dph, GOC:sart]
EOG8CJXXD	GO:0070983	1/85	dendrite guidance	biological_process	"The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
EOG8CJXXD	GO:0008285	1/85	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8CJXXD	GO:1900180	1/85	regulation of protein localization to nucleus	biological_process	"Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]
EOG8CJXXD	GO:0001078	1/85	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
EOG8F20HJ	GO:0005506	142/475	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8F20HJ	GO:0020037	142/475	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8F20HJ	GO:0016705	139/475	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8F20HJ	GO:0004497	138/475	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8F20HJ	GO:0005789	5/475	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8F20HJ	GO:0070330	1/475	aromatase activity	molecular_function	"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
EOG8F20HJ	GO:0033777	1/475	lithocholate 6beta-hydroxylase activity	molecular_function	"Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.13.94, RHEA:18860]
EOG8F20HJ	GO:0050591	1/475	quinine 3-monooxygenase activity	molecular_function	"Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152]
EOG8F20HJ	GO:0033780	1/475	taurochenodeoxycholate 6alpha-hydroxylase activity	molecular_function	"Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O." [EC:1.14.13.97]
EOG8F20HJ	GO:0035220	1/475	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG805VG7	GO:0005506	679/2000	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG805VG7	GO:0020037	679/2000	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG805VG7	GO:0016705	629/2000	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG805VG7	GO:0004497	607/2000	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG805VG7	GO:0070330	31/2000	aromatase activity	molecular_function	"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
EOG805VG7	GO:0005789	25/2000	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG805VG7	GO:0050591	15/2000	quinine 3-monooxygenase activity	molecular_function	"Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152]
EOG805VG7	GO:0004796	4/2000	thromboxane-A synthase activity	molecular_function	"Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17140]
EOG805VG7	GO:0031000	2/2000	response to caffeine	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah]
EOG805VG7	GO:0009055	2/2000	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG805VG7	GO:0016712	2/2000	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
EOG805VG7	GO:0017085	2/2000	response to insecticide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]
EOG805VG7	GO:0006697	1/2000	ecdysone biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732]
EOG805VG7	GO:0050829	1/2000	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG805VG7	GO:0030178	1/2000	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG805VG7	GO:0017143	1/2000	insecticide metabolic process	biological_process	"The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai]
EOG805VG7	GO:0046701	1/2000	insecticide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai]
EOG805VG7	GO:0022416	1/2000	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG805VG7	GO:0042742	1/2000	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG805VG7	GO:0048252	1/2000	lauric acid metabolic process	biological_process	"The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [CHEBI:30805, GOC:jid]
EOG805VG7	GO:0016020	1/2000	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG805VG7	GO:1901563	1/2000	response to camptothecin	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie]
EOG805VG7	GO:0018685	1/2000	alkane 1-monooxygenase activity	molecular_function	"Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3]
EOG805VG7	GO:0033777	1/2000	lithocholate 6beta-hydroxylase activity	molecular_function	"Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.13.94, RHEA:18860]
EOG805VG7	GO:0002118	1/2000	aggressive behavior	biological_process	"A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd]
EOG805VG7	GO:0046683	1/2000	response to organophosphorus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544]
EOG805VG7	GO:0035220	1/2000	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG805VG7	GO:0048638	1/2000	regulation of developmental growth	biological_process	"Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators]
EOG805VG7	GO:0040040	1/2000	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG805VG7	GO:0046680	1/2000	response to DDT	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544]
EOG805VG7	GO:0046689	1/2000	response to mercury ion	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai]
EOG8KSS2Z	GO:0007155	1/4	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8KSS2Z	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VT8D1	GO:0003700	23/96	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8VT8D1	GO:0043565	23/96	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8VT8D1	GO:0005634	22/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82Z756	GO:0004619	36/102	phosphoglycerate mutase activity	molecular_function	"Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1]
EOG82Z756	GO:0006096	36/102	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG82Z756	GO:0030018	1/102	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG82Z756	GO:0031430	1/102	M band	cellular_component	"The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194]
EOG82Z756	GO:0004083	1/102	bisphosphoglycerate 2-phosphatase activity	molecular_function	"Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate." [EC:3.1.3.13, RHEA:21907]
EOG82Z756	GO:0004082	1/102	bisphosphoglycerate mutase activity	molecular_function	"Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." [EC:5.4.2.4]
EOG81NX2G	GO:0016491	2/4	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG812PKZ	GO:0006979	3/8	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG812PKZ	GO:0020037	3/8	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG812PKZ	GO:0004601	3/8	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG8T7BJ1	GO:0022891	16/72	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8T7BJ1	GO:0016021	16/72	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8T7BJ1	GO:0008643	4/72	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8T7BJ1	GO:0032440	3/72	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8S4RX4	GO:0016021	39/114	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S4RX4	GO:0005886	37/114	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8S4RX4	GO:0050909	34/114	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8S4RX4	GO:0008527	6/114	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8S4RX4	GO:0032098	1/114	regulation of appetite	biological_process	"Any process which modulates appetite, the desire or physical craving for food." [GOC:add]
EOG8S4RX4	GO:0033041	1/114	sweet taste receptor activity	molecular_function	"Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah]
EOG8S4RX4	GO:0060259	1/114	regulation of feeding behavior	biological_process	"Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." [GOC:BHF, GOC:dph, GOC:tb]
EOG8S4RX4	GO:0071332	1/114	cellular response to fructose stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:mah]
EOG8S4RX4	GO:0001582	1/114	detection of chemical stimulus involved in sensory perception of sweet taste	biological_process	"The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
EOG8S4RX4	GO:0050912	1/114	detection of chemical stimulus involved in sensory perception of taste	biological_process	"The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8S4RX4	GO:0008343	1/114	adult feeding behavior	biological_process	"Feeding behavior in a fully developed and mature organism." [GOC:mah]
EOG8S4RX4	GO:0050916	1/114	sensory perception of sweet taste	biological_process	"The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG84QWFZ	GO:0003677	36/163	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X0Q8V	GO:0006281	5/37	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8X0Q8V	GO:0000723	5/37	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG8X0Q8V	GO:0003678	5/37	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG8X6FQ7	GO:0005634	2/6	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X6FQ7	GO:0008270	2/6	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X6FQ7	GO:0003676	2/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8T4G97	GO:0071013	1/90	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8T4G97	GO:0000398	1/90	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8T4G97	GO:0005634	1/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8T4G97	GO:0007399	1/90	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8DZ4BQ	GO:0030127	1/4	COPII vesicle coat	cellular_component	"One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]
EOG8DZ4BQ	GO:0006888	1/4	ER to Golgi vesicle-mediated transport	biological_process	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]
EOG8DZ4BQ	GO:0006886	1/4	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8GQSK0	GO:0035058	1/77	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG8GQSK0	GO:0034464	1/77	BBSome	cellular_component	"A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [GOC:BHF, PMID:17574030]
EOG8GQSK1	GO:0006511	26/93	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8GQSK1	GO:0004843	24/93	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG8GQSK1	GO:0008270	11/93	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GQSK1	GO:0008234	2/93	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8GQSK1	GO:0007399	1/93	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8GQSK1	GO:0016579	1/93	protein deubiquitination	biological_process	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]
EOG8C5FZV	GO:0016477	1/20	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG8C5FZV	GO:0007015	1/20	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8C5FZV	GO:0007155	1/20	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8C5FZV	GO:0007605	1/20	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8C5FZV	GO:0050954	1/20	sensory perception of mechanical stimulus	biological_process	"The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8C5FZV	GO:0016203	1/20	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8PK4NN	GO:0004842	28/137	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8PK4NN	GO:0046872	18/137	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8PK4NN	GO:0020037	15/137	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8PK4NN	GO:0008270	5/137	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PK4NN	GO:0005814	1/137	centriole	cellular_component	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
EOG8PK4NN	GO:0005549	1/137	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8PK4NN	GO:0005737	1/137	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8PK4NN	GO:0005634	1/137	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PK4NN	GO:0042787	1/137	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological_process	"The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]
EOG86T5FG	GO:0005524	26/95	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG86T5FG	GO:0005634	26/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86T5FG	GO:0003677	26/95	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86T5FG	GO:0004003	25/95	ATP-dependent DNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl]
EOG86T5FG	GO:0006289	25/95	nucleotide-excision repair	biological_process	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]
EOG86T5FG	GO:0009411	1/95	response to UV	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]
EOG86T5FG	GO:0010972	1/95	negative regulation of G2/M transition of mitotic cell cycle	biological_process	"Any cell cycle regulatory process that decreases the rate or extent of progression of a cell from G2 to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]
EOG86T5FG	GO:2001141	1/95	regulation of RNA biosynthetic process	biological_process	"Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph]
EOG86T5FG	GO:0000439	1/95	core TFIIH complex	cellular_component	"The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015]
EOG86T5FG	GO:0006367	1/95	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG86T5FG	GO:0032508	1/95	DNA duplex unwinding	biological_process	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]
EOG86T5FG	GO:0005703	1/95	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG86T5FG	GO:0005705	1/95	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG86T5FG	GO:0006974	1/95	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG86T5FG	GO:0051983	1/95	regulation of chromosome segregation	biological_process	"Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
EOG86T5FG	GO:0005700	1/95	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG86T5FG	GO:0007088	1/95	regulation of mitotic nuclear division	biological_process	"Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
EOG86T5FG	GO:0004386	1/95	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG86T5FG	GO:0005737	1/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86T5FG	GO:0005675	1/95	holo TFIIH complex	cellular_component	"A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of  the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]
EOG86T5FG	GO:0043141	1/95	ATP-dependent 5'-3' DNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl]
EOG8X6FQ8	GO:0043565	9/38	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8X6FQ8	GO:0003700	9/38	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8X6FQ8	GO:0005634	8/38	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X6FQ8	GO:0003677	2/38	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X6FQ8	GO:0006909	1/38	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8X6FQ8	GO:2000179	1/38	positive regulation of neural precursor cell proliferation	biological_process	"Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]
EOG8X6FQ8	GO:0001748	1/38	optic lobe placode development	biological_process	"The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833]
EOG8F20HT	GO:0016706	37/95	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG8F20HT	GO:0005506	5/95	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8CJXX0	GO:0005083	25/115	GTPase regulator activity	molecular_function	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
EOG8CJXX0	GO:0005524	24/115	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CJXX0	GO:0004674	13/115	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8CJXX0	GO:0004672	11/115	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8CJXX0	GO:0046330	1/115	positive regulation of JNK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8CJXX0	GO:0032006	1/115	regulation of TOR signaling	biological_process	"Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8CJXX0	GO:0007254	1/115	JNK cascade	biological_process	"An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974]
EOG8CJXX0	GO:0070328	1/115	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG8CJXX0	GO:0016301	1/115	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8CJXX0	GO:0006468	1/115	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8CJXX0	GO:0007030	1/115	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8CJXX0	GO:0006915	1/115	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8CJXX0	GO:0031931	1/115	TORC1 complex	cellular_component	"A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787]
EOG8CJXX0	GO:0046626	1/115	regulation of insulin receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8CJXX0	GO:0004702	1/115	receptor signaling protein serine/threonine kinase activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah]
EOG8CJXX0	GO:0040009	1/115	regulation of growth rate	biological_process	"Any process that modulates the rate of growth of all or part of an organism." [GOC:mah]
EOG8CJXX0	GO:0043065	1/115	positive regulation of apoptotic process	biological_process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8CJXX0	GO:0005737	1/115	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CJXX0	GO:0032008	1/115	positive regulation of TOR signaling	biological_process	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8CJXX0	GO:0008361	1/115	regulation of cell size	biological_process	"Any process that modulates the size of a cell." [GOC:go_curators]
EOG8CJXX0	GO:0048149	1/115	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8CJXX0	GO:0042059	1/115	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8BCH46	GO:0004622	1/71	lysophospholipase activity	molecular_function	"Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5]
EOG8M946W	GO:0004721	1/93	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8M946W	GO:0003012	1/93	muscle system process	biological_process	"A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio]
EOG8MD0D9	GO:0004867	23/93	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG8MD0D9	GO:0005576	21/93	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8MD0D9	GO:0008233	1/93	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8MD0D8	GO:0016020	1/92	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8MD0D8	GO:0004872	1/92	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8MD0D8	GO:0007275	1/92	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8P5NSB	GO:0005886	1/103	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8P5NSB	GO:0043195	1/103	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG8P5NSB	GO:0007270	1/103	neuron-neuron synaptic transmission	biological_process	"The process of communication from a neuron to another neuron across a synapse." [GOC:add, GOC:jl, MeSH:D009435]
EOG8P5NSB	GO:0007274	1/103	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8P5NSB	GO:0070073	1/103	clustering of voltage-gated calcium channels	biological_process	"The process in which voltage-gated calcium channels become localized together in high densities." [GOC:BHF, GOC:sart, PMID:18385325]
EOG8P5NSB	GO:0042734	1/103	presynaptic membrane	cellular_component	"A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194]
EOG8X3KFW	GO:0005524	27/97	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X3KFW	GO:0004674	25/97	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8X3KFW	GO:0004672	3/97	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8X3KFW	GO:0004712	2/97	protein serine/threonine/tyrosine kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]
EOG8X3KFW	GO:0016772	2/97	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8X3KFW	GO:0071011	1/97	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8X3KFW	GO:0022008	1/97	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8X3KFW	GO:0008360	1/97	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8X3KFW	GO:0000398	1/97	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8X3KFW	GO:0071013	1/97	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8X3KFW	GO:0006468	1/97	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8X3KFW	GO:0007155	1/97	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG89S8RK	GO:0005506	2/5	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG89S8RK	GO:0020037	2/5	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG89S8RK	GO:0016705	2/5	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8TB6TR	GO:0005886	2/9	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8TB6TR	GO:0016021	2/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TB6TR	GO:0050909	2/9	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG88D3C2	GO:0003700	25/99	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG88D3C2	GO:0005634	25/99	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88D3C2	GO:0043565	24/99	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG88D3C2	GO:0007494	1/99	midgut development	biological_process	"The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
EOG88D3C2	GO:0030154	1/99	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG88D3C2	GO:0046982	1/99	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG88D3C2	GO:0045944	1/99	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG88D3C2	GO:0035284	1/99	brain segmentation	biological_process	"Division of the brain into a series of semi-repetitive parts or segments." [GOC:bf]
EOG88D3C2	GO:0006366	1/99	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG88D3C2	GO:0000976	1/99	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG88D3C2	GO:0001709	1/99	cell fate determination	biological_process	"A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
EOG88D3C2	GO:0004000	1/99	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG88D3C2	GO:0007420	1/99	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG8GF5VB	GO:0000226	28/99	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG8GF5VB	GO:0005874	28/99	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8GF5VB	GO:0007017	1/99	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8GF5VB	GO:0008017	1/99	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8GF5VB	GO:0005875	1/99	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8GJ24C	GO:0042302	2/10	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8VHNMG	GO:0006904	28/106	vesicle docking involved in exocytosis	biological_process	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]
EOG8VHNMG	GO:0007317	1/106	regulation of pole plasm oskar mRNA localization	biological_process	"Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb]
EOG8VHNMG	GO:0016020	1/106	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8VHNMG	GO:0016082	1/106	synaptic vesicle priming	biological_process	"The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342]
EOG8VHNMG	GO:0000281	1/106	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8VHNMG	GO:0000149	1/106	SNARE binding	molecular_function	"Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]
EOG8VHNMG	GO:0032940	1/106	secretion by cell	biological_process	"The controlled release of a substance by a cell." [GOC:mah]
EOG8VHNMG	GO:0007268	1/106	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8VHNMG	GO:0006887	1/106	exocytosis	biological_process	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
EOG8VHNMG	GO:0005737	1/106	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8VHNMG	GO:0015031	1/106	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8VHNMG	GO:0005829	1/106	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8VHNMG	GO:0043195	1/106	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG8VHNMG	GO:0016192	1/106	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8VHNMG	GO:0019898	1/106	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8VHNMG	GO:0009416	1/106	response to light stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
EOG8VHNMG	GO:0048489	1/106	synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr]
EOG8VHNMG	GO:0007269	1/106	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8H1D9B	GO:0005524	85/230	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8H1D9B	GO:0004674	78/230	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8H1D9B	GO:0004691	9/230	cAMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11]
EOG8H1D9B	GO:0006468	4/230	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8H1D9B	GO:0005952	3/230	cAMP-dependent protein kinase complex	cellular_component	"An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732]
EOG8H1D9B	GO:0007476	2/230	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8H1D9B	GO:0005515	2/230	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8H1D9B	GO:0007480	1/230	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8H1D9B	GO:0007611	1/230	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG8H1D9B	GO:0007314	1/230	oocyte anterior/posterior axis specification	biological_process	"Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8H1D9B	GO:0050804	1/230	modulation of synaptic transmission	biological_process	"Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
EOG8H1D9B	GO:0022008	1/230	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8H1D9B	GO:0045187	1/230	regulation of circadian sleep/wake cycle, sleep	biological_process	"Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981]
EOG8H1D9B	GO:0007615	1/230	anesthesia-resistant memory	biological_process	"The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531]
EOG8H1D9B	GO:0042981	1/230	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8H1D9B	GO:0048749	1/230	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8H1D9B	GO:0005886	1/230	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8H1D9B	GO:0007612	1/230	learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544]
EOG8H1D9B	GO:0007622	1/230	rhythmic behavior	biological_process	"The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr]
EOG8H1D9B	GO:0007448	1/230	anterior/posterior pattern specification, imaginal disc	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238]
EOG8H1D9B	GO:0040040	1/230	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG8H1D9B	GO:0004672	1/230	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8H1D9B	GO:0019933	1/230	cAMP-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
EOG8H1D9B	GO:0048149	1/230	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8H1D9B	GO:0007613	1/230	memory	biological_process	"The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089]
EOG8H1D9B	GO:0007228	1/230	positive regulation of hh target transcription factor activity	biological_process	"Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited." [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936]
EOG8H1D9B	GO:0008103	1/230	oocyte microtubule cytoskeleton polarization	biological_process	"Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042]
EOG8H1D9B	GO:0045879	1/230	negative regulation of smoothened signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG8H1D9B	GO:0008355	1/230	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8H1D9B	GO:0007317	1/230	regulation of pole plasm oskar mRNA localization	biological_process	"Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb]
EOG8H1D9B	GO:0045475	1/230	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8H1D9B	GO:0048477	1/230	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8H1D9B	GO:0008359	1/230	regulation of bicoid mRNA localization	biological_process	"Any process that modulates the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:hb]
EOG84BDGB	GO:0006281	54/171	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG84BDGB	GO:0003913	50/171	DNA photolyase activity	molecular_function	"Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949]
EOG84BDGB	GO:0009882	5/171	blue light photoreceptor activity	molecular_function	"The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb]
EOG84BDGB	GO:0005634	5/171	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84BDGB	GO:0045892	5/171	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG84BDGB	GO:0009785	5/171	blue light signaling pathway	biological_process	"The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm." [GOC:lr, GOC:sm]
EOG84BDGB	GO:0018298	5/171	protein-chromophore linkage	biological_process	"The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma]
EOG84BDGB	GO:0048471	5/171	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG84BDGB	GO:0005737	5/171	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84BDGB	GO:0006351	5/171	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG84BDGB	GO:0000060	5/171	protein import into nucleus, translocation	biological_process	"A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope." [GOC:curators, ISBN:0198506732, PMID:14570049, PMID:9126736]
EOG84BDGB	GO:0050660	5/171	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG84BDGB	GO:0042752	5/171	regulation of circadian rhythm	biological_process	"Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]
EOG84BDGB	GO:0005641	5/171	nuclear envelope lumen	cellular_component	"The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide." [GOC:ai]
EOG84BDGB	GO:0048511	4/171	rhythmic process	biological_process	"Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid]
EOG84BDGB	GO:0003904	2/171	deoxyribodipyrimidine photo-lyase activity	molecular_function	"Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light." [EC:4.1.99.3]
EOG84BDGB	GO:0043234	1/171	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG84BDGB	GO:0045475	1/171	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG84BDGB	GO:0050980	1/171	detection of light stimulus involved in magnetoreception	biological_process	"The series of events involved in magnetoception in which a light stimulus is received and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field." [GOC:ai, GOC:dos, PMID:15886990, Wikipedia:Magnetoception]
EOG84BDGB	GO:0007602	1/171	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG84BDGB	GO:0043153	1/171	entrainment of circadian clock by photoperiod	biological_process	"The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl]
EOG84BDGB	GO:0009416	1/171	response to light stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
EOG84BDGB	GO:0009637	1/171	response to blue light	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:ai, GOC:mtg_far_red]
EOG84BDGB	GO:0007623	1/171	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG84BDGB	GO:0005515	1/171	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG84BDGB	GO:0009649	1/171	entrainment of circadian clock	biological_process	"The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid]
EOG84BDGB	GO:0003914	1/171	DNA (6-4) photolyase activity	molecular_function	"Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA." [GOC:mah, PMID:11124949]
EOG84BDGB	GO:0071949	1/171	FAD binding	molecular_function	"Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]
EOG84BDGB	GO:0050958	1/171	magnetoreception	biological_process	"The series of events required for an organism to receive a stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Stimuli may be chemical, mechanical or electrical and interpreting these stimuli allows an organism to determine the orientation of a magnetic field. Magnetoreception also involves the perception of light; birds cannot orient without the presence of short wavelength (blue/green) light." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]
EOG84BDGB	GO:0009881	1/171	photoreceptor activity	molecular_function	"The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators]
EOG84BDGB	GO:0042332	1/171	gravitaxis	biological_process	"The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
EOG84BDGB	GO:0071000	1/171	response to magnetism	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:sl]
EOG8KD91C	GO:0080019	36/163	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG85QKTJ	GO:0003677	4/95	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG85QKTJ	GO:0008270	4/95	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RFP70	GO:0005525	2/4	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8RFP70	GO:0005874	2/4	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8RFP70	GO:0003924	2/4	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8RFP70	GO:0005200	2/4	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8RFP70	GO:0051258	2/4	protein polymerization	biological_process	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
EOG8RFP70	GO:0005737	2/4	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RFP70	GO:0007017	2/4	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8JWXVM	GO:0046872	27/93	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8JWXVM	GO:0016491	27/93	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8JWXVM	GO:0051537	27/93	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8JWXVM	GO:0007552	1/93	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG8JWXVM	GO:0045456	1/93	ecdysteroid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators]
EOG8JWXVM	GO:0002168	1/93	instar larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8JWXVM	GO:0035264	1/93	multicellular organism growth	biological_process	"The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb]
EOG8N06VM	GO:0005506	35/104	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8N06VM	GO:0016705	35/104	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8N06VM	GO:0020037	35/104	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8N06VM	GO:0004497	34/104	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG85QKTS	GO:0016020	18/93	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG85QKTS	GO:0008045	1/93	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG84BDGP	GO:0003735	30/87	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG84BDGP	GO:0005763	30/87	mitochondrial small ribosomal subunit	cellular_component	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
EOG84BDGP	GO:0006412	1/87	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8KM1H9	GO:0003677	15/68	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8KM1H9	GO:0016020	1/68	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8KM1H9	GO:0055085	1/68	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG879HN5	GO:0005506	116/248	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG879HN5	GO:0020037	116/248	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG879HN5	GO:0016705	114/248	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG879HN5	GO:0004497	107/248	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG879HN5	GO:0031966	7/248	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG879HN5	GO:0017085	3/248	response to insecticide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]
EOG879HN5	GO:0008386	2/248	cholesterol monooxygenase (side-chain-cleaving) activity	molecular_function	"Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6]
EOG879HN5	GO:0046680	2/248	response to DDT	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544]
EOG879HN5	GO:0005739	1/248	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG879HN5	GO:0030342	1/248	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	molecular_function	"Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)." [PMID:8506296]
EOG879HN5	GO:0055114	1/248	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG85QKTW	GO:0005634	19/122	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85QKTW	GO:0008270	18/122	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG85QKTW	GO:0003676	6/122	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85QKTW	GO:0046872	4/122	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GTNVW	GO:0005615	233/444	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8GTNVW	GO:0010951	13/444	negative regulation of endopeptidase activity	biological_process	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0004867	13/444	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG8GTNVW	GO:0016740	13/444	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8GTNVW	GO:0030162	12/444	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8GTNVW	GO:0045861	10/444	negative regulation of proteolysis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
EOG8GTNVW	GO:0008233	8/444	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8GTNVW	GO:0032504	7/444	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8GTNVW	GO:0000155	6/444	phosphorelay sensor kinase activity	molecular_function	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
EOG8GTNVW	GO:0016020	6/444	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8GTNVW	GO:0019732	1/444	antifungal humoral response	biological_process	"An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8GTNVW	GO:0008063	1/444	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8GTNVW	GO:0002784	1/444	regulation of antimicrobial peptide production	biological_process	"Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
EOG8GTNVW	GO:0003677	1/444	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GTNVW	GO:0005576	1/444	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8GTNVW	GO:0006281	1/444	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8GTNVW	GO:0050829	1/444	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GTNVW	GO:0060570	1/444	negative regulation of peptide hormone processing	biological_process	"Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0006955	1/444	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8GTNVW	GO:0004869	1/444	cysteine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb]
EOG8GTNVW	GO:0010955	1/444	negative regulation of protein processing	biological_process	"Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]
EOG8GTNVW	GO:0042562	1/444	hormone binding	molecular_function	"Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
EOG8GTNVW	GO:0045751	1/444	negative regulation of Toll signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8GTNVW	GO:0050832	1/444	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8KD91Q	GO:0050909	56/82	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8KD91Q	GO:0016021	56/82	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KD91Q	GO:0005886	56/82	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8KD91Q	GO:0008527	3/82	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8KD91Q	GO:0050912	3/82	detection of chemical stimulus involved in sensory perception of taste	biological_process	"The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8KD91Q	GO:0008049	2/82	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8KD91Q	GO:0016544	1/82	male courtship behavior, tapping to detect pheromone	biological_process	"The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827]
EOG83BQ36	GO:0016779	9/97	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG83BQ36	GO:0009058	8/97	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG83BQ36	GO:0003743	6/97	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG83BQ36	GO:0005829	1/97	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG83BQ36	GO:0005085	1/97	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG83BQ36	GO:0016740	1/97	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG83BQ36	GO:0005851	1/97	eukaryotic translation initiation factor 2B complex	cellular_component	"A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375]
EOG83BQ36	GO:0019134	1/97	glucosamine-1-phosphate N-acetyltransferase activity	molecular_function	"Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H(+)." [EC:2.3.1.157, RHEA:13728]
EOG83BQ36	GO:0006413	1/97	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG83BQ36	GO:0043087	1/97	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8HDW7B	GO:0045475	1/146	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8HDW7B	GO:0072347	1/146	response to anesthetic	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart]
EOG8T1M35	GO:0005783	31/91	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8T1M35	GO:0005811	1/91	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8T1M35	GO:0045169	1/91	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG8JDKNM	GO:0050790	38/89	regulation of catalytic activity	biological_process	"Any process that modulates the activity of an enzyme." [GOC:ai]
EOG8JDKNM	GO:0004197	38/89	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8JDKNM	GO:0035071	1/89	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8JDKNM	GO:0008234	1/89	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8JDKNM	GO:0048102	1/89	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG81K1SS	GO:0007476	1/91	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG81K1SS	GO:0048149	1/91	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG81K1SS	GO:0048865	1/91	stem cell fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete]
EOG81K1SS	GO:0007601	1/91	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG81K1SS	GO:0042461	1/91	photoreceptor cell development	biological_process	"Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators]
EOG81K1SS	GO:0001751	1/91	compound eye photoreceptor cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
EOG81K1SS	GO:0097038	1/91	perinuclear endoplasmic reticulum	cellular_component	"The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]
EOG81K1SS	GO:0007421	1/91	stomatogastric nervous system development	biological_process	"The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jid]
EOG81K1SS	GO:0005794	1/91	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG81K1SS	GO:0007173	1/91	epidermal growth factor receptor signaling pathway	biological_process	"A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933]
EOG81K1SS	GO:0005789	1/91	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG81K1SS	GO:0005886	1/91	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG81K1SS	GO:0035225	1/91	determination of genital disc primordium	biological_process	"Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318]
EOG81K1SS	GO:0000139	1/91	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG81K1SS	GO:0042058	1/91	regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG81K1SS	GO:0048477	1/91	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG81K1SS	GO:0061331	1/91	epithelial cell proliferation involved in Malpighian tubule morphogenesis	biological_process	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG81K1SS	GO:0016318	1/91	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG81K1SS	GO:0046667	1/91	compound eye retinal cell programmed cell death	biological_process	"Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672]
EOG81K1SS	GO:0000042	1/91	protein targeting to Golgi	biological_process	"The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah]
EOG81K1SS	GO:0007422	1/91	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG81K1SS	GO:0007498	1/91	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG81K1SS	GO:0038004	1/91	epidermal growth factor receptor ligand maturation	biological_process	"Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor." [GOC:signaling, PMID:11672524]
EOG81K1SS	GO:0016021	1/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81K1SS	GO:0016020	1/91	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG81K1SS	GO:0005783	1/91	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG81K1SS	GO:0046845	1/91	branched duct epithelial cell fate determination, open tracheal system	biological_process	"Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581]
EOG8KM1H5	GO:0051539	24/91	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8KM1H5	GO:0009451	24/91	RNA modification	biological_process	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]
EOG8KM1H5	GO:0016740	23/91	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8KM1H5	GO:0032440	2/91	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8KM1H5	GO:0003824	2/91	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8KM1H5	GO:0000079	1/91	regulation of cyclin-dependent protein serine/threonine kinase activity	biological_process	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]
EOG8KM1H5	GO:0046872	1/91	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8KM1H5	GO:0051536	1/91	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG81K1SQ	GO:0030170	74/266	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG81K1SQ	GO:0019752	72/266	carboxylic acid metabolic process	biological_process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]
EOG81K1SQ	GO:0016831	67/266	carboxy-lyase activity	molecular_function	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]
EOG81K1SQ	GO:0004782	5/266	sulfinoalanine decarboxylase activity	molecular_function	"Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2." [EC:4.1.1.29]
EOG81K1SQ	GO:0004351	2/266	glutamate decarboxylase activity	molecular_function	"Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2." [EC:4.1.1.15]
EOG81K1SQ	GO:0008345	1/266	larval locomotory behavior	biological_process	"Locomotory behavior in a larval (immature) organism." [GOC:ai]
EOG81K1SQ	GO:0007528	1/266	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG81K1SQ	GO:0004068	1/266	aspartate 1-decarboxylase activity	molecular_function	"Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11]
EOG81K1SQ	GO:0008355	1/266	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG81K1SQ	GO:0019483	1/266	beta-alanine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732]
EOG81K1SQ	GO:0007632	1/266	visual behavior	biological_process	"The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr]
EOG81K1SQ	GO:0009612	1/266	response to mechanical stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]
EOG81K1SQ	GO:0006212	1/266	uracil catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators]
EOG81K1SQ	GO:0045213	1/266	neurotransmitter receptor metabolic process	biological_process	"The chemical reactions and pathways involving neurotransmitter receptors." [GOC:go_curators]
EOG81K1SQ	GO:0007416	1/266	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG81K1SQ	GO:0042136	1/266	neurotransmitter biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [CHEBI:25512, GOC:jl]
EOG81K1SQ	GO:0048066	1/266	developmental pigmentation	biological_process	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
EOG81K1SQ	GO:0009449	1/266	gamma-aminobutyric acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai]
EOG81K1SQ	GO:0006538	1/266	glutamate catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
EOG8KPWRM	GO:0006884	1/234	cell volume homeostasis	biological_process	"Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8KPWRM	GO:0006821	1/234	chloride transport	biological_process	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8KPWRM	GO:0016021	1/234	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KPWRM	GO:0072320	1/234	volume-sensitive chloride channel activity	molecular_function	"Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:mah]
EOG8KPWRM	GO:0044070	1/234	regulation of anion transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
EOG8KPWRM	GO:0005254	1/234	chloride channel activity	molecular_function	"Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8KPWRM	GO:1902476	1/234	chloride transmembrane transport	biological_process	"The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw]
EOG8KPWRM	GO:0005777	1/234	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG825885	GO:0005634	1/317	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG825885	GO:0005576	1/317	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG825885	GO:0003743	1/317	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG825885	GO:0050830	1/317	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG825885	GO:0032504	1/317	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG825885	GO:0002759	1/317	regulation of antimicrobial humoral response	biological_process	"Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]
EOG825885	GO:0050829	1/317	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG825885	GO:0005615	1/317	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8XSP67	GO:0003677	3/51	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XSP67	GO:0005634	3/51	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG825880	GO:0004252	24/106	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG825880	GO:0008237	1/106	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG825880	GO:0016020	1/106	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG825880	GO:0008241	1/106	peptidyl-dipeptidase activity	molecular_function	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]
EOG825880	GO:0006508	1/106	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG825880	GO:0008233	1/106	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8RFP7S	GO:0003824	35/102	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8RFP7S	GO:0016787	2/102	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8RFP7S	GO:0008704	1/102	5-carboxymethyl-2-hydroxymuconate delta-isomerase activity	molecular_function	"Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate." [EC:5.3.3.10]
EOG8RFP7S	GO:0018800	1/102	5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity	molecular_function	"Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2." [EC:4.1.1.68]
EOG8MPM4C	GO:0080019	109/262	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG8MPM4C	GO:0005737	1/262	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8MPM4C	GO:0050062	1/262	long-chain-fatty-acyl-CoA reductase activity	molecular_function	"Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH." [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN]
EOG8MPM4C	GO:0005509	1/262	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8MPM4C	GO:0016042	1/262	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8MPM4C	GO:0035002	1/262	liquid clearance, open tracheal system	biological_process	"The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352]
EOG8MPM4C	GO:0004043	1/262	L-aminoadipate-semialdehyde dehydrogenase activity	molecular_function	"Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31]
EOG8MPM4C	GO:0045177	1/262	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8MPM4C	GO:0035149	1/262	lumen formation, open tracheal system	biological_process	"Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
EOG8MPM4C	GO:0004623	1/262	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG8MPM4C	GO:0055114	1/262	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8P8J1Q	GO:0016301	1/33	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8RFP7V	GO:0016021	12/199	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RFP7V	GO:0007519	1/199	skeletal muscle tissue development	biological_process	"The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
EOG8RFP7V	GO:0016020	1/199	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RFP7V	GO:0007520	1/199	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG83JFJJ	GO:0035556	82/275	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG83JFJJ	GO:0016021	78/275	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83JFJJ	GO:0000166	76/275	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG83JFJJ	GO:0004016	72/275	adenylate cyclase activity	molecular_function	"Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]
EOG83JFJJ	GO:0009190	12/275	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG83JFJJ	GO:0016849	11/275	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG83JFJJ	GO:0006171	3/275	cAMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]
EOG83JFJJ	GO:0007611	1/275	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG83JFJJ	GO:0007186	1/275	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG83JFJJ	GO:0001582	1/275	detection of chemical stimulus involved in sensory perception of sweet taste	biological_process	"The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
EOG83JFJJ	GO:0046872	1/275	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83JFJJ	GO:0007614	1/275	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG83JFJJ	GO:0007619	1/275	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG83JFJJ	GO:0007617	1/275	mating behavior	biological_process	"The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph]
EOG83JFJJ	GO:0001661	1/275	conditioned taste aversion	biological_process	"A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659]
EOG83JFJJ	GO:0007591	1/275	molting cycle, chitin-based cuticle	biological_process	"The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu]
EOG83JFJJ	GO:0005524	1/275	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG83JFJJ	GO:0007612	1/275	learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544]
EOG83JFJJ	GO:0007268	1/275	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG83JFJJ	GO:0004383	1/275	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG83JFJJ	GO:0008306	1/275	associative learning	biological_process	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
EOG83JFJJ	GO:0042302	1/275	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG83JFJJ	GO:0009744	1/275	response to sucrose	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl]
EOG83JFJJ	GO:0008340	1/275	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG83JFJJ	GO:0016020	1/275	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG83JFJJ	GO:0010353	1/275	response to trehalose	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512]
EOG83JFJJ	GO:0048149	1/275	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG83JFJJ	GO:0008294	1/275	calcium- and calmodulin-responsive adenylate cyclase activity	molecular_function	"Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin." [EC:4.6.1.1, GOC:mah]
EOG83JFJJ	GO:0009408	1/275	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG83JFJJ	GO:0007625	1/275	grooming behavior	biological_process	"The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl, GOC:pr]
EOG83JFJJ	GO:0007613	1/275	memory	biological_process	"The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089]
EOG83JFJJ	GO:0003676	1/275	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83JFJJ	GO:0010738	1/275	regulation of protein kinase A signaling	biological_process	"Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]
EOG83JFJJ	GO:0019933	1/275	cAMP-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
EOG83JFJJ	GO:0031000	1/275	response to caffeine	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah]
EOG83JFJJ	GO:0090328	1/275	regulation of olfactory learning	biological_process	"Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb]
EOG83JFJJ	GO:0030431	1/275	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG83JFJJ	GO:0048675	1/275	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG83JFJJ	GO:0004930	1/275	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG83JFJJ	GO:0008355	1/275	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG83JFJJ	GO:0007274	1/275	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG83JFJJ	GO:0007528	1/275	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG83JFJJ	GO:0006979	1/275	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8MPM4X	GO:0055085	2/8	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8MPM4X	GO:0016021	2/8	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84BDG2	GO:0035091	22/99	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG84BDG2	GO:0003824	20/99	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG84BDG2	GO:0070290	3/99	N-acylphosphatidylethanolamine-specific phospholipase D activity	molecular_function	"Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE)." [GOC:elh, PMID:14634025, PMID:15878693]
EOG84BDG2	GO:0004630	3/99	phospholipase D activity	molecular_function	"Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4]
EOG84BDG2	GO:0032440	2/99	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG84BDG2	GO:0007030	1/99	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG84BDG2	GO:0031410	1/99	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG84BDG2	GO:0007349	1/99	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG84BDG2	GO:0048215	1/99	positive regulation of Golgi vesicle fusion to target membrane	biological_process	"Any process that activates or increases the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG84BDG2	GO:0010004	1/99	gastrulation involving germ band extension	biological_process	"A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG84BDG2	GO:0007602	1/99	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG8Z652M	GO:0006886	26/94	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8Z652M	GO:0016192	25/94	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8Z652M	GO:0030117	25/94	membrane coat	cellular_component	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]
EOG8Z652M	GO:0008565	19/94	protein transporter activity	molecular_function	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
EOG8Z652M	GO:0005794	18/94	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8Z652M	GO:0046907	1/94	intracellular transport	biological_process	"The directed movement of substances within a cell." [GOC:ai]
EOG8Z652M	GO:0005795	1/94	Golgi stack	cellular_component	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
EOG8Z652M	GO:0060967	1/94	negative regulation of gene silencing by RNA	biological_process	"Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb]
EOG8Z652M	GO:0008057	1/94	eye pigment granule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295]
EOG8Z652M	GO:0004222	1/94	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8Z652M	GO:0005770	1/94	late endosome	cellular_component	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
EOG8Z652M	GO:0006726	1/94	eye pigment biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
EOG8Z652M	GO:0007220	1/94	Notch receptor processing	biological_process	"The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]
EOG8Z652M	GO:0008055	1/94	ocellus pigment biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706]
EOG8Z652M	GO:0030665	1/94	clathrin-coated vesicle membrane	cellular_component	"The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah]
EOG8Z652M	GO:0006895	1/94	Golgi to endosome transport	biological_process	"The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes." [GOC:jl, ISBN:0716731363, PMID:10873832]
EOG8Z652M	GO:0008340	1/94	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8Z652M	GO:0005783	1/94	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8Z652M	GO:0006897	1/94	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8Z652M	GO:0007041	1/94	lysosomal transport	biological_process	"The directed movement of substances into, out of or within a lysosome." [GOC:ai]
EOG8Z652M	GO:0007040	1/94	lysosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]
EOG8Z652M	GO:0008270	1/94	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Z652M	GO:0006887	1/94	exocytosis	biological_process	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
EOG8Z652M	GO:0005798	1/94	Golgi-associated vesicle	cellular_component	"Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]
EOG8Z652M	GO:0006727	1/94	ommochrome biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732]
EOG8Z652M	GO:0048072	1/94	compound eye pigmentation	biological_process	"Establishment of a pattern of pigment in the compound eye." [GOC:jid]
EOG8Z652M	GO:0030123	1/94	AP-3 adaptor complex	cellular_component	"A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [GOC:mah, PMID:10611976, PMID:21097499]
EOG8H74W7	GO:0022857	1/2	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8H74W7	GO:0016021	1/2	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81K1S5	GO:0006281	10/111	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG81K1S5	GO:0003677	10/111	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81K1S5	GO:0005634	1/111	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83V2BD	GO:0006338	1/105	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG83V2BD	GO:0046872	1/105	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83V2BD	GO:0003677	1/105	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG83V2BD	GO:0005634	1/105	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8JDKPK	GO:0031032	28/308	actomyosin structure organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]
EOG8JDKPK	GO:0003779	3/308	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8JDKPK	GO:0007520	1/308	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG8JDKPK	GO:0008360	1/308	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8JDKPK	GO:0004252	1/308	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8JDKPK	GO:1901739	1/308	regulation of myoblast fusion	biological_process	"Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]
EOG8JDKPK	GO:0006939	1/308	smooth muscle contraction	biological_process	"A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
EOG8JDKPK	GO:0005865	1/308	striated muscle thin filament	cellular_component	"Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194]
EOG8JDKPK	GO:0005515	1/308	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8JDKPK	GO:0070594	1/308	juvenile hormone response element binding	molecular_function	"Interacting selectively and non-covalently with the juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone." [GOC:sart, PMID:17956872]
EOG8JDKPK	GO:0035626	1/308	juvenile hormone mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of juvenile hormone to a receptor, and ending with regulation of cell state or activity." [GOC:bf, GOC:sart]
EOG8JDKPK	GO:0007155	1/308	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG82RGQJ	GO:0016021	26/83	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J9QFZ	GO:0019028	86/300	viral capsid	cellular_component	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
EOG83XXJ5	GO:0006511	23/108	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG83XXJ5	GO:0008234	16/108	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG83XXJ5	GO:0004221	2/108	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG83XXJ5	GO:0045880	1/108	positive regulation of smoothened signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG83XXJ5	GO:0016579	1/108	protein deubiquitination	biological_process	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]
EOG83XXJ5	GO:0008587	1/108	imaginal disc-derived wing margin morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG83XXJ5	GO:0090263	1/108	positive regulation of canonical Wnt signaling pathway	biological_process	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]
EOG83XXJ5	GO:0005737	1/108	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83XXJ5	GO:0004843	1/108	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG81G5JT	GO:0035091	24/97	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG81G5JT	GO:0097194	1/97	execution phase of apoptosis	biological_process	"A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595]
EOG81G5JT	GO:0006886	1/97	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG81G5JT	GO:0005768	1/97	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG81G5JT	GO:0045335	1/97	phagocytic vesicle	cellular_component	"A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]
EOG89KJ6W	GO:0030036	9/39	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG89KJ6W	GO:0005856	9/39	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG87DCZV	GO:0006919	6/32	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
EOG87DCZV	GO:0005739	6/32	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG87DCZV	GO:0005840	1/32	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG80P6ND	GO:0016021	230/726	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6ND	GO:0022891	177/726	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG80P6ND	GO:0022857	38/726	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG80P6ND	GO:0008643	18/726	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG80P6ND	GO:0005886	18/726	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80P6ND	GO:0015771	15/726	trehalose transport	biological_process	"The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai]
EOG80P6ND	GO:0015574	15/726	trehalose transmembrane transporter activity	molecular_function	"Enables the transfer of trehalose from one side of the membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
EOG80P6ND	GO:0032440	8/726	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG80P6ND	GO:0016020	2/726	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG80P6ND	GO:0046427	1/726	positive regulation of JAK-STAT cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG8K0T29	GO:0008138	22/109	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG8K0T29	GO:0004725	21/109	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8K0T29	GO:0016314	3/109	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	molecular_function	"Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67]
EOG8K0T29	GO:0007155	1/109	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8K0T29	GO:0035206	1/109	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8K0T29	GO:0035069	1/109	larval midgut histolysis	biological_process	"The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683]
EOG8K0T29	GO:0009888	1/109	tissue development	biological_process	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]
EOG8K0T29	GO:0030308	1/109	negative regulation of cell growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8K0T29	GO:0016322	1/109	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG8K0T29	GO:0002164	1/109	larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088]
EOG8K0T29	GO:0007436	1/109	larval salivary gland morphogenesis	biological_process	"The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8K0T29	GO:0045792	1/109	negative regulation of cell size	biological_process	"Any process that reduces cell size." [GOC:go_curators]
EOG8K0T29	GO:0003779	1/109	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8K0T29	GO:0008361	1/109	regulation of cell size	biological_process	"Any process that modulates the size of a cell." [GOC:go_curators]
EOG8K0T29	GO:0030036	1/109	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8K0T29	GO:0031104	1/109	dendrite regeneration	biological_process	"The regrowth of dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb]
EOG8K0T29	GO:0006470	1/109	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8K0T29	GO:0035011	1/109	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG8K0T29	GO:0009987	1/109	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8K0T29	GO:0004726	1/109	non-membrane spanning protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8K0T29	GO:0046620	1/109	regulation of organ growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
EOG8K0T29	GO:0004721	1/109	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8K0T29	GO:0035335	1/109	peptidyl-tyrosine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
EOG8K0T29	GO:0045786	1/109	negative regulation of cell cycle	biological_process	"Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8K0T29	GO:0046621	1/109	negative regulation of organ growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
EOG8K0T29	GO:0007425	1/109	epithelial cell fate determination, open tracheal system	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940]
EOG8K0T29	GO:0034613	1/109	cellular protein localization	biological_process	"Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]
EOG8K0T29	GO:0042052	1/109	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8K0T29	GO:0040015	1/109	negative regulation of multicellular organism growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG8K0T29	GO:0048681	1/109	negative regulation of axon regeneration	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
EOG8K0T29	GO:0046856	1/109	phosphatidylinositol dephosphorylation	biological_process	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]
EOG8K0T29	GO:0010506	1/109	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8K0T29	GO:0008283	1/109	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8K0T29	GO:0006629	1/109	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8K0T29	GO:0046627	1/109	negative regulation of insulin receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8K0T29	GO:0009887	1/109	organ morphogenesis	biological_process	"Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]
EOG8K0T29	GO:0019915	1/109	lipid storage	biological_process	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]
EOG8K0T29	GO:0016491	1/109	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8K0T29	GO:0005216	1/109	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8K0T29	GO:0050773	1/109	regulation of dendrite development	biological_process	"Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai]
EOG8K0T29	GO:0090175	1/109	regulation of establishment of planar polarity	biological_process	"Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8K0T29	GO:0008360	1/109	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8K0T29	GO:0006914	1/109	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG8K0T29	GO:0007010	1/109	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8K0T29	GO:0042594	1/109	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8K0T29	GO:0016021	1/109	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8K0T29	GO:1901888	1/109	regulation of cell junction assembly	biological_process	"Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]
EOG8K0T29	GO:0007552	1/109	metamorphosis	biological_process	"A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544]
EOG8K0T29	GO:0006915	1/109	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8K0T29	GO:0040014	1/109	regulation of multicellular organism growth	biological_process	"Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG8K0T29	GO:0008286	1/109	insulin receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]
EOG8K0T29	GO:0045926	1/109	negative regulation of growth	biological_process	"Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
EOG8K0T29	GO:0007015	1/109	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8K0T29	GO:0004722	1/109	protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
EOG8VHNM6	GO:0003676	56/206	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VHNM6	GO:0005524	56/206	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8VHNM6	GO:0008026	54/206	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8VHNM6	GO:0000398	2/206	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8VHNM6	GO:0004386	2/206	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8VHNM6	GO:0003724	1/206	RNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah]
EOG8VHNM6	GO:0008565	1/206	protein transporter activity	molecular_function	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
EOG8VHNM6	GO:0071013	1/206	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8VHNM6	GO:0006200	1/206	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8VHNM6	GO:0030532	1/206	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8VHNM6	GO:0005622	1/206	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8VHNM6	GO:0031204	1/206	posttranslational protein targeting to membrane, translocation	biological_process	"The process in which a protein translocates through the ER membrane posttranslationally." [PMID:12518317, PMID:8707814]
EOG8VHNM6	GO:0008380	1/206	RNA splicing	biological_process	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]
EOG8VHNM6	GO:0005682	1/206	U5 snRNP	cellular_component	"A ribonucleoprotein complex that contains small nuclear RNA U5." [GOC:krc, GOC:mah]
EOG8VHNM6	GO:0005681	1/206	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8VHNM6	GO:0000381	1/206	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8VHNM6	GO:0005634	1/206	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VHNM6	GO:0004004	1/206	ATP-dependent RNA helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8VHNM6	GO:0071011	1/206	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8VHNM6	GO:0007067	1/206	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8J6V57	GO:0003723	25/105	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8J6V57	GO:0005634	24/105	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8J6V57	GO:0006397	21/105	mRNA processing	biological_process	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]
EOG8J6V57	GO:0006396	4/105	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8J6V57	GO:0005622	1/105	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8J6V57	GO:0000381	1/105	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG87H83R	GO:0005509	25/165	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG87H83R	GO:0008270	24/165	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87H83R	GO:0004725	2/165	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG87H83R	GO:0003779	1/165	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG87H83R	GO:0050699	1/165	WW domain binding	molecular_function	"Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions." [PMID:14531730]
EOG87H83R	GO:0008586	1/165	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG87H83R	GO:0005737	1/165	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87H83R	GO:0046716	1/165	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG87H83R	GO:0048172	1/165	regulation of short-term neuronal synaptic plasticity	biological_process	"A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290]
EOG87H83R	GO:0030010	1/165	establishment of cell polarity	biological_process	"The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG87H83R	GO:0008092	1/165	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG87H83R	GO:0016021	1/165	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87H83R	GO:0046928	1/165	regulation of neurotransmitter secretion	biological_process	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
EOG87H83R	GO:0005515	1/165	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG87H83R	GO:0016010	1/165	dystrophin-associated glycoprotein complex	cellular_component	"A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]
EOG87H83R	GO:0007274	1/165	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG87H83R	GO:0055085	1/165	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG87H83R	GO:0005856	1/165	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG87H83R	GO:0045202	1/165	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG87H83R	GO:0042383	1/165	sarcolemma	cellular_component	"The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]
EOG87H83R	GO:0007474	1/165	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG87H83R	GO:0005198	1/165	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8JQ6BG	GO:0016021	23/284	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JQ6BG	GO:0005216	21/284	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8JQ6BG	GO:0005249	4/284	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8JQ6BG	GO:0006812	2/284	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8JQ6BG	GO:0004692	2/284	cGMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
EOG8JQ6BG	GO:0005887	2/284	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JQ6BG	GO:0019935	2/284	cyclic-nucleotide-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
EOG8JQ6BG	GO:0042391	2/284	regulation of membrane potential	biological_process	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
EOG8JQ6BG	GO:0005221	2/284	intracellular cyclic nucleotide activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG8JQ6BG	GO:0071805	2/284	potassium ion transmembrane transport	biological_process	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
EOG8JQ6BG	GO:0017071	2/284	intracellular cyclic nucleotide activated cation channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah]
EOG8JQ6BG	GO:0005223	1/284	intracellular cGMP activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG8JQ6BG	GO:0005222	1/284	intracellular cAMP activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG8JQ6BG	GO:0030553	1/284	cGMP binding	molecular_function	"Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai]
EOG8JQ6BG	GO:0007603	1/284	phototransduction, visible light	biological_process	"The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
EOG81G5N1	GO:0016055	2/24	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG81G5N1	GO:0007275	2/24	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG81G5N1	GO:0005578	2/24	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG81G5N3	GO:0003676	1/34	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG81G5N3	GO:0000166	1/34	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8PP0ZP	GO:0016740	1/6	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8PP0ZP	GO:0005737	1/6	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8PP0ZP	GO:0009072	1/6	aromatic amino acid family metabolic process	biological_process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]
EOG8TB6T7	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8TB6T7	GO:0000166	2/5	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8BGCBN	GO:0007264	27/90	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8BGCBN	GO:0005525	27/90	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8BGCBN	GO:0005622	27/90	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8SFCMB	GO:0006886	26/91	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8SFCMB	GO:0005622	24/91	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG80GG5K	GO:0016787	32/103	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG80GG5K	GO:0003948	11/103	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	molecular_function	"Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)." [EC:3.5.1.26, RHEA:11547]
EOG80GG5K	GO:0006517	8/103	protein deglycosylation	biological_process	"The removal of sugar residues from a glycosylated protein." [GOC:mah]
EOG80GG5K	GO:0008233	8/103	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG80GG5K	GO:0005764	8/103	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8J3ZZ0	GO:0003677	16/36	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8VHNMS	GO:0008299	25/81	isoprenoid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
EOG8VHNMS	GO:0004163	25/81	diphosphomevalonate decarboxylase activity	molecular_function	"Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate." [EC:4.1.1.33, RHEA:23735]
EOG8VHNMS	GO:0005524	23/81	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG869T7W	GO:0005730	1/72	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG80GG5C	GO:0046872	107/320	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80GG5C	GO:0003676	107/320	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80GG5C	GO:0016787	102/320	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG80GG5C	GO:0006309	4/320	apoptotic DNA fragmentation	biological_process	"The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520]
EOG80GG5C	GO:0005739	4/320	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG80GG5C	GO:0004518	4/320	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG80GG5C	GO:0004519	1/320	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG82586J	GO:0005089	29/101	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG82586J	GO:0046928	1/101	regulation of neurotransmitter secretion	biological_process	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
EOG82586J	GO:0035011	1/101	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG82586J	GO:0007480	1/101	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG82586J	GO:0031594	1/101	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG82586J	GO:0016740	1/101	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8QJV2Z	GO:0007606	16/1207	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8QJV2Z	GO:0005515	9/1207	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QJV2Z	GO:0016021	3/1207	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QJV2Z	GO:0008039	1/1207	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8QJV2Z	GO:0050914	1/1207	sensory perception of salty taste	biological_process	"The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8QJV2Z	GO:0002115	1/1207	store-operated calcium entry	biological_process	"A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991]
EOG8QJV2Z	GO:0035199	1/1207	salt aversion	biological_process	"The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf]
EOG8QJV2Z	GO:0048149	1/1207	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8QJV2Z	GO:0005886	1/1207	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG83XXH8	GO:0017112	1/79	Rab guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG83XXH8	GO:0032313	1/79	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG83XXH8	GO:0035011	1/79	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG83XXH8	GO:0032483	1/79	regulation of Rab protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]
EOG8GB9MZ	GO:0050660	281/974	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8GB9MZ	GO:0008812	249/974	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG8GB9MZ	GO:0006066	249/974	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG8GB9MZ	GO:0016614	32/974	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8GB9MZ	GO:0004198	12/974	calcium-dependent cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]
EOG8GB9MZ	GO:0005622	12/974	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8GB9MZ	GO:0004344	11/974	glucose dehydrogenase activity	molecular_function	"Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10]
EOG8GB9MZ	GO:0005509	10/974	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8GB9MZ	GO:0016491	9/974	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8GB9MZ	GO:0045455	9/974	ecdysteroid metabolic process	biological_process	"The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732]
EOG8GB9MZ	GO:0008270	1/974	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GB9MZ	GO:0006915	1/974	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8GB9MZ	GO:0042600	1/974	chorion	cellular_component	"A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
EOG8GB9MZ	GO:0004190	1/974	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8GB9MZ	GO:0003676	1/974	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GB9MZ	GO:0004197	1/974	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8GB9MZ	GO:0046331	1/974	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8GB9MZ	GO:0015074	1/974	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8CZDXB	GO:0005975	21/49	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8CZDXB	GO:0016757	18/49	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8CZDXB	GO:0003945	2/49	N-acetyllactosamine synthase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90]
EOG8CZDXB	GO:0005794	1/49	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8CZDXB	GO:0033842	1/49	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244]
EOG8CZDXB	GO:0009247	1/49	glycolipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators]
EOG8CZDXB	GO:0008376	1/49	acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]
EOG8CZDXB	GO:0006044	1/49	N-acetylglucosamine metabolic process	biological_process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
EOG8XD65X	GO:0004984	25/128	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8XD65X	GO:0005549	25/128	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8XD65X	GO:0016021	21/128	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XD65X	GO:0004930	21/128	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8XD65X	GO:0005886	12/128	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8XD65X	GO:0016020	4/128	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8GB9PT	GO:0008233	1/9	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG83N9VW	GO:0005634	95/339	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83N9VW	GO:0003700	95/339	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG83N9VW	GO:0043565	89/339	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG83N9VW	GO:0019101	1/339	female somatic sex determination	biological_process	"The determination of sex and sexual phenotypes in a female organism's soma." [GOC:mah]
EOG83N9VW	GO:0000398	1/339	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG83N9VW	GO:0003677	1/339	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG83N9VW	GO:0007548	1/339	sex differentiation	biological_process	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]
EOG83N9VW	GO:0045497	1/339	female analia development	biological_process	"The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
EOG83N9VW	GO:0001078	1/339	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
EOG83N9VW	GO:0008049	1/339	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG83N9VW	GO:0045892	1/339	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0046661	1/339	male sex differentiation	biological_process	"The establishment of the sex of a male organism by physical differentiation." [GOC:bf]
EOG83N9VW	GO:0048086	1/339	negative regulation of developmental pigmentation	biological_process	"Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
EOG83N9VW	GO:0045433	1/339	male courtship behavior, veined wing generated song production	biological_process	"The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
EOG83N9VW	GO:0018993	1/339	somatic sex determination	biological_process	"The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems]
EOG83N9VW	GO:0006355	1/339	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0042803	1/339	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG83N9VW	GO:0045893	1/339	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0048071	1/339	sex-specific pigmentation	biological_process	"Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jid]
EOG83N9VW	GO:0045496	1/339	male analia development	biological_process	"The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
EOG83N9VW	GO:0007619	1/339	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG83N9VW	GO:0007283	1/339	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG83N9VW	GO:0007417	1/339	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG83N9VW	GO:0016199	1/339	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG83N9VW	GO:0035215	1/339	genital disc development	biological_process	"Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318]
EOG83N9VW	GO:0045944	1/339	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0046872	1/339	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83N9VW	GO:0003729	1/339	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG83N9VW	GO:0045498	1/339	sex comb development	biological_process	"The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk]
EOG83N9VW	GO:0005515	1/339	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG83N9VW	GO:0000122	1/339	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0007483	1/339	genital disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238]
EOG83N9VW	GO:0001077	1/339	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG83N9VW	GO:0007530	1/339	sex determination	biological_process	"Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732]
EOG83N9VW	GO:0007486	1/339	imaginal disc-derived female genitalia development	biological_process	"The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
EOG83N9VW	GO:0006357	1/339	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG83N9VW	GO:0019102	1/339	male somatic sex determination	biological_process	"The determination of sex and sexual phenotypes in a male organism's soma." [GOC:mah]
EOG83N9VW	GO:0007485	1/339	imaginal disc-derived male genitalia development	biological_process	"The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
EOG83N9VW	GO:0035263	1/339	genital disc sexually dimorphic development	biological_process	"The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781]
EOG83N9VW	GO:0046660	1/339	female sex differentiation	biological_process	"The establishment of the sex of a female organism by physical differentiation." [GOC:bf]
EOG83N9VW	GO:0045570	1/339	regulation of imaginal disc growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators]
EOG837TWZ	GO:0007267	4/48	cell-cell signaling	biological_process	"Any process that mediates the transfer of information from one cell to another." [GOC:mah]
EOG837TWZ	GO:0007275	4/48	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8PCD88	GO:0006886	27/100	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8PCD88	GO:0016021	27/100	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PCD88	GO:0005783	27/100	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8DZ492	GO:0016620	2/4	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG8FTZJJ	GO:0016020	1/2	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8FTZJJ	GO:0007156	1/2	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8FTZJJ	GO:0005509	1/2	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8SJ7WT	GO:0006509	4/16	membrane protein ectodomain proteolysis	biological_process	"The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/]
EOG8SJ7WT	GO:0007219	4/16	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG8SJ7WT	GO:0004222	4/16	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8SJ7WT	GO:0008270	3/16	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D81N7	GO:0005215	4/22	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8D81N7	GO:0005622	4/22	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8DV814	GO:0046872	20/78	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DV814	GO:0003682	14/78	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8DV814	GO:0003677	14/78	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DV814	GO:0005634	14/78	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8DV814	GO:0003676	6/78	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DV814	GO:0005524	2/78	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88D396	GO:0032440	2/117	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG88D396	GO:0008544	1/117	epidermis development	biological_process	"The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]
EOG88D396	GO:0035317	1/117	imaginal disc-derived wing hair organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853]
EOG88D396	GO:0048477	1/117	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG88D396	GO:0045177	1/117	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG88D396	GO:0030725	1/117	germline ring canal formation	biological_process	"Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts." [ISBN:0879694238]
EOG88D396	GO:0016311	1/117	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG88D396	GO:0007560	1/117	imaginal disc morphogenesis	biological_process	"The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid]
EOG88D396	GO:0017018	1/117	myosin phosphatase activity	molecular_function	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]
EOG88D396	GO:0048675	1/117	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG88D396	GO:0007391	1/117	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG88D396	GO:0045314	1/117	regulation of compound eye photoreceptor development	biological_process	"Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
EOG88D396	GO:0045179	1/117	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8P8HZV	GO:0035206	1/93	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8DV818	GO:0004252	33/110	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8DV818	GO:0070008	31/110	serine-type exopeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE, ISBN:0716720094]
EOG8DV818	GO:0004177	1/110	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG8DV818	GO:0052689	1/110	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG8M946K	GO:0046872	14/67	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8J13P1	GO:0008021	22/123	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8J13P1	GO:0005215	22/123	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8J13P1	GO:0016020	22/123	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8J13P1	GO:0006886	8/123	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8J13P1	GO:0046872	1/123	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8J13P1	GO:0035005	1/123	1-phosphatidylinositol-4-phosphate 3-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.154, RHEA:18376]
EOG81VNJK	GO:0016301	2/95	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG81VNJG	GO:0035556	6/50	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG81VNJG	GO:0046872	6/50	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8X0Q69	GO:0008859	2/95	exoribonuclease II activity	molecular_function	"Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684]
EOG8X0Q69	GO:0022008	1/95	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8X0Q69	GO:0071027	1/95	nuclear RNA surveillance	biological_process	"The set of processes involved in identifying and degrading defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]
EOG8X0Q69	GO:0010468	1/95	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8X0Q69	GO:0005634	1/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X0Q69	GO:0000176	1/95	nuclear exosome (RNase complex)	cellular_component	"Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]
EOG8X0Q69	GO:0005652	1/95	nuclear lamina	cellular_component	"The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363]
EOG81RS7Z	GO:0016740	46/887	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG81RS7Z	GO:0004364	41/887	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG81RS7Z	GO:0006749	24/887	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG81RS7Z	GO:0018833	4/887	DDT-dehydrochlorinase activity	molecular_function	"Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)." [EC:4.5.1.1, RHEA:19220]
EOG81RS7Z	GO:0005515	2/887	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG81RS7Z	GO:0005576	2/887	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG81RS7Z	GO:0004602	2/887	glutathione peroxidase activity	molecular_function	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9]
EOG81RS7Z	GO:0009408	1/887	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG81RS7Z	GO:0055114	1/887	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG81RS7Z	GO:0022008	1/887	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG81RS7Z	GO:0008152	1/887	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8D2951	GO:0003677	20/68	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8D2951	GO:0003682	19/68	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8D2951	GO:0008270	6/68	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D2951	GO:0016573	1/68	histone acetylation	biological_process	"The modification of a histone by the addition of an acetyl group." [GOC:ai]
EOG8D2951	GO:0043967	1/68	histone H4 acetylation	biological_process	"The modification of histone H4 by the addition of an acetyl group." [GOC:jl]
EOG8D2951	GO:0000123	1/68	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG8D2951	GO:0006338	1/68	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG8D2951	GO:0004402	1/68	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8D2951	GO:0043966	1/68	histone H3 acetylation	biological_process	"The modification of histone H3 by the addition of an acetyl group." [GOC:jl]
EOG8DV81R	GO:0016192	2/15	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8DV81R	GO:0016021	2/15	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QJV1Z	GO:0007155	24/111	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8QJV1Z	GO:0006030	20/111	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8QJV1Z	GO:0005576	20/111	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8QJV1Z	GO:0008061	20/111	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8QJV1Z	GO:0042060	1/111	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8QJV1Z	GO:0047712	1/111	Cypridina-luciferin 2-monooxygenase activity	molecular_function	"Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light." [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN]
EOG8QJV1Z	GO:0042381	1/111	hemolymph coagulation	biological_process	"Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949]
EOG8QJV1Z	GO:0042803	1/111	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8QJV1Z	GO:0003676	1/111	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QJV1Z	GO:0007599	1/111	hemostasis	biological_process	"The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732]
EOG8QJV1Z	GO:0008270	1/111	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GF5XM	GO:0003700	50/194	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8GF5XM	GO:0043565	49/194	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8GF5XM	GO:0005634	49/194	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GF5XM	GO:0007275	20/194	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8GF5XM	GO:0009952	4/194	anterior/posterior pattern specification	biological_process	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8GF5XM	GO:0006355	4/194	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8GF5XM	GO:0003677	3/194	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GF5XM	GO:0007507	2/194	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8GF5XM	GO:0045944	2/194	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8GF5XM	GO:0014019	2/194	neuroblast development	biological_process	"The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585]
EOG8GF5XM	GO:0004000	2/194	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8GF5XM	GO:0006366	2/194	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8GF5XM	GO:0003705	2/194	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG8GF5XM	GO:0042694	2/194	muscle cell fate specification	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators]
EOG8GF5XM	GO:0007494	2/194	midgut development	biological_process	"The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
EOG8GF5XM	GO:0035053	1/194	dorsal vessel heart proper cell fate commitment	biological_process	"The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110]
EOG8GF5XM	GO:0009987	1/194	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8GF5XM	GO:0007383	1/194	specification of segmental identity, antennal segment	biological_process	"The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
EOG8GF5XM	GO:0009948	1/194	anterior/posterior axis specification	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8GF5XM	GO:0048636	1/194	positive regulation of muscle organ development	biological_process	"Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators]
EOG8GF5XM	GO:0048738	1/194	cardiac muscle tissue development	biological_process	"The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]
EOG8GF5XM	GO:0007384	1/194	specification of segmental identity, thorax	biological_process	"The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
EOG8GF5XM	GO:0007422	1/194	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8GF5XM	GO:0048806	1/194	genitalia development	biological_process	"The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid]
EOG8GF5XM	GO:0007280	1/194	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG8GF5XM	GO:0007506	1/194	gonadal mesoderm development	biological_process	"The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai]
EOG8GF5XM	GO:0007400	1/194	neuroblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
EOG8GF5XM	GO:0007501	1/194	mesodermal cell fate specification	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
EOG8GF5XM	GO:0005737	1/194	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8GF5XM	GO:0008406	1/194	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG8GF5XM	GO:0010002	1/194	cardioblast differentiation	biological_process	"The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG8GF5XM	GO:0035224	1/194	genital disc anterior/posterior pattern formation	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318]
EOG8GF5XM	GO:0008354	1/194	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8GF5XM	GO:0048542	1/194	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG8GF5XM	GO:0005667	1/194	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8GF5XM	GO:0035225	1/194	determination of genital disc primordium	biological_process	"Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318]
EOG8GF5XM	GO:0006915	1/194	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8GF5XM	GO:0007399	1/194	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8GF5XM	GO:0007438	1/194	oenocyte development	biological_process	"The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397]
EOG8J13PD	GO:0016020	26/99	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8J13PD	GO:0006493	23/99	protein O-linked glycosylation	biological_process	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]
EOG8J13PD	GO:0000030	23/99	mannosyltransferase activity	molecular_function	"Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm]
EOG8J13PD	GO:0004169	4/99	dolichyl-phosphate-mannose-protein mannosyltransferase activity	molecular_function	"Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109, GOC:pr]
EOG8J13PD	GO:0005783	2/99	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8J13PD	GO:0016021	2/99	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J13PD	GO:0007517	2/99	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8J13PD	GO:0030259	2/99	lipid glycosylation	biological_process	"Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah]
EOG8J13PD	GO:0005789	2/99	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8J13PD	GO:0045214	1/99	sarcomere organization	biological_process	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
EOG8J13PD	GO:0007525	1/99	somatic muscle development	biological_process	"The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
EOG8J13PD	GO:0005515	1/99	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8J13PD	GO:0016203	1/99	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8J13PD	GO:0035269	1/99	protein O-linked mannosylation	biological_process	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]
EOG85F05P	GO:0000166	81/311	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG85F05P	GO:0003676	76/311	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85F05P	GO:0003723	5/311	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG85F05P	GO:0017148	3/311	negative regulation of translation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG85F05P	GO:0003729	2/311	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG85F05P	GO:0005515	1/311	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG85F05P	GO:0005634	1/311	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85F05P	GO:0036099	1/311	female germ-line stem cell population maintenance	biological_process	"The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart]
EOG85F05P	GO:0043234	1/311	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG85F05P	GO:0042803	1/311	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG85F05P	GO:0048477	1/311	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG85F05P	GO:0031536	1/311	positive regulation of exit from mitosis	biological_process	"Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah]
EOG85F05P	GO:0007319	1/311	negative regulation of oskar mRNA translation	biological_process	"Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems]
EOG85F05P	GO:0002121	1/311	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG85F05P	GO:0046011	1/311	regulation of oskar mRNA translation	biological_process	"Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512]
EOG85F05P	GO:0043186	1/311	P granule	cellular_component	"A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
EOG85F05P	GO:0003730	1/311	mRNA 3'-UTR binding	molecular_function	"Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah]
EOG85F05P	GO:0007281	1/311	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG85F05P	GO:0030727	1/311	germarium-derived female germ-line cyst formation	biological_process	"Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902]
EOG85F05P	GO:0005737	1/311	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG85F05P	GO:2000738	1/311	positive regulation of stem cell differentiation	biological_process	"Any process that activates or increases the frequency, rate or extent of stem cell differentiation." [GOC:obol]
EOG85F05P	GO:0006378	1/311	mRNA polyadenylation	biological_process	"The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]
EOG85F05P	GO:0007476	1/311	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG85F05P	GO:0007286	1/311	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG85F05P	GO:0042078	1/311	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG85F05P	GO:0000381	1/311	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8DZ49Z	GO:0003676	6/41	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8B0164	GO:0005509	2/6	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8P8HZ1	GO:0019829	4/8	cation-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]
EOG8P8HZ1	GO:0046872	4/8	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8P8HZ1	GO:0005524	4/8	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8P8HZ1	GO:0016021	4/8	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8P8HZ1	GO:0015077	2/8	monovalent inorganic cation transmembrane transporter activity	molecular_function	"Enables the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8P8HZ1	GO:0006754	2/8	ATP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]
EOG8GB9MT	GO:0005643	2/7	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG85F05F	GO:0008289	41/142	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG85F05F	GO:0005215	41/142	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG85F05F	GO:0005875	1/142	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG85F05F	GO:0007616	1/142	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8DZ49B	GO:0016301	2/112	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8DZ49B	GO:0046872	1/112	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DZ49B	GO:0036090	1/112	cleavage furrow ingression	biological_process	"Advancement of the cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed." [PMID:15811947, PMID:20687468]
EOG8DZ49B	GO:0071212	1/112	subsynaptic reticulum	cellular_component	"An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:1460464, PMID:18171947, PMID:19244343, PMID:7946331]
EOG8DZ49B	GO:0005543	1/112	phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8DZ49B	GO:0007269	1/112	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8DZ49B	GO:0045211	1/112	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8DZ49B	GO:0061024	1/112	membrane organization	biological_process	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]
EOG8DZ49B	GO:0003677	1/112	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DZ49B	GO:0007112	1/112	male meiosis cytokinesis	biological_process	"A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
EOG8DZ49B	GO:0006355	1/112	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8DZ49B	GO:0030496	1/112	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG8DZ49B	GO:0048488	1/112	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8DZ49B	GO:0005886	1/112	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8DZ49B	GO:0032154	1/112	cleavage furrow	cellular_component	"In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409]
EOG8DZ49B	GO:0007053	1/112	spindle assembly involved in male meiosis	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah]
EOG8DZ49B	GO:0008289	1/112	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG8DZ49B	GO:0045887	1/112	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8DZ49B	GO:0000281	1/112	mitotic cytokinesis	biological_process	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]
EOG8DZ49B	GO:0005515	1/112	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8DZ49B	GO:0005634	1/112	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85F05D	GO:0004364	32/318	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG85F05D	GO:0016740	19/318	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG85F05D	GO:0004667	6/318	prostaglandin-D synthase activity	molecular_function	"Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2)." [EC:5.3.99.2, RHEA:10603]
EOG85F05D	GO:0008152	1/318	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG85F05D	GO:0006749	1/318	glutathione metabolic process	biological_process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732]
EOG85F05D	GO:0055114	1/318	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG85F05D	GO:0004602	1/318	glutathione peroxidase activity	molecular_function	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9]
EOG8V9X72	GO:0008270	41/538	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8V9X72	GO:0003676	38/538	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8V9X72	GO:0003964	3/538	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8V9X72	GO:0003723	3/538	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8V9X72	GO:0006811	1/538	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8V9X72	GO:0005921	1/538	gap junction	cellular_component	"A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181]
EOG8J13PV	GO:0000234	1/15	phosphoethanolamine N-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103]
EOG8J13PV	GO:0008610	1/15	lipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8J13PV	GO:0008168	1/15	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8D295V	GO:0004852	32/94	uroporphyrinogen-III synthase activity	molecular_function	"Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III." [EC:4.2.1.75, RHEA:18968]
EOG8D295V	GO:0033014	32/94	tetrapyrrole biosynthetic process	biological_process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah]
EOG8M3CQD	GO:0046331	1/79	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG803062	GO:0008270	22/92	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG803062	GO:0006886	11/92	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG803062	GO:0016192	11/92	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG803062	GO:0016197	1/92	endosomal transport	biological_process	"The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]
EOG803062	GO:0035542	1/92	regulation of SNARE complex assembly	biological_process	"Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
EOG803062	GO:0033263	1/92	CORVET complex	cellular_component	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]
EOG803062	GO:0030897	1/92	HOPS complex	cellular_component	"A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161]
EOG8N5ZBC	GO:0016021	3/100	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8N5ZBC	GO:0007420	1/100	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG84BDHV	GO:0016021	2/31	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FN6ZR	GO:0005634	26/114	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FN6ZR	GO:0003700	26/114	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8FN6ZR	GO:0000976	20/114	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8FN6ZR	GO:0043565	5/114	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8FN6ZR	GO:0002807	1/114	positive regulation of antimicrobial peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
EOG8FN6ZR	GO:0007487	1/114	analia development	biological_process	"The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu]
EOG8FN6ZR	GO:0007442	1/114	hindgut morphogenesis	biological_process	"The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
EOG8FN6ZR	GO:0007350	1/114	blastoderm segmentation	biological_process	"The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8FN6ZR	GO:0007379	1/114	segment specification	biological_process	"The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8FN6ZR	GO:0004000	1/114	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8FN6ZR	GO:0007377	1/114	germ-band extension	biological_process	"Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:08795694238]
EOG8FN6ZR	GO:0010004	1/114	gastrulation involving germ band extension	biological_process	"A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8FN6ZR	GO:0000977	1/114	RNA polymerase II regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
EOG8FN6ZR	GO:0045893	1/114	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8FN6ZR	GO:0006351	1/114	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8FN6ZR	GO:0005737	1/114	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8FN6ZR	GO:0035215	1/114	genital disc development	biological_process	"Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318]
EOG8FN6ZR	GO:0035224	1/114	genital disc anterior/posterior pattern formation	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318]
EOG8FN6ZR	GO:0007443	1/114	Malpighian tubule morphogenesis	biological_process	"The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089]
EOG8FN6ZR	GO:0009948	1/114	anterior/posterior axis specification	biological_process	"The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8FN6ZR	GO:0045944	1/114	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8FN6ZR	GO:0008284	1/114	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG841SRR	GO:0016021	10/159	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG841SRR	GO:0022857	9/159	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG841SRR	GO:0003677	2/159	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG841SRR	GO:0000278	1/159	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG841SRR	GO:0016905	1/159	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG841SRR	GO:0042023	1/159	DNA endoreduplication	biological_process	"Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw]
EOG841SRR	GO:0005215	1/159	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG841SRR	GO:0055085	1/159	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG841SRR	GO:0035185	1/159	preblastoderm mitotic cell cycle	biological_process	"The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238]
EOG85XBB4	GO:0008061	10/92	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG85XBB4	GO:0006030	10/92	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG85XBB4	GO:0005576	10/92	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG85XBB4	GO:0008233	4/92	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG85XBB4	GO:0004871	3/92	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG85XBB4	GO:0004435	3/92	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG85XBB4	GO:0035556	3/92	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG85XBB4	GO:0006629	3/92	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG85XBB4	GO:0046872	1/92	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG85XBB4	GO:0005201	1/92	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG85XBB4	GO:0031012	1/92	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG85XBB4	GO:0005509	1/92	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG85XBB4	GO:0042302	1/92	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8WM77H	GO:0004725	36/112	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8WM77H	GO:0050254	2/112	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8WM77H	GO:0007424	1/112	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8WM77H	GO:0006470	1/112	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8WM77H	GO:0008045	1/112	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8WM77H	GO:0007411	1/112	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8WM77H	GO:0007417	1/112	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8WM77H	GO:0004721	1/112	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8WM77H	GO:0030424	1/112	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8WM77H	GO:0045177	1/112	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8WM77H	GO:0035335	1/112	peptidyl-tyrosine dephosphorylation	biological_process	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]
EOG8WM77H	GO:0005886	1/112	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8WM77H	GO:0007616	1/112	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8WM77H	GO:0004602	1/112	glutathione peroxidase activity	molecular_function	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9]
EOG8WM77H	GO:0006979	1/112	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8WM77H	GO:0005001	1/112	transmembrane receptor protein tyrosine phosphatase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8WM77H	GO:0016021	1/112	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DFS31	GO:0046872	23/98	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DFS31	GO:0045570	1/98	regulation of imaginal disc growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators]
EOG8DFS31	GO:0003714	1/98	transcription corepressor activity	molecular_function	"Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8DFS31	GO:0007476	1/98	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8DFS31	GO:0006886	1/98	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8DFS31	GO:0008345	1/98	larval locomotory behavior	biological_process	"Locomotory behavior in a larval (immature) organism." [GOC:ai]
EOG8DFS31	GO:0090389	1/98	phagosome-lysosome fusion involved in apoptotic cell clearance	biological_process	"The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb]
EOG8DFS31	GO:0048190	1/98	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8DFS31	GO:0005547	1/98	phosphatidylinositol-3,4,5-trisphosphate binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl]
EOG8DFS31	GO:0045335	1/98	phagocytic vesicle	cellular_component	"A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]
EOG8DFS31	GO:0007412	1/98	axon target recognition	biological_process	"The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437]
EOG8DFS31	GO:0007411	1/98	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8DFS31	GO:0000122	1/98	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8DFS31	GO:0045879	1/98	negative regulation of smoothened signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG8DFS31	GO:0005634	1/98	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG841SRV	GO:0004402	1/100	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG841SRV	GO:0005737	1/100	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG85B3XG	GO:0016021	1/66	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85B3XG	GO:0006865	1/66	amino acid transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG85B3XG	GO:0016020	1/66	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8TTJZV	GO:0004842	24/91	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8TTJZV	GO:0005634	24/91	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TTJZV	GO:0006511	24/91	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8TTJZV	GO:0008270	24/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TTJZV	GO:0007275	20/91	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8TTJZV	GO:0005737	4/91	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8TTJZV	GO:0007601	4/91	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8TTJZV	GO:0050896	4/91	response to stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
EOG8TTJZV	GO:0007423	4/91	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8TTJZV	GO:0045676	4/91	regulation of R7 cell differentiation	biological_process	"Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators]
EOG8TTJZV	GO:0016874	3/91	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8TTJZV	GO:0010498	1/91	proteasomal protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]
EOG8TTJZV	GO:0000151	1/91	ubiquitin ligase complex	cellular_component	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
EOG8TTJZV	GO:0042802	1/91	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG8TTJZV	GO:0005515	1/91	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8TTJZV	GO:0007465	1/91	R7 cell fate commitment	biological_process	"The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883]
EOG8TTJZV	GO:0043621	1/91	protein self-association	molecular_function	"Interacting selectively and non-covalently with a domain within the same polypeptide." [GOC:jl]
EOG8TTJZV	GO:0006508	1/91	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8935ZS	GO:0005634	8/42	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8935ZS	GO:0006260	8/42	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8VMHX1	GO:0016779	11/50	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG8VMHX1	GO:0046872	5/50	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8VMHX1	GO:0000166	2/50	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8VMHX1	GO:0003676	2/50	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VMHX1	GO:0016740	1/50	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8CG2SJ	GO:0008233	2/68	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG83V28P	GO:0046872	18/65	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83V28P	GO:0003676	17/65	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X0Q8F	GO:0016459	3/36	myosin complex	cellular_component	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
EOG8X0Q8F	GO:0005524	3/36	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X0Q8F	GO:0003774	3/36	motor activity	molecular_function	"Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
EOG8SBHDK	GO:0005215	3/31	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8SBHDK	GO:0008289	3/31	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG8WDGSN	GO:0004742	21/95	dihydrolipoyllysine-residue acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12]
EOG8WDGSN	GO:0045254	20/95	pyruvate dehydrogenase complex	cellular_component	"Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3)." [ISBN:0716720094]
EOG8WDGSN	GO:0006090	20/95	pyruvate metabolic process	biological_process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]
EOG8WDGSN	GO:0016746	5/95	transferase activity, transferring acyl groups	molecular_function	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8WDGSN	GO:0043754	2/95	dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity	molecular_function	"Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine." [EC:2.3.1.168]
EOG8WDGSN	GO:0005811	1/95	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8NZX9J	GO:0016021	6/19	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NZX9J	GO:0022857	4/19	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8NZX9J	GO:0022891	2/19	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8NZX9J	GO:0008643	1/19	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8SBHDC	GO:0008270	11/64	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SBHDC	GO:0005634	10/64	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SBHDB	GO:0003676	2/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SBHDB	GO:0046872	2/7	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8SBHDB	GO:0008270	1/7	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SBHDB	GO:0005634	1/7	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8642SZ	GO:0046872	2/7	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8642SZ	GO:0003676	2/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8G4K4R	GO:0016534	28/115	cyclin-dependent protein kinase 5 activator activity	molecular_function	"Binds to and increases the activity of cyclin-dependent protein kinase 5." [GOC:mah]
EOG8G4K4R	GO:0016533	28/115	cyclin-dependent protein kinase 5 holoenzyme complex	cellular_component	"A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits." [PMID:15689152]
EOG8G4K4R	GO:0016301	6/115	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8G4K4R	GO:0007409	1/115	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8G4K4R	GO:0004693	1/115	cyclin-dependent protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]
EOG8G4K4R	GO:0043025	1/115	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8G4K4R	GO:0035011	1/115	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG8G4K4R	GO:0030426	1/115	growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194]
EOG8G4K4R	GO:0030424	1/115	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8G4K4R	GO:0030425	1/115	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8G4K4R	GO:0070059	1/115	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	biological_process	"A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708]
EOG8G4K4R	GO:0008045	1/115	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8G4K4R	GO:0008344	1/115	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG8G4K4R	GO:0071902	1/115	positive regulation of protein serine/threonine kinase activity	biological_process	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]
EOG8G4K4R	GO:0008340	1/115	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8KPWST	GO:0016021	27/105	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KPWST	GO:0046872	1/105	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8KPWST	GO:0004784	1/105	superoxide dismutase activity	molecular_function	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]
EOG89CST3	GO:0016021	1/2	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG89CST3	GO:0004930	1/2	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8VX4M0	GO:0008270	76/1021	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VX4M0	GO:0003676	72/1021	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VX4M0	GO:0003964	70/1021	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8VX4M0	GO:0015074	70/1021	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8VX4M0	GO:0003723	69/1021	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8VX4M0	GO:0005198	14/1021	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8VX4M0	GO:0005882	14/1021	intermediate filament	cellular_component	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]
EOG8VX4M0	GO:0004190	10/1021	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8VX4M0	GO:0003677	4/1021	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8VX4M0	GO:0005634	2/1021	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80P6NF	GO:0016021	97/327	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6NF	GO:0004995	41/327	tachykinin receptor activity	molecular_function	"Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:7639617, Wikipedia:Tachykinin]
EOG80P6NF	GO:0005886	40/327	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80P6NF	GO:0004983	35/327	neuropeptide Y receptor activity	molecular_function	"Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
EOG80P6NF	GO:0006935	33/327	chemotaxis	biological_process	"The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732]
EOG80P6NF	GO:0004950	33/327	chemokine receptor activity	molecular_function	"Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, http://en.wikipedia.org/wiki/Chemokine, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823]
EOG80P6NF	GO:0004930	13/327	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG80P6NF	GO:0050254	8/327	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG80P6NF	GO:0007186	3/327	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG80P6NF	GO:0008188	3/327	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG80P6NF	GO:0007218	3/327	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG80P6NF	GO:0007217	2/327	tachykinin receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor." [GOC:mah, PMID:14723970]
EOG80P6NF	GO:0005887	2/327	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6NF	GO:0050911	1/327	detection of chemical stimulus involved in sensory perception of smell	biological_process	"The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG80P6NF	GO:0050805	1/327	negative regulation of synaptic transmission	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
EOG80P6NF	GO:0042048	1/327	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG80P6NF	GO:0007166	1/327	cell surface receptor signaling pathway	biological_process	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
EOG80P6NF	GO:0004715	1/327	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG80P6NF	GO:0001653	1/327	peptide receptor activity	molecular_function	"Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl]
EOG80P6NF	GO:0002121	1/327	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG85MQK9	GO:0030983	29/98	mismatched DNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]
EOG85MQK9	GO:0005524	29/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG85MQK9	GO:0006298	29/98	mismatch repair	biological_process	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
EOG85MQK9	GO:0032389	29/98	MutLalpha complex	cellular_component	"A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2." [GOC:vk]
EOG85MQK9	GO:0005875	1/98	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG85MQK9	GO:0006200	1/98	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG85MQK9	GO:0016887	1/98	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG85MQK9	GO:0003697	1/98	single-stranded DNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, PMID:22976174]
EOG88SK95	GO:0005605	1/36	basal lamina	cellular_component	"A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix." [ISBN:0198547684]
EOG88SK95	GO:0043113	1/36	receptor clustering	biological_process	"The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460]
EOG88SK95	GO:0007213	1/36	G-protein coupled acetylcholine receptor signaling pathway	biological_process	"Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194]
EOG8RV55W	GO:0010586	1/112	miRNA metabolic process	biological_process	"The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]
EOG8RV55W	GO:0070920	1/112	regulation of production of small RNA involved in gene silencing by RNA	biological_process	"Any process that modulates the frequency, rate or extent of the production of small RNA involved in gene silencing by RNA." [GOC:mah]
EOG8RV55W	GO:0004525	1/112	ribonuclease III activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]
EOG8RV55W	GO:0030422	1/112	production of siRNA involved in RNA interference	biological_process	"Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674]
EOG8RV55W	GO:0070918	1/112	production of small RNA involved in gene silencing by RNA	biological_process	"The process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease." [GOC:mah, PMID:19239886]
EOG8RV55W	GO:0031054	1/112	pre-miRNA processing	biological_process	"Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]
EOG8RV55W	GO:0003725	1/112	double-stranded RNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]
EOG8RV55W	GO:0030718	1/112	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8RV55W	GO:0005515	1/112	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8RV55W	GO:0007417	1/112	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8RV55W	GO:0005737	1/112	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RV55W	GO:0009047	1/112	dosage compensation by hyperactivation of X chromosome	biological_process	"Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577]
EOG8RV55W	GO:0048132	1/112	female germ-line stem cell asymmetric division	biological_process	"The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu]
EOG8QRKK3	GO:0005643	26/94	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG8QRKK3	GO:0006606	1/94	protein import into nucleus	biological_process	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]
EOG8QRKK3	GO:0006605	1/94	protein targeting	biological_process	"The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]
EOG8QRKK3	GO:0005487	1/94	nucleocytoplasmic transporter activity	molecular_function	"Enables the directed movement of substances between the nucleus and the cytoplasm of a cell." [GOC:ai]
EOG8QRKK3	GO:0006607	1/94	NLS-bearing protein import into nucleus	biological_process	"The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai]
EOG8QRKK3	GO:0051028	1/94	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8QRKK3	GO:0006913	1/94	nucleocytoplasmic transport	biological_process	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]
EOG8NCPT4	GO:0034464	13/70	BBSome	cellular_component	"A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [GOC:BHF, PMID:17574030]
EOG8NCPT4	GO:0035058	13/70	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG8KPWSH	GO:0007059	2/176	chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
EOG8KPWSH	GO:0005515	1/176	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG82RGQB	GO:0008233	1/86	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8DZ484	GO:0003676	1/92	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DZ484	GO:0046872	1/92	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HDW7K	GO:0005524	25/95	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8HDW7K	GO:0004674	23/95	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8HDW7K	GO:0043652	1/95	engulfment of apoptotic cell	biological_process	"The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]
EOG8HDW7K	GO:0034605	1/95	cellular response to heat	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]
EOG8HDW7K	GO:0001934	1/95	positive regulation of protein phosphorylation	biological_process	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
EOG8HDW7K	GO:0004623	1/95	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG8HDW7K	GO:0004702	1/95	receptor signaling protein serine/threonine kinase activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah]
EOG8HDW7K	GO:0004709	1/95	MAP kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
EOG8HDW7K	GO:0006468	1/95	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8HDW7K	GO:0031452	1/95	negative regulation of heterochromatin assembly	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation." [GOC:mah]
EOG8HDW7K	GO:0046330	1/95	positive regulation of JNK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8HDW7K	GO:0006979	1/95	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8HDW7K	GO:0071243	1/95	cellular response to arsenic-containing substance	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:mah]
EOG8HDW7K	GO:0045793	1/95	positive regulation of cell size	biological_process	"Any process that increases cell size." [GOC:go_curators]
EOG8HDW7K	GO:0032440	1/95	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8HDW7K	GO:0071276	1/95	cellular response to cadmium ion	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:mah]
EOG8HDW7K	GO:0070059	1/95	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	biological_process	"A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708]
EOG8HDW7K	GO:0002385	1/95	mucosal immune response	biological_process	"An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
EOG8HDW7K	GO:0000186	1/95	activation of MAPKK activity	biological_process	"The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK)." [PMID:9561267]
EOG8HDW7K	GO:0000165	1/95	MAPK cascade	biological_process	"An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267]
EOG8HDW7K	GO:0004672	1/95	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8HDW7K	GO:0031434	1/95	mitogen-activated protein kinase kinase binding	molecular_function	"Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase." [GOC:mah]
EOG8HDW7K	GO:0071475	1/95	cellular hyperosmotic salinity response	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah]
EOG85MQK4	GO:0008270	25/108	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG85MQK4	GO:0030163	25/108	protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]
EOG85MQK4	GO:0004842	22/108	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG85MQK4	GO:0016874	2/108	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8R268K	GO:0016747	22/101	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8R268K	GO:0040003	1/101	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8R268K	GO:0030421	1/101	defecation	biological_process	"The expulsion of feces from the rectum." [GOC:mah]
EOG8R268K	GO:0048477	1/101	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8R268K	GO:0007586	1/101	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG8R268K	GO:0022600	1/101	digestive system process	biological_process	"A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio]
EOG82VBX5	GO:0003723	22/88	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG81RS89	GO:0055085	250/817	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG81RS89	GO:0005215	250/817	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG81RS89	GO:0016021	249/817	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81RS89	GO:0016020	2/817	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG81RS89	GO:0006814	1/817	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG81RS89	GO:0051780	1/817	behavioral response to nutrient	biological_process	"Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus." [GOC:ai]
EOG81RS89	GO:0008343	1/817	adult feeding behavior	biological_process	"Feeding behavior in a fully developed and mature organism." [GOC:mah]
EOG81RS89	GO:0016323	1/817	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG81RS89	GO:0015293	1/817	symporter activity	molecular_function	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
EOG81RS89	GO:0007156	1/817	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG81RS89	GO:0005509	1/817	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG84F8QW	GO:0000228	25/90	nuclear chromosome	cellular_component	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
EOG84F8QW	GO:0006338	24/90	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG84F8QW	GO:0007474	1/90	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG84F8QW	GO:0007517	1/90	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG84F8QW	GO:0008587	1/90	imaginal disc-derived wing margin morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG84F8QW	GO:0006357	1/90	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG84F8QW	GO:0044772	1/90	mitotic cell cycle phase transition	biological_process	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]
EOG84F8QW	GO:0048813	1/90	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG84F8QW	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG84F8QW	GO:0005634	1/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84F8QW	GO:0008544	1/90	epidermis development	biological_process	"The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]
EOG84F8QW	GO:0043044	1/90	ATP-dependent chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors." [GOC:jl, PMID:12042764]
EOG84F8QW	GO:0008285	1/90	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG84F8QW	GO:0006337	1/90	nucleosome disassembly	biological_process	"The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG84F8QW	GO:0070983	1/90	dendrite guidance	biological_process	"The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
EOG84F8QW	GO:0070984	1/90	SET domain binding	molecular_function	"Interacting selectively and non-covalently with a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation." [GOC:sart, Pfam:PF00856, PMID:12575990]
EOG84F8QW	GO:0035060	1/90	brahma complex	cellular_component	"A SWI/SNF-type complex that contains the ATPase product of the Drosophila brahma gene, or an ortholog thereof." [GOC:bf, PMID:10809665, PMID:12482982]
EOG84F8QW	GO:0008586	1/90	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG84F8QW	GO:0045893	1/90	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG84F8QW	GO:0006281	1/90	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8H48KS	GO:0004045	43/155	aminoacyl-tRNA hydrolase activity	molecular_function	"Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]
EOG8QVFRT	GO:0007156	1/92	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8QVFRT	GO:0005887	1/92	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QVFRT	GO:0042802	1/92	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG83FKBQ	GO:0051001	1/88	negative regulation of nitric-oxide synthase activity	biological_process	"Any process that stops or reduces the activity of the enzyme nitric-oxide synthase." [GOC:ai]
EOG83FKBQ	GO:0071013	1/88	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG83FKBQ	GO:0005634	1/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83FKBQ	GO:0000398	1/88	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG83FKBQ	GO:0043086	1/88	negative regulation of catalytic activity	biological_process	"Any process that stops or reduces the activity of an enzyme." [GOC:jl, GOC:tb]
EOG83FKBQ	GO:0005737	1/88	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZKN13	GO:0031532	25/103	actin cytoskeleton reorganization	biological_process	"A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]
EOG8ZKN13	GO:0004674	23/103	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8ZKN13	GO:0005524	23/103	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZKN13	GO:0035556	21/103	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8ZKN13	GO:0046872	21/103	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZKN13	GO:0005083	20/103	GTPase regulator activity	molecular_function	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
EOG8ZKN13	GO:0004697	2/103	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG8ZKN13	GO:0030424	1/103	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8ZKN13	GO:0008154	1/103	actin polymerization or depolymerization	biological_process	"Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]
EOG8ZKN13	GO:0008039	1/103	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8ZKN13	GO:0006468	1/103	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8ZKN13	GO:0005515	1/103	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8ZKN13	GO:0030426	1/103	growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194]
EOG8ZKN13	GO:0032440	1/103	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8ZKN13	GO:0004672	1/103	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8ZKN13	GO:0030833	1/103	regulation of actin filament polymerization	biological_process	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG84TRPH	GO:0005975	41/141	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG84TRPH	GO:0016757	39/141	transferase activity, transferring glycosyl groups	molecular_function	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG84TRPH	GO:0008344	1/141	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG84TRPH	GO:0033842	1/141	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244]
EOG84TRPH	GO:0005794	1/141	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG84TRPH	GO:0007528	1/141	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG84TRPH	GO:0009247	1/141	glycolipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators]
EOG84TRPH	GO:0003945	1/141	N-acetyllactosamine synthase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90]
EOG84TRPH	GO:0008376	1/141	acetylgalactosaminyltransferase activity	molecular_function	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]
EOG84TRPH	GO:0006044	1/141	N-acetylglucosamine metabolic process	biological_process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]
EOG80VZ3H	GO:0003682	2/6	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG80VZ3H	GO:0016021	1/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80VZ3H	GO:0030054	1/6	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG80VZ3H	GO:0005886	1/6	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80VZ3H	GO:0045202	1/6	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG80VZ3H	GO:0005230	1/6	extracellular ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG82VBX8	GO:0005215	5/52	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG82VBX8	GO:0005622	5/52	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8ZW7RX	GO:0016021	44/122	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZW7RX	GO:0006810	39/122	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8ZW7RX	GO:0055085	4/122	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8ZW7RX	GO:0006310	2/122	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8ZW7RX	GO:0015074	2/122	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8ZW7RX	GO:0003677	2/122	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8ZW7RX	GO:0035435	1/122	phosphate ion transmembrane transport	biological_process	"The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
EOG8ZW7RX	GO:0015114	1/122	phosphate ion transmembrane transporter activity	molecular_function	"Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai]
EOG8ZW7RX	GO:0005811	1/122	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8ZW7RX	GO:0048190	1/122	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8ZW7RX	GO:0006817	1/122	phosphate ion transport	biological_process	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8ZW7RX	GO:0005743	1/122	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8DRCW4	GO:0003677	26/86	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DRCW4	GO:0045089	1/86	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8DRCW4	GO:0050829	1/86	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8TF2ZZ	GO:0005524	22/180	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8TF2ZZ	GO:0004674	21/180	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8TF2ZZ	GO:0004687	2/180	myosin light chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18]
EOG8TF2ZZ	GO:0008307	1/180	structural constituent of muscle	molecular_function	"The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah]
EOG8TF2ZZ	GO:0045214	1/180	sarcomere organization	biological_process	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
EOG8TF2ZZ	GO:0016020	1/180	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8TF2ZZ	GO:0004930	1/180	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8TF2ZZ	GO:0006468	1/180	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8TF2ZZ	GO:0016021	1/180	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TF2ZZ	GO:0007156	1/180	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8TF2ZZ	GO:0007498	1/180	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8TF2ZZ	GO:0005509	1/180	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8TF2ZZ	GO:0030018	1/180	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8VQD3N	GO:0048268	27/112	clathrin coat assembly	biological_process	"The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage." [GOC:jid, PMID:11460887, PMID:11977118, PMID:9531549]
EOG8VQD3N	GO:0030118	27/112	clathrin coat	cellular_component	"A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549]
EOG8VQD3N	GO:0005545	27/112	1-phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732]
EOG8VQD3N	GO:0008021	1/112	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8VQD3N	GO:0032440	1/112	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8VQD3N	GO:0005543	1/112	phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8VQD3N	GO:0007269	1/112	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8VQD3N	GO:0006898	1/112	receptor-mediated endocytosis	biological_process	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]
EOG8VQD3N	GO:0048489	1/112	synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr]
EOG8VQD3N	GO:0030276	1/112	clathrin binding	molecular_function	"Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]
EOG8VQD3N	GO:0005794	1/112	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8VQD3N	GO:0048488	1/112	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8VQD3N	GO:0005905	1/112	coated pit	cellular_component	"A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]
EOG8VQD3N	GO:0016183	1/112	synaptic vesicle coating	biological_process	"A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:curators, PMID:10099709]
EOG8VQD3N	GO:0007268	1/112	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8VQD3N	GO:0007270	1/112	neuron-neuron synaptic transmission	biological_process	"The process of communication from a neuron to another neuron across a synapse." [GOC:add, GOC:jl, MeSH:D009435]
EOG8VQD3N	GO:0042331	1/112	phototaxis	biological_process	"The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981]
EOG8B2WBV	GO:0003824	5/146	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8B2WBV	GO:0016787	2/146	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8B2WBV	GO:0005789	1/146	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8B2WBV	GO:0030433	1/146	ER-associated ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]
EOG8B2WBV	GO:0006950	1/146	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8B2WBV	GO:0033961	1/146	cis-stilbene-oxide hydrolase activity	molecular_function	"Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9]
EOG8B2WBV	GO:0008233	1/146	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8B2WBV	GO:0016021	1/146	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8B2WBV	GO:0006515	1/146	misfolded or incompletely synthesized protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]
EOG8S1WR3	GO:0003777	1/8	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8S1WR3	GO:0007018	1/8	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG84F8QM	GO:0005975	94/390	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG84F8QM	GO:0004553	93/390	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG84F8QM	GO:0008422	1/390	beta-glucosidase activity	molecular_function	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21]
EOG84F8QM	GO:0008970	1/390	phosphatidylcholine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32]
EOG84F8QM	GO:0052740	1/390	1-acyl-2-lysophosphatidylserine acylhydrolase activity	molecular_function	"Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32]
EOG84F8QM	GO:0052739	1/390	phosphatidylserine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG:R04034]
EOG847J9W	GO:0043565	5/19	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG847J9W	GO:0005634	5/19	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VQD36	GO:0006281	11/96	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8VQD36	GO:0004518	11/96	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8VQD36	GO:0008586	1/96	imaginal disc-derived wing vein morphogenesis	biological_process	"The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu]
EOG8VQD36	GO:0001752	1/96	compound eye photoreceptor fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
EOG8VQD36	GO:0007173	1/96	epidermal growth factor receptor signaling pathway	biological_process	"A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933]
EOG8VQD36	GO:0007476	1/96	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8VQD36	GO:0007526	1/96	larval somatic muscle development	biological_process	"The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG8VQD36	GO:0001745	1/96	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8M945K	GO:0050660	36/104	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8M945K	GO:0008812	33/104	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG8M945K	GO:0006066	33/104	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG8M945K	GO:0016614	4/104	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8M945K	GO:0004344	3/104	glucose dehydrogenase activity	molecular_function	"Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10]
EOG8M945K	GO:0016491	2/104	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8M945K	GO:0045455	2/104	ecdysteroid metabolic process	biological_process	"The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732]
EOG8M945K	GO:0007498	1/104	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8HB10F	GO:0003777	1/7	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8HB10F	GO:0007018	1/7	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8HB10F	GO:0005871	1/7	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8HB10F	GO:0005524	1/7	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8HB10F	GO:0005874	1/7	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8MWBQ1	GO:0005506	1/72	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8MWBQ1	GO:0005815	1/72	microtubule organizing center	cellular_component	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416]
EOG8MWBQ1	GO:0005819	1/72	spindle	cellular_component	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
EOG8MWBQ1	GO:0020037	1/72	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8MWBQ1	GO:0016705	1/72	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8MWBQ1	GO:0005737	1/72	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG80P6MJ	GO:0016021	24/100	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80P6MJ	GO:0005509	24/100	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG80P6MJ	GO:0030154	23/100	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG80P6MJ	GO:0007219	23/100	Notch signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]
EOG80P6MJ	GO:0007275	22/100	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG80P6MJ	GO:0050793	18/100	regulation of developmental process	biological_process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]
EOG80P6MJ	GO:0007498	1/100	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG80P6MJ	GO:0000122	1/100	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG80P6MJ	GO:0003682	1/100	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG80P6MJ	GO:0004623	1/100	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG80P6MJ	GO:0048749	1/100	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG80P6MJ	GO:0035153	1/100	epithelial cell type specification, open tracheal system	biological_process	"Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940]
EOG80P6MJ	GO:0061331	1/100	epithelial cell proliferation involved in Malpighian tubule morphogenesis	biological_process	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG80P6MJ	GO:0010629	1/100	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG80P6MJ	GO:0007423	1/100	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG80P6MJ	GO:0035172	1/100	hemocyte proliferation	biological_process	"The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG80P6MJ	GO:0004872	1/100	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG80P6MJ	GO:0045316	1/100	negative regulation of compound eye photoreceptor development	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
EOG80P6MJ	GO:0045468	1/100	regulation of R8 cell spacing in compound eye	biological_process	"Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc." [GOC:dph, GOC:tb, PMID:11880339]
EOG80P6MJ	GO:0046666	1/100	retinal cell programmed cell death	biological_process	"Programmed cell death that occurs in the developing retina." [GOC:bf]
EOG80P6MJ	GO:0005622	1/100	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG80P6MJ	GO:0045944	1/100	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG80P6MJ	GO:0007440	1/100	foregut morphogenesis	biological_process	"The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid]
EOG80P6MJ	GO:0045466	1/100	R7 cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339]
EOG80P6MJ	GO:0008284	1/100	positive regulation of cell proliferation	biological_process	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
EOG80P6MJ	GO:0045465	1/100	R8 cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor." [PMID:11880339]
EOG80P6MJ	GO:0005634	1/100	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80P6MJ	GO:0048542	1/100	lymph gland development	biological_process	"The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
EOG80P6MJ	GO:0035157	1/100	negative regulation of fusion cell fate specification	biological_process	"Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [PMID:10684581]
EOG80P6MJ	GO:0061382	1/100	Malpighian tubule tip cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells." [GOC:dph, GOC:mtg_kidney_jan10, PMID:7821213]
EOG80P6MJ	GO:0007616	1/100	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG80P6MJ	GO:0008356	1/100	asymmetric cell division	biological_process	"The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
EOG80P6MJ	GO:0043234	1/100	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG80P6MJ	GO:0007293	1/100	germarium-derived egg chamber formation	biological_process	"Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG80P6MJ	GO:1900087	1/100	positive regulation of G1/S transition of mitotic cell cycle	biological_process	"Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]
EOG80P6MJ	GO:0007297	1/100	ovarian follicle cell migration	biological_process	"The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG80P6MJ	GO:0005737	1/100	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG80P6MJ	GO:0050877	1/100	neurological system process	biological_process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]
EOG80P6MJ	GO:0030713	1/100	ovarian follicle cell stalk formation	biological_process	"Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG80P6MJ	GO:0008407	1/100	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG80P6MJ	GO:0007473	1/100	wing disc proximal/distal pattern formation	biological_process	"The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing." [GOC:bf]
EOG80P6MJ	GO:0035003	1/100	subapical complex	cellular_component	"The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938]
EOG80P6MJ	GO:0048052	1/100	R1/R6 cell differentiation	biological_process	"The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid]
EOG80P6MJ	GO:0010001	1/100	glial cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]
EOG80P6MJ	GO:0007446	1/100	imaginal disc growth	biological_process	"The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387]
EOG80P6MJ	GO:0007464	1/100	R3/R4 cell fate commitment	biological_process	"The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
EOG80P6MJ	GO:0005886	1/100	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80P6MJ	GO:0005654	1/100	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG80P6MJ	GO:0007422	1/100	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG80P6MJ	GO:0042676	1/100	compound eye cone cell fate commitment	biological_process	"The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu]
EOG80P6MJ	GO:0035167	1/100	larval lymph gland hemopoiesis	biological_process	"The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385]
EOG80P6MJ	GO:0035222	1/100	wing disc pattern formation	biological_process	"The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf]
EOG80P6MJ	GO:0040008	1/100	regulation of growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]
EOG80P6MJ	GO:0007424	1/100	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG80P6MJ	GO:0007519	1/100	skeletal muscle tissue development	biological_process	"The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
EOG80P6MJ	GO:0050767	1/100	regulation of neurogenesis	biological_process	"Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]
EOG80P6MJ	GO:0016330	1/100	second mitotic wave involved in compound eye morphogenesis	biological_process	"A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224]
EOG80P6MJ	GO:0016787	1/100	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG80P6MJ	GO:0007157	1/100	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]
EOG80P6MJ	GO:0035171	1/100	lamellocyte differentiation	biological_process	"The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104]
EOG80P6MJ	GO:0007419	1/100	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG80P6MJ	GO:0001708	1/100	cell fate specification	biological_process	"The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators]
EOG80P6MJ	GO:0050768	1/100	negative regulation of neurogenesis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]
EOG80P6MJ	GO:0051489	1/100	regulation of filopodium assembly	biological_process	"Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG80P6MJ	GO:0007015	1/100	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG80P6MJ	GO:0048477	1/100	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG80P6MJ	GO:0030718	1/100	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG80P6MJ	GO:0007400	1/100	neuroblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
EOG80P6MJ	GO:0016333	1/100	morphogenesis of follicular epithelium	biological_process	"The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl]
EOG80P6MJ	GO:0030720	1/100	oocyte localization involved in germarium-derived egg chamber formation	biological_process	"Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356]
EOG80P6MJ	GO:0008045	1/100	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG80P6MJ	GO:0007521	1/100	muscle cell fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators]
EOG80P6MJ	GO:0035155	1/100	negative regulation of terminal cell fate specification, open tracheal system	biological_process	"Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [GOC:mtg_sensu, PMID:10684581]
EOG80P6MJ	GO:0005515	1/100	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG80P6MJ	GO:0030708	1/100	germarium-derived female germ-line cyst encapsulation	biological_process	"Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336]
EOG80P6MJ	GO:0008340	1/100	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG80P6MJ	GO:0042688	1/100	crystal cell differentiation	biological_process	"The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
EOG80P6MJ	GO:0035170	1/100	lymph gland crystal cell differentiation	biological_process	"The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
EOG80P6MJ	GO:0046667	1/100	compound eye retinal cell programmed cell death	biological_process	"Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672]
EOG80P6MJ	GO:0007450	1/100	dorsal/ventral pattern formation, imaginal disc	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238]
EOG80P6MJ	GO:0005796	1/100	Golgi lumen	cellular_component	"The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks." [GOC:mah]
EOG80P6MJ	GO:0007346	1/100	regulation of mitotic cell cycle	biological_process	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG80P6MJ	GO:0007447	1/100	imaginal disc pattern formation	biological_process	"The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid]
EOG80P6MJ	GO:0007155	1/100	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG80P6MJ	GO:0007252	1/100	I-kappaB phosphorylation	biological_process	"The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:21772278, PMID:7594468]
EOG80P6MJ	GO:0042067	1/100	establishment of ommatidial planar polarity	biological_process	"The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
EOG80P6MJ	GO:0007314	1/100	oocyte anterior/posterior axis specification	biological_process	"Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG80P6MJ	GO:0030707	1/100	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG80P6MJ	GO:0009986	1/100	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG80P6MJ	GO:0022416	1/100	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG80P6MJ	GO:0007478	1/100	leg disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
EOG80P6MJ	GO:0045747	1/100	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG80P6MJ	GO:0007474	1/100	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG80P6MJ	GO:0007391	1/100	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG80P6MJ	GO:0005768	1/100	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG80P6MJ	GO:0007298	1/100	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG80P6MJ	GO:0030139	1/100	endocytic vesicle	cellular_component	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]
EOG80P6MJ	GO:0045463	1/100	R8 cell development	biological_process	"The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium." [PMID:11880339]
EOG80P6MJ	GO:0046843	1/100	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG80P6MJ	GO:0009952	1/100	anterior/posterior pattern specification	biological_process	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG80P6MJ	GO:0060288	1/100	formation of a compartment boundary	biological_process	"Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph]
EOG80P6MJ	GO:0045595	1/100	regulation of cell differentiation	biological_process	"Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]
EOG80P6MJ	GO:0016348	1/100	imaginal disc-derived leg joint morphogenesis	biological_process	"The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG80P6MJ	GO:0035162	1/100	embryonic hemopoiesis	biological_process	"The stages of blood cell formation that take place within the embryo." [GOC:bf]
EOG80P6MJ	GO:0008347	1/100	glial cell migration	biological_process	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
EOG80P6MJ	GO:0007460	1/100	R8 cell fate commitment	biological_process	"The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883]
EOG80P6MJ	GO:0005829	1/100	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG80P6MJ	GO:0036011	1/100	imaginal disc-derived leg segmentation	biological_process	"Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf]
EOG80P6MJ	GO:0007451	1/100	dorsal/ventral lineage restriction, imaginal disc	biological_process	"Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402]
EOG80P6MJ	GO:0007476	1/100	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG80P6MJ	GO:0042689	1/100	regulation of crystal cell differentiation	biological_process	"Any process that modulates the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]
EOG80P6MJ	GO:0042686	1/100	regulation of cardioblast cell fate specification	biological_process	"Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG80P6MJ	GO:0005912	1/100	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG80P6MJ	GO:0004888	1/100	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG80P6MJ	GO:0008587	1/100	imaginal disc-derived wing margin morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG80P6MJ	GO:0007398	1/100	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG80P6MJ	GO:0004714	1/100	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG80P6MJ	GO:0009608	1/100	response to symbiont	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732]
EOG80P6MJ	GO:0006351	1/100	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG80P6MJ	GO:0007411	1/100	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG80P6MJ	GO:0048666	1/100	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG80P6MJ	GO:0005788	1/100	endoplasmic reticulum lumen	cellular_component	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]
EOG80P6MJ	GO:0007403	1/100	glial cell fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, GOC:mtg_sensu]
EOG80P6MJ	GO:0035165	1/100	embryonic crystal cell differentiation	biological_process	"The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
EOG80P6MJ	GO:0048803	1/100	imaginal disc-derived male genitalia morphogenesis	biological_process	"The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu]
EOG80P6MJ	GO:0048190	1/100	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG80P6MJ	GO:0046331	1/100	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG80P6MJ	GO:0032440	1/100	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG80P6MJ	GO:0036335	1/100	intestinal stem cell homeostasis	biological_process	"Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells." [GOC:nhn, PMID:22042863]
EOG80P6MJ	GO:0035214	1/100	eye-antennal disc development	biological_process	"Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG80P6MJ	GO:0001745	1/100	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG80P6MJ	GO:0048863	1/100	stem cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]
EOG80P6MJ	GO:0046329	1/100	negative regulation of JNK cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG818F4D	GO:0006412	26/89	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG818F4D	GO:0003735	26/89	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG818F4D	GO:0005840	26/89	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG818F4D	GO:0000022	1/89	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG818F4D	GO:0051298	1/89	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG818F4D	GO:0007052	1/89	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8642RV	GO:0035556	27/130	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8642RV	GO:0046872	26/130	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HB10N	GO:0004725	23/89	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8HB10N	GO:0005938	1/89	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8HB10N	GO:0009611	1/89	response to wounding	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators]
EOG8HB10N	GO:0006470	1/89	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8HB10N	GO:0030031	1/89	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG8HB10N	GO:0004438	1/89	phosphatidylinositol-3-phosphatase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64]
EOG8HB10N	GO:0000278	1/89	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8HB10N	GO:0007059	1/89	chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
EOG8HB10N	GO:0008138	1/89	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG8HB10N	GO:0032456	1/89	endocytic recycling	biological_process	"The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635]
EOG8HB10N	GO:0005515	1/89	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8HB10N	GO:0030866	1/89	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8HB10N	GO:0016020	1/89	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RZ1HR	GO:0004674	1/2	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8RZ1HR	GO:0005524	1/2	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8642RQ	GO:0004525	29/109	ribonuclease III activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]
EOG8642RQ	GO:0003723	28/109	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8642RQ	GO:0006396	28/109	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8642RQ	GO:0004386	26/109	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8642RQ	GO:0005524	26/109	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8642RQ	GO:0003676	3/109	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8642RQ	GO:0016891	2/109	endoribonuclease activity, producing 5'-phosphomonoesters	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
EOG8642RQ	GO:0070883	1/109	pre-miRNA binding	molecular_function	"Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA." [PMID:18951094]
EOG8642RQ	GO:0003727	1/109	single-stranded RNA binding	molecular_function	"Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl]
EOG8642RQ	GO:0007367	1/109	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG8642RQ	GO:0016443	1/109	bidentate ribonuclease III activity	molecular_function	"Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference." [PMID:15242644]
EOG8642RQ	GO:0042078	1/109	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG8642RQ	GO:0003725	1/109	double-stranded RNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]
EOG8642RQ	GO:0045448	1/109	mitotic cell cycle, embryonic	biological_process	"The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators]
EOG8642RQ	GO:0046872	1/109	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8642RQ	GO:0031054	1/109	pre-miRNA processing	biological_process	"Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]
EOG8642RQ	GO:0016246	1/109	RNA interference	biological_process	"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
EOG8642RQ	GO:0030727	1/109	germarium-derived female germ-line cyst formation	biological_process	"Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902]
EOG8642RQ	GO:0033227	1/109	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8642RQ	GO:0007294	1/109	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8642RQ	GO:0005737	1/109	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8642RQ	GO:0090501	1/109	RNA phosphodiester bond hydrolysis	biological_process	"The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
EOG8642RQ	GO:0030422	1/109	production of siRNA involved in RNA interference	biological_process	"Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674]
EOG8642RQ	GO:0035087	1/109	siRNA loading onto RISC involved in RNA interference	biological_process	"The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference." [GOC:bf, GOC:mah, PMID:14512631]
EOG8642RQ	GO:0035196	1/109	production of miRNAs involved in gene silencing by miRNA	biological_process	"Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein." [GOC:dph, GOC:tb, PMID:15066275, PMID:15066283]
EOG8642RQ	GO:0090502	1/109	RNA phosphodiester bond hydrolysis, endonucleolytic	biological_process	"The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
EOG8642RQ	GO:0007279	1/109	pole cell formation	biological_process	"Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
EOG8642RQ	GO:0016442	1/109	RISC complex	cellular_component	"A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]
EOG8642RQ	GO:0005515	1/109	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8642RQ	GO:0048813	1/109	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8642RS	GO:0005524	25/106	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8642RS	GO:0005856	21/106	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8642RS	GO:0004715	17/106	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8642RS	GO:0004713	8/106	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8642RS	GO:0016020	4/106	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8642RS	GO:0035556	3/106	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8642RS	GO:0007259	1/106	JAK-STAT cascade	biological_process	"Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028]
EOG8642RS	GO:0016318	1/106	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG8642RS	GO:0007399	1/106	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8642RS	GO:0048477	1/106	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8642RS	GO:0045610	1/106	regulation of hemocyte differentiation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG8642RS	GO:0006355	1/106	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8642RS	GO:0046425	1/106	regulation of JAK-STAT cascade	biological_process	"Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf]
EOG8642RS	GO:0012505	1/106	endomembrane system	cellular_component	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]
EOG8642RS	GO:0045475	1/106	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8642RS	GO:0007616	1/106	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8642RS	GO:0016301	1/106	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8642RS	GO:0042386	1/106	hemocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723]
EOG8642RS	GO:0007442	1/106	hindgut morphogenesis	biological_process	"The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
EOG8642RS	GO:0007350	1/106	blastoderm segmentation	biological_process	"The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8642RS	GO:0035171	1/106	lamellocyte differentiation	biological_process	"The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104]
EOG8642RS	GO:0006959	1/106	humoral immune response	biological_process	"An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]
EOG8642RS	GO:0042078	1/106	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG8642RS	GO:0007365	1/106	periodic partitioning	biological_process	"The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma]
EOG8642RS	GO:0007260	1/106	tyrosine phosphorylation of STAT protein	biological_process	"The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594]
EOG8642RS	GO:0001745	1/106	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8642RS	GO:0060031	1/106	mediolateral intercalation	biological_process	"The interdigitation of cells along the mediolateral axis during gastrulation." [GOC:dgf, GOC:dph, PMID:12062082]
EOG8642RS	GO:0007455	1/106	eye-antennal disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
EOG8642RS	GO:0035010	1/106	encapsulation of foreign target	biological_process	"Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920]
EOG8642RS	GO:0004672	1/106	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8642RS	GO:0007298	1/106	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8642RS	GO:0045317	1/106	equator specification	biological_process	"The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves." [GOC:bf]
EOG8642RS	GO:0030713	1/106	ovarian follicle cell stalk formation	biological_process	"Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8642RS	GO:0016476	1/106	regulation of embryonic cell shape	biological_process	"Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb]
EOG8642RS	GO:0005737	1/106	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8642RS	GO:0008283	1/106	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8642RS	GO:0007262	1/106	STAT protein import into nucleus	biological_process	"The directed movement of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028]
EOG8642RS	GO:0006351	1/106	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8642RS	GO:0006955	1/106	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8642RS	GO:0048749	1/106	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8642RS	GO:0030097	1/106	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG8642RS	GO:0007530	1/106	sex determination	biological_process	"Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732]
EOG8642RS	GO:0003383	1/106	apical constriction	biological_process	"The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8642RS	GO:0006968	1/106	cellular defense response	biological_process	"A defense response that is mediated by cells." [GOC:ebc]
EOG8642RS	GO:0006468	1/106	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8642RS	GO:0030707	1/106	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8642RS	GO:0048103	1/106	somatic stem cell division	biological_process	"The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089]
EOG8642RS	GO:0007480	1/106	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8642RS	GO:0007424	1/106	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8642RS	GO:0042067	1/106	establishment of ommatidial planar polarity	biological_process	"The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
EOG8642RS	GO:0007476	1/106	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8642RS	GO:0051607	1/106	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG8642RS	GO:0035206	1/106	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8642RS	GO:0001751	1/106	compound eye photoreceptor cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
EOG8642RS	GO:0035172	1/106	hemocyte proliferation	biological_process	"The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG8642RS	GO:0035167	1/106	larval lymph gland hemopoiesis	biological_process	"The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385]
EOG8642RS	GO:0019827	1/106	stem cell population maintenance	biological_process	"The process by which an organism or tissue maintains a population of stem cells of a single type.  This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437]
EOG8642RS	GO:0007538	1/106	primary sex determination	biological_process	"The sex determination process that results in the initial specification of sexual status of an individual organism." [GOC:mah]
EOG85HVD9	GO:0005549	8/23	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG85HVD9	GO:0006810	7/23	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG85HVD9	GO:0007608	1/23	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG85HVD9	GO:0050896	1/23	response to stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
EOG8F7R0T	GO:0045475	1/58	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8F7R0T	GO:0043153	1/58	entrainment of circadian clock by photoperiod	biological_process	"The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl]
EOG8PRW6H	GO:0042384	1/69	cilium assembly	biological_process	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]
EOG8FJBPM	GO:0005622	25/102	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8FJBPM	GO:0007165	24/102	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8FJBPM	GO:0016021	24/102	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FJBPM	GO:0007275	23/102	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8FJBPM	GO:0004872	23/102	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8FJBPM	GO:0016199	1/102	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG8FJBPM	GO:0017154	1/102	semaphorin receptor activity	molecular_function	"Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:15239958]
EOG8FJBPM	GO:0071889	1/102	14-3-3 protein binding	molecular_function	"Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins." [GOC:cna, GOC:mah, InterPro:IPR000308, PMID:15167810, PMID:19575580, PR:000003237]
EOG8FJBPM	GO:0008201	1/102	heparin binding	molecular_function	"Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]
EOG8FJBPM	GO:0007411	1/102	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8FJBPM	GO:0005515	1/102	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FJBPM	GO:2000305	1/102	semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance	biological_process	"Any semaphorin-plexin signaling pathway that is involved in regulation of photoreceptor cell axon guidance." [GOC:obol]
EOG8FJBPM	GO:0008045	1/102	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8B2WB8	GO:0005509	23/103	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8B2WB8	GO:0008270	21/103	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8B2WB8	GO:0005737	8/103	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8B2WB8	GO:0008092	1/103	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8B2WB8	GO:0016014	1/103	dystrobrevin complex	cellular_component	"A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex." [PMID:15117830, PMID:16710609]
EOG8B2WB8	GO:0005328	1/103	neurotransmitter:sodium symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
EOG8B2WB8	GO:0016021	1/103	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG81ZHRG	GO:0046872	4/10	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81ZHRG	GO:0003676	3/10	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG81ZHRG	GO:0003677	2/10	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81ZHRG	GO:0008270	1/10	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG81ZHRG	GO:0005634	1/10	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG818F4T	GO:0004930	1/5	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG818F4T	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG86Q98Z	GO:0003676	27/123	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88973R	GO:0046872	2/3	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8G4K48	GO:0030529	4/94	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8G4K48	GO:0019013	3/94	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8G4K48	GO:0003723	2/94	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8G4K48	GO:0005829	1/94	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8G4K48	GO:0005634	1/94	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8G4K48	GO:0006396	1/94	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8G4K48	GO:0000001	1/94	mitochondrion inheritance	biological_process	"The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764]
EOG8G4K48	GO:0035186	1/94	syncytial blastoderm mitotic cell cycle	biological_process	"Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238]
EOG8G4K48	GO:0005737	1/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8G4K48	GO:0048102	1/94	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8G4K48	GO:0035071	1/94	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8G4K48	GO:0007053	1/94	spindle assembly involved in male meiosis	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah]
EOG8G4K48	GO:0007140	1/94	male meiosis	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
EOG85MQKK	GO:0016021	18/54	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85MQKK	GO:0005272	18/54	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8RJJFF	GO:0046872	18/83	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8RJJFF	GO:0003676	18/83	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RJJFF	GO:0005524	18/83	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8RJJFF	GO:0008026	16/83	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8RJJFF	GO:0004386	4/83	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8RJJFF	GO:0008152	1/83	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8QC3MN	GO:0030246	46/187	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8QC3MN	GO:0006810	2/187	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8QC3MN	GO:0016021	2/187	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QC3MN	GO:0016020	1/187	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QC3MN	GO:0008233	1/187	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8N333V	GO:0006355	22/105	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8N333V	GO:0003677	21/105	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8N333V	GO:0048813	1/105	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8N333V	GO:0043565	1/105	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8N333V	GO:0007399	1/105	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8N333V	GO:0046872	1/105	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8N333V	GO:0007605	1/105	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8QC3M4	GO:0008270	27/93	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8QC3M4	GO:0006355	26/93	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8QC3M4	GO:0006352	26/93	DNA-templated transcription, initiation	biological_process	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]
EOG8QC3M4	GO:0003743	3/93	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8QC3M4	GO:0005634	2/93	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8QC3M4	GO:0001174	1/93	transcriptional start site selection at RNA polymerase II promoter	biological_process	"Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104]
EOG8QC3M4	GO:0006357	1/93	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8QC3M4	GO:0051101	1/93	regulation of DNA binding	biological_process	"Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb]
EOG8QC3M4	GO:0006367	1/93	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG8QC3M4	GO:0005667	1/93	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8QC3M4	GO:0008134	1/93	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8QC3M4	GO:0005515	1/93	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QC3M2	GO:0005524	26/95	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QC3M2	GO:0006281	26/95	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8QC3M2	GO:0003684	26/95	damaged DNA binding	molecular_function	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
EOG8QC3M2	GO:0008094	26/95	DNA-dependent ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl]
EOG8QC3M2	GO:0016740	1/95	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8QC3M2	GO:0010569	1/95	regulation of double-strand break repair via homologous recombination	biological_process	"Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]
EOG8QC3M2	GO:0009994	1/95	oocyte differentiation	biological_process	"The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu]
EOG8QC3M2	GO:0005515	1/95	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QC3M2	GO:0005634	1/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8QC3M2	GO:0007143	1/95	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8QC3M2	GO:0008298	1/95	intracellular mRNA localization	biological_process	"Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai]
EOG8QC3M2	GO:0048477	1/95	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8QC3M2	GO:0009949	1/95	polarity specification of anterior/posterior axis	biological_process	"Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators]
EOG8QC3M2	GO:0030717	1/95	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG8QC3M2	GO:0007294	1/95	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8QC3M2	GO:0045003	1/95	double-strand break repair via synthesis-dependent strand annealing	biological_process	"SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855]
EOG8QC3M2	GO:0009951	1/95	polarity specification of dorsal/ventral axis	biological_process	"Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators]
EOG8QRKKJ	GO:0016021	19/53	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QRKKJ	GO:0046331	1/53	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8QRKKJ	GO:0030097	1/53	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG8QRKKJ	GO:0005802	1/53	trans-Golgi network	cellular_component	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]
EOG8QRKKJ	GO:0048471	1/53	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8KPWS1	GO:0008033	24/87	tRNA processing	biological_process	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]
EOG8KPWS1	GO:0008168	24/87	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8KPWS1	GO:0006364	24/87	rRNA processing	biological_process	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
EOG8KPWS1	GO:0003723	24/87	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8KPWS1	GO:0006396	2/87	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8KPWS1	GO:0018160	2/87	peptidyl-pyrromethane cofactor linkage	biological_process	"The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine." [CHEBI:30410, RESID:AA0252]
EOG8KPWS1	GO:0001651	2/87	dense fibrillar component	cellular_component	"A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561]
EOG8KPWS1	GO:0033014	2/87	tetrapyrrole biosynthetic process	biological_process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah]
EOG8KPWS1	GO:0004418	2/87	hydroxymethylbilane synthase activity	molecular_function	"Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+)." [EC:2.5.1.61, RHEA:13188]
EOG8KPWS1	GO:0015030	1/87	Cajal body	cellular_component	"A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]
EOG8KPWS1	GO:0030532	1/87	small nuclear ribonucleoprotein complex	cellular_component	"A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8KPWS1	GO:0005730	1/87	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8KPWS1	GO:0030529	1/87	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8KPWS1	GO:0051297	1/87	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8KPWS1	GO:0005732	1/87	small nucleolar ribonucleoprotein complex	cellular_component	"A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type." [GOC:krc, GOC:mah, ISBN:0879695897]
EOG8RR8ZT	GO:0051539	23/91	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8RR8ZT	GO:0016020	23/91	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RR8ZT	GO:0016651	21/91	oxidoreductase activity, acting on NAD(P)H	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8RR8ZT	GO:0003954	2/91	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8RR8ZT	GO:0005739	1/91	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8VX4MM	GO:0016020	78/216	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8VX4MM	GO:0016021	3/216	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VX4MM	GO:0005515	1/216	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VX4MM	GO:0097206	1/216	nephrocyte filtration	biological_process	"The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929]
EOG8VX4MM	GO:0006909	1/216	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8VX4MM	GO:0005917	1/216	nephrocyte diaphragm	cellular_component	"A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]
EOG8W6R8R	GO:0016021	2/114	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W6R8R	GO:0050808	1/114	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG8W6R8R	GO:0051124	1/114	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8W6R8R	GO:0007155	1/114	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8W6R8R	GO:0045211	1/114	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8W6R8R	GO:0043005	1/114	neuron projection	cellular_component	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
EOG8W6R8R	GO:0016200	1/114	synaptic target attraction	biological_process	"The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437]
EOG8W6R8R	GO:0034116	1/114	positive regulation of heterotypic cell-cell adhesion	biological_process	"Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add]
EOG8W6R8R	GO:0031005	1/114	filamin binding	molecular_function	"Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain." [GOC:mah, PMID:11336782]
EOG8W6R8R	GO:0005515	1/114	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8W6R8R	GO:0042802	1/114	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG8W6R8R	GO:0097090	1/114	presynaptic membrane organization	biological_process	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction." [GOC:BHF, GOC:pr, GOC:sjp, PMID:19730411]
EOG8W6R8R	GO:0043025	1/114	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8W6R8R	GO:0042051	1/114	compound eye photoreceptor development	biological_process	"The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
EOG8W6R8R	GO:0046982	1/114	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8W6R8R	GO:0005887	1/114	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W6R8R	GO:0005578	1/114	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG8W6R8R	GO:0048499	1/114	synaptic vesicle membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle." [GOC:dph, GOC:jl, GOC:mah, PMID:10620806]
EOG8W6R8R	GO:0048790	1/114	maintenance of presynaptic active zone structure	biological_process	"The process in which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr]
EOG8W6R8R	GO:0005737	1/114	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8W6R8R	GO:0001941	1/114	postsynaptic membrane organization	biological_process	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph, GOC:pr]
EOG8W6R8R	GO:0008045	1/114	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8W6R8R	GO:0045467	1/114	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8W6R8R	GO:0031122	1/114	cytoplasmic microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
EOG8W6R8R	GO:2000331	1/114	regulation of terminal button organization	biological_process	"Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah]
EOG8W6R8R	GO:0001745	1/114	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8W6R8R	GO:0048058	1/114	compound eye corneal lens development	biological_process	"The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells." [GOC:jid]
EOG8W6R8R	GO:0008360	1/114	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8W6R8R	GO:0022416	1/114	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8W6R8R	GO:0030054	1/114	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8W6R8R	GO:0007274	1/114	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8W6R8R	GO:0008039	1/114	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8W6R8R	GO:0042803	1/114	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8W6R8R	GO:0040017	1/114	positive regulation of locomotion	biological_process	"Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]
EOG8W6R8R	GO:0031594	1/114	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8W6R8R	GO:0004714	1/114	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8W6R8R	GO:0034110	1/114	regulation of homotypic cell-cell adhesion	biological_process	"Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add]
EOG88SK9S	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG86MF0S	GO:0001522	29/93	pseudouridine synthesis	biological_process	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]
EOG86MF0S	GO:0009982	29/93	pseudouridine synthase activity	molecular_function	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]
EOG86MF0S	GO:0003723	29/93	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8W6R8V	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W6R8V	GO:0046872	2/5	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WSZRQ	GO:0080019	5/14	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG85MQKS	GO:0004867	66/258	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG85MQKS	GO:0004064	3/258	arylesterase activity	molecular_function	"Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2]
EOG85MQKS	GO:0005576	1/258	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG81G5J9	GO:0046872	2/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81G5J9	GO:0003676	1/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG866Z30	GO:0034587	1/86	piRNA metabolic process	biological_process	"The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]
EOG866Z30	GO:0046331	1/86	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG866Z30	GO:0005739	1/86	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8P5NRX	GO:0008270	66/179	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8P5NRX	GO:0005634	2/179	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8P5NRX	GO:0032183	1/179	SUMO binding	molecular_function	"Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO." [GOC:mah]
EOG8P5NRX	GO:0045893	1/179	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8P5NRX	GO:0004842	1/179	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8P5NRX	GO:0070201	1/179	regulation of establishment of protein localization	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah]
EOG8P5NRX	GO:0016567	1/179	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8P5NRX	GO:0005737	1/179	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8P5NRX	GO:0033768	1/179	SUMO-targeted ubiquitin ligase complex	cellular_component	"A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes." [GOC:vw, PMID:17762864, PMID:17762865]
EOG8P5NRX	GO:0007530	1/179	sex determination	biological_process	"Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732]
EOG8P5NRX	GO:0001103	1/179	RNA polymerase II repressing transcription factor binding	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription." [GOC:txnOH]
EOG8P5NRX	GO:0043393	1/179	regulation of protein binding	biological_process	"Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators]
EOG8P5NRX	GO:0022008	1/179	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8D296V	GO:0005634	6/48	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84XN0N	GO:0016301	1/87	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8K6JM4	GO:0000166	28/101	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8K6JM4	GO:0003676	24/101	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K6JM4	GO:0042048	1/101	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG8K6JM4	GO:0005634	1/101	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8K6JM4	GO:0022611	1/101	dormancy process	biological_process	"A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated." [GOC:isa_complete, GOC:PO_curators, PO_REF:00009]
EOG8K6JM4	GO:0035206	1/101	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8K6JM4	GO:0009987	1/101	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8K6JM4	GO:0003729	1/101	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8K6JM4	GO:0007268	1/101	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8K6JM4	GO:0007275	1/101	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG883GNT	GO:0003964	338/1363	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG883GNT	GO:0003723	333/1363	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG883GNT	GO:0008270	44/1363	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG883GNT	GO:0003676	19/1363	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG883GNT	GO:0004519	4/1363	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG883GNT	GO:0004523	3/1363	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG883GNT	GO:0006511	2/1363	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG883GNT	GO:0046872	2/1363	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG883GNT	GO:0005634	1/1363	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG883GNT	GO:0016020	1/1363	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG883GNT	GO:0034450	1/1363	ubiquitin-ubiquitin ligase activity	molecular_function	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]
EOG883GNT	GO:0005524	1/1363	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG883GNT	GO:0004674	1/1363	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG883GNT	GO:0015074	1/1363	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG883GNT	GO:0006281	1/1363	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG883GNT	GO:0000723	1/1363	telomere maintenance	biological_process	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
EOG883GNT	GO:0003677	1/1363	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG883GNT	GO:0000786	1/1363	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG883GNT	GO:0003678	1/1363	DNA helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
EOG883GNT	GO:0016758	1/1363	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG883GNT	GO:0006334	1/1363	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG883GNT	GO:0000151	1/1363	ubiquitin ligase complex	cellular_component	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
EOG8NGK1J	GO:0006801	24/102	superoxide metabolic process	biological_process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl]
EOG8NGK1J	GO:0046872	24/102	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NGK1J	GO:0055114	24/102	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8NGK1J	GO:0055085	4/102	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8NGK1J	GO:0016021	4/102	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X99X4	GO:0005524	23/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X99X4	GO:0004386	22/104	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8X99X4	GO:0003677	22/104	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X99X4	GO:0016740	2/104	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8X99X4	GO:0016020	1/104	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8X99X4	GO:0005272	1/104	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8X99X4	GO:0003676	1/104	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG876NDP	GO:0006614	28/89	SRP-dependent cotranslational protein targeting to membrane	biological_process	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]
EOG876NDP	GO:0008312	27/89	7S RNA binding	molecular_function	"Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]
EOG876NDP	GO:0005786	24/89	signal recognition particle, endoplasmic reticulum targeting	cellular_component	"A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732]
EOG876NDP	GO:0048500	3/89	signal recognition particle	cellular_component	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]
EOG876NDP	GO:0033227	1/89	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8DZ48C	GO:0008270	20/63	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DZ48C	GO:0043565	18/63	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8DZ48C	GO:0003700	18/63	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8DZ48C	GO:0005634	15/63	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8DZ48C	GO:0006357	1/63	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8DZ48C	GO:0006366	1/63	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8DZ48C	GO:0000981	1/63	RNA polymerase II transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
EOG8QFZV1	GO:0016491	24/86	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8QFZV1	GO:0016152	1/86	mercury (II) reductase activity	molecular_function	"Catalysis of the reaction: H(+) + Hg + NADP(+) = Hg(2+) + NADPH." [EC:1.16.1.1, RHEA:23859]
EOG8QFZV1	GO:0008860	1/86	ferredoxin-NAD+ reductase activity	molecular_function	"Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+." [EC:1.18.1.3]
EOG876NDT	GO:0003677	8/55	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG876NDT	GO:0006310	2/55	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG876NDT	GO:0015074	2/55	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG876NDT	GO:0003676	1/55	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG84N17F	GO:0000179	3/64	rRNA (adenine-N6,N6-)-dimethyltransferase activity	molecular_function	"Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410]
EOG8HB131	GO:0008121	25/82	ubiquinol-cytochrome-c reductase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]
EOG8HB131	GO:0005811	1/82	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8NKFB8	GO:0004089	104/367	carbonate dehydratase activity	molecular_function	"Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1]
EOG8NKFB8	GO:0006730	100/367	one-carbon metabolic process	biological_process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
EOG8NKFB8	GO:0008270	99/367	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NKFB8	GO:0031233	1/367	intrinsic component of external side of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah]
EOG8WDGTR	GO:0006813	1/3	potassium ion transport	biological_process	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8WDGTR	GO:0005890	1/3	sodium:potassium-exchanging ATPase complex	cellular_component	"Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732]
EOG8WDGTR	GO:0006814	1/3	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8TXF5R	GO:0007165	1/27	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8TXF5R	GO:0005622	1/27	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8DRCV1	GO:0006508	24/81	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8DRCV1	GO:0016787	3/81	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG876NDC	GO:0016787	24/115	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG876NDC	GO:0052689	3/115	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG876NDC	GO:0003990	2/115	acetylcholinesterase activity	molecular_function	"Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
EOG876NDC	GO:0004104	1/115	cholinesterase activity	molecular_function	"Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8]
EOG876NDB	GO:0005524	142/420	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG876NDB	GO:0006950	24/420	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG876NDB	GO:0005875	8/420	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG876NDB	GO:0009408	7/420	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG876NDB	GO:0032440	7/420	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG876NDB	GO:0001666	6/420	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG876NDB	GO:0035080	6/420	heat shock-mediated polytene chromosome puffing	biological_process	"The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus." [GOC:bf, PMID:12543962]
EOG876NDB	GO:0006986	4/420	response to unfolded protein	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl]
EOG876NDB	GO:0005811	3/420	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG876NDB	GO:0005515	2/420	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG876NDB	GO:0031427	2/420	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG876NDB	GO:0016021	1/420	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG876NDB	GO:0031209	1/420	SCAR complex	cellular_component	"A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:pg, PMID:12181570]
EOG876NDB	GO:0042594	1/420	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG876NDB	GO:0005634	1/420	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG876NDB	GO:0006909	1/420	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG876NDB	GO:0007528	1/420	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG876NDB	GO:0007010	1/420	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG876NDB	GO:0030866	1/420	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG876NDB	GO:0007520	1/420	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG876NDB	GO:0000902	1/420	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG876NDB	GO:0048471	1/420	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG876NDB	GO:0030031	1/420	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG876NDB	GO:0008407	1/420	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG876NDB	GO:0008360	1/420	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG876NDB	GO:0008340	1/420	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG876NDB	GO:0001764	1/420	neuron migration	biological_process	"The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]
EOG876NDB	GO:0005886	1/420	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG876NDB	GO:0007417	1/420	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG876NDB	GO:0030036	1/420	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG876NDB	GO:0007409	1/420	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG876NDB	GO:0022008	1/420	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8XPSW4	GO:0005524	36/114	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8XPSW4	GO:0004674	28/114	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8XPSW4	GO:0004672	5/114	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8XPSW4	GO:0004709	3/114	MAP kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
EOG8XPSW4	GO:0004713	1/114	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8XPSW4	GO:0046872	1/114	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XPSW4	GO:0006963	1/114	positive regulation of antibacterial peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475]
EOG8XPSW4	GO:0051607	1/114	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG8XPSW4	GO:0007256	1/114	activation of JNKK activity	biological_process	"The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549]
EOG8XPSW4	GO:0007249	1/114	I-kappaB kinase/NF-kappaB signaling	biological_process	"The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:12773372, Reactome:REACT_13696.1]
EOG8XPSW4	GO:0004706	1/114	JUN kinase kinase kinase activity	molecular_function	"Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs)." [GOC:bf]
EOG8XPSW4	GO:0010506	1/114	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8XPSW4	GO:0007391	1/114	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8XPSW4	GO:0048802	1/114	notum morphogenesis	biological_process	"The process in which the anatomical structures of the dorsal part of the body are generated and organized." [GOC:jid]
EOG8XPSW4	GO:0006955	1/114	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8XPSW4	GO:0006915	1/114	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8XPSW4	GO:0016318	1/114	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG8XPSW4	GO:0050829	1/114	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8XPSW4	GO:0048749	1/114	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8XPSW4	GO:0045087	1/114	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8XPSW4	GO:0071222	1/114	cellular response to lipopolysaccharide	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]
EOG8XPSW4	GO:0046330	1/114	positive regulation of JNK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8XPSW4	GO:0006964	1/114	positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
EOG8XPSW4	GO:0006468	1/114	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8XPSW4	GO:0016301	1/114	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8XPSW4	GO:0007254	1/114	JNK cascade	biological_process	"An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974]
EOG8XPSW4	GO:0005515	1/114	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG876NDD	GO:0016021	46/177	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG876NDD	GO:0005886	39/177	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG876NDD	GO:0004948	27/177	calcitonin receptor activity	molecular_function	"Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:21649645]
EOG876NDD	GO:0004930	21/177	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG876NDD	GO:0008188	2/177	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG876NDD	GO:0007186	2/177	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG876NDD	GO:0007218	2/177	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG876NDD	GO:0016020	2/177	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG876NDD	GO:0005887	1/177	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG876NDD	GO:0009755	1/177	hormone-mediated signaling pathway	biological_process	"A series of molecular signals mediated by the detection of a hormone." [GOC:sm]
EOG876NDD	GO:0008036	1/177	diuretic hormone receptor activity	molecular_function	"Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling]
EOG876NDD	GO:0008049	1/177	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8XPSW6	GO:0008270	224/674	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8XPSW6	GO:0004222	224/674	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8XPSW6	GO:0006909	1/674	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8XPSW6	GO:0016020	1/674	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XPSW6	GO:0004175	1/674	endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8XPSW6	GO:0032504	1/674	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8XPSW6	GO:0006508	1/674	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8XPSW6	GO:0046331	1/674	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8XPSW6	GO:0005615	1/674	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8XPSW6	GO:0022008	1/674	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG81K1T5	GO:0051287	73/226	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG81K1T5	GO:0016616	67/226	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG81K1T5	GO:0030267	4/226	glyoxylate reductase (NADP) activity	molecular_function	"Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [EC:1.1.1.79]
EOG81K1T5	GO:0047964	2/226	glyoxylate reductase activity	molecular_function	"Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH." [EC:1.1.1.26, MetaCyc:GLYCOLATE-REDUCTASE-RXN]
EOG81K1T5	GO:0004617	1/226	phosphoglycerate dehydrogenase activity	molecular_function	"Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95]
EOG81K1T5	GO:0005576	1/226	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG81K1T5	GO:0048037	1/226	cofactor binding	molecular_function	"Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]
EOG81K1T5	GO:0003676	1/226	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8F4VRM	GO:0005524	26/101	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8F4VRM	GO:0004672	21/101	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8F4VRM	GO:0004674	2/101	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8F4VRM	GO:0004709	2/101	MAP kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
EOG8F4VRM	GO:0004702	1/101	receptor signaling protein serine/threonine kinase activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah]
EOG8F4VRM	GO:0035220	1/101	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8F4VRM	GO:0023014	1/101	signal transduction by protein phosphorylation	biological_process	"A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling]
EOG8F4VRM	GO:0008366	1/101	axon ensheathment	biological_process	"Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437]
EOG8F4VRM	GO:0006468	1/101	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8F4VRM	GO:0008065	1/101	establishment of blood-nerve barrier	biological_process	"The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier." [GOC:dgh]
EOG8F4VRM	GO:0008362	1/101	chitin-based embryonic cuticle biosynthetic process	biological_process	"Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232]
EOG8F4VRM	GO:0005737	1/101	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86T5GZ	GO:0005515	1/90	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG86T5GZ	GO:0006606	1/90	protein import into nucleus	biological_process	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]
EOG86T5GZ	GO:0019730	1/90	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG86T5GZ	GO:0051028	1/90	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG86T5GZ	GO:0005643	1/90	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG86T5GZ	GO:0007424	1/90	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG86T5GZ	GO:0022008	1/90	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG86T5GZ	GO:0046826	1/90	negative regulation of protein export from nucleus	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf]
EOG86T5GZ	GO:0005635	1/90	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG86T5GZ	GO:0035147	1/90	branch fusion, open tracheal system	biological_process	"Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584]
EOG86T5GZ	GO:0031965	1/90	nuclear membrane	cellular_component	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
EOG84BDJ1	GO:0005198	27/92	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG84BDJ1	GO:0005615	1/92	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG84BDJ1	GO:0050829	1/92	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG84BDJ1	GO:0060074	1/92	synapse maturation	biological_process	"The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development." [GOC:dph, GOC:ef]
EOG84BDJ1	GO:0007269	1/92	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG84BDJ1	GO:0005886	1/92	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG84BDJ1	GO:0008021	1/92	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG84BDJ1	GO:0031122	1/92	cytoplasmic microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
EOG84BDJ1	GO:0016082	1/92	synaptic vesicle priming	biological_process	"The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342]
EOG84BDJ1	GO:0007528	1/92	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG84BDJ1	GO:0005811	1/92	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG84BDJ1	GO:0005783	1/92	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG84BDJ1	GO:0008088	1/92	axon cargo transport	biological_process	"The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194]
EOG84BDJ1	GO:0046488	1/92	phosphatidylinositol metabolic process	biological_process	"The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [CHEBI:28874, ISBN:0198506732]
EOG8X9B0N	GO:0003676	2/429	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X9B0N	GO:0003899	1/429	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8X9B0N	GO:0003677	1/429	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X9B0N	GO:0006351	1/429	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8X9B0N	GO:0031012	1/429	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8X9B0N	GO:0004222	1/429	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8X9B0N	GO:0008270	1/429	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WHC13	GO:0003824	19/69	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8WHC13	GO:0005777	1/69	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8WHC13	GO:0006950	1/69	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG880MBV	GO:0016772	28/93	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG880MBV	GO:0004305	3/93	ethanolamine kinase activity	molecular_function	"Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine." [EC:2.7.1.82, RHEA:13072]
EOG880MBV	GO:0016319	1/93	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG880MBV	GO:0008306	1/93	associative learning	biological_process	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
EOG880MBV	GO:0007420	1/93	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG880MBV	GO:0016301	1/93	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG880MBV	GO:0046337	1/93	phosphatidylethanolamine metabolic process	biological_process	"The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [CHEBI:16038, GOC:curators, ISBN:0198506732]
EOG880MBV	GO:0046959	1/93	habituation	biological_process	"A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089]
EOG880MBV	GO:0007616	1/93	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG880MBV	GO:0009612	1/93	response to mechanical stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]
EOG880MBV	GO:0001666	1/93	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG880MBV	GO:0004103	1/93	choline kinase activity	molecular_function	"Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+)." [EC:2.7.1.32, RHEA:12840]
EOG880MBV	GO:0005524	1/93	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG880MBV	GO:0055059	1/93	asymmetric neuroblast division	biological_process	"The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
EOG880MBV	GO:0016310	1/93	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG880MBV	GO:0006646	1/93	phosphatidylethanolamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732]
EOG880MBV	GO:0007638	1/93	mechanosensory behavior	biological_process	"Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators]
EOG880MBV	GO:0005737	1/93	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG880MBV	GO:0006657	1/93	CDP-choline pathway	biological_process	"The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [ISBN:0471331309, MetaCyc:PWY3O-450]
EOG841SRM	GO:0005216	25/73	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG841SRM	GO:0016021	25/73	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG841SRM	GO:0019934	1/73	cGMP-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling]
EOG841SRM	GO:0071805	1/73	potassium ion transmembrane transport	biological_process	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
EOG841SRM	GO:0005249	1/73	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG841SRM	GO:0005223	1/73	intracellular cGMP activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG841SRM	GO:0017071	1/73	intracellular cyclic nucleotide activated cation channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah]
EOG841SRM	GO:0007603	1/73	phototransduction, visible light	biological_process	"The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
EOG841SRM	GO:0005221	1/73	intracellular cyclic nucleotide activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG841SRM	GO:0042391	1/73	regulation of membrane potential	biological_process	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
EOG841SRM	GO:0030553	1/73	cGMP binding	molecular_function	"Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai]
EOG841SRM	GO:0001666	1/73	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG841SRM	GO:0005222	1/73	intracellular cAMP activated cation channel activity	molecular_function	"Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
EOG841SRM	GO:0004692	1/73	cGMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
EOG841SRM	GO:0005887	1/73	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG841SRM	GO:0006812	1/73	cation transport	biological_process	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8KWN72	GO:0006457	26/105	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8KWN72	GO:0003755	6/105	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8KWN72	GO:0018208	1/105	peptidyl-proline modification	biological_process	"The modification of peptidyl-proline." [GOC:go_curators]
EOG8KWN72	GO:0051924	1/105	regulation of calcium ion transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8KWN72	GO:0000413	1/105	protein peptidyl-prolyl isomerization	biological_process	"The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570]
EOG8KWN72	GO:0007422	1/105	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8KWN72	GO:0050908	1/105	detection of light stimulus involved in visual perception	biological_process	"The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
EOG8KWN72	GO:0016027	1/105	inaD signaling complex	cellular_component	"A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815]
EOG8KWN72	GO:0005515	1/105	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KWN72	GO:0005528	1/105	FK506 binding	molecular_function	"Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506." [GOC:jl]
EOG86T5GM	GO:0016787	17/63	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG86T5GM	GO:0006470	1/63	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG86T5GM	GO:0016791	1/63	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG86T5GM	GO:0005794	1/63	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8J3ZWT	GO:0004736	27/113	pyruvate carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847]
EOG8J3ZWT	GO:0006094	27/113	gluconeogenesis	biological_process	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]
EOG8J3ZWT	GO:0005524	27/113	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8J3ZWT	GO:0003677	27/113	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8J3ZWT	GO:0004075	27/113	biotin carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]
EOG8J3ZWT	GO:0046872	26/113	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8J3ZWT	GO:0005875	1/113	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8J3ZWT	GO:0016829	1/113	lyase activity	molecular_function	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
EOG8J3ZWT	GO:0003824	1/113	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8J3ZWT	GO:0005811	1/113	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8P2SGS	GO:0016021	6/204	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8P2SGS	GO:0055085	5/204	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8P2SGS	GO:0005886	1/204	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8P2SGS	GO:0003009	1/204	skeletal muscle contraction	biological_process	"A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle]
EOG80P6PV	GO:0005634	2/367	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80P6PV	GO:0032440	2/367	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG80P6PV	GO:0007411	2/367	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG80P6PV	GO:0003705	2/367	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG80P6PV	GO:0006366	2/367	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG80P6PV	GO:0045944	2/367	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG80P6PV	GO:0007417	2/367	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG80P6PV	GO:0007399	1/367	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG80P6PV	GO:0009950	1/367	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG80P6PV	GO:0006355	1/367	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG80P6PV	GO:0006909	1/367	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG80P6PV	GO:0010468	1/367	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG80P6PV	GO:0007420	1/367	brain development	biological_process	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
EOG80P6PV	GO:0008134	1/367	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG80P6PV	GO:0007442	1/367	hindgut morphogenesis	biological_process	"The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
EOG80P6PV	GO:0007350	1/367	blastoderm segmentation	biological_process	"The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG80P6PV	GO:0070983	1/367	dendrite guidance	biological_process	"The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
EOG80P6PV	GO:0005737	1/367	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG80P6PV	GO:0060810	1/367	intracellular mRNA localization involved in pattern specification process	biological_process	"Any process in which mRNA is transported to, or maintained in, a specific location within an oocyte that results in a pattern being established in the embryo." [GOC:dph, GOC:sdb_2009, GOC:tb]
EOG80P6PV	GO:0030111	1/367	regulation of Wnt signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]
EOG80P6PV	GO:0002168	1/367	instar larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG80P6PV	GO:0003677	1/367	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80P6PV	GO:0035120	1/367	post-embryonic appendage morphogenesis	biological_process	"The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]
EOG80P6PV	GO:0008301	1/367	DNA binding, bending	molecular_function	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]
EOG80P6PV	GO:0006357	1/367	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG80P6PV	GO:0043565	1/367	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG80P6PV	GO:0003700	1/367	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG80P6PV	GO:0005515	1/367	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG80P6PV	GO:0000122	1/367	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG80P6PV	GO:0003730	1/367	mRNA 3'-UTR binding	molecular_function	"Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah]
EOG80P6PV	GO:0031490	1/367	chromatin DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah]
EOG80P6PV	GO:0045893	1/367	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82FVXS	GO:0016758	251/467	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG82FVXS	GO:0015020	15/467	glucuronosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17]
EOG82FVXS	GO:0030259	7/467	lipid glycosylation	biological_process	"Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah]
EOG82FVXS	GO:0016999	4/467	antibiotic metabolic process	biological_process	"The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2]
EOG82FVXS	GO:0030246	4/467	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG82FVXS	GO:0003851	1/467	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45]
EOG8K9DSM	GO:0006584	1/104	catecholamine metabolic process	biological_process	"The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
EOG8K9DSM	GO:0007126	1/104	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8K9DSM	GO:0005634	1/104	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8K9DSM	GO:0005700	1/104	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8K9DSM	GO:0004500	1/104	dopamine beta-monooxygenase activity	molecular_function	"Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O." [EC:1.14.17.1, RHEA:19120]
EOG8K9DSM	GO:0005737	1/104	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8K9DSM	GO:0005730	1/104	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8K9DSM	GO:0055114	1/104	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8K9DSM	GO:0005874	1/104	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8K9DSM	GO:0006997	1/104	nucleus organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
EOG8K9DSM	GO:0051225	1/104	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG8K9DSM	GO:0007067	1/104	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8K9DSM	GO:0005819	1/104	spindle	cellular_component	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
EOG808QQJ	GO:0017053	29/86	transcriptional repressor complex	cellular_component	"A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah]
EOG808QQJ	GO:0007049	29/86	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG808QQJ	GO:0048477	1/86	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG808QQJ	GO:0031523	1/86	Myb complex	cellular_component	"A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624]
EOG808QQJ	GO:0007283	1/86	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG808QQJ	GO:0000122	1/86	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG808QQJ	GO:0007307	1/86	eggshell chorion gene amplification	biological_process	"Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771]
EOG8V71X1	GO:0004185	56/160	serine-type carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8V71X1	GO:0005576	1/160	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8V71X1	GO:0033227	1/160	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG81G5MC	GO:0006850	25/97	mitochondrial pyruvate transport	biological_process	"The directed movement of pyruvate, 2-oxopropanoate, into, out of or within a mitochondrion." [GOC:ai]
EOG81G5MC	GO:0005743	24/97	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG81G5MC	GO:0006090	1/97	pyruvate metabolic process	biological_process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]
EOG81G5MC	GO:0005739	1/97	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG81G5MC	GO:0050833	1/97	pyruvate transmembrane transporter activity	molecular_function	"Enables the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other." [GOC:ai]
EOG81G5MC	GO:1901475	1/97	pyruvate transmembrane transport	biological_process	"The directed movement of pyruvate across a membrane." [GOC:TermGenie]
EOG81G5MC	GO:0031305	1/97	integral component of mitochondrial inner membrane	cellular_component	"The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
EOG8GXJ2W	GO:0007165	18/74	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8GXJ2W	GO:0045089	1/74	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8GXJ2W	GO:0005622	1/74	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8GXJ2W	GO:0019730	1/74	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG8GXJ2W	GO:0006959	1/74	humoral immune response	biological_process	"An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]
EOG8GXJ2W	GO:0006963	1/74	positive regulation of antibacterial peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475]
EOG8GXJ2W	GO:0070513	1/74	death domain binding	molecular_function	"Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531]
EOG8GXJ2W	GO:0019731	1/74	antibacterial humoral response	biological_process	"An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8GXJ2W	GO:0006964	1/74	positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
EOG8GXJ2W	GO:0061057	1/74	peptidoglycan recognition protein signaling pathway	biological_process	"A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280]
EOG8GXJ2W	GO:0005515	1/74	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8GXJ2W	GO:0042742	1/74	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8GXJ2W	GO:0002230	1/74	positive regulation of defense response to virus by host	biological_process	"Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
EOG8GXJ2W	GO:0050829	1/74	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GXJ2W	GO:0045087	1/74	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8GXJ2W	GO:0006952	1/74	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8GXJ2W	GO:0009617	1/74	response to bacterium	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]
EOG8GXJ2W	GO:0006955	1/74	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8GXJ2W	GO:0035556	1/74	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8GXJ2W	GO:0007399	1/74	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8FJBPS	GO:0046872	15/102	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8FJBPS	GO:0003676	15/102	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NS5S1	GO:0006012	38/146	galactose metabolic process	biological_process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]
EOG8NS5S1	GO:0003978	38/146	UDP-glucose 4-epimerase activity	molecular_function	"Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2]
EOG8NS5S1	GO:0050662	38/146	coenzyme binding	molecular_function	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
EOG8NS5S1	GO:0044237	38/146	cellular metabolic process	biological_process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
EOG8NS5S1	GO:0003974	1/146	UDP-N-acetylglucosamine 4-epimerase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7]
EOG8Z654D	GO:0005198	28/93	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8Z654D	GO:0030130	28/93	clathrin coat of trans-Golgi network vesicle	cellular_component	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]
EOG8Z654D	GO:0030132	28/93	clathrin coat of coated pit	cellular_component	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]
EOG8Z654D	GO:0006886	28/93	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8Z654D	GO:0016192	27/93	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8Z654D	GO:0030136	1/93	clathrin-coated vesicle	cellular_component	"A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]
EOG8Z654D	GO:0030125	1/93	clathrin vesicle coat	cellular_component	"A clathrin coat found on a vesicle." [GOC:mah]
EOG8Z654D	GO:0016183	1/93	synaptic vesicle coating	biological_process	"A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:curators, PMID:10099709]
EOG8Z654D	GO:0008021	1/93	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8Z654D	GO:0030135	1/93	coated vesicle	cellular_component	"Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]
EOG8Z654D	GO:0005905	1/93	coated pit	cellular_component	"A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]
EOG8Z654D	GO:0007269	1/93	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8Z654D	GO:0072583	1/93	clathrin-mediated endocytosis	biological_process	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]
EOG854CH7	GO:0016747	1/4	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG81RS8W	GO:0043565	19/81	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG81RS8W	GO:0003700	19/81	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG81RS8W	GO:0005634	14/81	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG81RS8W	GO:0007275	8/81	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG81RS8W	GO:0003677	2/81	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG81RS8W	GO:0048813	1/81	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG81RS8W	GO:0007517	1/81	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8QRKJG	GO:0004618	37/104	phosphoglycerate kinase activity	molecular_function	"Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+)." [EC:2.7.2.3, RHEA:14804]
EOG8QRKJG	GO:0006096	37/104	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8QRKJG	GO:0005524	34/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QRKJG	GO:0007268	1/104	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8QRKJG	GO:0016310	1/104	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG8QRKJG	GO:0031430	1/104	M band	cellular_component	"The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194]
EOG8QRKJG	GO:0030018	1/104	Z disc	cellular_component	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
EOG8QRKJG	GO:0046716	1/104	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG80S2VZ	GO:0005634	25/90	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80S2VZ	GO:0051090	25/90	regulation of sequence-specific DNA binding transcription factor activity	biological_process	"Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]
EOG80S2VZ	GO:0006352	21/90	DNA-templated transcription, initiation	biological_process	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]
EOG80S2VZ	GO:0003743	4/90	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG80S2VZ	GO:0005669	1/90	transcription factor TFIID complex	cellular_component	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]
EOG80S2VZ	GO:0006367	1/90	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG80S2VZ	GO:0051123	1/90	RNA polymerase II transcriptional preinitiation complex assembly	biological_process	"The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:10882737, PMID:15020047]
EOG80S2VZ	GO:0006366	1/90	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG80S2VZ	GO:0000124	1/90	SAGA complex	cellular_component	"A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012]
EOG80S2VZ	GO:0022008	1/90	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG80ZTC5	GO:0006281	21/93	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG80ZTC5	GO:0016799	21/93	hydrolase activity, hydrolyzing N-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]
EOG80ZTC5	GO:0003677	17/93	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80ZTC5	GO:0006974	1/93	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG80ZTC5	GO:0006298	1/93	mismatch repair	biological_process	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]
EOG80ZTC5	GO:0008263	1/93	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	molecular_function	"Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site." [GOC:elh, PMID:9224623]
EOG80ZTC5	GO:0003690	1/93	double-stranded DNA binding	molecular_function	"Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh]
EOG8DNHJK	GO:0004806	1/92	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG8DNHJK	GO:0007274	1/92	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8DNHJK	GO:0022008	1/92	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8DNHJK	GO:0005737	1/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8DNHJK	GO:0004771	1/92	sterol esterase activity	molecular_function	"Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13]
EOG8DNHJK	GO:0008582	1/92	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8DNHJK	GO:0046785	1/92	microtubule polymerization	biological_process	"The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]
EOG8F4VR0	GO:0006511	26/93	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8F4VR0	GO:0030330	4/93	DNA damage response, signal transduction by p53 class mediator	biological_process	"A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators]
EOG8F4VR0	GO:0016579	4/93	protein deubiquitination	biological_process	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]
EOG8F4VR0	GO:0004843	4/93	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG8F4VR0	GO:0008234	2/93	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8F4VR0	GO:0045747	1/93	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8F4VR0	GO:0004221	1/93	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG8F4VR0	GO:0008233	1/93	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8F7R0H	GO:0045127	2/100	N-acetylglucosamine kinase activity	molecular_function	"Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H(+)." [EC:2.7.1.59, RHEA:17420]
EOG8F7R0H	GO:0016301	1/100	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8F7R0H	GO:0004252	1/100	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG82FVX9	GO:0000139	21/93	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG82FVX9	GO:0048208	21/93	COPII vesicle coating	biological_process	"The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:mah, GOC:tb, ISBN:0716731363, PMID:10219233]
EOG82FVX9	GO:0004326	1/93	tetrahydrofolylpolyglutamate synthase activity	molecular_function	"Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17]
EOG82FVX9	GO:0016020	1/93	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82FVX9	GO:0003400	1/93	regulation of COPII vesicle coating	biological_process	"Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]
EOG82FVX9	GO:0070971	1/93	endoplasmic reticulum exit site	cellular_component	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]
EOG82FVX9	GO:0007030	1/93	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG82FVX9	GO:0017016	1/93	Ras GTPase binding	molecular_function	"Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG82FVX9	GO:0070973	1/93	protein localization to endoplasmic reticulum exit site	biological_process	"A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site." [GOC:mah]
EOG82FVX9	GO:0034198	1/93	cellular response to amino acid starvation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]
EOG82FVX9	GO:0007029	1/93	endoplasmic reticulum organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
EOG82FVX9	GO:0005524	1/93	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82FVX9	GO:0070863	1/93	positive regulation of protein exit from endoplasmic reticulum	biological_process	"Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum." [GOC:mah]
EOG8P5NRT	GO:0008237	1/13	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8J9QDG	GO:0016020	20/108	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8J9QDG	GO:0005886	1/108	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8J9QDG	GO:0008039	1/108	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG80CKWR	GO:0007264	55/204	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG80CKWR	GO:0005085	53/204	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG80CKWR	GO:0007417	2/204	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG80CKWR	GO:0032863	2/204	activation of GTPase activity	biological_process	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]
EOG80CKWR	GO:0005737	2/204	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG80CKWR	GO:0030036	1/204	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG80CKWR	GO:0005089	1/204	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG80CKWR	GO:0007391	1/204	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG80CKWR	GO:0007523	1/204	larval visceral muscle development	biological_process	"The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid]
EOG80CKWR	GO:0001726	1/204	ruffle	cellular_component	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]
EOG80CKWR	GO:0035212	1/204	cell competition in a multicellular organism	biological_process	"Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286]
EOG80CKWR	GO:0007298	1/204	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG80CKWR	GO:0030676	1/204	Rac guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG80CKWR	GO:0016203	1/204	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG80CKWR	GO:0045466	1/204	R7 cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339]
EOG80CKWR	GO:0007519	1/204	skeletal muscle tissue development	biological_process	"The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
EOG80CKWR	GO:0005515	1/204	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG80CKWR	GO:0007010	1/204	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG80CKWR	GO:0061327	1/204	anterior Malpighian tubule development	biological_process	"The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135]
EOG80CKWR	GO:0007520	1/204	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG80CKWR	GO:0032314	1/204	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG80CKWR	GO:0005886	1/204	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80CKWR	GO:0000902	1/204	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG80CKWR	GO:0019897	1/204	extrinsic component of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]
EOG8FFGHB	GO:0006950	26/583	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8FFGHB	GO:0005212	9/583	structural constituent of eye lens	molecular_function	"The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah]
EOG8FFGHB	GO:0008340	3/583	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8FFGHB	GO:0005875	3/583	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8FFGHB	GO:0010998	2/583	regulation of translational initiation by eIF2 alpha phosphorylation	biological_process	"Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha." [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb]
EOG8FFGHB	GO:0009631	2/583	cold acclimation	biological_process	"Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr]
EOG8FFGHB	GO:0005515	2/583	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FFGHB	GO:0007275	1/583	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8FFGHB	GO:0017022	1/583	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8FFGHB	GO:0042595	1/583	behavioral response to starvation	biological_process	"Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators]
EOG8FFGHB	GO:0009408	1/583	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8FFGHB	GO:0007476	1/583	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8FFGHB	GO:0010506	1/583	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8FFGHB	GO:0003779	1/583	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8FFGHB	GO:0006497	1/583	protein lipidation	biological_process	"The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]
EOG8FFGHB	GO:0001666	1/583	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG8FFGHB	GO:0006979	1/583	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8FFGHB	GO:0031427	1/583	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG8FFGHB	GO:0050832	1/583	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8FFGHB	GO:0042742	1/583	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8JHFVH	GO:0005089	22/97	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8JHFVH	GO:0007474	1/97	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG8JHFVH	GO:0007480	1/97	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8JHFVH	GO:0000502	1/97	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG8JHFVH	GO:0017160	1/97	Ral GTPase binding	molecular_function	"Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG8JHFVH	GO:0032489	1/97	regulation of Cdc42 protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction." [GOC:mah]
EOG8JHFVH	GO:0016740	1/97	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8JHFVH	GO:0032319	1/97	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8Z38VR	GO:0016021	33/157	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z38VR	GO:0005432	32/157	calcium:sodium antiporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597]
EOG8Z38VR	GO:0007154	23/157	cell communication	biological_process	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]
EOG8Z38VR	GO:0005509	1/157	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8Z38VR	GO:0035725	1/157	sodium ion transmembrane transport	biological_process	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
EOG8Z38VR	GO:0055085	1/157	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8Z38VR	GO:0007602	1/157	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG8XPSWN	GO:0004221	1/84	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG80CKWZ	GO:0031418	25/105	L-ascorbic acid binding	molecular_function	"Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]
EOG80CKWZ	GO:0005506	25/105	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG80CKWZ	GO:0016706	23/105	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG80CKWZ	GO:0008475	2/105	procollagen-lysine 5-dioxygenase activity	molecular_function	"Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4]
EOG80CKWZ	GO:0005581	2/105	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG80CKWZ	GO:0005615	1/105	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG80CKWZ	GO:0007295	1/105	growth of a germarium-derived egg chamber	biological_process	"Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG80CKWZ	GO:0005783	1/105	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG80CKWZ	GO:0048471	1/105	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG83N9TJ	GO:0005506	404/1184	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG83N9TJ	GO:0020037	404/1184	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG83N9TJ	GO:0016705	391/1184	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG83N9TJ	GO:0004497	374/1184	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG83N9TJ	GO:0005789	17/1184	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG83N9TJ	GO:0070330	6/1184	aromatase activity	molecular_function	"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
EOG83N9TJ	GO:0052869	6/1184	arachidonic acid omega-hydroxylase activity	molecular_function	"Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid." [KEGG:R07041]
EOG83N9TJ	GO:0018685	6/1184	alkane 1-monooxygenase activity	molecular_function	"Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3]
EOG83N9TJ	GO:0016539	3/1184	intein-mediated protein splicing	biological_process	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]
EOG83N9TJ	GO:0007165	2/1184	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG83N9TJ	GO:0005622	2/1184	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG83N9TJ	GO:0007618	1/1184	mating	biological_process	"The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546]
EOG83N9TJ	GO:0005201	1/1184	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG83N9TJ	GO:0005581	1/1184	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG83N9TJ	GO:0050051	1/1184	leukotriene-B4 20-monooxygenase activity	molecular_function	"Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN]
EOG83N9TJ	GO:0052871	1/1184	alpha-tocopherol omega-hydroxylase activity	molecular_function	"Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003]
EOG83N9TJ	GO:0006629	1/1184	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG83N9TJ	GO:0005737	1/1184	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG83N9TJ	GO:0005811	1/1184	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8C8B8F	GO:0005576	19/64	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8C8B8F	GO:0001664	1/64	G-protein coupled receptor binding	molecular_function	"Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph]
EOG8C8B8F	GO:0005184	1/64	neuropeptide hormone activity	molecular_function	"The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]
EOG8C8B8F	GO:0008613	1/64	diuretic hormone activity	molecular_function	"The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion." [GOC:mah, InterPro:IPR003621, PMID:8618894]
EOG8C8B8F	GO:0007186	1/64	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8C8B8F	GO:0007218	1/64	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8C8B8F	GO:0005615	1/64	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8C8B8F	GO:0007589	1/64	body fluid secretion	biological_process	"The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb]
EOG8C8B8F	GO:0009755	1/64	hormone-mediated signaling pathway	biological_process	"A series of molecular signals mediated by the detection of a hormone." [GOC:sm]
EOG84XMZ2	GO:0004602	43/144	glutathione peroxidase activity	molecular_function	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9]
EOG84XMZ2	GO:0006979	43/144	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG84XMZ2	GO:0005794	1/144	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG84XMZ2	GO:0005615	1/144	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG84XMZ2	GO:0047066	1/144	phospholipid-hydroperoxide glutathione peroxidase activity	molecular_function	"Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione." [EC:1.11.1.12, MetaCyc:1.11.1.12-RXN]
EOG84XMZ2	GO:0032504	1/144	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG84XMZ2	GO:0004601	1/144	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG80CKWS	GO:0003677	2/91	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80CKWS	GO:0008270	2/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80CKWS	GO:0005634	1/91	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80CKWS	GO:0016577	1/91	histone demethylation	biological_process	"The modification of histones by removal of methyl groups." [GOC:ai]
EOG80CKWS	GO:0032452	1/91	histone demethylase activity	molecular_function	"Catalysis of the removal of a methyl group from a histone." [GOC:mah]
EOG80CKWS	GO:2001020	1/91	regulation of response to DNA damage stimulus	biological_process	"Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]
EOG8GF5WR	GO:0009253	197/521	peptidoglycan catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
EOG8GF5WR	GO:0008745	196/521	N-acetylmuramoyl-L-alanine amidase activity	molecular_function	"Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]
EOG8GF5WR	GO:0008270	180/521	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GF5WR	GO:0045087	14/521	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8GF5WR	GO:0005576	12/521	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8GF5WR	GO:0042834	11/521	peptidoglycan binding	molecular_function	"Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226]
EOG8GF5WR	GO:0006955	10/521	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8GF5WR	GO:0050830	5/521	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GF5WR	GO:0005515	4/521	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8GF5WR	GO:0061057	3/521	peptidoglycan recognition protein signaling pathway	biological_process	"A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280]
EOG8GF5WR	GO:0002221	3/521	pattern recognition receptor signaling pathway	biological_process	"Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
EOG8GF5WR	GO:0016019	3/521	peptidoglycan receptor activity	molecular_function	"Combining with a peptidoglycan and transmitting the signal to initiate a change in cell activity." [PMID:14698226]
EOG8GF5WR	GO:0045824	3/521	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG8GF5WR	GO:0008329	2/521	signaling pattern recognition receptor activity	molecular_function	"Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity." [GOC:ar, PMID:12507420, PMID:12925128, PMID:14523544, Wikipedia:Pattern_recognition_receptor]
EOG8GF5WR	GO:0008340	2/521	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8GF5WR	GO:0009617	2/521	response to bacterium	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]
EOG8GF5WR	GO:0005887	2/521	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GF5WR	GO:0019731	2/521	antibacterial humoral response	biological_process	"An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8GF5WR	GO:0006964	1/521	positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
EOG8GF5WR	GO:0042742	1/521	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8GF5WR	GO:0044214	1/521	spanning component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:ecd]
EOG8GF5WR	GO:0006965	1/521	positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475]
EOG8GF5WR	GO:0001875	1/521	lipopolysaccharide receptor activity	molecular_function	"Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [PMID:14609719, PMID:15379975]
EOG8GF5WR	GO:0000270	1/521	peptidoglycan metabolic process	biological_process	"The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
EOG8GF5WR	GO:0008233	1/521	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8GF5WR	GO:0046983	1/521	protein dimerization activity	molecular_function	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]
EOG8GF5WR	GO:0032500	1/521	muramyl dipeptide binding	molecular_function	"Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan." [GOC:rl]
EOG8GF5WR	GO:0008592	1/521	regulation of Toll signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8GF5WR	GO:0051607	1/521	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG8GF5WR	GO:0031240	1/521	external side of cell outer membrane	cellular_component	"The side of the outer membrane that is opposite to the side that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu]
EOG8GF5WR	GO:0045089	1/521	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG8GF5WR	GO:0006963	1/521	positive regulation of antibacterial peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475]
EOG8GF5WR	GO:0008063	1/521	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8GF5WR	GO:0016327	1/521	apicolateral plasma membrane	cellular_component	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
EOG8GF5WR	GO:0005875	1/521	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8GF5WR	GO:0016021	1/521	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GF5WR	GO:0007165	1/521	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8GF5WR	GO:0031663	1/521	lipopolysaccharide-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [GOC:mah, GOC:signaling, PMID:15379975]
EOG8GF5WR	GO:0006909	1/521	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8GF5WR	GO:0004040	1/521	amidase activity	molecular_function	"Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4]
EOG8GF5WR	GO:0032494	1/521	response to peptidoglycan	biological_process	"Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464]
EOG8GF5WR	GO:0050829	1/521	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8GF5WR	GO:0035007	1/521	regulation of melanization defense response	biological_process	"Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf]
EOG8GF5WR	GO:0019730	1/521	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG8GF5WR	GO:0004180	1/521	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8GF5WR	GO:0046329	1/521	negative regulation of JNK cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8GF5WR	GO:0002920	1/521	regulation of humoral immune response	biological_process	"Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add]
EOG8GF5WR	GO:0061060	1/521	negative regulation of peptidoglycan recognition protein signaling pathway	biological_process	"Any process that decreases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph]
EOG8X99XM	GO:0016021	24/72	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D55DP	GO:0019153	2/33	protein-disulfide reductase (glutathione) activity	molecular_function	"Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol." [EC:1.8.4.2]
EOG8D55DP	GO:0045454	2/33	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG808QQS	GO:0003676	7/236	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG808QQS	GO:0008270	3/236	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8QJV24	GO:0046872	47/147	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QJV24	GO:0004222	35/147	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8QJV24	GO:0003824	12/147	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8WDGT1	GO:0042052	1/90	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8WDGT1	GO:0017137	1/90	Rab GTPase binding	molecular_function	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG8JHFVT	GO:0005524	2/4	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8JHFVT	GO:0003677	2/4	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8JHFVT	GO:0003910	2/4	DNA ligase (ATP) activity	molecular_function	"Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]
EOG8JHFVT	GO:0006310	2/4	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8JHFVT	GO:0051103	1/4	DNA ligation involved in DNA repair	biological_process	"The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair." [GOC:ai]
EOG8JHFVT	GO:0006281	1/4	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8JHFVT	GO:0006260	1/4	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8PK4PC	GO:0004402	2/92	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8SN45J	GO:0005856	2/19	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8SN45J	GO:0005737	1/19	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SN45J	GO:0019898	1/19	extrinsic component of membrane	cellular_component	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]
EOG8JHFVQ	GO:0046872	26/104	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8JHFVQ	GO:0008970	1/104	phosphatidylcholine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32]
EOG8JHFVQ	GO:0052739	1/104	phosphatidylserine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG:R04034]
EOG8JHFVQ	GO:0052740	1/104	1-acyl-2-lysophosphatidylserine acylhydrolase activity	molecular_function	"Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32]
EOG8QZB47	GO:0008270	5/36	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FTZFX	GO:0016491	152/463	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8FTZFX	GO:0016630	12/463	protochlorophyllide reductase activity	molecular_function	"Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33]
EOG8FTZFX	GO:0004316	2/463	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
EOG8NCPV8	GO:0016021	56/128	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NCPV8	GO:0005525	1/128	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8NCPV8	GO:0003746	1/128	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG86Q97V	GO:0006629	37/110	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG86Q97V	GO:0004806	3/110	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG86Q97V	GO:0005811	1/110	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG86Q97V	GO:0019433	1/110	triglyceride catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732]
EOG86Q97V	GO:0055088	1/110	lipid homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]
EOG86Q97V	GO:0008340	1/110	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG86Q97V	GO:0016042	1/110	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG86Q97V	GO:0006642	1/110	triglyceride mobilization	biological_process	"The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625]
EOG86Q97V	GO:0008152	1/110	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG86Q97V	GO:0010884	1/110	positive regulation of lipid storage	biological_process	"Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
EOG873S52	GO:0050660	110/344	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG873S52	GO:0009055	107/344	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG873S52	GO:0051537	105/344	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG873S52	GO:0016614	104/344	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG873S52	GO:0005506	90/344	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG873S52	GO:0046872	23/344	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG873S52	GO:0016491	9/344	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG873S52	GO:0008762	6/344	UDP-N-acetylmuramate dehydrogenase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158]
EOG873S52	GO:0051536	2/344	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG873S52	GO:0018492	1/344	carbon-monoxide dehydrogenase (acceptor) activity	molecular_function	"Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.99.2]
EOG873S52	GO:0007155	1/344	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG873S52	GO:0016020	1/344	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82JR7S	GO:0032542	28/62	sulfiredoxin activity	molecular_function	"Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R." [EC:1.8.98.2, PMID:16102934]
EOG82JR7S	GO:0005524	26/62	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZKN35	GO:0052689	2/163	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG8RFP6P	GO:0005524	25/94	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8RFP6P	GO:0016021	23/94	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RFP6P	GO:0042626	22/94	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8RFP6P	GO:0016020	3/94	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RFP6P	GO:0006810	3/94	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8RFP6P	GO:0016887	2/94	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8RFP6P	GO:0008559	1/94	xenobiotic-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44]
EOG808QRG	GO:0016740	1/23	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG82NMG1	GO:0005549	18/64	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG82NMG1	GO:0005550	1/64	pheromone binding	molecular_function	"Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai]
EOG82NMG1	GO:0007606	1/64	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG82NMG1	GO:0005576	1/64	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Z653J	GO:0005576	30/178	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8Z653J	GO:0008270	1/178	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Z653J	GO:0004222	1/178	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8Z653J	GO:0031012	1/178	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8ZW7R4	GO:0007015	10/56	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8ZW7R4	GO:0016477	10/56	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG8ZW7R4	GO:0007155	10/56	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8NP9KC	GO:0003700	22/69	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NP9KC	GO:0016602	9/69	CCAAT-binding factor complex	cellular_component	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bm, PMID:7828851]
EOG8NP9KC	GO:0003677	9/69	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NP9KC	GO:0045466	1/69	R7 cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339]
EOG8NP9KC	GO:0051726	1/69	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8NP9KC	GO:0046331	1/69	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8NP9KC	GO:0006909	1/69	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8NP9KC	GO:0000976	1/69	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8NP9KC	GO:0045893	1/69	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG83R62Q	GO:0003676	55/341	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG83R62Q	GO:0005622	1/341	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG83R62Q	GO:0008270	1/341	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83R62Q	GO:0046872	1/341	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83R62Q	GO:0003964	1/341	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG83R62Q	GO:0003723	1/341	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG83R62Q	GO:0042981	1/341	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8MGVPJ	GO:0003676	23/88	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MGVPJ	GO:0004527	20/88	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8MGVPJ	GO:0008859	1/88	exoribonuclease II activity	molecular_function	"Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684]
EOG8FXTQD	GO:0004252	6/16	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG87DCWX	GO:0016787	125/753	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG87DCWX	GO:0003990	29/753	acetylcholinesterase activity	molecular_function	"Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
EOG87DCWX	GO:0052689	10/753	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG87DCWX	GO:0004104	5/753	cholinesterase activity	molecular_function	"Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8]
EOG87DCWX	GO:0005576	3/753	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG87DCWX	GO:0005524	1/753	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87DCWX	GO:0006730	1/753	one-carbon metabolic process	biological_process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
EOG87DCWX	GO:0004013	1/753	adenosylhomocysteinase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1]
EOG87DCWX	GO:0003677	1/753	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG87DCWX	GO:0016021	1/753	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87DCWX	GO:0006260	1/753	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG8B8MSV	GO:0007018	31/98	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8B8MSV	GO:0003777	31/98	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8B8MSV	GO:0001539	30/98	cilium or flagellum-dependent cell motility	biological_process	"Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc]
EOG8B8MSV	GO:0030031	30/98	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG8B8MSV	GO:0005524	21/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8B8MSV	GO:0016887	20/98	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8B8MSV	GO:0030286	19/98	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8B8MSV	GO:0035721	1/98	intraciliary retrograde transport	biological_process	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]
EOG8B8MSV	GO:0042623	1/98	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8B8MSV	GO:0045433	1/98	male courtship behavior, veined wing generated song production	biological_process	"The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
EOG8B8MSV	GO:0031223	1/98	auditory behavior	biological_process	"The behavior of an organism in response to a sound." [GOC:pr, GOC:rc]
EOG8B8MSV	GO:0007628	1/98	adult walking behavior	biological_process	"The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907]
EOG8B8MSV	GO:0008049	1/98	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8B8MSV	GO:0007605	1/98	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8B8MSV	GO:0005868	1/98	cytoplasmic dynein complex	cellular_component	"Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:mah, PMID:12600311]
EOG8B8MSV	GO:0006200	1/98	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8RFP6C	GO:0007018	28/116	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8RFP6C	GO:0005871	28/116	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8RFP6C	GO:0003777	28/116	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8RFP6C	GO:0005874	28/116	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8RFP6C	GO:0005524	28/116	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8RFP6C	GO:0008152	2/116	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8RFP6C	GO:0007080	1/116	mitotic metaphase plate congression	biological_process	"The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis." [GOC:mah, ISBN:0815316194]
EOG8RFP6C	GO:0000940	1/116	condensed chromosome outer kinetochore	cellular_component	"The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983]
EOG8RFP6C	GO:0007052	1/116	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8RFP6C	GO:0005875	1/116	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8RFP6C	GO:0000776	1/116	kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG8RFP6C	GO:0022008	1/116	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8RFP6C	GO:0000278	1/116	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG8RFP6C	GO:0008574	1/116	ATP-dependent microtubule motor activity, plus-end-directed	molecular_function	"Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP." [EC:3.6.4.4, GOC:vw]
EOG8RBSZJ	GO:0005856	21/111	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8RBSZJ	GO:0005634	1/111	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RBSZJ	GO:0003677	1/111	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RBSZJ	GO:0000786	1/111	nucleosome	cellular_component	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
EOG8RBSZJ	GO:0016906	1/111	sterol 3-beta-glucosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol." [EC:2.4.1.173]
EOG8RBSZJ	GO:0006334	1/111	nucleosome assembly	biological_process	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
EOG8JQ6CW	GO:0015031	72/218	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8JQ6CW	GO:0005525	72/218	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8JQ6CW	GO:0007264	72/218	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8JQ6CW	GO:0004767	4/218	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8JQ6CW	GO:0043025	2/218	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8JQ6CW	GO:0005515	1/218	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8JQ6CW	GO:0006897	1/218	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8JQ6CW	GO:0045202	1/218	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG87SVW2	GO:0005524	1/3	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG87SVW2	GO:0004674	1/3	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG87SVW2	GO:0007165	1/3	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8BCH68	GO:0008270	1/3	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TMTHP	GO:0031024	1/85	interphase microtubule organizing center assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center." [GOC:mah, PMID:15068790]
EOG8TMTHP	GO:0005814	1/85	centriole	cellular_component	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
EOG8TMTHP	GO:0071539	1/85	protein localization to centrosome	biological_process	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]
EOG8STVM6	GO:0005524	1/98	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8STVM6	GO:0004222	1/98	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG89GNWV	GO:0004781	28/117	sulfate adenylyltransferase (ATP) activity	molecular_function	"Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4]
EOG89GNWV	GO:0000103	28/117	sulfate assimilation	biological_process	"The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl]
EOG89GNWV	GO:0005524	27/117	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG89GNWV	GO:0004020	27/117	adenylylsulfate kinase activity	molecular_function	"Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate." [EC:2.7.1.25]
EOG89GNWV	GO:0070814	2/117	hydrogen sulfide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S." [CHEBI:16136, GOC:mah]
EOG89GNWV	GO:0007476	1/117	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8NW203	GO:0004871	36/117	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8NW203	GO:0004713	36/117	protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
EOG8NW203	GO:0005925	36/117	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8NW203	GO:0007172	36/117	signal complex assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell." [GOC:bf, GOC:signaling, PMID:9646862]
EOG8NW203	GO:0005524	24/117	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8NW203	GO:0005856	24/117	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8NW203	GO:0004715	3/117	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8NW203	GO:0004672	2/117	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8NW203	GO:0045886	1/117	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8NW203	GO:0007016	1/117	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG8NW203	GO:0008360	1/117	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8NW203	GO:0006468	1/117	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8NW203	GO:0061177	1/117	type Is terminal bouton	cellular_component	"Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons." [GOC:dph, GOC:mc]
EOG8NW203	GO:0061176	1/117	type Ib terminal bouton	cellular_component	"Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons." [GOC:dph, GOC:mc]
EOG8NW203	GO:0018108	1/117	peptidyl-tyrosine phosphorylation	biological_process	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
EOG8H48HJ	GO:0008270	29/98	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8H48HJ	GO:0004181	29/98	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG8H48HJ	GO:0005975	1/98	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8H48HJ	GO:0007476	1/98	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8H48HJ	GO:0016998	1/98	cell wall macromolecule catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators]
EOG8H48HJ	GO:0003796	1/98	lysozyme activity	molecular_function	"Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17]
EOG8H48HJ	GO:0004180	1/98	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8H48HJ	GO:0005576	1/98	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8H48HJ	GO:0009253	1/98	peptidoglycan catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
EOG8H48HJ	GO:0016021	1/98	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8H48HJ	GO:0007616	1/98	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8H48HJ	GO:0048471	1/98	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8H48HJ	GO:0042302	1/98	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8H48HJ	GO:0006909	1/98	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8H48HK	GO:0003950	24/98	NAD+ ADP-ribosyltransferase activity	molecular_function	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]
EOG8H48HK	GO:0032440	2/98	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8H48HK	GO:0005515	1/98	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8H48HK	GO:0022416	1/98	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8H48HK	GO:0005634	1/98	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8H48HK	GO:0003700	1/98	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8H48HK	GO:0016055	1/98	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG8H48HK	GO:0090364	1/98	regulation of proteasome assembly	biological_process	"Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:dph, GOC:elh, GOC:tb]
EOG8H48HK	GO:0043565	1/98	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8H48HK	GO:0006471	1/98	protein ADP-ribosylation	biological_process	"The transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:pr, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295]
EOG8H48HK	GO:0032212	1/98	positive regulation of telomere maintenance via telomerase	biological_process	"Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]
EOG8H48HK	GO:0004623	1/98	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG8H48HK	GO:0035220	1/98	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8H48HK	GO:0051225	1/98	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG8H48HH	GO:0009235	4/153	cobalamin metabolic process	biological_process	"The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators]
EOG8H48HH	GO:0005739	4/153	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8H48HH	GO:0048488	1/153	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG8H48HH	GO:0030036	1/153	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8CRPD4	GO:0003676	2/26	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CRPD4	GO:0046872	2/26	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CRPD3	GO:0003677	25/96	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CRPD3	GO:0006355	25/96	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8CRPD3	GO:0005737	1/96	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CRPD3	GO:0009047	1/96	dosage compensation by hyperactivation of X chromosome	biological_process	"Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577]
EOG8CRPD3	GO:0042714	1/96	dosage compensation complex assembly	biological_process	"The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes." [GOC:jl, PMID:11102361, PMID:12672493]
EOG8CRPD3	GO:0003730	1/96	mRNA 3'-UTR binding	molecular_function	"Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah]
EOG8CRPD3	GO:0005515	1/96	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8CRPD3	GO:0017148	1/96	negative regulation of translation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8CRPD3	GO:0046331	1/96	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8FTZG1	GO:0016881	24/88	acid-amino acid ligase activity	molecular_function	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]
EOG8FTZG1	GO:0004842	3/88	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8FTZG1	GO:0005524	1/88	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8FTZG1	GO:0006464	1/88	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG8FTZG1	GO:0016567	1/88	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG8FTZG1	GO:0045879	1/88	negative regulation of smoothened signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG8FTZG1	GO:0018169	1/88	ribosomal S6-glutamic acid ligase activity	molecular_function	"Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6." [GOC:mah, PMID:2570347]
EOG8FTZG1	GO:0045116	1/88	protein neddylation	biological_process	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]
EOG8FTZG1	GO:0019788	1/88	NEDD8 transferase activity	molecular_function	"Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages." [GOC:mah]
EOG8B5RMV	GO:0003677	5/28	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8JDKQV	GO:0005249	6/63	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8JDKQV	GO:0008076	6/63	voltage-gated potassium channel complex	cellular_component	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
EOG8RBSZP	GO:0005975	19/72	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8RBSZP	GO:0030246	18/72	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8RBSZP	GO:0004553	14/72	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8RBSZP	GO:0032450	3/72	maltose alpha-glucosidase activity	molecular_function	"Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141]
EOG8RBSZP	GO:0004339	2/72	glucan 1,4-alpha-glucosidase activity	molecular_function	"Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose." [EC:3.2.1.3]
EOG8W10VX	GO:0003747	23/68	translation release factor activity	molecular_function	"Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]
EOG870WXC	GO:0051225	1/99	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG870WXC	GO:0007098	1/99	centrosome cycle	biological_process	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]
EOG870WXC	GO:0007059	1/99	chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
EOG870WXC	GO:0006909	1/99	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG870WXC	GO:0051297	1/99	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG870WXC	GO:0051298	1/99	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG870WXC	GO:0008601	1/99	protein phosphatase type 2A regulator activity	molecular_function	"Modulation of the activity of the enzyme protein phosphatase type 2A." [GOC:ai]
EOG870WXC	GO:0006914	1/99	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG870WXC	GO:0000159	1/99	protein phosphatase type 2A complex	cellular_component	"A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]
EOG870WXC	GO:0006470	1/99	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG870WXC	GO:0007099	1/99	centriole replication	biological_process	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194]
EOG870WXC	GO:0022008	1/99	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG870WXC	GO:0050790	1/99	regulation of catalytic activity	biological_process	"Any process that modulates the activity of an enzyme." [GOC:ai]
EOG870WXC	GO:0007052	1/99	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG870WXC	GO:0005737	1/99	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG870WXC	GO:0005814	1/99	centriole	cellular_component	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
EOG8XH2J0	GO:0046872	2/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XH2J0	GO:0003676	1/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X0Q6T	GO:0005856	26/100	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8X0Q6T	GO:0030036	26/100	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8X0Q6T	GO:0000902	1/100	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8X0Q6T	GO:0008335	1/100	female germline ring canal stabilization	biological_process	"Maintenance of the structural integrity of the ring canals connecting the female germline cyst." [GOC:curators]
EOG8X0Q6T	GO:0007520	1/100	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG8X0Q6T	GO:0007015	1/100	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8X0Q6T	GO:0030037	1/100	actin filament reorganization involved in cell cycle	biological_process	"The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah]
EOG8X0Q6T	GO:0001764	1/100	neuron migration	biological_process	"The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]
EOG8X0Q6T	GO:0030029	1/100	actin filament-based process	biological_process	"Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah]
EOG8X0Q6T	GO:0030866	1/100	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8X0Q6T	GO:0006909	1/100	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8X0Q6T	GO:0051489	1/100	regulation of filopodium assembly	biological_process	"Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG8X0Q6T	GO:0005515	1/100	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8X0Q6T	GO:0005634	1/100	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X0Q6T	GO:0031209	1/100	SCAR complex	cellular_component	"A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:pg, PMID:12181570]
EOG8X0Q6T	GO:0007030	1/100	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8X0Q6T	GO:0034314	1/100	Arp2/3 complex-mediated actin nucleation	biological_process	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]
EOG8X0Q6T	GO:0001745	1/100	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8X0Q6T	GO:0008360	1/100	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8X0Q6T	GO:0030031	1/100	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG8X0Q6T	GO:0007409	1/100	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8X0Q6T	GO:0051491	1/100	positive regulation of filopodium assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG8X0Q6T	GO:0005737	1/100	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8X0Q6T	GO:0010592	1/100	positive regulation of lamellipodium assembly	biological_process	"Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG8X0Q6T	GO:0051125	1/100	regulation of actin nucleation	biological_process	"Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai]
EOG8X0Q6T	GO:0048846	1/100	axon extension involved in axon guidance	biological_process	"The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jid]
EOG8X0Q6T	GO:0060305	1/100	regulation of cell diameter	biological_process	"Any process that modulates the diameter of a cell, the length of a line segment that crosses through the center of a circular section through a cell." [GOC:dph, GOC:tb]
EOG8X0Q6T	GO:0003779	1/100	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8X0Q6T	GO:0007413	1/100	axonal fasciculation	biological_process	"The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh]
EOG8X6FPD	GO:0020037	75/249	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8X6FPD	GO:0004601	75/249	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG8X6FPD	GO:0006979	74/249	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8X6FPD	GO:0042600	2/249	chorion	cellular_component	"A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
EOG8X6FPD	GO:0042744	1/249	hydrogen peroxide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]
EOG8X6FPD	GO:0008270	1/249	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X6FPD	GO:0022008	1/249	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8X6FPD	GO:0046872	1/249	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8X6FPD	GO:0007306	1/249	eggshell chorion assembly	biological_process	"Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8X6FPD	GO:0005576	1/249	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8X6FPD	GO:0006909	1/249	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG80VZ45	GO:0000178	1/83	exosome (RNase complex)	cellular_component	"Complex of 3'-5' exoribonucleases." [PMID:10465791]
EOG80VZ45	GO:0009022	1/83	tRNA nucleotidyltransferase activity	molecular_function	"Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate." [EC:2.7.7.56]
EOG80VZ45	GO:0016787	1/83	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG80VZ45	GO:0004527	1/83	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8JQ6C1	GO:0003743	3/89	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8JQ6C1	GO:0043022	1/89	ribosome binding	molecular_function	"Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators]
EOG8JQ6C1	GO:0005515	1/89	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8JQ6C1	GO:0031369	1/89	translation initiation factor binding	molecular_function	"Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]
EOG8JQ6C1	GO:0007616	1/89	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8JQ6C1	GO:0005737	1/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8JQ6C1	GO:0016199	1/89	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG8JQ6C1	GO:0048149	1/89	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8JQ6C1	GO:0044295	1/89	axonal growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954]
EOG8JQ6C1	GO:0048477	1/89	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8JQ6C1	GO:0051491	1/89	positive regulation of filopodium assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG8JQ6C1	GO:0043025	1/89	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8JQ6C1	GO:0030424	1/89	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8JQ6C1	GO:0017148	1/89	negative regulation of translation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8JQ6C1	GO:0030175	1/89	filopodium	cellular_component	"Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194]
EOG8NW20X	GO:0035556	22/96	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8NW20X	GO:0016021	22/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NW20X	GO:0000166	22/96	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8NW20X	GO:0016849	13/96	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG8NW20X	GO:0009190	13/96	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG8NW20X	GO:0004383	9/96	guanylate cyclase activity	molecular_function	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
EOG8NW20X	GO:0006182	1/96	cGMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]
EOG8CNT7B	GO:0000045	25/85	autophagosome assembly	biological_process	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]
EOG8CNT7B	GO:0005737	25/85	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CNT7B	GO:0006914	1/85	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG8CNT7B	GO:0016236	1/85	macroautophagy	biological_process	"The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure.  Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464]
EOG8CNT7B	GO:0035071	1/85	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8CNT7B	GO:0048102	1/85	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8VDSD2	GO:0016021	2/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VDSD2	GO:0022857	1/5	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8VDSD2	GO:0022891	1/5	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG8VDSD2	GO:0008643	1/5	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8FTZGM	GO:0046872	1/92	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG84N175	GO:0006457	2/6	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG84N175	GO:0007126	1/6	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG84N175	GO:0048477	1/6	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG84N175	GO:0031047	1/6	gene silencing by RNA	biological_process	"Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054]
EOG84N175	GO:0051879	1/6	Hsp90 protein binding	molecular_function	"Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]
EOG84N175	GO:0005737	1/6	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG84N175	GO:0003755	1/6	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG869T8W	GO:0003924	24/88	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG869T8W	GO:0000287	24/88	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG869T8W	GO:0005525	24/88	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG869T8W	GO:0004826	1/88	phenylalanine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]
EOG869T8W	GO:0000049	1/88	tRNA binding	molecular_function	"Interacting selectively and non-covalently with transfer RNA." [GOC:ai]
EOG869T8W	GO:0008033	1/88	tRNA processing	biological_process	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]
EOG869T8W	GO:0006432	1/88	phenylalanyl-tRNA aminoacylation	biological_process	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG869T8W	GO:0007264	1/88	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG869T8W	GO:0005524	1/88	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG869T8W	GO:0005622	1/88	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8X99ZD	GO:0005549	3/7	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8X99ZD	GO:0004984	3/7	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8X99ZD	GO:0016020	2/7	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8X99ZD	GO:0004930	1/7	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8X99ZD	GO:0016021	1/7	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NW20Q	GO:0005634	42/146	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NW20Q	GO:0003700	41/146	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NW20Q	GO:0045944	2/146	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8NW20Q	GO:0008063	2/146	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8NW20Q	GO:0035206	2/146	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8NW20Q	GO:0006955	2/146	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8NW20Q	GO:0043565	2/146	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NW20Q	GO:0006952	2/146	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8NW20Q	GO:0001077	2/146	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG8NW20Q	GO:0006964	2/146	positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
EOG8NW20Q	GO:0042387	2/146	plasmatocyte differentiation	biological_process	"The process in which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response." [PMID:11921077, PMID:8174791]
EOG8NW20Q	GO:0005515	2/146	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8NW20Q	GO:0048935	2/146	peripheral nervous system neuron development	biological_process	"The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh]
EOG8NW20Q	GO:0005737	2/146	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8NW20Q	GO:0000381	1/146	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8NW20Q	GO:0006974	1/146	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8NW20Q	GO:0007507	1/146	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8NW20Q	GO:0006967	1/146	positive regulation of antifungal peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah]
EOG8NW20Q	GO:0045893	1/146	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8NW20Q	GO:0009953	1/146	dorsal/ventral pattern formation	biological_process	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8NW20Q	GO:0010629	1/146	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8NW20Q	GO:0010004	1/146	gastrulation involving germ band extension	biological_process	"A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8NW20Q	GO:0010628	1/146	positive regulation of gene expression	biological_process	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8NW20Q	GO:0006366	1/146	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8NW20Q	GO:0050830	1/146	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG8NW20Q	GO:0007498	1/146	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8NW20Q	GO:0035070	1/146	salivary gland histolysis	biological_process	"The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683]
EOG8NW20Q	GO:0000122	1/146	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8NW20Q	GO:0007369	1/146	gastrulation	biological_process	"A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]
EOG8NW20Q	GO:0008354	1/146	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8NW20Q	GO:0009952	1/146	anterior/posterior pattern specification	biological_process	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8NW20Q	GO:0003677	1/146	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NW20Q	GO:0007501	1/146	mesodermal cell fate specification	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
EOG8NW20Q	GO:0002781	1/146	antifungal peptide production	biological_process	"The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
EOG8NW20Q	GO:0009620	1/146	response to fungus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
EOG8NW20Q	GO:0000977	1/146	RNA polymerase II regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
EOG8NW20Q	GO:0009950	1/146	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8NW20Q	GO:0007398	1/146	ectoderm development	biological_process	"The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
EOG8NW20Q	GO:0070491	1/146	repressing transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH]
EOG8NW20Q	GO:0031594	1/146	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8NW20Q	GO:0045087	1/146	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8NW20Q	GO:0001715	1/146	ectodermal cell fate specification	biological_process	"The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
EOG8NW20Q	GO:0006355	1/146	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8NW20Q	GO:0050832	1/146	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8NW20Q	GO:0007419	1/146	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8NW20Q	GO:0070379	1/146	high mobility group box 1 binding	molecular_function	"Interacting selectively and non-covalently with high mobility group box 1 (HMBGB1)." [GOC:add, PMID:18431461]
EOG8NW20Q	GO:0045892	1/146	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8NW20Q	GO:0035006	1/146	melanization defense response	biological_process	"The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809]
EOG8NW20Q	GO:0035171	1/146	lamellocyte differentiation	biological_process	"The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104]
EOG812PKG	GO:0005615	81/266	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG812PKG	GO:0004866	81/266	endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl]
EOG812PKG	GO:0006909	2/266	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG812PKG	GO:0050830	1/266	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG812PKG	GO:0032504	1/266	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG812PKG	GO:0050829	1/266	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8VX4NB	GO:0043565	25/89	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8VX4NB	GO:0005634	25/89	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VX4NB	GO:0003700	25/89	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8VX4NB	GO:0035071	1/89	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8VX4NB	GO:0060322	1/89	head development	biological_process	"The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph]
EOG8VX4NB	GO:0042803	1/89	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8VX4NB	GO:0046982	1/89	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8VX4NB	GO:0045944	1/89	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8VX4NB	GO:0048102	1/89	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8W10V6	GO:0048190	1/125	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8W10V6	GO:0042309	1/125	homoiothermy	biological_process	"Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment." [ISBN:0192801023]
EOG8W10V6	GO:0050825	1/125	ice binding	molecular_function	"Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal." [GOC:curators]
EOG8W10V6	GO:0050826	1/125	response to freezing	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:jl]
EOG8WWV1R	GO:0003676	182/2316	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8WWV1R	GO:0008270	149/2316	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WWV1R	GO:0003677	110/2316	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8WWV1R	GO:0005634	107/2316	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8WWV1R	GO:0015074	83/2316	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8WWV1R	GO:0003964	8/2316	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8WWV1R	GO:0003723	4/2316	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8WWV1R	GO:0004519	4/2316	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8WWV1R	GO:0046872	2/2316	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WWV1R	GO:0004190	1/2316	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8WWV1R	GO:0005524	1/2316	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WWV1R	GO:0008762	1/2316	UDP-N-acetylmuramate dehydrogenase activity	molecular_function	"Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158]
EOG8WWV1R	GO:0006351	1/2316	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8WWV1R	GO:0050660	1/2316	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8WWV1R	GO:0016043	1/2316	cellular component organization	biological_process	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]
EOG8WWV1R	GO:0016787	1/2316	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8WWV1R	GO:0016491	1/2316	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8W10V0	GO:0005975	167/551	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8W10V0	GO:0006032	166/551	chitin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8W10V0	GO:0004568	166/551	chitinase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
EOG8W10V0	GO:0008061	105/551	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8W10V0	GO:0005576	104/551	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8W10V0	GO:0006030	4/551	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8W10V0	GO:0016021	3/551	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W10V0	GO:0004553	3/551	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8W10V0	GO:0005615	2/551	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8W10V0	GO:0000272	2/551	polysaccharide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:go_curators]
EOG8F7R4F	GO:0016301	1/5	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8X6FPP	GO:0004657	30/95	proline dehydrogenase activity	molecular_function	"Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8]
EOG8X6FPP	GO:0006562	30/95	proline catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
EOG8X6FPP	GO:0006537	29/95	glutamate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
EOG8X6FPP	GO:0007626	1/95	locomotory behavior	biological_process	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
EOG8X6FPP	GO:0005759	1/95	mitochondrial matrix	cellular_component	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]
EOG8X6FPP	GO:0042331	1/95	phototaxis	biological_process	"The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981]
EOG8X6FPP	GO:0010133	1/95	proline catabolic process to glutamate	biological_process	"The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz]
EOG8X6FPP	GO:0005739	1/95	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8X6FPP	GO:0071949	1/95	FAD binding	molecular_function	"Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]
EOG80P6N2	GO:0005524	26/97	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG80P6N2	GO:0008026	26/97	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG80P6N2	GO:0003676	25/97	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80P6N2	GO:0005643	1/97	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG80P6N2	GO:0051028	1/97	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG80P6N2	GO:0031965	1/97	nuclear membrane	cellular_component	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
EOG80P6N2	GO:0003723	1/97	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG80P6N2	GO:0015031	1/97	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG80P6N2	GO:0005737	1/97	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG812PKR	GO:0005524	25/85	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG812PKR	GO:0004674	23/85	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG812PKR	GO:0004672	2/85	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG812PKR	GO:0016301	1/85	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG851H5R	GO:0006950	1/105	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8X6FPX	GO:0003824	177/787	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8X6FPX	GO:0047077	20/787	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	molecular_function	"Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin." [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN]
EOG8X6FPX	GO:0016874	19/787	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8X6FPX	GO:0004497	7/787	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8X6FPX	GO:0008756	4/787	o-succinylbenzoate-CoA ligase activity	molecular_function	"Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate." [EC:6.2.1.26]
EOG8X6FPX	GO:0004467	2/787	long-chain fatty acid-CoA ligase activity	molecular_function	"Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.3]
EOG8X6FPX	GO:0005524	2/787	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8X6FPX	GO:0006637	1/787	acyl-CoA metabolic process	biological_process	"The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732]
EOG8X6FPX	GO:0046627	1/787	negative regulation of insulin receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8X6FPX	GO:0046949	1/787	fatty-acyl-CoA biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732]
EOG8X6FPX	GO:0005777	1/787	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8X6FPX	GO:0019433	1/787	triglyceride catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732]
EOG8X6FPX	GO:0001676	1/787	long-chain fatty acid metabolic process	biological_process	"The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ajp]
EOG8X6FPX	GO:0004321	1/787	fatty-acyl-CoA synthase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86]
EOG8X6FPX	GO:0071616	1/787	acyl-CoA biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [GOC:cjk]
EOG8X6FPX	GO:0016021	1/787	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8X6FPX	GO:0042626	1/787	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8X6FPX	GO:0009062	1/787	fatty acid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]
EOG8X6FPX	GO:0016887	1/787	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8X6FPX	GO:0008218	1/787	bioluminescence	biological_process	"The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732]
EOG8K0T2G	GO:0051056	12/100	regulation of small GTPase mediated signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
EOG8K0T2G	GO:0005083	12/100	GTPase regulator activity	molecular_function	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
EOG8K0T2G	GO:0005096	12/100	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8K0T2G	GO:0003964	4/100	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8K0T2G	GO:0008270	4/100	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8K0T2G	GO:0003723	4/100	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8K0T2G	GO:0015074	3/100	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8K0T2G	GO:0004190	1/100	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8Z6538	GO:0004046	96/196	aminoacylase activity	molecular_function	"Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14]
EOG8Z6538	GO:0006520	96/196	cellular amino acid metabolic process	biological_process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]
EOG8Z6538	GO:0005737	96/196	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Z6538	GO:0008237	53/196	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8Z6538	GO:0016787	4/196	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8Z6538	GO:0004180	1/196	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8Z6539	GO:0045930	1/75	negative regulation of mitotic cell cycle	biological_process	"Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8Z6539	GO:0007030	1/75	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG83FK9M	GO:0008270	74/433	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83FK9M	GO:0009058	72/433	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG83FK9M	GO:0016491	46/433	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG83FK9M	GO:0016747	38/433	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG83FK9M	GO:0016788	37/433	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG83FK9M	GO:0004313	36/433	[acyl-carrier-protein] S-acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38]
EOG83FK9M	GO:0004315	35/433	3-oxoacyl-[acyl-carrier-protein] synthase activity	molecular_function	"Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.41]
EOG83FK9M	GO:0004319	35/433	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	molecular_function	"Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10]
EOG83FK9M	GO:0016295	35/433	myristoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14, MetaCyc:RXN-10727]
EOG83FK9M	GO:0004320	35/433	oleoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14]
EOG83FK9M	GO:0016296	35/433	palmitoyl-[acyl-carrier-protein] hydrolase activity	molecular_function	"Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14, MetaCyc:RXN-9549]
EOG83FK9M	GO:0004316	35/433	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
EOG83FK9M	GO:0004314	35/433	[acyl-carrier-protein] S-malonyltransferase activity	molecular_function	"Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39]
EOG83FK9M	GO:0004317	35/433	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.61]
EOG83FK9M	GO:0016740	23/433	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG83FK9M	GO:0004312	19/433	fatty acid synthase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85]
EOG83FK9M	GO:0047451	3/433	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	molecular_function	"Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [EC:4.2.1.59, MetaCyc:4.2.1.59-RXN]
EOG83FK9M	GO:0003960	2/433	NADPH:quinone reductase activity	molecular_function	"Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5]
EOG83FK9M	GO:0005811	2/433	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG83FK9M	GO:0050111	1/433	mycocerosate synthase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + 7n H(+) + n methylmalonyl-CoA + 2n NADPH = n CO(2) + n CoA + n H(2)O + multi-methyl-branched acyl-CoA + 2n NADP(+)." [EC:2.3.1.111, RHEA:10591]
EOG89CSP0	GO:0030170	24/89	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG89CSP0	GO:0019752	21/89	carboxylic acid metabolic process	biological_process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]
EOG89CSP0	GO:0016831	20/89	carboxy-lyase activity	molecular_function	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]
EOG89CSP0	GO:0003824	3/89	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG89CSP0	GO:0004837	1/89	tyrosine decarboxylase activity	molecular_function	"Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25]
EOG8WSZQ9	GO:0005524	30/117	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8WSZQ9	GO:0003989	27/117	acetyl-CoA carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2]
EOG8WSZQ9	GO:0006633	27/117	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8WSZQ9	GO:0004075	26/117	biotin carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]
EOG8WSZQ9	GO:0046872	25/117	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WSZQ9	GO:0004658	2/117	propionyl-CoA carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3]
EOG8WSZQ9	GO:0016021	1/117	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WSZQ9	GO:0042626	1/117	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8WSZQ9	GO:0005811	1/117	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8WSZQ9	GO:0005737	1/117	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WSZQ9	GO:0016874	1/117	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8WSZQ9	GO:0000902	1/117	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8G1PWP	GO:0016021	83/226	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8G1PWP	GO:0055085	83/226	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8G1PWP	GO:0008643	1/226	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8G1PWP	GO:0046872	1/226	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z6536	GO:0007517	1/93	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8Z6536	GO:0048644	1/93	muscle organ morphogenesis	biological_process	"The process in which the anatomical structures of muscle are generated and organized." [GOC:jid]
EOG8Z6536	GO:0009952	1/93	anterior/posterior pattern specification	biological_process	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8Z6536	GO:0007498	1/93	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8Z6536	GO:0042694	1/93	muscle cell fate specification	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators]
EOG8FJBR5	GO:0008270	1/185	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FJBR5	GO:0003677	1/185	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8MGVP3	GO:0008270	14/476	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MGVP3	GO:0003676	4/476	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89PDFN	GO:0005549	1/113	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8FJBS3	GO:0003676	72/1100	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8FJBS3	GO:0003964	71/1100	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8FJBS3	GO:0004523	69/1100	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8FJBS3	GO:0003723	34/1100	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8FJBS3	GO:0008270	8/1100	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FJBS3	GO:0004519	1/1100	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8FJBS3	GO:0004842	1/1100	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8ZKN1G	GO:0008270	3/13	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZKN1G	GO:0003676	3/13	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZKN1G	GO:0005634	3/13	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZKN1G	GO:0046872	1/13	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82VBZM	GO:0046658	1/59	anchored component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]
EOG82VBZM	GO:0046928	1/59	regulation of neurotransmitter secretion	biological_process	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
EOG8PP0WX	GO:0005524	55/227	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8PP0WX	GO:0004692	45/227	cGMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
EOG8PP0WX	GO:0030553	14/227	cGMP binding	molecular_function	"Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai]
EOG8PP0WX	GO:0004674	11/227	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8PP0WX	GO:0005952	7/227	cAMP-dependent protein kinase complex	cellular_component	"An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732]
EOG8PP0WX	GO:0008603	7/227	cAMP-dependent protein kinase regulator activity	molecular_function	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]
EOG8PP0WX	GO:0006468	2/227	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8PP0WX	GO:0032095	1/227	regulation of response to food	biological_process	"Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add]
EOG8PP0WX	GO:0005886	1/227	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8PP0WX	GO:0007526	1/227	larval somatic muscle development	biological_process	"The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG8PP0WX	GO:0008345	1/227	larval locomotory behavior	biological_process	"Locomotory behavior in a larval (immature) organism." [GOC:ai]
EOG8PP0WX	GO:0007616	1/227	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8PP0WX	GO:0046959	1/227	habituation	biological_process	"A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089]
EOG8PP0WX	GO:0009744	1/227	response to sucrose	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl]
EOG8PP0WX	GO:0016301	1/227	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8PP0WX	GO:0030536	1/227	larval feeding behavior	biological_process	"Feeding behavior in a larval (immature) organism." [GOC:mah]
EOG8PP0WX	GO:0007631	1/227	feeding behavior	biological_process	"Behavior associated with the intake of food." [GOC:mah]
EOG8PP0WX	GO:0004672	1/227	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8PP0WX	GO:0004690	1/227	cyclic nucleotide-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a cyclic nucleotide." [GOC:mah]
EOG8PP0WX	GO:0008016	1/227	regulation of heart contraction	biological_process	"Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8PP0WX	GO:0007614	1/227	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG80306V	GO:0008270	329/890	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80306V	GO:0004181	329/890	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG80306V	GO:0005319	8/890	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG80306V	GO:0005615	3/890	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG80306V	GO:0007586	1/890	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG80306V	GO:0022008	1/890	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG80306V	GO:0031982	1/890	vesicle	cellular_component	"Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz]
EOG80306V	GO:0004180	1/890	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG80306V	GO:0005515	1/890	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG80306V	GO:0005576	1/890	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG80306V	GO:0016021	1/890	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80306V	GO:0004930	1/890	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8CVJN0	GO:0005089	20/94	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8CVJN0	GO:0030833	1/94	regulation of actin filament polymerization	biological_process	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG8CVJN0	GO:0005544	1/94	calcium-dependent phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]
EOG8CVJN0	GO:1900029	1/94	positive regulation of ruffle assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf]
EOG8CVJN0	GO:0032319	1/94	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8CVJN0	GO:0016319	1/94	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8CVJN0	GO:0035022	1/94	positive regulation of Rac protein signal transduction	biological_process	"Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction." [GOC:bf]
EOG8CVJN0	GO:0005622	1/94	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8FBM93	GO:0046331	1/118	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8FBM94	GO:0016597	11/116	amino acid binding	molecular_function	"Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]
EOG8FBM94	GO:0008152	8/116	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8FBM94	GO:0004794	6/116	L-threonine ammonia-lyase activity	molecular_function	"Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [EC:4.3.1.19]
EOG8FBM94	GO:0006567	4/116	threonine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]
EOG8FBM94	GO:0003824	1/116	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8XWJD7	GO:0038032	22/98	termination of G-protein coupled receptor signaling pathway	biological_process	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]
EOG8XWJD7	GO:0005057	21/98	receptor signaling protein activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf]
EOG8XWJD7	GO:0030695	15/98	GTPase regulator activity	molecular_function	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
EOG8XWJD7	GO:0014045	1/98	establishment of endothelial blood-brain barrier	biological_process	"Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dgh, GOC:dph, GOC:sart]
EOG8XWJD7	GO:0008069	1/98	dorsal/ventral axis specification, ovarian follicular epithelium	biological_process	"Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb]
EOG8XWJD7	GO:0009786	1/98	regulation of asymmetric cell division	biological_process	"Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr]
EOG8XWJD7	GO:0000578	1/98	embryonic axis specification	biological_process	"The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb]
EOG8XWJD7	GO:0007186	1/98	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8XWJD7	GO:0008105	1/98	asymmetric protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma]
EOG8XWJD7	GO:0005096	1/98	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8XWJD7	GO:0005886	1/98	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8XWJD7	GO:0045179	1/98	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8XWJD7	GO:0010001	1/98	glial cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]
EOG8XWJD7	GO:0005515	1/98	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8XWJD7	GO:0043547	1/98	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8XWJD7	GO:0007310	1/98	oocyte dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8XWJD7	GO:0001965	1/98	G-protein alpha-subunit binding	molecular_function	"Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd]
EOG8XWJD7	GO:0016324	1/98	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8XWJD7	GO:0009408	1/98	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG8XWJD7	GO:0005092	1/98	GDP-dissociation inhibitor activity	molecular_function	"Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah]
EOG8XWJD7	GO:0005737	1/98	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XWJD7	GO:0003015	1/98	heart process	biological_process	"A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]
EOG8XWJD7	GO:0060857	1/98	establishment of glial blood-brain barrier	biological_process	"Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
EOG8XWJD7	GO:0050790	1/98	regulation of catalytic activity	biological_process	"Any process that modulates the activity of an enzyme." [GOC:ai]
EOG8XWJD7	GO:0007049	1/98	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG8XWJD7	GO:0055059	1/98	asymmetric neuroblast division	biological_process	"The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
EOG8XWJD7	GO:0008277	1/98	regulation of G-protein coupled receptor protein signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators]
EOG8XWJD7	GO:0006979	1/98	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8XWJD7	GO:0019991	1/98	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG8XWJD7	GO:0050832	1/98	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8XWJD7	GO:0030866	1/98	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8XWJD7	GO:0007419	1/98	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8XWJD7	GO:0032291	1/98	axon ensheathment in central nervous system	biological_process	"The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh]
EOG8XWJD7	GO:0007303	1/98	cytoplasmic transport, nurse cell to oocyte	biological_process	"The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238]
EOG8XWJD7	GO:0042594	1/98	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8XSP4N	GO:0020037	39/685	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8XSP4N	GO:0006629	26/685	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8XSP4N	GO:0046872	15/685	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8XSP4N	GO:0005576	13/685	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8XSP4N	GO:0016717	12/685	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]
EOG8XSP4N	GO:0005506	12/685	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8XSP4N	GO:0006633	12/685	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8XSP4N	GO:0042438	9/685	melanin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [CHEBI:25179, GOC:curators]
EOG8XSP4N	GO:0016853	9/685	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8XSP4N	GO:0048067	9/685	cuticle pigmentation	biological_process	"Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
EOG8XSP4N	GO:0007275	3/685	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8XSP4N	GO:0016021	2/685	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XSP4N	GO:0004965	1/685	G-protein coupled GABA receptor activity	molecular_function	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor]
EOG8XSP4N	GO:0004930	1/685	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8XSP4N	GO:0048082	1/685	regulation of adult chitin-containing cuticle pigmentation	biological_process	"Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
EOG8XSP4N	GO:0005739	1/685	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8XSP4N	GO:0006583	1/685	melanin biosynthetic process from tyrosine	biological_process	"The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators]
EOG8XSP4N	GO:0007602	1/685	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG8XSP4N	GO:0007601	1/685	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8XSP4N	GO:0005737	1/685	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XSP4N	GO:0018298	1/685	protein-chromophore linkage	biological_process	"The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma]
EOG8XSP4N	GO:0005811	1/685	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8XSP4N	GO:0046331	1/685	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8XSP4N	GO:0009881	1/685	photoreceptor activity	molecular_function	"The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators]
EOG8XSP4N	GO:0060179	1/685	male mating behavior	biological_process	"The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb]
EOG8XSP4N	GO:0048066	1/685	developmental pigmentation	biological_process	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
EOG8XSP4N	GO:0048065	1/685	male courtship behavior, veined wing extension	biological_process	"The process during courtship where the male insect extends his wings. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
EOG8XSP4N	GO:0070451	1/685	cell hair	cellular_component	"A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located." [PMID:11526084]
EOG8BZQKM	GO:0003964	7/71	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8BZQKM	GO:0004519	6/71	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8BZQKM	GO:0003723	2/71	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG89PDCG	GO:0003676	100/519	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89PDCG	GO:0046872	76/519	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89PDCG	GO:0008270	20/519	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG89PDCG	GO:0005634	20/519	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG89PDCG	GO:0015074	4/519	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG89PDCG	GO:0045931	1/519	positive regulation of mitotic cell cycle	biological_process	"Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG89PDCG	GO:0006357	1/519	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG89PDCG	GO:0030178	1/519	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG89PDCG	GO:0007476	1/519	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG89PDCG	GO:0046331	1/519	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG89PDCG	GO:0031935	1/519	regulation of chromatin silencing	biological_process	"Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah]
EOG89PDCG	GO:0007155	1/519	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG89PDCG	GO:0045892	1/519	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG80P6PC	GO:0004030	37/289	aldehyde dehydrogenase [NAD(P)+] activity	molecular_function	"Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5]
EOG80P6PC	GO:0006081	36/289	cellular aldehyde metabolic process	biological_process	"The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732]
EOG80P6PC	GO:0005975	28/289	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG80P6PC	GO:0005840	26/289	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG80P6PC	GO:0006412	26/289	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG80P6PC	GO:0003735	26/289	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG80P6PC	GO:0016773	26/289	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG80P6PC	GO:0016301	22/289	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG80P6PC	GO:0004370	2/289	glycerol kinase activity	molecular_function	"Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21647]
EOG80P6PC	GO:0005811	1/289	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG80P6PC	GO:0000022	1/289	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG80P6PC	GO:0007052	1/289	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG80P6PC	GO:0007264	1/289	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG80P6PC	GO:0016491	1/289	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG80P6PC	GO:0005525	1/289	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG80P6PC	GO:0005622	1/289	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG80P6PC	GO:0016020	1/289	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG815JV5	GO:0008569	1/86	ATP-dependent microtubule motor activity, minus-end-directed	molecular_function	"Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP." [EC:3.6.4.5, GOC:mah, GOC:vw]
EOG815JV5	GO:0008152	1/86	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG815JV5	GO:0051493	1/86	regulation of cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
EOG815JV5	GO:0008407	1/86	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG815JV5	GO:0016325	1/86	oocyte microtubule cytoskeleton organization	biological_process	"Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]
EOG815JV5	GO:0007309	1/86	oocyte axis specification	biological_process	"The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8XSP3N	GO:0008061	250/966	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8XSP3N	GO:0005576	250/966	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8XSP3N	GO:0006030	246/966	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8XSP3N	GO:0004252	27/966	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8XSP3N	GO:0005044	26/966	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8XSP3N	GO:0016020	24/966	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XSP3N	GO:0006032	4/966	chitin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8XSP3N	GO:0005975	4/966	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8XSP3N	GO:0004568	4/966	chitinase activity	molecular_function	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
EOG8XSP3N	GO:0006955	2/966	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8XSP3N	GO:0030247	2/966	polysaccharide binding	molecular_function	"Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah]
EOG8XSP3N	GO:0030246	2/966	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8XSP3N	GO:0006508	1/966	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8XSP3N	GO:0007616	1/966	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8XSP3N	GO:0004190	1/966	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8XSP3N	GO:0007614	1/966	short-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8FR35G	GO:0000151	25/95	ubiquitin ligase complex	cellular_component	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]
EOG8FR35G	GO:0006511	25/95	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8FR35G	GO:0034450	25/95	ubiquitin-ubiquitin ligase activity	molecular_function	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]
EOG8FR35D	GO:0008270	17/109	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8FR35D	GO:0016491	4/109	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8FR35D	GO:0004725	2/109	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8FR35D	GO:0043914	1/109	NADPH:sulfur oxidoreductase activity	molecular_function	"Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+." [GOC:jl, PMID:17449625]
EOG8FR35D	GO:0006098	1/109	pentose-phosphate shunt	biological_process	"The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]
EOG8FR35D	GO:0019417	1/109	sulfur oxidation	biological_process	"The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur." [GOC:jl, MetaCyc:FESULFOX-PWY, MetaCyc:SULFUROX-PWY]
EOG8FR35D	GO:0016709	1/109	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
EOG8FR35D	GO:0071949	1/109	FAD binding	molecular_function	"Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]
EOG8FR35D	GO:0003779	1/109	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8FR35D	GO:0043195	1/109	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG8FR35D	GO:0005829	1/109	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8FR35D	GO:0007411	1/109	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8FR35D	GO:0016322	1/109	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG8FR35D	GO:0070995	1/109	NADPH oxidation	biological_process	"A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP." [GOC:BHF, GOC:mah]
EOG8FR35D	GO:0055114	1/109	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8FR35D	GO:0005886	1/109	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8FR35D	GO:0004345	1/109	glucose-6-phosphate dehydrogenase activity	molecular_function	"Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49]
EOG8FR35D	GO:0030047	1/109	actin modification	biological_process	"Covalent modification of an actin molecule." [GOC:mah]
EOG8FR35D	GO:0048813	1/109	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8FR35D	GO:0050661	1/109	NADP binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]
EOG8FR35D	GO:0045214	1/109	sarcomere organization	biological_process	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
EOG8FR35D	GO:0030042	1/109	actin filament depolymerization	biological_process	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]
EOG84BDMK	GO:0005213	7/33	structural constituent of chorion	molecular_function	"The action of a molecule that contributes to the structural integrity of a chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu]
EOG84BDMK	GO:0042600	7/33	chorion	cellular_component	"A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
EOG84BDMK	GO:0007304	7/33	chorion-containing eggshell formation	biological_process	"The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG84BDMK	GO:0007275	7/33	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG83XXKB	GO:0008270	40/165	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83XXKB	GO:0016740	2/165	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG83XXKB	GO:0035218	1/165	leg disc development	biological_process	"Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
EOG83XXKB	GO:0002121	1/165	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG83XXKB	GO:0042220	1/165	response to cocaine	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [CHEBI:27958, GOC:ef, GOC:jl]
EOG83XXKB	GO:0007476	1/165	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG83XXKB	GO:0006909	1/165	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG83XXKB	GO:0045475	1/165	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG83XXKB	GO:0036011	1/165	imaginal disc-derived leg segmentation	biological_process	"Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf]
EOG83XXKB	GO:0022416	1/165	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG83XXKB	GO:0005634	1/165	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83XXKB	GO:0005515	1/165	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG83XXKB	GO:0045893	1/165	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8JWXW2	GO:0016021	3/38	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8JWXW2	GO:0006811	3/38	ion transport	biological_process	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG88WFH0	GO:0008270	5/7	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG88WFH0	GO:0005634	5/7	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88WFH0	GO:0003676	2/7	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZSCM0	GO:0005634	22/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZSCM0	GO:0030915	22/88	Smc5-Smc6 complex	cellular_component	"A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739]
EOG8ZSCM0	GO:0006281	22/88	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG8PZMQ1	GO:0005524	4/24	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8PZMQ1	GO:0004672	4/24	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8K0T2M	GO:0003997	51/180	acyl-CoA oxidase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6]
EOG8K0T2M	GO:0005777	51/180	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG8K0T2M	GO:0003995	51/180	acyl-CoA dehydrogenase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]
EOG8K0T2M	GO:0006635	48/180	fatty acid beta-oxidation	biological_process	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]
EOG8K0T2M	GO:0050660	48/180	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8K0T2M	GO:0006631	3/180	fatty acid metabolic process	biological_process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]
EOG8K0T2M	GO:0004970	1/180	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8K0T2M	GO:0005234	1/180	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8K0T2M	GO:0016020	1/180	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8K0T2M	GO:0006909	1/180	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG88KTRZ	GO:0016021	2/8	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88KTRZ	GO:0022857	2/8	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG88KTRZ	GO:0008643	1/8	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG8JT2K7	GO:0006511	24/103	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8JT2K7	GO:0008234	21/103	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8JT2K7	GO:0043687	1/103	post-translational protein modification	biological_process	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]
EOG8JT2K7	GO:0016579	1/103	protein deubiquitination	biological_process	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]
EOG8JT2K7	GO:0031647	1/103	regulation of protein stability	biological_process	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]
EOG8JT2K7	GO:0060968	1/103	regulation of gene silencing	biological_process	"Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb]
EOG8JT2K7	GO:0035220	1/103	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8JT2K7	GO:0030307	1/103	positive regulation of cell growth	biological_process	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8JT2K7	GO:0005634	1/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87WR5K	GO:0004672	3/17	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG87WR5K	GO:0005524	3/17	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG84QWDQ	GO:0016887	23/87	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG84QWDQ	GO:0005524	23/87	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8NCPV5	GO:0004672	1/3	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8NCPV5	GO:0005524	1/3	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG81C99G	GO:0003676	26/90	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG81C99G	GO:0008408	24/90	3'-5' exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]
EOG81C99G	GO:0046872	2/90	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG81C99G	GO:0030529	1/90	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG81C99G	GO:0044748	1/90	3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing	molecular_function	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming distinct miRNA isoforms from a mature miRNA." [GOC:sart]
EOG81C99G	GO:0005234	1/90	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG81C99G	GO:0016020	1/90	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG81C99G	GO:0044747	1/90	mature miRNA 3'-end processing	biological_process	"Any process involved in forming distinct miRNA isoforms from a mature miRNA that differ at their 3'-ends." [PMID:22055292, PMID:22055293]
EOG81C99G	GO:0004970	1/90	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8PVRD4	GO:0006685	2/3	sphingomyelin catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732]
EOG8PVRD4	GO:0004767	2/3	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG82C0PS	GO:0003743	2/70	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG82C0PS	GO:0005737	1/70	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82C0PS	GO:0005634	1/70	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG82C0PS	GO:0000932	1/70	cytoplasmic mRNA processing body	cellular_component	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603]
EOG8HQH24	GO:0006879	2/3	cellular iron ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah]
EOG8HQH24	GO:0006826	2/3	iron ion transport	biological_process	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8HQH24	GO:0008199	2/3	ferric iron binding	molecular_function	"Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai]
EOG8NZX8B	GO:0016021	3/176	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NZX8B	GO:0006506	2/176	GPI anchor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
EOG8NZX8B	GO:0000139	2/176	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8NZX8B	GO:0015031	2/176	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8NZX8B	GO:0005789	2/176	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8NZX8B	GO:0008565	2/176	protein transporter activity	molecular_function	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]
EOG82RGN2	GO:0005886	30/114	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG82RGN2	GO:0005509	30/114	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG82RGN2	GO:0007156	30/114	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG82RGN2	GO:0016021	29/114	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82RGN2	GO:0004022	2/114	alcohol dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
EOG82RGN2	GO:0005887	1/114	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82RGN2	GO:0030950	1/114	establishment or maintenance of actin cytoskeleton polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures." [GOC:mah]
EOG82RGN2	GO:0004714	1/114	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG82RGN2	GO:0005198	1/114	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG82RGN2	GO:0007295	1/114	growth of a germarium-derived egg chamber	biological_process	"Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG82RGN2	GO:0050829	1/114	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG82RGN2	GO:0048477	1/114	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG82RGN2	GO:0007442	1/114	hindgut morphogenesis	biological_process	"The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
EOG82RGN2	GO:0005925	1/114	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG82RGN2	GO:0016339	1/114	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
EOG82RGN2	GO:0050839	1/114	cell adhesion molecule binding	molecular_function	"Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai]
EOG82RGN2	GO:0007440	1/114	foregut morphogenesis	biological_process	"The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid]
EOG82RGN2	GO:0042247	1/114	establishment of planar polarity of follicular epithelium	biological_process	"Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
EOG82RGN2	GO:0045089	1/114	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG82RGN2	GO:0007431	1/114	salivary gland development	biological_process	"The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044]
EOG82RGN2	GO:0007424	1/114	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG82RGN2	GO:0009925	1/114	basal plasma membrane	cellular_component	"The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG82RGN2	GO:0004872	1/114	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG82RGN2	GO:0045571	1/114	negative regulation of imaginal disc growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators]
EOG85B3WT	GO:0016020	1/59	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG85B3WT	GO:0000155	1/59	phosphorelay sensor kinase activity	molecular_function	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
EOG8NZX8F	GO:0003676	3/18	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NZX8F	GO:0046872	2/18	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NZX8F	GO:0005634	1/18	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NZX8F	GO:0008270	1/18	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8S1WNM	GO:0006464	23/93	cellular protein modification process	biological_process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
EOG8S1WNM	GO:0003824	21/93	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8S1WNM	GO:0016740	2/93	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8S1WNM	GO:0009249	1/93	protein lipoylation	biological_process	"The addition of a lipoyl group to an amino acid residue in a protein." [GOC:mah]
EOG8S1WNM	GO:0016874	1/93	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG80S309	GO:0006508	1/2	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG80S309	GO:0016020	1/2	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG89360V	GO:0016740	1/7	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG82RGN8	GO:0005506	11/48	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG82RGN8	GO:0020037	11/48	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG82RGN8	GO:0016705	11/48	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG82RGN8	GO:0004497	10/48	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG8S4RWX	GO:0003677	4/32	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8F20HQ	GO:0008270	9/89	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZW7QV	GO:0005578	11/59	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG8ZW7QV	GO:0005201	11/59	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG8ZW7QV	GO:0005509	11/59	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8ZW7QV	GO:0016020	2/59	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8ZW7QV	GO:0016787	1/59	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8ZW7QV	GO:0004714	1/59	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG8ZW7QV	GO:0007596	1/59	blood coagulation	biological_process	"The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [http://www.graylab.ac.uk/omd/, ISBN:0198506732]
EOG8ZW7QV	GO:0008061	1/59	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8ZW7QV	GO:0004888	1/59	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8ZW7QV	GO:0006030	1/59	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8ZW7QV	GO:0004867	1/59	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG8ZW7QV	GO:0005044	1/59	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8ZW7QV	GO:0004447	1/59	iodide peroxidase activity	molecular_function	"Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O." [EC:1.11.1.8]
EOG8G7FC2	GO:0016773	26/127	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8G7FC2	GO:0016301	12/127	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8G7FC2	GO:0005524	12/127	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8G7FC2	GO:0005634	1/127	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8G7FC2	GO:0000184	1/127	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	biological_process	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]
EOG8G7FC2	GO:0006396	1/127	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8G7FC2	GO:0046777	1/127	protein autophosphorylation	biological_process	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
EOG8G7FC2	GO:0007274	1/127	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8G7FC2	GO:0004674	1/127	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8G7FC2	GO:0016310	1/127	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG8G7FC2	GO:0006950	1/127	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8G7FC2	GO:0050808	1/127	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG8G7FC2	GO:0018105	1/127	peptidyl-serine phosphorylation	biological_process	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]
EOG8G7FC2	GO:0005737	1/127	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8G7FC2	GO:0004672	1/127	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8G7FC2	GO:0046872	1/127	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8G7FC2	GO:0008144	1/127	drug binding	molecular_function	"Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732]
EOG8G7FC2	GO:0048489	1/127	synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr]
EOG8X99X5	GO:0005622	2/114	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8X99X5	GO:0008270	2/114	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X99X5	GO:0035194	1/114	posttranscriptional gene silencing by RNA	biological_process	"Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation." [GOC:mah, PMID:15020054, PMID:15066275, PMID:15066283]
EOG8X99X5	GO:0005634	1/114	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8X99X5	GO:0043186	1/114	P granule	cellular_component	"A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
EOG8FR37K	GO:0005634	23/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FR37K	GO:0007049	23/88	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG8FR37K	GO:0004601	1/88	peroxidase activity	molecular_function	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]
EOG8H74TV	GO:0008270	4/22	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PCD95	GO:0004725	1/4	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8ZW7QX	GO:0006888	24/97	ER to Golgi vesicle-mediated transport	biological_process	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]
EOG8ZW7QX	GO:0008270	24/97	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZW7QX	GO:0030127	24/97	COPII vesicle coat	cellular_component	"One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]
EOG8ZW7QX	GO:0006886	24/97	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8ZW7QX	GO:0016021	1/97	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZW7QX	GO:0035151	1/97	regulation of tube size, open tracheal system	biological_process	"Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]
EOG8ZW7QX	GO:0007030	1/97	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8ZW7QX	GO:0007157	1/97	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]
EOG8ZW7QX	GO:0022409	1/97	positive regulation of cell-cell adhesion	biological_process	"Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
EOG8ZW7QX	GO:0006511	1/97	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8ZW7QX	GO:0009306	1/97	protein secretion	biological_process	"The controlled release of proteins from a cell." [GOC:ai]
EOG8ZW7QX	GO:0040003	1/97	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8ZW7QX	GO:0007029	1/97	endoplasmic reticulum organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
EOG8ZW7QX	GO:0000902	1/97	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8ZW7QX	GO:0004674	1/97	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8ZW7QX	GO:0005524	1/97	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZW7QX	GO:0005811	1/97	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8ZW7QX	GO:0070403	1/97	NAD+ binding	molecular_function	"Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
EOG8ZW7QX	GO:0048081	1/97	positive regulation of cuticle pigmentation	biological_process	"Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
EOG8ZW7QX	GO:0070971	1/97	endoplasmic reticulum exit site	cellular_component	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]
EOG8ZW7QX	GO:0006457	1/97	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8ZW7QX	GO:0035158	1/97	regulation of tube diameter, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584]
EOG8ZW7QX	GO:0008360	1/97	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8ZW7QX	GO:0003331	1/97	positive regulation of extracellular matrix constituent secretion	biological_process	"Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
EOG8ZW7QX	GO:0016203	1/97	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8ZW7QX	GO:0009405	1/97	pathogenesis	biological_process	"The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators]
EOG8ZW7QX	GO:0034394	1/97	protein localization to cell surface	biological_process	"A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah]
EOG8ZW7QX	GO:0071711	1/97	basement membrane organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah]
EOG8ZW7QX	GO:0003755	1/97	peptidyl-prolyl cis-trans isomerase activity	molecular_function	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
EOG8ZW7QX	GO:0030011	1/97	maintenance of cell polarity	biological_process	"The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8ZW7QX	GO:0035149	1/97	lumen formation, open tracheal system	biological_process	"Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
EOG87WR59	GO:0008270	1/3	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG87WR59	GO:0005634	1/3	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83FK9S	GO:0005543	1/94	phospholipid binding	molecular_function	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8WQ3J5	GO:0030008	1/88	TRAPP complex	cellular_component	"A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]
EOG8WQ3J5	GO:0016192	1/88	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8WQ3J5	GO:0005737	1/88	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WQ3J5	GO:0022008	1/88	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8WQ3J5	GO:0033227	1/88	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8VT8B5	GO:0030424	3/282	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8VT8B5	GO:0007411	3/282	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8VT8B5	GO:0008406	3/282	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG8VT8B5	GO:0022409	2/282	positive regulation of cell-cell adhesion	biological_process	"Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
EOG8VT8B5	GO:0016319	2/282	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8VT8B5	GO:2000274	2/282	regulation of epithelial cell migration, open tracheal system	biological_process	"Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system." [GOC:obol]
EOG8VT8B5	GO:0003151	2/282	outflow tract morphogenesis	biological_process	"The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145]
EOG8VT8B5	GO:0048036	2/282	central complex development	biological_process	"The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252]
EOG8VT8B5	GO:0035050	2/282	embryonic heart tube development	biological_process	"The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
EOG8VT8B5	GO:0004872	2/282	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8VT8B5	GO:0008038	2/282	neuron recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators]
EOG8VT8B5	GO:0007419	2/282	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8VT8B5	GO:0007432	2/282	salivary gland boundary specification	biological_process	"Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957]
EOG8VT8B5	GO:0005886	1/282	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8VT8B5	GO:0031987	1/282	locomotion involved in locomotory behavior	biological_process	"Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
EOG8VT8B5	GO:0048854	1/282	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG8VT8B5	GO:0009649	1/282	entrainment of circadian clock	biological_process	"The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid]
EOG8VT8B5	GO:0001764	1/282	neuron migration	biological_process	"The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]
EOG8VT8B5	GO:0007427	1/282	epithelial cell migration, open tracheal system	biological_process	"The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8VT8B5	GO:0043025	1/282	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8VT8B5	GO:0005887	1/282	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VT8B5	GO:0005515	1/282	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VT8B5	GO:0035385	1/282	Roundabout signaling pathway	biological_process	"A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling]
EOG8VT8B5	GO:0044295	1/282	axonal growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954]
EOG8VT8B5	GO:0016199	1/282	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG8VT8B5	GO:0030425	1/282	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8VT8B5	GO:0001964	1/282	startle response	biological_process	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
EOG8VT8B5	GO:0046716	1/282	muscle cell cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
EOG8VT8B5	GO:0042685	1/282	cardioblast cell fate specification	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
EOG8VT8B5	GO:0071666	1/282	Slit-Robo signaling complex	cellular_component	"A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate." [GOC:sart, PMID:17062560, PMID:18359766]
EOG8VT8B5	GO:0072499	1/282	photoreceptor cell axon guidance	biological_process	"The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
EOG8VT8B5	GO:0042803	1/282	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8VT8B5	GO:0031982	1/282	vesicle	cellular_component	"Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz]
EOG8VT8B5	GO:0007426	1/282	tracheal outgrowth, open tracheal system	biological_process	"The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8VT8B5	GO:0008201	1/282	heparin binding	molecular_function	"Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]
EOG8VT8B5	GO:0048813	1/282	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8VT8B5	GO:0008039	1/282	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8VT8B5	GO:0043234	1/282	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8VT8B5	GO:0070983	1/282	dendrite guidance	biological_process	"The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
EOG8VT8B5	GO:0050773	1/282	regulation of dendrite development	biological_process	"Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai]
EOG8VT8B5	GO:0008045	1/282	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8WM785	GO:0005856	5/44	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8JT2KB	GO:0005525	1/37	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8JT2KB	GO:0007264	1/37	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8NCPVD	GO:0051537	25/86	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8NCPVD	GO:0009055	25/86	electron carrier activity	molecular_function	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]
EOG8NCPVD	GO:0046872	25/86	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NCPVD	GO:0055114	1/86	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8NCPVD	GO:0005759	1/86	mitochondrial matrix	cellular_component	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]
EOG82RGNZ	GO:0016021	22/91	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82RGNZ	GO:0055085	4/91	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG82RGNZ	GO:0000139	1/91	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG82RGNZ	GO:0005798	1/91	Golgi-associated vesicle	cellular_component	"Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]
EOG82RGNZ	GO:0015783	1/91	GDP-fucose transport	biological_process	"The directed movement of GDP-fucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
EOG82RGNZ	GO:0007625	1/91	grooming behavior	biological_process	"The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl, GOC:pr]
EOG82RGNZ	GO:0005457	1/91	GDP-fucose transmembrane transporter activity	molecular_function	"Enables the transfer of a GDP-fucose from one side of the membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG82RGNZ	GO:0036071	1/91	N-glycan fucosylation	biological_process	"The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains." [CHEBI:59520, GOC:sart, PMID:19948734]
EOG82RGNZ	GO:0036085	1/91	GDP-fucose import into Golgi lumen	biological_process	"The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237]
EOG82RGNZ	GO:0036066	1/91	protein O-linked fucosylation	biological_process	"The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:sart, PMID:19948734]
EOG82RGNZ	GO:0016020	1/91	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82RGNZ	GO:0008643	1/91	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG82RGNZ	GO:0048193	1/91	Golgi vesicle transport	biological_process	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG82RGNZ	GO:0005794	1/91	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8PVRCT	GO:0005643	28/100	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG8PVRCT	GO:0006629	1/100	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8PVRCT	GO:0007184	1/100	SMAD protein import into nucleus	biological_process	"The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph]
EOG8PVRCT	GO:0005737	1/100	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8PVRCT	GO:0051297	1/100	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8PVRCT	GO:0006231	1/100	dTMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732]
EOG8PVRCT	GO:0042332	1/100	gravitaxis	biological_process	"The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
EOG8PVRCT	GO:0004799	1/100	thymidylate synthase activity	molecular_function	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate." [EC:2.1.1.45, RHEA:12107]
EOG8PVRCT	GO:0022008	1/100	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8JT2KJ	GO:0007155	25/113	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8JT2KJ	GO:0015629	25/113	actin cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
EOG8JT2KJ	GO:0005200	24/113	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8JT2KJ	GO:0001726	24/113	ruffle	cellular_component	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]
EOG8JT2KJ	GO:0007016	24/113	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG8JT2KJ	GO:0005925	24/113	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8JT2KJ	GO:0005198	3/113	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8JT2KJ	GO:0005856	2/113	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8JT2KJ	GO:0007298	1/113	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8JT2KJ	GO:0007430	1/113	terminal branching, open tracheal system	biological_process	"Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG8JT2KJ	GO:0003779	1/113	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8JT2KJ	GO:0016203	1/113	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8JT2KJ	GO:0008360	1/113	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8JT2KJ	GO:0006909	1/113	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8JT2KJ	GO:0007475	1/113	apposition of dorsal and ventral imaginal disc-derived wing surfaces	biological_process	"The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu]
EOG8JT2KJ	GO:0045892	1/113	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8JT2KJ	GO:0005515	1/113	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8JT2KJ	GO:0005178	1/113	integrin binding	molecular_function	"Interacting selectively and non-covalently with an integrin." [GOC:ceb]
EOG8JT2KJ	GO:0035160	1/113	maintenance of epithelial integrity, open tracheal system	biological_process	"Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process." [GOC:mtg_sensu, PMID:10694415, PMID:14681183]
EOG8JT2KJ	GO:0060439	1/113	trachea morphogenesis	biological_process	"The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG8JT2KJ	GO:0007526	1/113	larval somatic muscle development	biological_process	"The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid]
EOG8KD90X	GO:0016787	24/120	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8KD90X	GO:0003824	6/120	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8KD90X	GO:0046872	3/120	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8KD90X	GO:0004725	3/120	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8S7N42	GO:0005524	53/187	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8S7N42	GO:0004674	50/187	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8S7N42	GO:0035556	8/187	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8S7N42	GO:0000287	8/187	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8S7N42	GO:0016021	3/187	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8S7N42	GO:0005840	3/187	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8S7N42	GO:0006468	2/187	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8S7N42	GO:0005515	2/187	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8S7N42	GO:0004683	2/187	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG8S7N42	GO:0004672	2/187	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8S7N42	GO:0004711	1/187	ribosomal protein S6 kinase activity	molecular_function	"Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608]
EOG8S7N42	GO:0046533	1/187	negative regulation of photoreceptor cell differentiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
EOG8S7N42	GO:0008340	1/187	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8S7N42	GO:0046777	1/187	protein autophosphorylation	biological_process	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]
EOG8S7N42	GO:0008306	1/187	associative learning	biological_process	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
EOG8S7N42	GO:0042308	1/187	negative regulation of protein import into nucleus	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl]
EOG8S7N42	GO:0005700	1/187	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8S7N42	GO:0035106	1/187	operant conditioning	biological_process	"Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior." [PMID:14662373]
EOG8S7N42	GO:0018105	1/187	peptidyl-serine phosphorylation	biological_process	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]
EOG8S7N42	GO:0050941	1/187	negative regulation of pigment cell differentiation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai]
EOG8S7N42	GO:0016456	1/187	X chromosome located dosage compensation complex, transcription activating	cellular_component	"An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster." [GOC:ma, GOC:mtg_sensu]
EOG8S7N42	GO:0035175	1/187	histone kinase activity (H3-S10 specific)	molecular_function	"Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3." [GOC:bf, PMID:15041176]
EOG8S7N42	GO:0046580	1/187	negative regulation of Ras protein signal transduction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
EOG8S7N42	GO:0031936	1/187	negative regulation of chromatin silencing	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah]
EOG8S7N42	GO:0005703	1/187	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG8S7N42	GO:0005705	1/187	polytene chromosome interband	cellular_component	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
EOG8S7N42	GO:0007275	1/187	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8S7N42	GO:0042683	1/187	negative regulation of compound eye cone cell fate specification	biological_process	"Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell." [GOC:mtg_sensu]
EOG8S7N42	GO:0007528	1/187	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8S7N42	GO:0004697	1/187	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG8S7N42	GO:0045475	1/187	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8S7N42	GO:0007474	1/187	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG8S7N42	GO:0043987	1/187	histone H3-S10 phosphorylation	biological_process	"The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone." [GOC:jl]
EOG8S7N42	GO:0031594	1/187	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8S7N42	GO:0051276	1/187	chromosome organization	biological_process	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8S7N42	GO:0048477	1/187	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8S7N42	GO:0016321	1/187	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8S7N42	GO:0003677	1/187	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8S7N42	GO:0006351	1/187	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8S7N42	GO:0016572	1/187	histone phosphorylation	biological_process	"The modification of histones by addition of phosphate groups." [GOC:ai]
EOG8S7N42	GO:0006325	1/187	chromatin organization	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
EOG8S7N42	GO:0000228	1/187	nuclear chromosome	cellular_component	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
EOG85HVCG	GO:0003676	24/78	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG85HVCG	GO:0008168	24/78	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8H74TB	GO:0016787	2/5	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8JQ6DF	GO:0006412	27/90	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8JQ6DF	GO:0003735	27/90	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8JQ6DF	GO:0005840	27/90	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8616MV	GO:0000155	1/5	phosphorelay sensor kinase activity	molecular_function	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
EOG8616MV	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8616MV	GO:0071555	1/5	cell wall organization	biological_process	"A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah]
EOG8ZGRV0	GO:0003713	3/104	transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8ZGRV0	GO:0046975	3/104	histone methyltransferase activity (H3-K36 specific)	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein." [GOC:ai]
EOG8ZGRV0	GO:0046331	1/104	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8ZGRV0	GO:0030785	1/104	[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine." [EC:2.1.1.127]
EOG82RGNQ	GO:0004096	47/133	catalase activity	molecular_function	"Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6]
EOG82RGNQ	GO:0020037	47/133	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG82RGNQ	GO:0046872	40/133	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82RGNQ	GO:0006979	26/133	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG82RGNQ	GO:0042744	21/133	hydrogen peroxide catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]
EOG82RGNQ	GO:0007568	1/133	aging	biological_process	"A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death (GO:0016265) and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators]
EOG82RGNQ	GO:0042542	1/133	response to hydrogen peroxide	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]
EOG82RGNQ	GO:0016209	1/133	antioxidant activity	molecular_function	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
EOG82RGNQ	GO:0005777	1/133	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG82RGNQ	GO:0035206	1/133	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG82RGNQ	GO:0008340	1/133	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG815JVW	GO:0016788	11/57	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG815JVW	GO:0003676	1/57	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K0T3X	GO:0016021	2/6	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D2962	GO:0003964	185/1227	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8D2962	GO:0003723	151/1227	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8D2962	GO:0004519	49/1227	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8D2962	GO:0006355	11/1227	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8D2962	GO:0003676	2/1227	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8D2962	GO:0003677	2/1227	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8D2962	GO:0008270	1/1227	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D2962	GO:0046872	1/1227	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8D2962	GO:0008234	1/1227	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8D2962	GO:0050660	1/1227	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8D2962	GO:0016021	1/1227	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D2962	GO:0008033	1/1227	tRNA processing	biological_process	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]
EOG8D2962	GO:0005634	1/1227	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D2962	GO:0022857	1/1227	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8JWXVJ	GO:0005525	1/46	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8JWXVJ	GO:0003924	1/46	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8J13QX	GO:0005509	39/105	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8J13QX	GO:0003676	7/105	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8J13QX	GO:0005524	7/105	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8J13QX	GO:0008026	7/105	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8J13QX	GO:0005856	2/105	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8J13QX	GO:0032440	2/105	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8D2968	GO:0003677	56/1616	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8D2968	GO:0006313	36/1616	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG8D2968	GO:0015074	36/1616	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8D2968	GO:0004803	36/1616	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG8D2968	GO:0006355	9/1616	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8D2968	GO:0008270	4/1616	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8D2968	GO:0007275	3/1616	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8D2968	GO:0005634	3/1616	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8D2968	GO:0006351	3/1616	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8V19F4	GO:0006694	14/93	steroid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]
EOG8V19F4	GO:0017127	14/93	cholesterol transporter activity	molecular_function	"Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai]
EOG8V19F4	GO:0015485	14/93	cholesterol binding	molecular_function	"Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732]
EOG8V19F4	GO:0008289	6/93	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG80P6P7	GO:0005576	94/324	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG80P6P7	GO:0008061	94/324	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG80P6P7	GO:0006030	94/324	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG80P6P7	GO:0005581	1/324	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8XKXPR	GO:0005509	33/85	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG88972C	GO:0016021	28/94	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88972C	GO:0006810	22/94	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG88972C	GO:0055085	5/94	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG88972C	GO:0005811	1/94	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG88972C	GO:0005739	1/94	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG88972C	GO:0006843	1/94	mitochondrial citrate transport	biological_process	"The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a mitochondrion." [GOC:ai]
EOG88972C	GO:0016006	1/94	Nebenkern	cellular_component	"A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma]
EOG88972C	GO:0015746	1/94	citrate transport	biological_process	"The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG86HJTB	GO:0006450	28/52	regulation of translational fidelity	biological_process	"Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]
EOG86HJTB	GO:0032543	24/52	mitochondrial translation	biological_process	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]
EOG86HJTB	GO:0070681	24/52	glutaminyl-tRNAGln biosynthesis via transamidation	biological_process	"A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921]
EOG86HJTB	GO:0005739	24/52	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG86HJTB	GO:0050567	24/52	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	molecular_function	"Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN]
EOG86HJTB	GO:0005524	24/52	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG86HJTB	GO:0030956	24/52	glutamyl-tRNA(Gln) amidotransferase complex	cellular_component	"A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg]
EOG8NKF8B	GO:0005319	30/134	lipid transporter activity	molecular_function	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
EOG8NKF8B	GO:0005576	1/134	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8NKF8B	GO:0006629	1/134	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8NKF8B	GO:0015918	1/134	sterol transport	biological_process	"The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]
EOG8NKF8B	GO:0005875	1/134	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8NKF8B	GO:0034196	1/134	acylglycerol transport	biological_process	"The directed movement of an acylglycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:BHF, GOC:rl]
EOG8NKF8B	GO:0003700	1/134	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NKF8B	GO:0045178	1/134	basal part of cell	cellular_component	"The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194]
EOG8NKF8B	GO:0043565	1/134	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NKF8B	GO:0004806	1/134	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG8NKF8B	GO:0005615	1/134	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8TTK3J	GO:0046872	1/21	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8TTK3J	GO:0003676	1/21	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HX7FQ	GO:0008092	1/100	cytoskeletal protein binding	molecular_function	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
EOG8HX7FQ	GO:0001654	1/100	eye development	biological_process	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
EOG8HX7FQ	GO:0042052	1/100	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8HX7FQ	GO:0016013	1/100	syntrophin complex	cellular_component	"A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [http://www.dmd.nl/DGC.html#syn]
EOG8HX7FQ	GO:0008582	1/100	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8KD936	GO:0016021	77/225	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8KD936	GO:0005918	3/225	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG8KD936	GO:0019991	3/225	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG8KD936	GO:0060857	3/225	establishment of glial blood-brain barrier	biological_process	"Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
EOG8KD936	GO:0035151	2/225	regulation of tube size, open tracheal system	biological_process	"Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]
EOG8KD936	GO:0007424	2/225	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8KD936	GO:0005919	1/225	pleated septate junction	cellular_component	"A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298]
EOG8KD936	GO:0005198	1/225	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8KD936	GO:0005923	1/225	bicellular tight junction	cellular_component	"An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181]
EOG8KD936	GO:0005886	1/225	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8KD936	GO:0061343	1/225	cell adhesion involved in heart morphogenesis	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
EOG8KD936	GO:0005515	1/225	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KD936	GO:0035159	1/225	regulation of tube length, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
EOG8KD936	GO:0003015	1/225	heart process	biological_process	"A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]
EOG8KD936	GO:0007391	1/225	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8KD936	GO:0035002	1/225	liquid clearance, open tracheal system	biological_process	"The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352]
EOG87SVVD	GO:0005634	25/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87SVVD	GO:0003700	25/103	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG87SVVD	GO:0007165	5/103	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG87SVVD	GO:0003677	1/103	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG87SVVD	GO:0005737	1/103	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG87SVVD	GO:0051607	1/103	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG87SVVD	GO:0006967	1/103	positive regulation of antifungal peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah]
EOG87SVVD	GO:0045429	1/103	positive regulation of nitric oxide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators]
EOG87SVVD	GO:0048935	1/103	peripheral nervous system neuron development	biological_process	"The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh]
EOG87SVVD	GO:0006974	1/103	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG87SVVD	GO:0045089	1/103	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG87SVVD	GO:0045944	1/103	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG87SVVD	GO:0006963	1/103	positive regulation of antibacterial peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475]
EOG87SVVD	GO:0034198	1/103	cellular response to amino acid starvation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]
EOG87SVVD	GO:0008063	1/103	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG87SVVD	GO:0061057	1/103	peptidoglycan recognition protein signaling pathway	biological_process	"A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280]
EOG87SVVD	GO:0048813	1/103	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG87SVVD	GO:0005515	1/103	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG87SVVD	GO:0006964	1/103	positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
EOG87SVVD	GO:0000981	1/103	RNA polymerase II transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
EOG87SVVD	GO:0001077	1/103	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG87SVVD	GO:0002230	1/103	positive regulation of defense response to virus by host	biological_process	"Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
EOG87SVVD	GO:0009617	1/103	response to bacterium	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]
EOG87SVVD	GO:0006366	1/103	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG87SVVD	GO:0050829	1/103	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG87SVVD	GO:0045087	1/103	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG87SVVD	GO:0043565	1/103	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG87SVVD	GO:0010628	1/103	positive regulation of gene expression	biological_process	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG87SVVD	GO:0006955	1/103	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG82RGNT	GO:0016740	1/73	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG82RGNT	GO:0004597	1/73	peptide-aspartate beta-dioxygenase activity	molecular_function	"Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2." [EC:1.14.11.16]
EOG8QJV2C	GO:0046872	16/71	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QJV2C	GO:0043186	1/71	P granule	cellular_component	"A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
EOG8QJV2C	GO:0030717	1/71	karyosome formation	biological_process	"The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
EOG8QJV2C	GO:0048471	1/71	perinuclear region of cytoplasm	cellular_component	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]
EOG8QJV2C	GO:0003676	1/71	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QJV2C	GO:0007310	1/71	oocyte dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8QJV2C	GO:0007319	1/71	negative regulation of oskar mRNA translation	biological_process	"Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems]
EOG8QJV2C	GO:0016788	1/71	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG8H1DBQ	GO:0008270	3/25	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8H1DBQ	GO:0003676	3/25	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8H1DBQ	GO:0004190	1/25	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8NKF8H	GO:0016021	22/110	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NKF8H	GO:0005524	3/110	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8NKF8H	GO:0044267	3/110	cellular protein metabolic process	biological_process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]
EOG8NKF8H	GO:0016485	1/110	protein processing	biological_process	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]
EOG8NKF8H	GO:0035103	1/110	sterol regulatory element binding protein cleavage	biological_process	"The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids." [GOC:bf, GOC:vw, PMID:12923525]
EOG8RR8X6	GO:0007018	9/40	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8RR8X6	GO:0003777	9/40	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8T7BHH	GO:0016740	1/90	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8T7BHH	GO:0005737	1/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8THZ82	GO:0003824	41/113	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8THZ82	GO:0004165	3/113	dodecenoyl-CoA delta-isomerase activity	molecular_function	"Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [EC:5.3.3.8]
EOG8THZ82	GO:0016853	2/113	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG805VH4	GO:0016491	1/3	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8HB11R	GO:0003700	25/88	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8HB11R	GO:0005634	23/88	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8HB11R	GO:0043565	23/88	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8HB11R	GO:0003677	2/88	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8HB11R	GO:0050911	1/88	detection of chemical stimulus involved in sensory perception of smell	biological_process	"The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8HB11R	GO:0048813	1/88	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8HB11R	GO:0007411	1/88	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8HB11R	GO:0006351	1/88	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8HB11R	GO:0008039	1/88	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8HB11R	GO:0070983	1/88	dendrite guidance	biological_process	"The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
EOG8HB11R	GO:0003714	1/88	transcription corepressor activity	molecular_function	"Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG8HB11R	GO:0007636	1/88	chemosensory jump behavior	biological_process	"The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance." [GOC:jid]
EOG8HB11R	GO:0045944	1/88	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8ZPH8Q	GO:0008306	1/99	associative learning	biological_process	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
EOG8ZPH8Q	GO:0048172	1/99	regulation of short-term neuronal synaptic plasticity	biological_process	"A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290]
EOG8ZPH8Q	GO:0045202	1/99	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8ZPH8Q	GO:0007268	1/99	synaptic transmission	biological_process	"The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
EOG8NKF8P	GO:0019783	2/88	ubiquitin-like protein-specific protease activity	molecular_function	"Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated." [GOC:ma, GOC:mah]
EOG8NKF8P	GO:0016790	2/88	thiolester hydrolase activity	molecular_function	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [http://www.onelook.com]
EOG8NKF8P	GO:0005044	1/88	scavenger receptor activity	molecular_function	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]
EOG8NKF8P	GO:0030247	1/88	polysaccharide binding	molecular_function	"Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah]
EOG8NKF8P	GO:0016020	1/88	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NKF8P	GO:0006955	1/88	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG805VFC	GO:0003924	46/161	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG805VFC	GO:0003746	46/161	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG805VFC	GO:0005525	46/161	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG805VFC	GO:0005737	43/161	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG805VFC	GO:0005811	2/161	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG805VFC	GO:0005853	2/161	eukaryotic translation elongation factor 1 complex	cellular_component	"A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950]
EOG805VFC	GO:0006414	2/161	translational elongation	biological_process	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]
EOG805VFC	GO:0005829	1/161	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG805VFC	GO:0005875	1/161	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG805VFC	GO:0016779	1/161	nucleotidyltransferase activity	molecular_function	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
EOG805VFC	GO:0008340	1/161	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG805VFC	GO:0004781	1/161	sulfate adenylyltransferase (ATP) activity	molecular_function	"Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4]
EOG805VFC	GO:0022008	1/161	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG803073	GO:0004842	28/103	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG803073	GO:0023051	27/103	regulation of signaling	biological_process	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
EOG803073	GO:0008270	23/103	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG803073	GO:0005509	23/103	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG803073	GO:0005634	19/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG803073	GO:0004871	19/103	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG803073	GO:0007166	18/103	cell surface receptor signaling pathway	biological_process	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
EOG803073	GO:0048134	1/103	germ-line cyst formation	biological_process	"Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920]
EOG803073	GO:0030971	1/103	receptor tyrosine kinase binding	molecular_function	"Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity." [GOC:mah]
EOG803073	GO:0009950	1/103	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG803073	GO:0016874	1/103	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG803073	GO:0001784	1/103	phosphotyrosine binding	molecular_function	"Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein." [PMID:14636584]
EOG803073	GO:0007465	1/103	R7 cell fate commitment	biological_process	"The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883]
EOG803073	GO:0006508	1/103	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG803073	GO:0005938	1/103	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG803073	GO:0008340	1/103	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG803073	GO:0042127	1/103	regulation of cell proliferation	biological_process	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
EOG803073	GO:0006897	1/103	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG803073	GO:0010941	1/103	regulation of cell death	biological_process	"Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]
EOG803073	GO:0033500	1/103	carbohydrate homeostasis	biological_process	"A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah]
EOG803073	GO:0005515	1/103	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG803073	GO:0008069	1/103	dorsal/ventral axis specification, ovarian follicular epithelium	biological_process	"Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb]
EOG803073	GO:0042059	1/103	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG803073	GO:0007476	1/103	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG803073	GO:0007175	1/103	negative regulation of epidermal growth factor-activated receptor activity	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators]
EOG803073	GO:0005737	1/103	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG803073	GO:0007298	1/103	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG803073	GO:0007173	1/103	epidermal growth factor receptor signaling pathway	biological_process	"A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933]
EOG803073	GO:0001754	1/103	eye photoreceptor cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators]
EOG8T1M19	GO:0007018	2/4	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8T1M19	GO:0003777	2/4	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8T1M19	GO:0030286	2/4	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8323DX	GO:0016491	12/27	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8T7BHF	GO:0008021	34/124	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8T7BHF	GO:0007269	33/124	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8T7BHF	GO:0005524	32/124	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8T7BHF	GO:0003824	21/124	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8T7BHF	GO:0046872	4/124	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8T7BHF	GO:0016079	1/124	synaptic vesicle exocytosis	biological_process	"Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]
EOG8T7BHF	GO:0008355	1/124	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG8T7BHF	GO:0008049	1/124	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8T7BHF	GO:0008306	1/124	associative learning	biological_process	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
EOG8T7BHF	GO:0071632	1/124	optomotor response	biological_process	"Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish." [GOC:dos, PMID:12726833, PMID:2469195]
EOG8T7BHF	GO:0043195	1/124	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG8T7BHF	GO:0030054	1/124	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8T7BHF	GO:0007613	1/124	memory	biological_process	"The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089]
EOG8T7BHF	GO:0048149	1/124	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8T7BHF	GO:0009408	1/124	response to heat	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
EOG88D389	GO:0007165	19/141	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG88D389	GO:0007432	1/141	salivary gland boundary specification	biological_process	"Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957]
EOG88D389	GO:0008347	1/141	glial cell migration	biological_process	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
EOG88D389	GO:0050919	1/141	negative chemotaxis	biological_process	"The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete]
EOG88D389	GO:0008045	1/141	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG88D389	GO:0007411	1/141	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG88D389	GO:0005515	1/141	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG88D389	GO:0005043	1/141	netrin receptor activity involved in chemorepulsion	molecular_function	"Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin." [GOC:dph, GOC:signaling]
EOG88D389	GO:0016021	1/141	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG87WR3K	GO:0016884	23/84	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	molecular_function	"Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532]
EOG87WR3K	GO:0016740	2/84	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG87WR3K	GO:0004040	1/84	amidase activity	molecular_function	"Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4]
EOG87WR3K	GO:0005811	1/84	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8M945C	GO:0044267	23/106	cellular protein metabolic process	biological_process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]
EOG8M945C	GO:0005524	23/106	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8M945C	GO:0016307	20/106	phosphatidylinositol phosphate kinase activity	molecular_function	"Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495]
EOG8M945C	GO:0046872	19/106	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8M945C	GO:0035556	18/106	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8M945C	GO:0000285	3/106	1-phosphatidylinositol-3-phosphate 5-kinase activity	molecular_function	"Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13612]
EOG8M945C	GO:0005768	1/106	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG8M945C	GO:0000046	1/106	autophagosome maturation	biological_process	"The process in which autophagosomes, double-membraned vacuoles containing cytoplasmic material fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [GOC:autophagy, GOC:lf, PMID:11099404, PMID:16874026, PMID:17534139]
EOG8M945C	GO:0016308	1/106	1-phosphatidylinositol-4-phosphate 5-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.68, RHEA:14428]
EOG8M945C	GO:0010008	1/106	endosome membrane	cellular_component	"The lipid bilayer surrounding an endosome." [GOC:mah]
EOG8M945C	GO:0008333	1/106	endosome to lysosome transport	biological_process	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]
EOG8M945C	GO:0046854	1/106	phosphatidylinositol phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]
EOG8M945C	GO:0016310	1/106	phosphorylation	biological_process	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
EOG8M945C	GO:0008270	1/106	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8M945C	GO:0012506	1/106	vesicle membrane	cellular_component	"The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah]
EOG8VMHWQ	GO:0003676	2/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8VMHWQ	GO:0046872	1/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8VMHWQ	GO:0008270	1/4	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VMHWQ	GO:0005634	1/4	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SBHCS	GO:0016021	26/88	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SBHCS	GO:0008146	25/88	sulfotransferase activity	molecular_function	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]
EOG8SBHCS	GO:0004394	1/88	heparan sulfate 2-O-sulfotransferase activity	molecular_function	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate." [PMID:9153262]
EOG8SBHCS	GO:0000139	1/88	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8SBHCS	GO:0008152	1/88	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8SBHCS	GO:0007165	1/88	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8SBHCS	GO:0007424	1/88	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8SFCN5	GO:0006955	23/81	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8SFCN5	GO:0016020	22/81	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8SFCN5	GO:0045167	1/81	asymmetric protein localization involved in cell fate determination	biological_process	"Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai]
EOG8SFCN5	GO:0005164	1/81	tumor necrosis factor receptor binding	molecular_function	"Interacting selectively and non-covalently with the tumor necrosis factor receptor." [GOC:ai]
EOG8SFCN5	GO:0070050	1/81	neuron cellular homeostasis	biological_process	"The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah]
EOG8SFCN5	GO:0005515	1/81	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8SFCN5	GO:0035006	1/81	melanization defense response	biological_process	"The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809]
EOG8SFCN5	GO:0007254	1/81	JNK cascade	biological_process	"An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974]
EOG8SFCN5	GO:1900074	1/81	negative regulation of neuromuscular synaptic transmission	biological_process	"Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
EOG8SFCN5	GO:0006915	1/81	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8SFCN5	GO:0097191	1/81	extrinsic apoptotic signaling pathway	biological_process	"A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]
EOG8SFCN5	GO:0005886	1/81	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8SFCN5	GO:0045176	1/81	apical protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf]
EOG8SFCN5	GO:0044214	1/81	spanning component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:ecd]
EOG8SFCN5	GO:0043652	1/81	engulfment of apoptotic cell	biological_process	"The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]
EOG8SFCN5	GO:0050829	1/81	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8SFCN5	GO:0045087	1/81	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG81G5K3	GO:0030170	36/119	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG81G5K3	GO:0009058	35/119	biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
EOG81G5K3	GO:0003824	24/119	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG81G5K3	GO:0008483	6/119	transaminase activity	molecular_function	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]
EOG81G5K3	GO:0004021	6/119	L-alanine:2-oxoglutarate aminotransferase activity	molecular_function	"Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate." [EC:2.6.1.2, RHEA:19456]
EOG8W6R9H	GO:0006511	25/90	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8W6R9H	GO:0004221	4/90	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG8W6R9H	GO:0008234	2/90	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8W6R9H	GO:0045746	1/90	negative regulation of Notch signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8W6R9H	GO:0008233	1/90	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8W6R9H	GO:0016787	1/90	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8W6R9H	GO:0008270	1/90	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG88KTR5	GO:0006208	28/104	pyrimidine nucleobase catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [CHEBI:26432, GOC:go_curators]
EOG88KTR5	GO:0005737	28/104	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG88KTR5	GO:0016812	25/104	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	molecular_function	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]
EOG88KTR5	GO:0016810	6/104	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
EOG88KTR5	GO:0004157	5/104	dihydropyrimidinase activity	molecular_function	"Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate." [EC:3.5.2.2]
EOG88KTR5	GO:0045747	1/104	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG88KTR5	GO:0007265	1/104	Ras protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf]
EOG88KTR5	GO:0006207	1/104	'de novo' pyrimidine nucleobase biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]
EOG88KTR5	GO:0007613	1/104	memory	biological_process	"The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089]
EOG88KTR5	GO:0017153	1/104	sodium:dicarboxylate symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]
EOG88KTR5	GO:0016020	1/104	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG88KTR5	GO:0051642	1/104	centrosome localization	biological_process	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
EOG870WZK	GO:0046872	32/96	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG870WZK	GO:0005634	2/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG870WZK	GO:0008270	2/96	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG870WZK	GO:0003676	1/96	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG870WZK	GO:0045944	1/96	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG870WZK	GO:0007088	1/96	regulation of mitotic nuclear division	biological_process	"Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
EOG82FW0K	GO:0016740	9/186	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG82FW0K	GO:0004364	2/186	glutathione transferase activity	molecular_function	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
EOG82FW0K	GO:0005811	1/186	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG82FW0K	GO:0050220	1/186	prostaglandin-E synthase activity	molecular_function	"Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)." [EC:5.3.99.3, RHEA:12896]
EOG8ZKN4W	GO:0005615	1/6	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8RNDPG	GO:0016620	60/211	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG8RNDPG	GO:0001758	5/211	retinal dehydrogenase activity	molecular_function	"Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36]
EOG8RNDPG	GO:0004029	2/211	aldehyde dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]
EOG8RNDPG	GO:0045471	1/211	response to ethanol	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators]
EOG8RNDPG	GO:0008774	1/211	acetaldehyde dehydrogenase (acetylating) activity	molecular_function	"Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+." [EC:1.2.1.10]
EOG8RNDPG	GO:0005811	1/211	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8RNDPG	GO:0005739	1/211	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8RNDPG	GO:0005737	1/211	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8B5RKG	GO:0000166	21/77	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8B5RKG	GO:0003723	20/77	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8B5RKG	GO:0046872	20/77	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8B5RKG	GO:0005634	20/77	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8B5RKG	GO:0003729	1/77	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8B5RKG	GO:0005681	1/77	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8B5RKG	GO:0042060	1/77	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8B5RKG	GO:0000398	1/77	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8TXF88	GO:0016021	4/78	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RNDPC	GO:0007030	1/100	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8RNDPC	GO:0005829	1/100	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8RNDPC	GO:0007095	1/100	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8RNDPC	GO:0009306	1/100	protein secretion	biological_process	"The controlled release of proteins from a cell." [GOC:ai]
EOG8RNDPC	GO:0005794	1/100	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG89GP01	GO:0003676	1/3	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89GP01	GO:0046872	1/3	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8PK4QS	GO:0008270	1/72	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RNDPK	GO:0016021	1/108	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RNDPK	GO:0055085	1/108	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8R52JV	GO:0003700	1/7	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8R52JV	GO:0003677	1/7	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8R52JV	GO:0043565	1/7	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8R52JV	GO:0005634	1/7	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8R52JV	GO:0006355	1/7	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8TXF8M	GO:0007010	1/5	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8TXF8M	GO:0000902	1/5	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8KM1J7	GO:0030414	16/65	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8KM1J7	GO:0008233	1/65	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8P2SJ2	GO:0015074	13/185	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8P2SJ2	GO:0003677	13/185	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8P2SJ2	GO:0006310	13/185	DNA recombination	biological_process	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]
EOG8P2SJ2	GO:0003964	2/185	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8P2SJ2	GO:0003723	2/185	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8MGVNF	GO:0003676	5/132	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MGVNF	GO:0008270	5/132	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MGVNF	GO:0003723	2/132	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8MGVNF	GO:0003964	2/132	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8MGVNF	GO:0003677	2/132	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8MGVNF	GO:0015074	2/132	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8MGVNF	GO:0045202	1/132	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8MGVNF	GO:0003012	1/132	muscle system process	biological_process	"A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio]
EOG8MGVNF	GO:0042595	1/132	behavioral response to starvation	biological_process	"Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators]
EOG8MGVNF	GO:0030017	1/132	sarcomere	cellular_component	"The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]
EOG89S8NZ	GO:0031409	1/89	pigment binding	molecular_function	"Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah]
EOG89S8NZ	GO:0007476	1/89	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG89S8NZ	GO:0005576	1/89	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG82VBWZ	GO:0003993	33/135	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG82VBWZ	GO:0052826	1/135	inositol hexakisphosphate 2-phosphatase activity	molecular_function	"Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.62]
EOG87SVV0	GO:0006886	26/96	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG87SVV0	GO:0045335	26/96	phagocytic vesicle	cellular_component	"A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]
EOG87SVV0	GO:0005547	26/96	phosphatidylinositol-3,4,5-trisphosphate binding	molecular_function	"Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl]
EOG87SVV0	GO:0090389	26/96	phagosome-lysosome fusion involved in apoptotic cell clearance	biological_process	"The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb]
EOG87SVV0	GO:0007067	16/96	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG87SVV0	GO:0005886	1/96	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG87SVV0	GO:0005789	1/96	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG87SVV0	GO:0016023	1/96	cytoplasmic membrane-bounded vesicle	cellular_component	"A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
EOG87SVV0	GO:0016758	1/96	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG87SVV0	GO:0005768	1/96	endosome	cellular_component	"A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
EOG87SVV0	GO:0071456	1/96	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG87SVV0	GO:0000045	1/96	autophagosome assembly	biological_process	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]
EOG87SVV0	GO:0035091	1/96	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG8MGVNK	GO:0005524	25/92	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8MGVNK	GO:0004674	23/92	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8MGVNK	GO:0035556	22/92	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8MGVNK	GO:0008270	12/92	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MGVNK	GO:0046872	10/92	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8MGVNK	GO:0004697	3/92	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG8MGVNK	GO:0007613	1/92	memory	biological_process	"The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089]
EOG8MGVNK	GO:0016324	1/92	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8MGVNK	GO:0051491	1/92	positive regulation of filopodium assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG8MGVNK	GO:0030011	1/92	maintenance of cell polarity	biological_process	"The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8MGVNK	GO:0017022	1/92	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8MGVNK	GO:0007309	1/92	oocyte axis specification	biological_process	"The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8MGVNK	GO:0007294	1/92	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8MGVNK	GO:0002052	1/92	positive regulation of neuroblast proliferation	biological_process	"Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph]
EOG8MGVNK	GO:0090163	1/92	establishment of epithelial cell planar polarity	biological_process	"The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8MGVNK	GO:0045176	1/92	apical protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf]
EOG8MGVNK	GO:0055059	1/92	asymmetric neuroblast division	biological_process	"The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
EOG8MGVNK	GO:0045197	1/92	establishment or maintenance of epithelial cell apical/basal polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]
EOG8MGVNK	GO:0000132	1/92	establishment of mitotic spindle orientation	biological_process	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
EOG8MGVNK	GO:0045186	1/92	zonula adherens assembly	biological_process	"Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf]
EOG8MGVNK	GO:0016327	1/92	apicolateral plasma membrane	cellular_component	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
EOG8MGVNK	GO:0007043	1/92	cell-cell junction assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai]
EOG8MGVNK	GO:0007314	1/92	oocyte anterior/posterior axis specification	biological_process	"Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8MGVNK	GO:0035011	1/92	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG8MGVNK	GO:0010592	1/92	positive regulation of lamellipodium assembly	biological_process	"Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG8MGVNK	GO:0045167	1/92	asymmetric protein localization involved in cell fate determination	biological_process	"Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai]
EOG8MGVNK	GO:0001738	1/92	morphogenesis of a polarized epithelium	biological_process	"The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]
EOG8MGVNK	GO:0007416	1/92	synapse assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
EOG8MGVNK	GO:0007423	1/92	sensory organ development	biological_process	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
EOG8MGVNK	GO:0003382	1/92	epithelial cell morphogenesis	biological_process	"The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8MGVNK	GO:0016334	1/92	establishment or maintenance of polarity of follicular epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah]
EOG8MGVNK	GO:0016332	1/92	establishment or maintenance of polarity of embryonic epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah]
EOG8MGVNK	GO:0046667	1/92	compound eye retinal cell programmed cell death	biological_process	"Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672]
EOG8MGVNK	GO:0060446	1/92	branching involved in open tracheal system development	biological_process	"The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph]
EOG8MGVNK	GO:0005938	1/92	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8MGVNK	GO:0045179	1/92	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8MGVNK	GO:0007163	1/92	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8MGVNK	GO:0045196	1/92	establishment or maintenance of neuroblast polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083]
EOG8MGVNK	GO:0005515	1/92	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8MGVNK	GO:0006468	1/92	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8MGVNK	GO:0035003	1/92	subapical complex	cellular_component	"The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938]
EOG8577MP	GO:0006511	26/94	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8577MP	GO:0008234	18/94	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8577MP	GO:0008233	3/94	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8577MP	GO:0016579	1/94	protein deubiquitination	biological_process	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]
EOG8577MP	GO:0004221	1/94	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG8F4VQZ	GO:0006265	37/111	DNA topological change	biological_process	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]
EOG8F4VQZ	GO:0003918	37/111	DNA topoisomerase type II (ATP-hydrolyzing) activity	molecular_function	"Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192]
EOG8F4VQZ	GO:0003677	37/111	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8F4VQZ	GO:0005524	37/111	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8F4VQZ	GO:0016491	2/111	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8F4VQZ	GO:0000400	1/111	four-way junction DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464]
EOG8F4VQZ	GO:0003729	1/111	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8F4VQZ	GO:0046872	1/111	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8F4VQZ	GO:0006200	1/111	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8F4VQZ	GO:0000712	1/111	resolution of meiotic recombination intermediates	biological_process	"The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]
EOG8F4VQZ	GO:0008623	1/111	CHRAC	cellular_component	"An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179, PMID:9252192]
EOG8F4VQZ	GO:0007052	1/111	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8F4VQZ	GO:0007126	1/111	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8F4VQZ	GO:0006312	1/111	mitotic recombination	biological_process	"The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles." [GOC:elh]
EOG8F4VQZ	GO:0007095	1/111	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8F4VQZ	GO:0000819	1/111	sister chromatid segregation	biological_process	"The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh]
EOG8F4VQZ	GO:0007076	1/111	mitotic chromosome condensation	biological_process	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
EOG8F4VQZ	GO:0005694	1/111	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8F4VQZ	GO:0007067	1/111	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8F4VQZ	GO:0004252	1/111	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8F4VQZ	GO:0006261	1/111	DNA-dependent DNA replication	biological_process	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]
EOG8F4VQZ	GO:0000795	1/111	synaptonemal complex	cellular_component	"A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh]
EOG8F4VQZ	GO:0051310	1/111	metaphase plate congression	biological_process	"The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ai]
EOG8F4VQZ	GO:0003696	1/111	satellite DNA binding	molecular_function	"Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005]
EOG8F4VQZ	GO:0000182	1/111	rDNA binding	molecular_function	"Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA." [GOC:mah]
EOG8F4VQZ	GO:0005634	1/111	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8F4VQZ	GO:0006342	1/111	chromatin silencing	biological_process	"Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
EOG88D38T	GO:0006066	3/6	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG88D38T	GO:0008812	3/6	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG88D38T	GO:0050660	3/6	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG88D38W	GO:0016788	294/950	hydrolase activity, acting on ester bonds	molecular_function	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]
EOG88D38W	GO:0016042	262/950	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG88D38W	GO:0006629	148/950	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG88D38W	GO:0004806	8/950	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG88D38W	GO:0005615	5/950	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG88D38W	GO:0032504	5/950	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG88D38W	GO:0016298	4/950	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG88D38W	GO:0030246	1/950	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG88D38W	GO:0016787	1/950	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG88D38W	GO:0003676	1/950	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG88D38W	GO:0007586	1/950	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG88D38W	GO:0042632	1/950	cholesterol homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]
EOG88D38W	GO:0006886	1/950	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG88D38W	GO:0048812	1/950	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG88D38W	GO:0016192	1/950	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG88D38W	GO:0005576	1/950	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG88D38W	GO:0030132	1/950	clathrin coat of coated pit	cellular_component	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]
EOG88D38W	GO:0030130	1/950	clathrin coat of trans-Golgi network vesicle	cellular_component	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]
EOG88D38W	GO:0005198	1/950	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG88D38W	GO:0031410	1/950	cytoplasmic vesicle	cellular_component	"A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
EOG88D38W	GO:0070328	1/950	triglyceride homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
EOG88D38W	GO:0004771	1/950	sterol esterase activity	molecular_function	"Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13]
EOG8SFCNC	GO:0007165	1/4	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG86MF14	GO:0005509	41/115	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG86MF14	GO:0016174	1/115	NAD(P)H oxidase activity	molecular_function	"Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide." [EC:1.6.3.1]
EOG86MF14	GO:0022008	1/115	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG86MF14	GO:0006909	1/115	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG82FW00	GO:0005509	26/84	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG82FW00	GO:0016301	2/84	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG82FW00	GO:0006184	1/84	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG82FW00	GO:0003924	1/84	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8XD64V	GO:0005216	20/141	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8XD64V	GO:0016021	20/141	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8XD64V	GO:0046873	1/141	metal ion transmembrane transporter activity	molecular_function	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]
EOG8XD64V	GO:0070838	1/141	divalent metal ion transport	biological_process	"The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG8XD64V	GO:0016049	1/141	cell growth	biological_process	"The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]
EOG8XD64V	GO:0016787	1/141	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8XD64V	GO:0010960	1/141	magnesium ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." [GOC:dph, GOC:tb]
EOG8XD64V	GO:0055069	1/141	zinc ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
EOG8XD64V	GO:0007005	1/141	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8XD64V	GO:0005261	1/141	cation channel activity	molecular_function	"Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8XD64V	GO:0034703	1/141	cation channel complex	cellular_component	"An ion channel complex through which cations pass." [GOC:mah]
EOG8W6R95	GO:0003924	29/112	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8W6R95	GO:0005525	29/112	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8W6R95	GO:0005783	2/112	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8W6R95	GO:0007030	1/112	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8W6R95	GO:0016021	1/112	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8W6R95	GO:0005509	1/112	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8W6R95	GO:0005515	1/112	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8W6R95	GO:0007528	1/112	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG8W6R95	GO:0042802	1/112	identical protein binding	molecular_function	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
EOG8W6R95	GO:0016320	1/112	endoplasmic reticulum membrane fusion	biological_process	"The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum." [GOC:elh, GOC:jid]
EOG8W6R95	GO:0016020	1/112	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8W6R95	GO:0042803	1/112	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG8W6R95	GO:0006184	1/112	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8W6R95	GO:0000139	1/112	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8W6R95	GO:0031227	1/112	intrinsic component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
EOG8W6R95	GO:0007517	1/112	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8W6R95	GO:0061025	1/112	membrane fusion	biological_process	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]
EOG8W6R95	GO:0007029	1/112	endoplasmic reticulum organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
EOG8W6R95	GO:0051124	1/112	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8W6R95	GO:0006457	1/112	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8W6R95	GO:0008582	1/112	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8W6R95	GO:0032561	1/112	guanyl ribonucleotide binding	molecular_function	"Interacting selectively and non-covalently with a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
EOG8W6R95	GO:0005794	1/112	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8W6R95	GO:0007019	1/112	microtubule depolymerization	biological_process	"The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194]
EOG8W6R95	GO:0005737	1/112	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8W6R95	GO:0051260	1/112	protein homooligomerization	biological_process	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
EOG8W6R95	GO:0031114	1/112	regulation of microtubule depolymerization	biological_process	"Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah]
EOG8577MB	GO:0004930	25/109	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8577MB	GO:0016021	25/109	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8577MB	GO:0007218	23/109	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8577MB	GO:0005886	23/109	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8577MB	GO:0005509	23/109	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8577MB	GO:0007156	22/109	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8577MB	GO:0048057	1/109	R3/R4 development	biological_process	"The process whose specific outcome is the progression of the R3 and R4 pair of photoreceptors in the eye over time, from their formation to the mature structures. R3 and R4 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid]
EOG8577MB	GO:0050839	1/109	cell adhesion molecule binding	molecular_function	"Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai]
EOG8577MB	GO:0016339	1/109	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
EOG8577MB	GO:0005057	1/109	receptor signaling protein activity	molecular_function	"Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf]
EOG8577MB	GO:0035159	1/109	regulation of tube length, open tracheal system	biological_process	"Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
EOG8577MB	GO:0042067	1/109	establishment of ommatidial planar polarity	biological_process	"The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
EOG8577MB	GO:0007409	1/109	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8577MB	GO:0004872	1/109	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8577MB	GO:0070593	1/109	dendrite self-avoidance	biological_process	"The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551]
EOG8577MB	GO:0051963	1/109	regulation of synapse assembly	biological_process	"Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
EOG8577MB	GO:0001738	1/109	morphogenesis of a polarized epithelium	biological_process	"The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]
EOG8577MB	GO:0045746	1/109	negative regulation of Notch signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8577MB	GO:0050770	1/109	regulation of axonogenesis	biological_process	"Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]
EOG8577MB	GO:0005887	1/109	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8577MB	GO:0007464	1/109	R3/R4 cell fate commitment	biological_process	"The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
EOG8577MB	GO:0004022	1/109	alcohol dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
EOG8577MB	GO:0030177	1/109	positive regulation of Wnt signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8577MB	GO:0001736	1/109	establishment of planar polarity	biological_process	"Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
EOG8577MB	GO:0005515	1/109	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8577MB	GO:0016319	1/109	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8577MB	GO:0005911	1/109	cell-cell junction	cellular_component	"A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah]
EOG8577MB	GO:0090175	1/109	regulation of establishment of planar polarity	biological_process	"Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8577MB	GO:0007367	1/109	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG8577MB	GO:0007411	1/109	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8577MB	GO:0016318	1/109	ommatidial rotation	biological_process	"The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
EOG8577MB	GO:0035556	1/109	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8577MB	GO:0016358	1/109	dendrite development	biological_process	"The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8577MB	GO:0007164	1/109	establishment of tissue polarity	biological_process	"Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid]
EOG8577MB	GO:0030178	1/109	negative regulation of Wnt signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8577MB	GO:0016055	1/109	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG8577MB	GO:0004888	1/109	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8577MB	GO:0007165	1/109	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8577MB	GO:0048813	1/109	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG82VBWF	GO:0005681	1/115	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG82VBWF	GO:0000398	1/115	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG80GG4R	GO:0046331	1/96	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8K6JMG	GO:0005549	2/6	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG83R61F	GO:0031409	16/120	pigment binding	molecular_function	"Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah]
EOG83R61F	GO:0005576	11/120	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG83R61F	GO:0005215	4/120	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG83R61F	GO:0036094	3/120	small molecule binding	molecular_function	"Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]
EOG83R61F	GO:0030682	3/120	evasion or tolerance of host defense response	biological_process	"Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
EOG83R61F	GO:0005501	2/120	retinoid binding	molecular_function	"Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732]
EOG83R61G	GO:0031990	1/96	mRNA export from nucleus in response to heat stress	biological_process	"The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export." [GOC:mah, GOC:vw]
EOG83R61G	GO:0005634	1/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG83R61G	GO:0048477	1/96	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG83R61G	GO:0000347	1/96	THO complex	cellular_component	"The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]
EOG8C5G07	GO:0004252	2199/5565	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8C5G07	GO:0006508	98/5565	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8C5G07	GO:0005615	18/5565	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8C5G07	GO:0005576	17/5565	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8C5G07	GO:0007586	11/5565	digestion	biological_process	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
EOG8C5G07	GO:0004175	8/5565	endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8C5G07	GO:0016021	6/5565	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8C5G07	GO:0016787	5/5565	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8C5G07	GO:0016301	5/5565	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8C5G07	GO:0008236	5/5565	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8C5G07	GO:0045087	4/5565	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8C5G07	GO:0006629	4/5565	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8C5G07	GO:0006952	3/5565	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8C5G07	GO:0045752	3/5565	positive regulation of Toll signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8C5G07	GO:0050830	3/5565	defense response to Gram-positive bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
EOG8C5G07	GO:0008063	3/5565	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8C5G07	GO:0008233	3/5565	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8C5G07	GO:0005829	3/5565	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8C5G07	GO:0008889	3/5565	glycerophosphodiester phosphodiesterase activity	molecular_function	"Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]
EOG8C5G07	GO:0006071	3/5565	glycerol metabolic process	biological_process	"The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]
EOG8C5G07	GO:0050832	3/5565	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8C5G07	GO:0022008	2/5565	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8C5G07	GO:0050829	2/5565	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8C5G07	GO:0009950	2/5565	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8C5G07	GO:0035006	2/5565	melanization defense response	biological_process	"The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809]
EOG8C5G07	GO:0007311	2/5565	maternal specification of dorsal/ventral axis, oocyte, germ-line encoded	biological_process	"Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8C5G07	GO:0031638	2/5565	zymogen activation	biological_process	"The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd]
EOG8C5G07	GO:0008270	1/5565	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8C5G07	GO:0006964	1/5565	positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria	biological_process	"Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
EOG8C5G07	GO:0005515	1/5565	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8C5G07	GO:0005622	1/5565	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8C5G07	GO:0004435	1/5565	phosphatidylinositol phospholipase C activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]
EOG8C5G07	GO:0048812	1/5565	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8C5G07	GO:0008592	1/5565	regulation of Toll signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
EOG8C5G07	GO:0006967	1/5565	positive regulation of antifungal peptide biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah]
EOG8C5G07	GO:0003964	1/5565	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8C5G07	GO:0035008	1/5565	positive regulation of melanization defense response	biological_process	"Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf]
EOG8C5G07	GO:0035007	1/5565	regulation of melanization defense response	biological_process	"Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf]
EOG8C5G07	GO:0035556	1/5565	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8C5G07	GO:0003723	1/5565	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8C5G07	GO:0005581	1/5565	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG8C5G07	GO:0004930	1/5565	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8C5G07	GO:0006909	1/5565	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8C5G07	GO:0004180	1/5565	carboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
EOG8C5G07	GO:0006959	1/5565	humoral immune response	biological_process	"An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]
EOG8C5G07	GO:0004471	1/5565	malate dehydrogenase (decarboxylating) (NAD+) activity	molecular_function	"Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39]
EOG8C5G07	GO:0016485	1/5565	protein processing	biological_process	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]
EOG8C5G07	GO:0003677	1/5565	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8C5G07	GO:0051287	1/5565	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8C5G07	GO:0042060	1/5565	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8RR8XB	GO:0005737	1/114	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8RR8XB	GO:0050839	1/114	cell adhesion molecule binding	molecular_function	"Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai]
EOG8RR8XB	GO:0016081	1/114	synaptic vesicle docking	biological_process	"The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342]
EOG8RR8XB	GO:0016080	1/114	synaptic vesicle targeting	biological_process	"The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:mah]
EOG8RR8XB	GO:0007163	1/114	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8RR8XB	GO:0007269	1/114	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8RR8XB	GO:0048749	1/114	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8C5G03	GO:0003779	2/344	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8C5G03	GO:0006936	1/344	muscle contraction	biological_process	"A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]
EOG8C5G03	GO:0051015	1/344	actin filament binding	molecular_function	"Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]
EOG8C5G03	GO:0048477	1/344	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8C5G03	GO:0007507	1/344	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8C5G03	GO:0030017	1/344	sarcomere	cellular_component	"The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]
EOG8C5G03	GO:0010591	1/344	regulation of lamellipodium assembly	biological_process	"Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG8C5G03	GO:0070865	1/344	investment cone	cellular_component	"A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization." [GOC:sart, PMID:15829565, PMID:9550716]
EOG8C5G03	GO:0045451	1/344	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8C5G03	GO:0007315	1/344	pole plasm assembly	biological_process	"Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8C5G03	GO:0048813	1/344	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8BCH2C	GO:0008199	21/83	ferric iron binding	molecular_function	"Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai]
EOG8BCH2C	GO:0005576	21/83	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8BCH2C	GO:0006826	21/83	iron ion transport	biological_process	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8BCH2C	GO:0006879	21/83	cellular iron ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah]
EOG8QNQ9R	GO:0005524	3/6	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QNQ9R	GO:0004672	3/6	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG82FW14	GO:0016020	26/128	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG82FW14	GO:0016192	26/128	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG82FW14	GO:0006886	26/128	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG82FW14	GO:0005484	1/128	SNAP receptor activity	molecular_function	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
EOG82FW14	GO:0016740	1/128	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8QNQ9T	GO:0005524	53/164	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8QNQ9T	GO:0004674	24/164	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8QNQ9T	GO:0005978	24/164	glycogen biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]
EOG8QNQ9T	GO:0005964	24/164	phosphorylase kinase complex	cellular_component	"An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a." [EC:2.7.11.19]
EOG8QNQ9T	GO:0004689	24/164	phosphorylase kinase activity	molecular_function	"Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a." [EC:2.7.11.19]
EOG8QNQ9T	GO:0004672	4/164	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8QNQ9T	GO:0008353	3/164	RNA polymerase II carboxy-terminal domain kinase activity	molecular_function	"Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah]
EOG8QNQ9T	GO:0006468	2/164	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8QNQ9T	GO:0007067	1/164	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8QNQ9T	GO:0032806	1/164	carboxy-terminal domain protein kinase complex	cellular_component	"A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683]
EOG8QNQ9T	GO:0006366	1/164	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8QNQ9T	GO:0004693	1/164	cyclin-dependent protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]
EOG8QNQ9T	GO:0006007	1/164	glucose catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai]
EOG8QNQ9T	GO:0012501	1/164	programmed cell death	biological_process	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]
EOG8QNQ9T	GO:2001141	1/164	regulation of RNA biosynthetic process	biological_process	"Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph]
EOG8QNQ9T	GO:0006367	1/164	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG8QNQ9T	GO:0001111	1/164	promoter clearance from RNA polymerase II promoter	biological_process	"Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047]
EOG8QNQ9T	GO:0005634	1/164	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8QNQ9T	GO:0048598	1/164	embryonic morphogenesis	biological_process	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]
EOG8QNQ9T	GO:0000079	1/164	regulation of cyclin-dependent protein serine/threonine kinase activity	biological_process	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]
EOG8QNQ9T	GO:0005737	1/164	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8QNQ9T	GO:0005675	1/164	holo TFIIH complex	cellular_component	"A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of  the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]
EOG89KJ4S	GO:0045466	1/215	R7 cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339]
EOG89KJ4S	GO:0007465	1/215	R7 cell fate commitment	biological_process	"The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883]
EOG89KJ4S	GO:0019897	1/215	extrinsic component of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]
EOG89KJ4S	GO:0007611	1/215	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG89KJ4S	GO:0048149	1/215	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG89KJ4S	GO:0042332	1/215	gravitaxis	biological_process	"The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl]
EOG89KJ4S	GO:0007616	1/215	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG89KJ4S	GO:0008355	1/215	olfactory learning	biological_process	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
EOG89KJ4S	GO:0007156	1/215	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8SJ7VC	GO:0008270	23/94	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8SJ7VC	GO:0004842	22/94	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8SJ7VC	GO:0007165	19/94	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8SJ7VC	GO:0042981	19/94	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8SJ7VC	GO:0016740	2/94	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8SJ7VC	GO:0007370	1/94	ventral furrow formation	biological_process	"Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238]
EOG8SJ7VC	GO:0008063	1/94	Toll signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860]
EOG8SJ7VC	GO:0002168	1/94	instar larval development	biological_process	"The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8SJ7VC	GO:0007391	1/94	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8SJ7VC	GO:0001654	1/94	eye development	biological_process	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
EOG8SJ7VC	GO:0045167	1/94	asymmetric protein localization involved in cell fate determination	biological_process	"Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai]
EOG8SJ7VC	GO:0046529	1/94	imaginal disc fusion, thorax closure	biological_process	"The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm]
EOG8SJ7VC	GO:0003384	1/94	apical constriction involved in gastrulation	biological_process	"The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8SJ7VC	GO:0005737	1/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8SJ7VC	GO:0043065	1/94	positive regulation of apoptotic process	biological_process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8SJ7VC	GO:0050829	1/94	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG8SJ7VC	GO:0035071	1/94	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8SJ7VC	GO:0034332	1/94	adherens junction organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah]
EOG8SJ7VC	GO:0045177	1/94	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8SJ7VC	GO:0005515	1/94	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8SJ7VC	GO:0046330	1/94	positive regulation of JNK cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
EOG8SJ7VC	GO:0006909	1/94	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8SJ7VC	GO:0048102	1/94	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8SJ7VC	GO:0045179	1/94	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8ZPH86	GO:0008270	1/91	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZPH86	GO:0003682	1/91	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8ZPH86	GO:0003676	1/91	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8ZPH86	GO:0010629	1/91	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8S4RZ6	GO:0005634	38/129	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8S4RZ6	GO:0006352	36/129	DNA-templated transcription, initiation	biological_process	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]
EOG8S4RZ6	GO:0003743	4/129	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8S4RZ6	GO:0005669	2/129	transcription factor TFIID complex	cellular_component	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]
EOG8S4RZ6	GO:0005737	2/129	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8S4RZ6	GO:0051123	2/129	RNA polymerase II transcriptional preinitiation complex assembly	biological_process	"The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:10882737, PMID:15020047]
EOG8S4RZ6	GO:0006367	2/129	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG8S4RZ6	GO:0000124	2/129	SAGA complex	cellular_component	"A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012]
EOG8S4RZ6	GO:0006355	2/129	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8S4RZ6	GO:0005515	1/129	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8S4RZ6	GO:0000123	1/129	histone acetyltransferase complex	cellular_component	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
EOG8BVV9G	GO:0004535	1/69	poly(A)-specific ribonuclease activity	molecular_function	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]
EOG8QNQ9M	GO:0016021	25/94	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QNQ9M	GO:0008324	25/94	cation transmembrane transporter activity	molecular_function	"Enables the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
EOG8HMMRJ	GO:0003723	2/5	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8HMMRJ	GO:0006396	2/5	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8HMMRJ	GO:0004525	2/5	ribonuclease III activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]
EOG8HMMRJ	GO:0016075	1/5	rRNA catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai]
EOG88GZJK	GO:0005549	3/9	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG88GZJK	GO:0004930	3/9	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG88GZJK	GO:0016021	3/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88GZJK	GO:0004984	3/9	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG88GZJK	GO:0005886	1/9	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG88GZJH	GO:0006633	2/4	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG88GZJH	GO:0016740	2/4	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG88GZJH	GO:0016021	2/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8D81N4	GO:0050262	20/86	ribosylnicotinamide kinase activity	molecular_function	"Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide." [EC:2.7.1.22, RHEA:14020]
EOG8D81N4	GO:0019359	20/86	nicotinamide nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators]
EOG8D81N4	GO:0005524	2/86	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8D81N4	GO:0004849	2/86	uridine kinase activity	molecular_function	"Catalysis of the reaction: ATP + uridine = ADP + UMP." [EC:2.7.1.48]
EOG8D81N4	GO:0009059	1/86	macromolecule biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah]
EOG8D81N4	GO:0016301	1/86	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8D81N4	GO:0030176	1/86	integral component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
EOG8R7XT3	GO:0006396	2/5	RNA processing	biological_process	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
EOG8R7XT3	GO:0004000	2/5	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8R7XT3	GO:0003723	2/5	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG85XBD5	GO:0005509	62/282	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG85XBD5	GO:0048190	1/282	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG85XBD5	GO:0048812	1/282	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8642S7	GO:0000166	27/117	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8642S7	GO:0003676	25/117	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8642S7	GO:0003729	1/117	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8642S7	GO:0006397	1/117	mRNA processing	biological_process	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]
EOG8642S7	GO:0008380	1/117	RNA splicing	biological_process	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]
EOG8642S7	GO:0043484	1/117	regulation of RNA splicing	biological_process	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]
EOG8642S7	GO:0007173	1/117	epidermal growth factor receptor signaling pathway	biological_process	"A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933]
EOG8642S7	GO:0005634	1/117	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85B3WW	GO:0007264	23/84	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG85B3WW	GO:0016020	23/84	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG85B3WW	GO:0006184	23/84	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG85B3WW	GO:0005525	23/84	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG85B3WW	GO:0022008	1/84	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8Q87BP	GO:0051287	44/136	NAD binding	molecular_function	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]
EOG8Q87BP	GO:0048038	44/136	quinone binding	molecular_function	"Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732]
EOG8Q87BP	GO:0016651	40/136	oxidoreductase activity, acting on NAD(P)H	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8Q87BP	GO:0003954	2/136	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8Q87BP	GO:0008137	2/136	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG8Q87BP	GO:0005739	1/136	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8Q87BP	GO:0048812	1/136	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8Q87BP	GO:0046331	1/136	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8THZ6V	GO:0003777	24/104	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8THZ6V	GO:0005871	24/104	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8THZ6V	GO:0005524	22/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8THZ6V	GO:0005874	22/104	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8THZ6V	GO:0007018	20/104	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8THZ6V	GO:0005737	4/104	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8THZ6V	GO:0005875	4/104	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8THZ6V	GO:0048489	4/104	synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr]
EOG8THZ6V	GO:0047496	4/104	vesicle transport along microtubule	biological_process	"The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl]
EOG85F03S	GO:0005524	22/92	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG85F03S	GO:0017111	21/92	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG85F03S	GO:0006260	1/92	DNA replication	biological_process	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
EOG85F03S	GO:0006629	1/92	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG85F03S	GO:0008283	1/92	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG85F03S	GO:0003689	1/92	DNA clamp loader activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778]
EOG85F03S	GO:0005634	1/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85F03S	GO:0005663	1/92	DNA replication factor C complex	cellular_component	"A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides." [PMID:14614842, PMID:14646196, PMID:16172520]
EOG88WFFT	GO:0048015	30/109	phosphatidylinositol-mediated signaling	biological_process	"A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]
EOG88WFFT	GO:0046854	26/109	phosphatidylinositol phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]
EOG88WFFT	GO:0016773	22/109	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG88WFFT	GO:0016301	21/109	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG88WFFT	GO:0004430	4/109	1-phosphatidylinositol 4-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.67, RHEA:19880]
EOG88WFFT	GO:0004797	1/109	thymidine kinase activity	molecular_function	"Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21]
EOG88WFFT	GO:0005524	1/109	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG88WFFT	GO:0005886	1/109	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8XSP4C	GO:0004571	37/107	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	molecular_function	"Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113]
EOG8XSP4C	GO:0005509	37/107	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8XSP4C	GO:0016020	36/107	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XSP4C	GO:0000139	1/107	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8XSP4C	GO:0006486	1/107	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8XSP4C	GO:0035010	1/107	encapsulation of foreign target	biological_process	"Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920]
EOG8XSP4C	GO:0008340	1/107	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8XSP4C	GO:0072347	1/107	response to anesthetic	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart]
EOG8XSP4C	GO:0016021	1/107	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88WFFX	GO:0046872	26/115	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG88WFFX	GO:0004222	23/115	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG88WFFX	GO:0005777	1/115	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG88WFFX	GO:0003824	1/115	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG88WFFX	GO:0008340	1/115	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG88WFFX	GO:0016787	1/115	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG88WFFX	GO:0090062	1/115	regulation of trehalose metabolic process	biological_process	"Any process that modulates the frequency, rate or extent of trehalose metabolism, the chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:dph, GOC:tb]
EOG88WFFX	GO:0008237	1/115	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG88WFFX	GO:0050829	1/115	defense response to Gram-negative bacterium	biological_process	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
EOG88WFFX	GO:0045089	1/115	positive regulation of innate immune response	biological_process	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
EOG88WFFX	GO:0045926	1/115	negative regulation of growth	biological_process	"Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
EOG88WFFX	GO:0046662	1/115	regulation of oviposition	biological_process	"Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:ai]
EOG8GXJ3J	GO:0005576	1/67	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8GXJ3J	GO:0001558	1/67	regulation of cell growth	biological_process	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8VDSFF	GO:0016020	35/2018	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8VDSFF	GO:0051781	22/2018	positive regulation of cell division	biological_process	"Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai]
EOG8VDSFF	GO:0007435	2/2018	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8VDSFF	GO:0035099	2/2018	hemocyte migration	biological_process	"The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551]
EOG8VDSFF	GO:0003964	1/2018	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8VDSFF	GO:0008039	1/2018	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8VDSFF	GO:0035172	1/2018	hemocyte proliferation	biological_process	"The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG8H74TG	GO:0003676	18/252	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8H74TG	GO:0046872	18/252	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8H74TG	GO:0016787	17/252	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8H74TG	GO:0009405	1/252	pathogenesis	biological_process	"The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators]
EOG8H74TG	GO:0004222	1/252	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8H74TG	GO:0005604	1/252	basement membrane	cellular_component	"A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]
EOG8H74TG	GO:0007155	1/252	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8H74TG	GO:0003824	1/252	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8H74TG	GO:0003677	1/252	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8H74TG	GO:0005509	1/252	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8H74TG	GO:0005576	1/252	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8NKFCJ	GO:0015074	4/97	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8NKFCJ	GO:0003676	4/97	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NKFCJ	GO:0003723	2/97	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8NKFCJ	GO:0008270	2/97	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NKFCJ	GO:0004190	2/97	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8NKFCJ	GO:0003964	2/97	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8CG2PV	GO:0006355	26/177	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8CG2PV	GO:0044237	19/177	cellular metabolic process	biological_process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
EOG8CG2PV	GO:0003743	5/177	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8CG2PV	GO:0005737	1/177	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CG2PV	GO:0071456	1/177	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG8CG2PV	GO:0005085	1/177	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8CG2PV	GO:0005829	1/177	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8CG2PV	GO:0000398	1/177	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8CG2PV	GO:0071013	1/177	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8CG2PV	GO:0016853	1/177	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8CG2PV	GO:0022008	1/177	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8CG2PV	GO:0006446	1/177	regulation of translational initiation	biological_process	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG8CG2PV	GO:0043087	1/177	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8CG2PV	GO:0005851	1/177	eukaryotic translation initiation factor 2B complex	cellular_component	"A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375]
EOG8CG2PV	GO:0046523	1/177	S-methyl-5-thioribose-1-phosphate isomerase activity	molecular_function	"Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate." [EC:5.3.1.23, RHEA:19992]
EOG8CG2PV	GO:0071011	1/177	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8CG2PV	GO:0006413	1/177	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG83N9T9	GO:0003743	27/97	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG83N9T9	GO:0016282	26/97	eukaryotic 43S preinitiation complex	cellular_component	"A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049]
EOG83N9T9	GO:0006446	26/97	regulation of translational initiation	biological_process	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
EOG83N9T9	GO:0001731	26/97	formation of translation preinitiation complex	biological_process	"The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd]
EOG83N9T9	GO:0005852	26/97	eukaryotic translation initiation factor 3 complex	cellular_component	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]
EOG83N9T9	GO:0033290	26/97	eukaryotic 48S preinitiation complex	cellular_component	"A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049]
EOG83N9T9	GO:0006413	1/97	translational initiation	biological_process	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
EOG83N9T9	GO:0004402	1/97	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG83N9T9	GO:0005875	1/97	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8M67ZH	GO:0016021	51/185	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M67ZH	GO:0004946	35/185	bombesin receptor activity	molecular_function	"Combining with bombesin to initiate a change in cell activity." [GOC:ai]
EOG8M67ZH	GO:0004930	12/185	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8M67ZH	GO:0004983	4/185	neuropeptide Y receptor activity	molecular_function	"Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
EOG8M67ZH	GO:0007186	2/185	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8M67ZH	GO:0008188	2/185	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8M67ZH	GO:0050254	2/185	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8M67ZH	GO:0007218	2/185	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8M67ZH	GO:0005887	1/185	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8M67ZH	GO:0004252	1/185	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8M67ZH	GO:0008261	1/185	allatostatin receptor activity	molecular_function	"Combining with allatostatin to initiate a change in cell activity." [GOC:ai]
EOG8PP0X3	GO:0016021	26/88	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PP0X3	GO:0016758	26/88	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8PP0X3	GO:0005789	1/88	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8PP0X3	GO:0006486	1/88	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG87M4CQ	GO:0022857	2/4	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG87M4CQ	GO:0016021	2/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z91B7	GO:0005887	1/100	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG869T9Q	GO:0008168	1/3	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG869T9Q	GO:0005634	1/3	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8VMHXJ	GO:0020037	88/334	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8VMHXJ	GO:0046872	70/334	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8VMHXJ	GO:0009703	3/334	nitrate reductase (NADH) activity	molecular_function	"Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+." [EC:1.7.1.1]
EOG8VMHXJ	GO:0045610	1/334	regulation of hemocyte differentiation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG8VMHXJ	GO:0005789	1/334	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8VMHXJ	GO:0055114	1/334	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8VMHXJ	GO:0003723	1/334	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8VMHXJ	GO:0016021	1/334	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VMHXJ	GO:0035206	1/334	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8VMHXJ	GO:0005811	1/334	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8B5RK3	GO:0004222	17/76	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8SN42X	GO:0003824	27/204	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8SN42X	GO:0004802	3/204	transketolase activity	molecular_function	"Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [EC:2.2.1.1, GOC:fmc]
EOG8SN42X	GO:0005875	2/204	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8SN42X	GO:0031122	2/204	cytoplasmic microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
EOG8SN42X	GO:0090063	1/204	positive regulation of microtubule nucleation	biological_process	"Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
EOG8SN42X	GO:0000922	1/204	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8SN42X	GO:0005515	1/204	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8SN42X	GO:0005813	1/204	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8SN42X	GO:0007067	1/204	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8SN42X	GO:0007029	1/204	endoplasmic reticulum organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
EOG8SN42X	GO:0008017	1/204	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8SN42X	GO:0007143	1/204	female meiotic division	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
EOG8SN42X	GO:0048477	1/204	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8SN42X	GO:0035371	1/204	microtubule plus-end	cellular_component	"The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]
EOG8SN42X	GO:0045450	1/204	bicoid mRNA localization	biological_process	"Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators]
EOG8SN42X	GO:0031935	1/204	regulation of chromatin silencing	biological_process	"Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah]
EOG8SN42X	GO:0007344	1/204	pronuclear fusion	biological_process	"The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X]
EOG8SN42X	GO:0016325	1/204	oocyte microtubule cytoskeleton organization	biological_process	"Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]
EOG8SN42X	GO:0005811	1/204	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8SN42X	GO:0007017	1/204	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8SN42X	GO:0000022	1/204	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8SN42X	GO:0007411	1/204	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8SN42X	GO:0015631	1/204	tubulin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]
EOG83N9WH	GO:0003677	1/68	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84BDH7	GO:0004022	74/125	alcohol dehydrogenase (NAD) activity	molecular_function	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
EOG84BDH7	GO:0006066	22/125	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG84BDH7	GO:0016491	17/125	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG84BDH7	GO:0046164	4/125	alcohol catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, GOC:ai]
EOG84BDH7	GO:0045735	2/125	nutrient reservoir activity	molecular_function	"Functions in the storage of nutritious substrates." [GOC:ai]
EOG84BDH7	GO:0005811	2/125	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG84BDH7	GO:0048149	1/125	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG84BDH7	GO:0005829	1/125	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG84BDH7	GO:0042572	1/125	retinol metabolic process	biological_process	"The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]
EOG84BDH7	GO:0042574	1/125	retinal metabolic process	biological_process	"The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [CHEBI:15035, GOC:curators, ISBN:0198506732]
EOG84BDH7	GO:0048812	1/125	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG84BDH7	GO:0004745	1/125	retinol dehydrogenase activity	molecular_function	"Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [EC:1.1.1.105]
EOG84BDH7	GO:0042803	1/125	protein homodimerization activity	molecular_function	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
EOG84BDH7	GO:0016404	1/125	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	molecular_function	"Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141]
EOG84BDH7	GO:0005875	1/125	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG84BDH7	GO:0006909	1/125	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG84BDH7	GO:0043234	1/125	protein complex	cellular_component	"A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]
EOG8BP3S3	GO:0016301	5/104	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8BP3S3	GO:0016618	2/104	hydroxypyruvate reductase activity	molecular_function	"Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+." [EC:1.1.1.81]
EOG8BP3S3	GO:0008887	1/104	glycerate kinase activity	molecular_function	"Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H(+)." [EC:2.7.1.31, RHEA:23519]
EOG8BP3S3	GO:0005737	1/104	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8BP3S3	GO:0006468	1/104	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8BP3S3	GO:0005524	1/104	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG83BQ4D	GO:0008146	43/146	sulfotransferase activity	molecular_function	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]
EOG83BQ4D	GO:0008459	4/146	chondroitin 6-sulfotransferase activity	molecular_function	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17]
EOG83BQ4D	GO:0016740	1/146	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8XWJCG	GO:0005525	86/367	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8XWJCG	GO:0006184	86/367	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8XWJCG	GO:0016020	86/367	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8XWJCG	GO:0007264	81/367	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8XWJCG	GO:0007165	5/367	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8XWJCG	GO:0005622	1/367	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8XWJCG	GO:0004767	1/367	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8XWJCG	GO:0006909	1/367	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG83BQ4B	GO:0005615	38/85	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG83BQ4B	GO:0008233	9/85	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG83BQ4B	GO:0010951	2/85	negative regulation of endopeptidase activity	biological_process	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
EOG83BQ4B	GO:0004867	2/85	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG83BQ4B	GO:0030162	2/85	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG83BQ4B	GO:0032504	2/85	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG83BQ4B	GO:0035009	1/85	negative regulation of melanization defense response	biological_process	"Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection." [GOC:bf, PMID:12408809]
EOG83BQ4B	GO:0005576	1/85	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG83BQ4B	GO:0045861	1/85	negative regulation of proteolysis	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
EOG8R52HX	GO:0008146	21/67	sulfotransferase activity	molecular_function	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]
EOG8R52HX	GO:0016021	4/67	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83N9WQ	GO:0008270	26/90	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG83N9WQ	GO:0004842	1/90	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG83N9WQ	GO:0016567	1/90	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG83N9WQ	GO:0016874	1/90	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8R52HZ	GO:0042302	1/116	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8VMHXZ	GO:0003723	26/80	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8VMHXZ	GO:0008270	26/80	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8VMHXZ	GO:0006378	1/80	mRNA polyadenylation	biological_process	"The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]
EOG8VMHXZ	GO:0007314	1/80	oocyte anterior/posterior axis specification	biological_process	"Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8VMHXZ	GO:0042078	1/80	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG8VMHXZ	GO:0008354	1/80	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8VMHXZ	GO:0017148	1/80	negative regulation of translation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8VMHXZ	GO:0045495	1/80	pole plasm	cellular_component	"Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380]
EOG8VMHXZ	GO:0007283	1/80	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8VMHXZ	GO:0030718	1/80	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8VMHXZ	GO:0007281	1/80	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8VMHXZ	GO:0035282	1/80	segmentation	biological_process	"The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689]
EOG8VMHXZ	GO:0008595	1/80	anterior/posterior axis specification, embryo	biological_process	"The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8VMHXZ	GO:0016321	1/80	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8VMHXZ	GO:0048477	1/80	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8VMHXZ	GO:0043066	1/80	negative regulation of apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8VMHXZ	GO:0007280	1/80	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG8VMHXZ	GO:0048134	1/80	germ-line cyst formation	biological_process	"Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920]
EOG8VMHXZ	GO:0045892	1/80	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8VMHXZ	GO:0048813	1/80	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8VMHXZ	GO:0005515	1/80	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VMHXZ	GO:0001709	1/80	cell fate determination	biological_process	"A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
EOG87M4CK	GO:0008299	12/130	isoprenoid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
EOG87M4CK	GO:0036422	1/130	heptaprenyl diphosphate synthase activity	molecular_function	"Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate." [EC:2.5.1.30, RHEA:27797]
EOG8MKQX5	GO:0005506	3/6	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG8MKQX5	GO:0020037	3/6	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8MKQX5	GO:0016705	3/6	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
EOG8MKQX5	GO:0004497	1/6	monooxygenase activity	molecular_function	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
EOG822D2F	GO:0003700	24/83	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG822D2F	GO:0005634	24/83	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG822D2F	GO:0043565	20/83	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG822D2F	GO:0000976	4/83	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8R269W	GO:0004222	32/200	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8R269W	GO:0008270	28/200	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8R269W	GO:0005578	23/200	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG8R269W	GO:0031012	2/200	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8R269W	GO:0004143	1/200	diacylglycerol kinase activity	molecular_function	"Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh]
EOG8R269W	GO:0007205	1/200	protein kinase C-activating G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]
EOG8R269W	GO:0003951	1/200	NAD+ kinase activity	molecular_function	"Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632]
EOG8R269W	GO:0042059	1/200	negative regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG8H1D8P	GO:0005524	30/95	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8H1D8P	GO:0004816	30/95	asparagine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+)." [EC:6.1.1.22, RHEA:11183]
EOG8H1D8P	GO:0006421	30/95	asparaginyl-tRNA aminoacylation	biological_process	"The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8H1D8P	GO:0005737	30/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8H1D8P	GO:0003676	27/95	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Z91BR	GO:0003700	85/407	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8Z91BR	GO:0005524	85/407	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8Z91BR	GO:0005634	85/407	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z91BR	GO:0003677	84/407	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Z91BR	GO:0006351	83/407	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8Z91BR	GO:0007031	24/407	peroxisome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
EOG8Z91BR	GO:0005779	24/407	integral component of peroxisomal membrane	cellular_component	"The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah]
EOG8Z91BR	GO:0043565	2/407	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8Z91BR	GO:0045944	2/407	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8Z91BR	GO:0048813	2/407	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8Z91BR	GO:0048592	2/407	eye morphogenesis	biological_process	"The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu]
EOG8Z91BR	GO:0001709	1/407	cell fate determination	biological_process	"A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
EOG8Z91BR	GO:0007469	1/407	antennal development	biological_process	"The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526]
EOG8Z91BR	GO:0000122	1/407	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8Z91BR	GO:0042675	1/407	compound eye cone cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu]
EOG8Z91BR	GO:0030154	1/407	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8Z91BR	GO:0045165	1/407	cell fate commitment	biological_process	"The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
EOG8Z91BR	GO:0048749	1/407	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8Z91BR	GO:0006366	1/407	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8Z91BR	GO:0003705	1/407	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
EOG8Z91BR	GO:0035162	1/407	embryonic hemopoiesis	biological_process	"The stages of blood cell formation that take place within the embryo." [GOC:bf]
EOG8Z91BR	GO:0007486	1/407	imaginal disc-derived female genitalia development	biological_process	"The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
EOG8Z91BR	GO:0030097	1/407	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG8Z91BR	GO:0035170	1/407	lymph gland crystal cell differentiation	biological_process	"The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
EOG8Z91BR	GO:0042688	1/407	crystal cell differentiation	biological_process	"The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
EOG8Z91BR	GO:0035163	1/407	embryonic hemocyte differentiation	biological_process	"The process in which a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu, PMID:14602069]
EOG8Z91BR	GO:0045893	1/407	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Z91BR	GO:0035211	1/407	spermathecum morphogenesis	biological_process	"The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097]
EOG8Z91BR	GO:0016360	1/407	sensory organ precursor cell fate determination	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
EOG8Z91BR	GO:0046672	1/407	positive regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG8Z91BR	GO:0009987	1/407	cellular process	biological_process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
EOG8Z91BR	GO:0007419	1/407	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8Z91BR	GO:0007165	1/407	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8Z91BR	GO:0045892	1/407	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8Z91BR	GO:0035314	1/407	scab formation	biological_process	"Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection." [GOC:bf, PMID:15269788]
EOG8Z91BR	GO:0044212	1/407	transcription regulatory region DNA binding	molecular_function	"Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836]
EOG8Z91BR	GO:0048477	1/407	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8Z91BR	GO:0007377	1/407	germ-band extension	biological_process	"Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:08795694238]
EOG8Z91BR	GO:0035168	1/407	larval lymph gland hemocyte differentiation	biological_process	"The process in which a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:14602069]
EOG8Z91BR	GO:0045467	1/407	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8Z91BR	GO:0035165	1/407	embryonic crystal cell differentiation	biological_process	"The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
EOG8Z91BR	GO:0007366	1/407	periodic partitioning by pair rule gene	biological_process	"Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG8Z91BR	GO:0042060	1/407	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8Z91BR	GO:0007411	1/407	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8Z91BR	GO:0007400	1/407	neuroblast fate determination	biological_process	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
EOG8Z91BR	GO:0007540	1/407	sex determination, establishment of X:A ratio	biological_process	"The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it." [GOC:isa_complete]
EOG8Z91BR	GO:0007367	1/407	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG82NMD8	GO:0005524	27/90	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG82NMD8	GO:0006418	27/90	tRNA aminoacylation for protein translation	biological_process	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]
EOG82NMD8	GO:0004812	24/90	aminoacyl-tRNA ligase activity	molecular_function	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
EOG82NMD8	GO:0005737	24/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG82NMD8	GO:0003676	22/90	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82NMD8	GO:0004815	3/90	aspartate-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [EC:6.1.1.12]
EOG8WDGSB	GO:0008270	56/160	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8PP0XP	GO:0006491	26/165	N-glycan processing	biological_process	"The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198]
EOG8PP0XP	GO:0005509	19/165	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8PP0XP	GO:0032450	2/165	maltose alpha-glucosidase activity	molecular_function	"Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141]
EOG8PP0XP	GO:0016301	1/165	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8PP0XP	GO:0046331	1/165	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8ZCWJG	GO:0005509	23/74	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8ZCWJG	GO:0006511	23/74	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8ZCWJG	GO:0004843	22/74	ubiquitin-specific protease activity	molecular_function	"Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709]
EOG8ZCWJG	GO:0008233	1/74	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8ZCWJG	GO:0008234	1/74	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8ZCWJG	GO:0004221	1/74	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG8Z91BX	GO:0016491	2/4	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG86DPGQ	GO:0043142	26/90	single-stranded DNA-dependent ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction." [GOC:go_curators]
EOG86DPGQ	GO:0017108	26/90	5'-flap endonuclease activity	molecular_function	"Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254]
EOG86DPGQ	GO:0033567	26/90	DNA replication, Okazaki fragment processing	biological_process	"The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand." [GOC:mah, ISBN:0716720094]
EOG86DPGQ	GO:0004386	4/90	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG86DPGQ	GO:0005524	3/90	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG86DPGQ	GO:0006777	1/90	Mo-molybdopterin cofactor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473]
EOG86DPGQ	GO:0031145	1/90	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [PMID:15380083]
EOG86DPGQ	GO:0005680	1/90	anaphase-promoting complex	cellular_component	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]
EOG86DPGQ	GO:0030071	1/90	regulation of mitotic metaphase/anaphase transition	biological_process	"Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle." [GOC:mah]
EOG8HHRGR	GO:0016787	6/173	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8HHRGR	GO:0052689	2/173	carboxylic ester hydrolase activity	molecular_function	"Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators]
EOG8HHRGR	GO:0016298	2/173	lipase activity	molecular_function	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
EOG8HHRGR	GO:0006629	2/173	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8HHRGR	GO:0035220	1/173	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8HHRGR	GO:0022416	1/173	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8HHRGR	GO:0016021	1/173	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88SK7X	GO:0003700	11/71	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG88SK7X	GO:0043565	11/71	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG88SK7X	GO:0006351	11/71	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG88SK7X	GO:0005634	11/71	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8B5RK9	GO:0000166	24/84	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8B5RK9	GO:0003676	23/84	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8B5RK9	GO:0005515	1/84	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8B5RK9	GO:0045451	1/84	pole plasm oskar mRNA localization	biological_process	"Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
EOG8B5RK9	GO:0007315	1/84	pole plasm assembly	biological_process	"Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8B5RK9	GO:0008298	1/84	intracellular mRNA localization	biological_process	"Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai]
EOG8B5RK9	GO:0048477	1/84	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8B5RK9	GO:0008270	1/84	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8B5RK9	GO:0048134	1/84	germ-line cyst formation	biological_process	"Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920]
EOG8B5RK9	GO:0046011	1/84	regulation of oskar mRNA translation	biological_process	"Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512]
EOG8B5RK9	GO:0005737	1/84	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8B5RK9	GO:0046012	1/84	positive regulation of oskar mRNA translation	biological_process	"Any process that activates or increases the frequency, rate or extent of oskar mRNA translation." [GOC:go_curators]
EOG8B5RK9	GO:0007294	1/84	germarium-derived oocyte fate determination	biological_process	"The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8B5RK9	GO:0007309	1/84	oocyte axis specification	biological_process	"The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8B5RK9	GO:0007281	1/84	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8B5RK9	GO:0005622	1/84	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8B5RK9	GO:0007314	1/84	oocyte anterior/posterior axis specification	biological_process	"Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
EOG8B5RK9	GO:0006378	1/84	mRNA polyadenylation	biological_process	"The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]
EOG8B5RK9	GO:0045727	1/84	positive regulation of translation	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8B5RK9	GO:0000578	1/84	embryonic axis specification	biological_process	"The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb]
EOG8B5RK9	GO:0007310	1/84	oocyte dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8B5RK9	GO:0003729	1/84	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8DRCSC	GO:0000166	24/100	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8DRCSC	GO:0003676	23/100	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DRCSC	GO:0007476	1/100	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8DRCSC	GO:0046331	1/100	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8DRCSC	GO:0008315	1/100	meiotic G2/MI transition	biological_process	"The cell cycle process in which a cell progresses from meiotic prophase to metaphase I." [PMID:15088480]
EOG8DRCSC	GO:0007140	1/100	male meiosis	biological_process	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
EOG8DRCSC	GO:0003729	1/100	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8DRCSC	GO:0003723	1/100	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8DRCSC	GO:0005634	1/100	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8DRCSC	GO:0007283	1/100	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8DRCSC	GO:0048137	1/100	spermatocyte division	biological_process	"The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238]
EOG8DRCSC	GO:0005737	1/100	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8DRCSC	GO:0006417	1/100	regulation of translation	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8DRCSC	GO:0043204	1/100	perikaryon	cellular_component	"The portion of the cell soma (cell body) that excludes the nucleus." [GOC:jl]
EOG8Z91BB	GO:0015074	44/793	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8Z91BB	GO:0003676	43/793	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Z91BB	GO:0003964	17/793	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8Z91BB	GO:0003723	15/793	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8Z91BB	GO:0003677	6/793	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8Z91BB	GO:0008270	4/793	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8Z91BB	GO:0004523	2/793	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8Z91BB	GO:0005622	1/793	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8Z91BB	GO:0019028	1/793	viral capsid	cellular_component	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]
EOG8Z91BB	GO:0046718	1/793	viral entry into host cell	biological_process	"The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm." [GOC:jl]
EOG8Z91BB	GO:0019076	1/793	viral release from host cell	biological_process	"The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane." [GOC:jl]
EOG8Z91BB	GO:0006351	1/793	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8Z91BB	GO:0003899	1/793	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8Z91BB	GO:0044163	1/793	host cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of host cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the host cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the host cell. The various elements of the host cytoskeleton not only serve in the maintenance of host cellular shape but also have roles in other host cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:rph]
EOG8Z91BB	GO:0075521	1/793	microtubule-dependent intracellular transport of viral material towards nucleus	biological_process	"The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules." [UniProtKB-KW:KW-1177, VZ:983]
EOG8Z91BB	GO:0042025	1/793	host cell nucleus	cellular_component	"A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
EOG8Z91BB	GO:0030430	1/793	host cell cytoplasm	cellular_component	"The cytoplasm of a host cell." [GOC:mah]
EOG8Z91BB	GO:0004190	1/793	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8XKXQ7	GO:0004129	43/117	cytochrome-c oxidase activity	molecular_function	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
EOG8XKXQ7	GO:0005740	43/117	mitochondrial envelope	cellular_component	"The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]
EOG8XKXQ7	GO:0005811	1/117	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG88SK7B	GO:0003700	1/188	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG88SK7B	GO:0016832	1/188	aldehyde-lyase activity	molecular_function	"Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [http://www.mercksource.com/]
EOG88SK7B	GO:0005887	1/188	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG88SK7B	GO:0005840	1/188	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG88SK7B	GO:0008270	1/188	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG88SK7B	GO:0005634	1/188	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG88SK7B	GO:0005975	1/188	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8642TP	GO:0016021	25/84	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8642TP	GO:0015266	1/84	protein channel activity	molecular_function	"Enables the energy-independent facilitated diffusion, mediated by passage of proteins through a transmembrane aqueous pore or channel." [GOC:rb]
EOG8642TP	GO:0045039	1/84	protein import into mitochondrial inner membrane	biological_process	"The process comprising the import of proteins into the mitochondrion from outside the organelle and their insertion into the mitochondrial inner membrane. The translocase of the outer membrane complex mediates the passage of these proteins across the outer membrane, after which they are guided by either of two inner membrane translocase complexes into their final destination in the inner membrane." [GOC:mcc, GOC:vw, PMID:18672008]
EOG8642TP	GO:0042721	1/84	mitochondrial inner membrane protein insertion complex	cellular_component	"A multi-subunit complex embedded in the mitochondrial inner membrane that mediates insertion of carrier proteins into the inner membrane." [PMID:12191765]
EOG88SK7N	GO:0003682	25/89	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG88SK7N	GO:0003677	25/89	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG88SK7N	GO:0005634	13/89	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8Z91BM	GO:0005272	54/138	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8Z91BM	GO:0016021	53/138	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Z91BM	GO:0051536	2/138	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8Z91BM	GO:0004252	2/138	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8Z91BM	GO:0016020	1/138	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8Z91BM	GO:0000439	1/138	core TFIIH complex	cellular_component	"The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015]
EOG8Z91BM	GO:0006289	1/138	nucleotide-excision repair	biological_process	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]
EOG8Z91BM	GO:0006355	1/138	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8QC3NM	GO:0016020	38/153	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QC3NM	GO:0016202	2/153	regulation of striated muscle tissue development	biological_process	"Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators]
EOG8QC3NM	GO:0005515	2/153	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QC3NM	GO:0005886	2/153	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8QC3NM	GO:0007520	2/153	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG8QC3NM	GO:0007156	2/153	homophilic cell adhesion via plasma membrane adhesion molecules	biological_process	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]
EOG8QC3NM	GO:0001745	2/153	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8QC3NM	GO:0005912	1/153	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8QC3NM	GO:0036059	1/153	nephrocyte diaphragm assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]
EOG8QC3NM	GO:0097206	1/153	nephrocyte filtration	biological_process	"The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929]
EOG8QC3NM	GO:0007157	1/153	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological_process	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]
EOG8QC3NM	GO:0030165	1/153	PDZ domain binding	molecular_function	"Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]
EOG8QC3NM	GO:0016021	1/153	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QC3NM	GO:0005913	1/153	cell-cell adherens junction	cellular_component	"An adherens junction which connects a cell to another cell." [GOC:hb]
EOG8QC3NM	GO:0046667	1/153	compound eye retinal cell programmed cell death	biological_process	"Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672]
EOG8QC3NM	GO:0045177	1/153	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8QC3NM	GO:0048749	1/153	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8QC3NM	GO:0046666	1/153	retinal cell programmed cell death	biological_process	"Programmed cell death that occurs in the developing retina." [GOC:bf]
EOG8QC3NM	GO:0061321	1/153	garland nephrocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000486, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135]
EOG8QC3NM	GO:0007523	1/153	larval visceral muscle development	biological_process	"The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid]
EOG8QC3NM	GO:1901739	1/153	regulation of myoblast fusion	biological_process	"Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]
EOG8QC3NM	GO:0005917	1/153	nephrocyte diaphragm	cellular_component	"A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]
EOG8QC3NM	GO:0050839	1/153	cell adhesion molecule binding	molecular_function	"Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai]
EOG8QC3NM	GO:0009986	1/153	cell surface	cellular_component	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
EOG8QC3NM	GO:0046331	1/153	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8QC3NM	GO:0036058	1/153	filtration diaphragm assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, PMID:18971929]
EOG8R268M	GO:0006108	4/9	malate metabolic process	biological_process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]
EOG8R268M	GO:0016615	4/9	malate dehydrogenase activity	molecular_function	"Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]
EOG8R268M	GO:0016616	3/9	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]
EOG8R268M	GO:0005975	3/9	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8V45P8	GO:0016021	94/315	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V45P8	GO:0015171	94/315	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8V45P8	GO:0003333	2/315	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG8V45P8	GO:0060356	2/315	leucine import	biological_process	"The directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb]
EOG8V45P8	GO:0006865	1/315	amino acid transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8V45P8	GO:0008049	1/315	male courtship behavior	biological_process	"The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr]
EOG8V45P8	GO:0007619	1/315	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG8V45P8	GO:0015813	1/315	L-glutamate transport	biological_process	"The directed movement of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:dph, GOC:tb]
EOG8V45P8	GO:0015734	1/315	taurine transport	biological_process	"The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG8V45P8	GO:0007635	1/315	chemosensory behavior	biological_process	"Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators]
EOG8V45P8	GO:0050832	1/315	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8V45P8	GO:0006868	1/315	glutamine transport	biological_process	"The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8V45P8	GO:0014047	1/315	glutamate secretion	biological_process	"The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." [GOC:ef]
EOG8V45P8	GO:0031594	1/315	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8642SX	GO:0046933	33/109	proton-transporting ATP synthase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]
EOG8642SX	GO:0046961	33/109	proton-transporting ATPase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]
EOG8642SX	GO:0033180	33/109	proton-transporting V-type ATPase, V1 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG8642SX	GO:0015991	33/109	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8642SX	GO:0008900	1/109	hydrogen:potassium-exchanging ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)." [EC:3.6.3.10]
EOG8642SX	GO:0033181	1/109	plasma membrane proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
EOG8W9MJ7	GO:0046872	22/81	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8W9MJ7	GO:0003676	21/81	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W9MJ7	GO:0031670	1/81	cellular response to nutrient	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:mah]
EOG8W9MJ7	GO:0007275	1/81	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8W9MJ7	GO:0003677	1/81	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8W9MJ7	GO:0048009	1/81	insulin-like growth factor receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands." [GOC:ceb]
EOG8W9MJ7	GO:0006351	1/81	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8W9MJ7	GO:0045893	1/81	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8W9MJ7	GO:0045892	1/81	negative regulation of transcription, DNA-templated	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8W9MJ7	GO:0000122	1/81	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8W9MJ7	GO:0042594	1/81	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8W9MJ7	GO:0016607	1/81	nuclear speck	cellular_component	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]
EOG8MWBM1	GO:0008152	40/136	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8MWBM1	GO:0051539	34/136	4 iron, 4 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG8MWBM1	GO:0003994	5/136	aconitate hydratase activity	molecular_function	"Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw]
EOG8MWBM1	GO:0007370	1/136	ventral furrow formation	biological_process	"Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238]
EOG8MWBM1	GO:0030350	1/136	iron-responsive element binding	molecular_function	"Interacting selectively and non-covalently with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins." [PMID:3198610, PMID:8710843]
EOG86DPHG	GO:0016787	71/270	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG86DPHG	GO:0004721	6/270	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG86DPHG	GO:0046872	3/270	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG86DPHG	GO:0006470	3/270	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG86DPHG	GO:0000278	3/270	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG86DPHG	GO:0004722	3/270	protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
EOG86DPHG	GO:0005737	3/270	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86DPHG	GO:0007059	1/270	chromosome segregation	biological_process	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
EOG86DPHG	GO:0060070	1/270	canonical Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488]
EOG86DPHG	GO:0051225	1/270	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG86DPHG	GO:0007098	1/270	centrosome cycle	biological_process	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]
EOG86DPHG	GO:0005814	1/270	centriole	cellular_component	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
EOG86DPHG	GO:0007155	1/270	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG86DPHG	GO:0007017	1/270	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG86DPHG	GO:0007346	1/270	regulation of mitotic cell cycle	biological_process	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG86DPHG	GO:0045880	1/270	positive regulation of smoothened signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
EOG86DPHG	GO:0007051	1/270	spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:mah]
EOG86DPHG	GO:0022008	1/270	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG86DPHG	GO:0007099	1/270	centriole replication	biological_process	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194]
EOG86DPHG	GO:0006909	1/270	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG86DPHG	GO:0007406	1/270	negative regulation of neuroblast proliferation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai]
EOG86DPHG	GO:0005634	1/270	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86DPHG	GO:0007465	1/270	R7 cell fate commitment	biological_process	"The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883]
EOG86DPHG	GO:0005813	1/270	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG86DPHG	GO:0007067	1/270	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG86DPHG	GO:0055059	1/270	asymmetric neuroblast division	biological_process	"The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
EOG86DPHG	GO:0007015	1/270	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG86DPHG	GO:0048477	1/270	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG86DPHG	GO:0000082	1/270	G1/S transition of mitotic cell cycle	biological_process	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]
EOG86DPHG	GO:0050790	1/270	regulation of catalytic activity	biological_process	"Any process that modulates the activity of an enzyme." [GOC:ai]
EOG86DPHG	GO:0090162	1/270	establishment of epithelial cell polarity	biological_process	"The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG86DPHG	GO:0008360	1/270	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG86DPHG	GO:0019208	1/270	phosphatase regulator activity	molecular_function	"Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]
EOG86DPHG	GO:0000226	1/270	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG86DPHG	GO:0009416	1/270	response to light stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
EOG86DPHG	GO:0000159	1/270	protein phosphatase type 2A complex	cellular_component	"A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]
EOG86DPHG	GO:0006914	1/270	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG86DPHG	GO:0051298	1/270	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG86DPHG	GO:0051297	1/270	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8QNQC3	GO:0003735	22/165	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8QNQC3	GO:0000166	22/165	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8QNQC3	GO:0005840	22/165	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8QNQC3	GO:0006412	22/165	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8QNQC3	GO:0042623	2/165	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8QNQC3	GO:0030286	2/165	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG8QNQC3	GO:0007018	2/165	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8QNQC3	GO:0006200	2/165	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8QNQC3	GO:0051298	1/165	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8QNQC3	GO:0007283	1/165	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8QNQC3	GO:0005875	1/165	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8J6V71	GO:0071011	1/119	precatalytic spliceosome	cellular_component	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
EOG8J6V71	GO:0008380	1/119	RNA splicing	biological_process	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]
EOG8J6V71	GO:0000398	1/119	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8J6V71	GO:0071013	1/119	catalytic step 2 spliceosome	cellular_component	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
EOG8ZKN1J	GO:0046872	2/3	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZKN1J	GO:0003676	2/3	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Z9198	GO:0005606	13/99	laminin-1 complex	cellular_component	"A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
EOG8Z9198	GO:0030155	13/99	regulation of cell adhesion	biological_process	"Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah]
EOG8Z9198	GO:0045995	13/99	regulation of embryonic development	biological_process	"Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators]
EOG8Z9198	GO:0030334	13/99	regulation of cell migration	biological_process	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]
EOG8Z9198	GO:0007155	5/99	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8Z9198	GO:0005604	2/99	basement membrane	cellular_component	"A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]
EOG8Z9198	GO:0007502	1/99	digestive tract mesoderm development	biological_process	"The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism." [GOC:ai]
EOG8Z9198	GO:0008406	1/99	gonad development	biological_process	"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
EOG8Z9198	GO:0005605	1/99	basal lamina	cellular_component	"A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix." [ISBN:0198547684]
EOG8Z9198	GO:0007476	1/99	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG80P6MS	GO:0006094	46/123	gluconeogenesis	biological_process	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]
EOG80P6MS	GO:0005525	46/123	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG80P6MS	GO:0004613	45/123	phosphoenolpyruvate carboxykinase (GTP) activity	molecular_function	"Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2." [EC:4.1.1.32]
EOG80P6MS	GO:0016301	8/123	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG80P6MS	GO:0004611	1/123	phosphoenolpyruvate carboxykinase activity	molecular_function	"Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products." [EC:4.1.1.-]
EOG80P6MS	GO:0046872	1/123	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8SR0FH	GO:0003676	1/3	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8SR0FH	GO:0046872	1/3	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8T1M3R	GO:0004521	39/92	endoribonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8T1M3R	GO:0009303	39/92	rRNA transcription	biological_process	"The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732]
EOG8T1M3R	GO:0016021	1/92	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8T1M3R	GO:0090502	1/92	RNA phosphodiester bond hydrolysis, endonucleolytic	biological_process	"The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
EOG8BCH22	GO:0016758	383/1077	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8BCH22	GO:0030259	14/1077	lipid glycosylation	biological_process	"Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah]
EOG8BCH22	GO:0015020	13/1077	glucuronosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17]
EOG8BCH22	GO:0030246	12/1077	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8BCH22	GO:0016999	11/1077	antibiotic metabolic process	biological_process	"The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2]
EOG8BCH22	GO:0016740	3/1077	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8BCH22	GO:0004181	1/1077	metallocarboxypeptidase activity	molecular_function	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
EOG8BCH22	GO:0008168	1/1077	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8BCH22	GO:0003851	1/1077	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45]
EOG8BCH22	GO:0008270	1/1077	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8BCH22	GO:0003676	1/1077	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BCH22	GO:0002121	1/1077	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG80ZTCK	GO:0006814	84/227	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG80ZTCK	GO:0016020	82/227	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG80ZTCK	GO:0055085	82/227	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG80ZTCK	GO:0005215	82/227	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG80ZTCK	GO:0008340	2/227	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG80ZTCK	GO:0015141	2/227	succinate transmembrane transporter activity	molecular_function	"Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of the membrane to the other." [ISBN:0198506732]
EOG80ZTCK	GO:0015744	2/227	succinate transport	biological_process	"The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG80ZTCK	GO:0006848	2/227	pyruvate transport	biological_process	"The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG80ZTCK	GO:0071422	2/227	succinate transmembrane transport	biological_process	"A process in which a succinate ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG80ZTCK	GO:0005887	2/227	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80ZTCK	GO:0015137	2/227	citrate transmembrane transporter activity	molecular_function	"Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other." [GOC:ai]
EOG80ZTCK	GO:0015746	2/227	citrate transport	biological_process	"The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
EOG80ZTCK	GO:1901475	2/227	pyruvate transmembrane transport	biological_process	"The directed movement of pyruvate across a membrane." [GOC:TermGenie]
EOG80ZTCK	GO:0050833	2/227	pyruvate transmembrane transporter activity	molecular_function	"Enables the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other." [GOC:ai]
EOG80ZTCK	GO:0000077	1/227	DNA damage checkpoint	biological_process	"A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle]
EOG80ZTCK	GO:0016323	1/227	basolateral plasma membrane	cellular_component	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
EOG80ZTCK	GO:0005886	1/227	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80ZTCK	GO:0010889	1/227	regulation of sequestering of triglyceride	biological_process	"Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
EOG80ZTCK	GO:0030896	1/227	checkpoint clamp complex	cellular_component	"Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]
EOG8MD0FC	GO:0003676	1/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8RFP7N	GO:0030246	26/95	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8WWV0B	GO:0097157	4/52	pre-mRNA intronic binding	molecular_function	"Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624]
EOG8WWV0B	GO:0005681	4/52	spliceosomal complex	cellular_component	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]
EOG8WWV0B	GO:0000398	4/52	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8XD67H	GO:0016874	2/16	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8NW21R	GO:0016020	1/3	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8NW21R	GO:0005509	1/3	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8F4VRC	GO:0045017	6/108	glycerolipid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]
EOG8F4VRC	GO:0004144	6/108	diacylglycerol O-acyltransferase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20]
EOG8WWV0F	GO:0016021	1/5	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WWV0F	GO:0022857	1/5	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8BS01X	GO:0020037	23/68	heme binding	molecular_function	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]
EOG8BS01X	GO:0046331	1/68	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8VMHVN	GO:0050660	29/95	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8VMHVN	GO:0045454	28/95	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8VMHVN	GO:0016491	27/95	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8VMHVN	GO:0008860	2/95	ferredoxin-NAD+ reductase activity	molecular_function	"Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+." [EC:1.18.1.3]
EOG8VMHVN	GO:0006915	1/95	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8VMHVN	GO:0042775	1/95	mitochondrial ATP synthesis coupled electron transport	biological_process	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363]
EOG8VMHVN	GO:0010623	1/95	developmental programmed cell death	biological_process	"The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:tb]
EOG8VMHVN	GO:0005758	1/95	mitochondrial intermembrane space	cellular_component	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]
EOG8VMHVN	GO:0050832	1/95	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8VMHVN	GO:0005739	1/95	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8CZDZX	GO:0003677	17/2665	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CZDZX	GO:0015074	6/2665	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8CZDZX	GO:0004803	6/2665	transposase activity	molecular_function	"Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]
EOG8CZDZX	GO:0006313	6/2665	transposition, DNA-mediated	biological_process	"Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090]
EOG8CZDZX	GO:0006355	3/2665	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8CZDZX	GO:0003676	3/2665	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CZDZX	GO:0016021	1/2665	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CZDZX	GO:0015171	1/2665	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG8CZDZX	GO:0046872	1/2665	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CZDZX	GO:0008270	1/2665	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8B013F	GO:0055085	21/84	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8B013F	GO:0016021	21/84	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VMHVB	GO:0007099	1/102	centriole replication	biological_process	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194]
EOG8VMHVB	GO:0010457	1/102	centriole-centriole cohesion	biological_process	"The process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb]
EOG8VMHVB	GO:0051297	1/102	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8VMHVB	GO:0051298	1/102	centrosome duplication	biological_process	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
EOG8VMHVB	GO:0005814	1/102	centriole	cellular_component	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
EOG8VMHVB	GO:0016798	1/102	hydrolase activity, acting on glycosyl bonds	molecular_function	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]
EOG8VMHVB	GO:0007052	1/102	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8VMHVB	GO:0032053	1/102	ciliary basal body organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum)." [GOC:cilia, GOC:dph, GOC:jl, GOC:mah, PMID:9889124]
EOG8VMHVB	GO:0036064	1/102	ciliary basal body	cellular_component	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]
EOG8NZX77	GO:0015074	206/1674	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8NZX77	GO:0003964	173/1674	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8NZX77	GO:0003723	170/1674	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8NZX77	GO:0003676	151/1674	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8NZX77	GO:0008270	67/1674	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8NZX77	GO:0004190	64/1674	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8NZX77	GO:0004523	2/1674	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8NZX77	GO:0003677	2/1674	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8NZX77	GO:0003899	1/1674	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8NZX77	GO:0043565	1/1674	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NZX77	GO:0005634	1/1674	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NZX77	GO:0003700	1/1674	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NZX77	GO:0004519	1/1674	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8NZX77	GO:0046872	1/1674	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NZX77	GO:0019048	1/1674	modulation by virus of host morphology or physiology	biological_process	"The process in which a virus effects a change in the structure or processes of its host organism." [GOC:bf, GOC:jl, ISBN:0781718325, UniProtKB-KW:KW-0945]
EOG8NZX77	GO:0019031	1/1674	viral envelope	cellular_component	"The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope]
EOG8NZX77	GO:0006351	1/1674	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8NZX77	GO:0008233	1/1674	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8PRW6D	GO:0016042	15/54	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8PRW6D	GO:0004623	15/54	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG8PRW6D	GO:0005509	15/54	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8PRW6D	GO:0006644	9/54	phospholipid metabolic process	biological_process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8PRW6D	GO:0005576	9/54	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8CJZ0X	GO:0016021	24/70	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CJZ0X	GO:0042246	24/70	tissue regeneration	biological_process	"The regrowth of lost or destroyed tissues." [GOC:curators]
EOG8CJZ0X	GO:0007155	24/70	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8BS01Q	GO:0051260	26/96	protein homooligomerization	biological_process	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
EOG8BS01Q	GO:0005886	1/96	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8BS01Q	GO:0004114	1/96	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular_function	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]
EOG8F20J0	GO:0016907	21/103	G-protein coupled acetylcholine receptor activity	molecular_function	"Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah]
EOG8F20J0	GO:0005887	21/103	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F20J0	GO:0016021	6/103	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F20J0	GO:0004930	5/103	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8F20J0	GO:0004715	2/103	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8F20J0	GO:0045211	1/103	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8F20J0	GO:0007200	1/103	phospholipase C-activating G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
EOG8F20J0	GO:0007213	1/103	G-protein coupled acetylcholine receptor signaling pathway	biological_process	"Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194]
EOG8F20J0	GO:0030054	1/103	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8F20J0	GO:0008227	1/103	G-protein coupled amine receptor activity	molecular_function	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
EOG8SXQT1	GO:0015450	24/96	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	molecular_function	"Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729]
EOG8SXQT1	GO:0006886	24/96	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG8SXQT1	GO:0005743	23/96	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8SXQT1	GO:0071456	1/96	cellular response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
EOG8SXQT1	GO:0016787	1/96	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8WWV0P	GO:0006914	25/87	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG8WWV0P	GO:0005737	25/87	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8WWV0P	GO:0016236	1/87	macroautophagy	biological_process	"The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure.  Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464]
EOG8WWV0P	GO:0015031	1/87	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8WWV0P	GO:0035071	1/87	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8WWV0P	GO:0034045	1/87	pre-autophagosomal structure membrane	cellular_component	"A cellular membrane associated with the pre-autophagosomal structure." [GOC:mah, GOC:rph, PMID:16874040, PMID:17382324]
EOG8WWV0P	GO:0048102	1/87	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG89S8MV	GO:0006379	1/89	mRNA cleavage	biological_process	"Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah]
EOG89S8MV	GO:0046872	1/89	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89S8MV	GO:0005654	1/89	nucleoplasm	cellular_component	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
EOG89S8MV	GO:0005848	1/89	mRNA cleavage stimulating factor complex	cellular_component	"A protein complex required for mRNA cleavage but not for poly(A) addition." [GOC:mah, PMID:10357856]
EOG8FTZFM	GO:0004721	23/82	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8FTZFM	GO:0005634	23/82	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FTZFM	GO:0046872	1/82	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8WWV0T	GO:0016021	149/294	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8WWV0T	GO:0008527	131/294	taste receptor activity	molecular_function	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
EOG8WWV0T	GO:0005886	29/294	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8WWV0T	GO:0050909	25/294	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8WWV0T	GO:0001582	8/294	detection of chemical stimulus involved in sensory perception of sweet taste	biological_process	"The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
EOG8WWV0T	GO:0050916	8/294	sensory perception of sweet taste	biological_process	"The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8WWV0T	GO:0033041	8/294	sweet taste receptor activity	molecular_function	"Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah]
EOG8WWV0T	GO:0050912	4/294	detection of chemical stimulus involved in sensory perception of taste	biological_process	"The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
EOG8WWV0T	GO:0007637	2/294	proboscis extension reflex	biological_process	"The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jid]
EOG8WWV0T	GO:0034289	1/294	detection of maltose stimulus	biological_process	"The series of events in which a maltose stimulus is received by a cell and converted into a molecular signal." [GOC:sart]
EOG8WWV0T	GO:0051594	1/294	detection of glucose	biological_process	"The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
EOG8WWV0T	GO:0010353	1/294	response to trehalose	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512]
EOG8WWV0T	GO:0009731	1/294	detection of sucrose stimulus	biological_process	"The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
EOG80ZTBC	GO:0003887	25/103	DNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]
EOG80ZTBC	GO:0008270	24/103	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80ZTBC	GO:0005634	24/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80ZTBC	GO:0000166	22/103	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG80ZTBC	GO:0003677	22/103	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG80ZTBC	GO:0006974	1/103	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG80ZTBC	GO:0006261	1/103	DNA-dependent DNA replication	biological_process	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]
EOG80ZTBC	GO:0022008	1/103	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG80ZTBC	GO:0008296	1/103	3'-5'-exodeoxyribonuclease activity	molecular_function	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah]
EOG80ZTBC	GO:0000278	1/103	mitotic cell cycle	biological_process	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
EOG80ZTBC	GO:0006281	1/103	DNA repair	biological_process	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
EOG80ZTBC	GO:0035265	1/103	organ growth	biological_process	"The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544]
EOG80ZTBC	GO:0008622	1/103	epsilon DNA polymerase complex	cellular_component	"A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046]
EOG80ZTBC	GO:0007113	1/103	endomitotic cell cycle	biological_process	"A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm]
EOG80ZTBC	GO:0000738	1/103	DNA catabolic process, exonucleolytic	biological_process	"The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
EOG8CNT4W	GO:0005524	32/105	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CNT4W	GO:0005737	32/105	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CNT4W	GO:0004827	27/105	proline-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15]
EOG8CNT4W	GO:0006433	27/105	prolyl-tRNA aminoacylation	biological_process	"The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510]
EOG8CNT4W	GO:0006424	22/105	glutamyl-tRNA aminoacylation	biological_process	"The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8CNT4W	GO:0004818	22/105	glutamate-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17]
EOG8CNT4W	GO:0003723	1/105	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CNT4W	GO:0006418	1/105	tRNA aminoacylation for protein translation	biological_process	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]
EOG8CNT4W	GO:0004812	1/105	aminoacyl-tRNA ligase activity	molecular_function	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
EOG8CNT4W	GO:0004819	1/105	glutamine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18]
EOG8DFS2H	GO:0003677	24/94	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DFS2H	GO:0008270	24/94	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DFS2H	GO:0005634	6/94	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8DFS2H	GO:0031519	1/94	PcG protein complex	cellular_component	"A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908]
EOG8DFS2H	GO:0034647	1/94	histone demethylase activity (H3-trimethyl-K4 specific)	molecular_function	"Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896]
EOG8DFS2H	GO:0006351	1/94	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8DFS2H	GO:0007379	1/94	segment specification	biological_process	"The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
EOG8DFS2H	GO:0033522	1/94	histone H2A ubiquitination	biological_process	"The modification of histone H2A by addition of one or more ubiquitin groups." [GOC:bf, GOC:mah, PMID:15509584, PMID:16473935, PMID:18430235]
EOG8DFS2H	GO:0006355	1/94	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8DFS2H	GO:0034721	1/94	histone H3-K4 demethylation, trimethyl-H3-K4-specific	biological_process	"The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone." [GOC:mah]
EOG8DFS2H	GO:0051864	1/94	histone demethylase activity (H3-K36 specific)	molecular_function	"Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein." [PMID:16362057]
EOG8DFS2H	GO:0070544	1/94	histone H3-K36 demethylation	biological_process	"The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone." [GOC:sart, PMID:19061644]
EOG8935Z9	GO:0016021	1/66	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8935Z9	GO:0006147	1/66	guanine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators]
EOG8935Z9	GO:0008892	1/66	guanine deaminase activity	molecular_function	"Catalysis of the reaction: guanine + H2O = xanthine + NH3." [EC:3.5.4.3]
EOG8935Z9	GO:0008270	1/66	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8935Z9	GO:0005549	1/66	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8935Z9	GO:0000902	1/66	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8NW21K	GO:0003723	24/86	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8NW21K	GO:0000178	23/86	exosome (RNase complex)	cellular_component	"Complex of 3'-5' exoribonucleases." [PMID:10465791]
EOG8NW21K	GO:0035327	1/86	transcriptionally active chromatin	cellular_component	"The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872]
EOG8NW21K	GO:0010468	1/86	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8NW21K	GO:0000176	1/86	nuclear exosome (RNase complex)	cellular_component	"Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]
EOG8NW21K	GO:0005737	1/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8NW21K	GO:0016787	1/86	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8GQSMS	GO:0008270	4/247	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GQSMS	GO:0009631	1/247	cold acclimation	biological_process	"Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr]
EOG86Q97H	GO:0045886	15/87	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG86Q97H	GO:0016567	15/87	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG86Q97H	GO:0007274	15/87	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG86Q97H	GO:0030054	15/87	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG86Q97H	GO:0007399	15/87	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG86Q97H	GO:0031594	15/87	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG86Q97H	GO:0005737	1/87	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86Q97H	GO:0045495	1/87	pole plasm	cellular_component	"Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380]
EOG86Q97H	GO:0043204	1/87	perikaryon	cellular_component	"The portion of the cell soma (cell body) that excludes the nucleus." [GOC:jl]
EOG86Q97H	GO:0005634	1/87	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86Q97H	GO:0005515	1/87	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG86Q97H	GO:0019005	1/87	SCF ubiquitin ligase complex	cellular_component	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
EOG86Q97H	GO:0045732	1/87	positive regulation of protein catabolic process	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]
EOG86Q97H	GO:0030424	1/87	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG86Q97H	GO:0010629	1/87	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG86Q97H	GO:0005938	1/87	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8TF318	GO:0005524	17/45	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8TF318	GO:0004674	17/45	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8TF318	GO:0006468	1/45	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8TF318	GO:0007155	1/45	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8TF318	GO:0042981	1/45	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8TF318	GO:0004683	1/45	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG8TF318	GO:0007476	1/45	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8TF318	GO:0007480	1/45	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8TF318	GO:0002009	1/45	morphogenesis of an epithelium	biological_process	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
EOG8TF318	GO:0008360	1/45	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG818F2V	GO:0003712	24/96	transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG818F2V	GO:0000124	24/96	SAGA complex	cellular_component	"A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012]
EOG818F2V	GO:0070461	1/96	SAGA-type complex	cellular_component	"A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [GOC:mah, PMID:10637607, PMID:17337012]
EOG818F2V	GO:0005634	1/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG87SVVK	GO:0003677	2/4	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG84F8R8	GO:0005216	27/104	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG84F8R8	GO:0016021	27/104	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84F8R8	GO:0048512	1/104	circadian behavior	biological_process	"The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr]
EOG84F8R8	GO:0008344	1/104	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG84F8R8	GO:0050975	1/104	sensory perception of touch	biological_process	"The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]
EOG84F8R8	GO:0042752	1/104	regulation of circadian rhythm	biological_process	"Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]
EOG84F8R8	GO:0086010	1/104	membrane depolarization during action potential	biological_process	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
EOG84F8R8	GO:0022008	1/104	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG84F8R8	GO:0070509	1/104	calcium ion import	biological_process	"The directed movement of calcium ions into a cell or organelle." [GOC:mah]
EOG84F8R8	GO:0005245	1/104	voltage-gated calcium channel activity	molecular_function	"Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
EOG84F8R8	GO:0045475	1/104	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG84F8R8	GO:0072347	1/104	response to anesthetic	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart]
EOG84F8R8	GO:0035176	1/104	social behavior	biological_process	"Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group." [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior]
EOG84F8R8	GO:0005886	1/104	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG84F8R8	GO:0043025	1/104	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG84F8R8	GO:0043679	1/104	axon terminus	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl]
EOG85F037	GO:0007264	27/102	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG85F037	GO:0005085	26/102	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG85F037	GO:0005089	1/102	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG85F037	GO:0035023	1/102	regulation of Rho protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]
EOG85F037	GO:0005509	1/102	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG85F037	GO:0032319	1/102	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG85F037	GO:0006909	1/102	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG85F037	GO:0035011	1/102	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG85F037	GO:0035010	1/102	encapsulation of foreign target	biological_process	"Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920]
EOG84F8RX	GO:0035220	1/77	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG84F8RX	GO:0048749	1/77	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG84F8RX	GO:0006909	1/77	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG84F8RX	GO:0045742	1/77	positive regulation of epidermal growth factor receptor signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
EOG84F8RX	GO:0090303	1/77	positive regulation of wound healing	biological_process	"Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF]
EOG84F8RX	GO:0042060	1/77	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG84F8RX	GO:0005634	1/77	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84F8RX	GO:0022416	1/77	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG86DPGS	GO:0004725	29/119	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG86DPGS	GO:0008138	29/119	protein tyrosine/serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
EOG86DPGS	GO:0006470	1/119	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG8T1M4F	GO:0042578	1/3	phosphoric ester hydrolase activity	molecular_function	"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]
EOG89W4VK	GO:0016020	220/802	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG89W4VK	GO:0005524	220/802	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG89W4VK	GO:0016887	209/802	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG89W4VK	GO:0015416	10/802	organic phosphonate transmembrane-transporting ATPase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:3.6.3.28]
EOG89W4VK	GO:0006909	1/802	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG89W4VK	GO:0042048	1/802	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG89W4VK	GO:0008559	1/802	xenobiotic-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44]
EOG89W4VK	GO:0022008	1/802	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG89W4VK	GO:0006641	1/802	triglyceride metabolic process	biological_process	"The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732]
EOG89W4VK	GO:0015439	1/802	heme-transporting ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [EC:3.6.3.41]
EOG89W4VK	GO:0045454	1/802	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8T7BHQ	GO:0017148	1/93	negative regulation of translation	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
EOG8T7BHQ	GO:0030014	1/93	CCR4-NOT complex	cellular_component	"The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins." [GOC:sart, PMID:11113136]
EOG8T7BHQ	GO:0006355	1/93	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8T7BHQ	GO:0031047	1/93	gene silencing by RNA	biological_process	"Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054]
EOG8T7BHQ	GO:0005737	1/93	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8T7BHQ	GO:0006402	1/93	mRNA catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]
EOG8T7BHQ	GO:0006351	1/93	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8T7BHQ	GO:0005634	1/93	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8XSP45	GO:0016787	21/89	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8XSP45	GO:0045134	2/89	uridine-diphosphatase activity	molecular_function	"Catalysis of the reaction: UDP + H2O = UMP + phosphate." [EC:3.6.1.6]
EOG8XSP45	GO:0008152	1/89	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8XSP45	GO:0004382	1/89	guanosine-diphosphatase activity	molecular_function	"Catalysis of the reaction: GDP + H2O = GMP + phosphate." [EC:3.6.1.42, PMID:2989286]
EOG8XSP45	GO:0005737	1/89	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XSP45	GO:0017111	1/89	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8G7FG0	GO:0003677	2/44	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8XSP42	GO:0032006	2/78	regulation of TOR signaling	biological_process	"Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah]
EOG8XSP42	GO:0008233	1/78	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8XSP42	GO:0008168	1/78	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8XSP40	GO:0006094	27/92	gluconeogenesis	biological_process	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]
EOG8XSP40	GO:0004347	27/92	glucose-6-phosphate isomerase activity	molecular_function	"Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.9]
EOG8XSP40	GO:0006096	27/92	glycolytic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]
EOG8XSP40	GO:0005737	2/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8XSP40	GO:0055114	1/92	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8XSP40	GO:0004616	1/92	phosphogluconate dehydrogenase (decarboxylating) activity	molecular_function	"Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44]
EOG8XSP40	GO:0005811	1/92	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8K6JJG	GO:0005524	37/100	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8K6JJG	GO:0042026	36/100	protein refolding	biological_process	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]
EOG8K6JJG	GO:0005737	34/100	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8K6JJG	GO:0005759	2/100	mitochondrial matrix	cellular_component	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]
EOG8K6JJG	GO:0006950	2/100	response to stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
EOG8K6JJG	GO:0007283	1/100	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8K6JJG	GO:0005811	1/100	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8K6JJG	GO:0044267	1/100	cellular protein metabolic process	biological_process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]
EOG8K6JJG	GO:0007424	1/100	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8K6JJG	GO:0030707	1/100	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8K6JJG	GO:0005875	1/100	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8K6JJG	GO:0005743	1/100	mitochondrial inner membrane	cellular_component	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
EOG8K6JJG	GO:0007301	1/100	female germline ring canal formation	biological_process	"Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238]
EOG8K6JJG	GO:0005739	1/100	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8K6JJG	GO:0007005	1/100	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8K6JJG	GO:0034605	1/100	cellular response to heat	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]
EOG8K6JJG	GO:0048477	1/100	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8J13R1	GO:0005549	3/9	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8J13R1	GO:0004984	3/9	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG8J13R1	GO:0016020	2/9	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8J13R1	GO:0004930	1/9	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8J13R1	GO:0016021	1/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8J13R1	GO:0005886	1/9	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8P8HXX	GO:0003676	2/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8P8HXX	GO:0046872	2/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8JDKPV	GO:0005549	46/151	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG8JDKPV	GO:0007606	2/151	sensory perception of chemical stimulus	biological_process	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
EOG8JDKPV	GO:0007608	2/151	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8JDKPV	GO:0006810	2/151	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8JDKPV	GO:0019236	2/151	response to pheromone	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl]
EOG8JDKPV	GO:0042048	2/151	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG8JDKPV	GO:0005576	2/151	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8JDKPV	GO:0045471	1/151	response to ethanol	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators]
EOG8JDKPV	GO:0005550	1/151	pheromone binding	molecular_function	"Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai]
EOG8JDKPV	GO:0035274	1/151	diphenyl phthalate binding	molecular_function	"Interacting selectively and non-covalently with diphenyl phthalate, C(20)H(14)O(4)." [http://www.sigmaaldrich.com]
EOG8JDKPV	GO:0035275	1/151	dibutyl phthalate binding	molecular_function	"Interacting selectively and non-covalently with dibutyl phthalate, C(16)H(22)O(4)." [http://www.sigmaaldrich.com]
EOG8JDKPV	GO:0007619	1/151	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG8TF31Z	GO:0000502	1/84	proteasome complex	cellular_component	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome]
EOG818F24	GO:0005525	26/123	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG818F24	GO:0007264	26/123	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG818F24	GO:0005524	26/123	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG818F24	GO:0005622	25/123	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG818F24	GO:0004674	24/123	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG818F24	GO:0004672	3/123	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG818F24	GO:0050808	1/123	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG818F24	GO:0032418	1/123	lysosome localization	biological_process	"Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]
EOG818F24	GO:1900242	1/123	regulation of synaptic vesicle endocytosis	biological_process	"Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie]
EOG818F24	GO:0018105	1/123	peptidyl-serine phosphorylation	biological_process	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]
EOG818F24	GO:0005737	1/123	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG818F24	GO:0090128	1/123	regulation of synapse maturation	biological_process	"Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG818F24	GO:0070507	1/123	regulation of microtubule cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG818F24	GO:2000331	1/123	regulation of terminal button organization	biological_process	"Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah]
EOG818F24	GO:0017137	1/123	Rab GTPase binding	molecular_function	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG818F24	GO:0016301	1/123	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG818F24	GO:0005515	1/123	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG818F24	GO:0031902	1/123	late endosome membrane	cellular_component	"The lipid bilayer surrounding a late endosome." [GOC:pz]
EOG818F24	GO:0005765	1/123	lysosomal membrane	cellular_component	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]
EOG818F24	GO:0007528	1/123	neuromuscular junction development	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
EOG818F24	GO:0048312	1/123	intracellular distribution of mitochondria	biological_process	"Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid]
EOG818F24	GO:0031594	1/123	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8TTK01	GO:0004252	46/163	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8TTK01	GO:0003824	4/163	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8TTK00	GO:0004751	26/89	ribose-5-phosphate isomerase activity	molecular_function	"Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.6, RHEA:14660]
EOG8TTK00	GO:0009052	26/89	pentose-phosphate shunt, non-oxidative branch	biological_process	"The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732, MetaCyc:NONOXIPENT-PWY]
EOG8TTK00	GO:0001315	1/89	age-dependent response to reactive oxygen species	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938]
EOG8D293N	GO:0016082	1/95	synaptic vesicle priming	biological_process	"The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342]
EOG8D293N	GO:0007269	1/95	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8D293N	GO:0008021	1/95	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG8TMTG5	GO:0016021	41/138	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TMTG5	GO:0004930	24/138	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8TMTG5	GO:0004997	16/138	thyrotropin-releasing hormone receptor activity	molecular_function	"Combining with thyrotropin-releasing hormone to initiate a change in cell activity." [GOC:mah]
EOG8TMTG5	GO:0005887	1/138	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TMTG5	GO:0007218	1/138	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8TMTG5	GO:0008227	1/138	G-protein coupled amine receptor activity	molecular_function	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
EOG8TMTG5	GO:0042654	1/138	ecdysis-triggering hormone receptor activity	molecular_function	"Combining with ecdysis-triggering hormone to initiate a change in cell activity." [GOC:ma]
EOG8TMTG5	GO:0009755	1/138	hormone-mediated signaling pathway	biological_process	"A series of molecular signals mediated by the detection of a hormone." [GOC:sm]
EOG8TMTG5	GO:0022008	1/138	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8TMTG5	GO:0007186	1/138	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8TMTG5	GO:0008188	1/138	neuropeptide receptor activity	molecular_function	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
EOG8TMTG5	GO:0048812	1/138	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8TMTG5	GO:0008528	1/138	G-protein coupled peptide receptor activity	molecular_function	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]
EOG84J4Z2	GO:0008270	20/123	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84J4Z2	GO:0008237	20/123	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG84J4Z2	GO:0005578	20/123	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG84J4Z2	GO:0008233	4/123	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG82JR9D	GO:0016021	1/2	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG82JR9D	GO:0022857	1/2	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8QJV3P	GO:0016772	2/6	transferase activity, transferring phosphorus-containing groups	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
EOG8XWJDB	GO:0051726	1/89	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG85F03G	GO:0016021	23/96	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85F03G	GO:0008158	22/96	hedgehog receptor activity	molecular_function	"Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137]
EOG85F03G	GO:0016020	2/96	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG85F03G	GO:0007275	1/96	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG85F03G	GO:0007280	1/96	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG85F03G	GO:0006887	1/96	exocytosis	biological_process	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
EOG85F03G	GO:0005215	1/96	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG85F03G	GO:0007224	1/96	smoothened signaling pathway	biological_process	"A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
EOG85F03H	GO:0030170	119/445	pyridoxal phosphate binding	molecular_function	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
EOG85F03H	GO:0006520	119/445	cellular amino acid metabolic process	biological_process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]
EOG85F03H	GO:0016831	110/445	carboxy-lyase activity	molecular_function	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]
EOG85F03H	GO:0004058	9/445	aromatic-L-amino-acid decarboxylase activity	molecular_function	"Catalysis of the reaction: L-amino acid + H+ = R-H + CO2." [EC:4.1.1.28]
EOG85F03H	GO:0016491	6/445	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG85F03H	GO:0006584	2/445	catecholamine metabolic process	biological_process	"The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0042302	2/445	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG85F03H	GO:0043052	2/445	thermotaxis	biological_process	"The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
EOG85F03H	GO:0040003	2/445	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG85F03H	GO:0004837	2/445	tyrosine decarboxylase activity	molecular_function	"Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25]
EOG85F03H	GO:0042423	2/445	catecholamine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0007611	1/445	learning or memory	biological_process	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
EOG85F03H	GO:0048066	1/445	developmental pigmentation	biological_process	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
EOG85F03H	GO:0035220	1/445	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG85F03H	GO:0007626	1/445	locomotory behavior	biological_process	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
EOG85F03H	GO:0007619	1/445	courtship behavior	biological_process	"The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
EOG85F03H	GO:0046592	1/445	polyamine oxidase activity	molecular_function	"Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380]
EOG85F03H	GO:0048148	1/445	behavioral response to cocaine	biological_process	"Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid]
EOG85F03H	GO:0048082	1/445	regulation of adult chitin-containing cuticle pigmentation	biological_process	"Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
EOG85F03H	GO:0048085	1/445	adult chitin-containing cuticle pigmentation	biological_process	"Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
EOG85F03H	GO:0007615	1/445	anesthesia-resistant memory	biological_process	"The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531]
EOG85F03H	GO:0006587	1/445	serotonin biosynthetic process from tryptophan	biological_process	"The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0048149	1/445	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG85F03H	GO:0009611	1/445	response to wounding	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators]
EOG85F03H	GO:0040040	1/445	thermosensory behavior	biological_process	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]
EOG85F03H	GO:0018991	1/445	oviposition	biological_process	"The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems]
EOG85F03H	GO:0019239	1/445	deaminase activity	molecular_function	"Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl]
EOG85F03H	GO:0040007	1/445	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG85F03H	GO:0008062	1/445	eclosion rhythm	biological_process	"The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043]
EOG85F03H	GO:0004398	1/445	histidine decarboxylase activity	molecular_function	"Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22]
EOG85F03H	GO:0006585	1/445	dopamine biosynthetic process from tyrosine	biological_process	"The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine." [GOC:bf, GOC:jl, ISBN:0198506732]
EOG85F03H	GO:0007616	1/445	long-term memory	biological_process	"The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
EOG8PK4RD	GO:0016012	30/113	sarcoglycan complex	cellular_component	"A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609]
EOG8PK4RD	GO:0016021	30/113	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PK4RD	GO:0060047	1/113	heart contraction	biological_process	"The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph]
EOG8PK4RD	GO:0043034	1/113	costamere	cellular_component	"Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732, PMID:6405378]
EOG8PK4RD	GO:0045214	1/113	sarcomere organization	biological_process	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
EOG8PK4RD	GO:0007498	1/113	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8PK4RD	GO:0007016	1/113	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG8DJNBC	GO:0016021	3/169	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DJNBC	GO:0007160	1/169	cell-matrix adhesion	biological_process	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]
EOG8DJNBC	GO:0016476	1/169	regulation of embryonic cell shape	biological_process	"Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb]
EOG8DJNBC	GO:0007015	1/169	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8DJNBC	GO:0003383	1/169	apical constriction	biological_process	"The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8DJNBC	GO:0016324	1/169	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8DJNBC	GO:0007476	1/169	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8DJNBC	GO:0005214	1/169	structural constituent of chitin-based cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8DJNBC	GO:0000902	1/169	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8GF5VZ	GO:0008270	28/95	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GF5VZ	GO:0003677	23/95	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GF5VZ	GO:0048188	1/95	Set1C/COMPASS complex	cellular_component	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]
EOG8GF5VZ	GO:0006351	1/95	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8GF5VZ	GO:0009072	1/95	aromatic amino acid family metabolic process	biological_process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]
EOG8GF5VZ	GO:0003824	1/95	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8GF5VZ	GO:0005737	1/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8GF5VZ	GO:0006355	1/95	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8GF5VZ	GO:0051568	1/95	histone H3-K4 methylation	biological_process	"The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai]
EOG82Z774	GO:0048047	1/66	mating behavior, sex discrimination	biological_process	"The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700]
EOG82Z774	GO:0005179	1/66	hormone activity	molecular_function	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]
EOG82Z774	GO:0048018	1/66	receptor agonist activity	molecular_function	"Interacts with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb, ISBN:0198506732]
EOG82Z774	GO:0005615	1/66	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG82Z774	GO:0007218	1/66	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG82Z774	GO:0007621	1/66	negative regulation of female receptivity	biological_process	"Any process that stops, prevents or reduces the receptiveness of a female to male advances." [GOC:bf, PMID:11092827]
EOG82Z774	GO:0071855	1/66	neuropeptide receptor binding	molecular_function	"Interacting selectively and non-covalently with a neuropeptide receptor." [GOC:kmv, GOC:mah]
EOG82Z774	GO:0005184	1/66	neuropeptide hormone activity	molecular_function	"The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]
EOG8QZB0S	GO:0016021	30/103	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QZB0S	GO:0035556	30/103	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8QZB0S	GO:0000166	29/103	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8QZB0S	GO:0009190	27/103	cyclic nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]
EOG8QZB0S	GO:0016849	27/103	phosphorus-oxygen lyase activity	molecular_function	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
EOG8QZB0S	GO:0004016	3/103	adenylate cyclase activity	molecular_function	"Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]
EOG8QZB0S	GO:0040015	1/103	negative regulation of multicellular organism growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG8QZB0S	GO:0042594	1/103	response to starvation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
EOG8QZB0S	GO:0006171	1/103	cAMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]
EOG8QZB0S	GO:0002165	1/103	instar larval or pupal development	biological_process	"The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
EOG8QZB0S	GO:0046872	1/103	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8QZB0S	GO:0005524	1/103	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8MSGCC	GO:0004252	1/103	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8MSGCC	GO:0005515	1/103	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG80ZTBF	GO:0008270	19/87	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80ZTBF	GO:0016874	3/87	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8M67XG	GO:0005634	2/5	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8M67XG	GO:0003676	2/5	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M67XG	GO:0008270	2/5	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WQ3GD	GO:0008270	16/46	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8WQ3GD	GO:0008237	16/46	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8WQ3GD	GO:0004177	2/46	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG8TTJXX	GO:0008270	50/79	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8TTJXX	GO:0008237	50/79	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8TTJXX	GO:0004177	6/79	aminopeptidase activity	molecular_function	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
EOG8TTJXX	GO:0006508	2/79	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8DFS5H	GO:0016021	1/9	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DFS5H	GO:0004930	1/9	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG86Q978	GO:0016787	2/5	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG80ZTBJ	GO:0005524	25/86	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG80ZTBJ	GO:0005737	25/86	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG80ZTBJ	GO:0006425	24/86	glutaminyl-tRNA aminoacylation	biological_process	"The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG80ZTBJ	GO:0004819	24/86	glutamine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18]
EOG80ZTBJ	GO:0006418	1/86	tRNA aminoacylation for protein translation	biological_process	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]
EOG80ZTBJ	GO:0004812	1/86	aminoacyl-tRNA ligase activity	molecular_function	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]
EOG80ZTBJ	GO:0005875	1/86	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG80ZTBJ	GO:0048813	1/86	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG89S8M7	GO:0046856	15/84	phosphatidylinositol dephosphorylation	biological_process	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]
EOG89S8M7	GO:0000166	14/84	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG89S8M7	GO:0042578	13/84	phosphoric ester hydrolase activity	molecular_function	"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]
EOG89S8M7	GO:0004439	3/84	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36, RHEA:22767]
EOG89S8M7	GO:0003676	2/84	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG89S8M7	GO:0016311	1/84	dephosphorylation	biological_process	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]
EOG89S8M7	GO:0046030	1/84	inositol trisphosphate phosphatase activity	molecular_function	"Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate." [GOC:bf]
EOG89S8M7	GO:0012506	1/84	vesicle membrane	cellular_component	"The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah]
EOG89S8M7	GO:0004445	1/84	inositol-polyphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56]
EOG89S8M7	GO:0050803	1/84	regulation of synapse structure or activity	biological_process	"Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]
EOG89S8M7	GO:0048488	1/84	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG89S8M7	GO:0048790	1/84	maintenance of presynaptic active zone structure	biological_process	"The process in which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr]
EOG89S8M7	GO:0043195	1/84	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG89S8M7	GO:0052659	1/84	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56, RHEA:11395]
EOG89S8M7	GO:0007269	1/84	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG89S8M7	GO:0052658	1/84	inositol-1,4,5-trisphosphate 5-phosphatase activity	molecular_function	"Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate." [EC:3.1.3.56, RHEA:19800]
EOG89S8M6	GO:0005737	20/105	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG89S8M6	GO:0050807	2/105	regulation of synapse organization	biological_process	"Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]
EOG89S8M6	GO:0030866	2/105	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG89S8M6	GO:0031209	2/105	SCAR complex	cellular_component	"A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:pg, PMID:12181570]
EOG89S8M6	GO:0007411	2/105	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG89S8M6	GO:0022416	2/105	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG89S8M6	GO:0008360	2/105	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG89S8M6	GO:0030031	2/105	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG89S8M6	GO:0006909	1/105	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG89S8M6	GO:0005515	1/105	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG89S8M6	GO:0045177	1/105	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG89S8M6	GO:0001745	1/105	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG89S8M6	GO:0046872	1/105	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG89S8M6	GO:0000902	1/105	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8W6RD1	GO:0003676	26/237	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8W6RD1	GO:0008270	25/237	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8W6RD1	GO:0003677	1/237	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8W6RD1	GO:0004523	1/237	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8W6RD1	GO:0003964	1/237	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8W6RD1	GO:0003723	1/237	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CZDW8	GO:0005524	45/139	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CZDW8	GO:0008568	43/139	microtubule-severing ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766]
EOG8CZDW8	GO:0051013	43/139	microtubule severing	biological_process	"The process in which a microtubule is broken down into smaller segments." [GOC:ai, PMID:14657234]
EOG8CZDW8	GO:0005813	41/139	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG8CZDW8	GO:0030496	41/139	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG8CZDW8	GO:0000922	41/139	spindle pole	cellular_component	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
EOG8CZDW8	GO:0005874	41/139	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8CZDW8	GO:0007126	41/139	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG8CZDW8	GO:0005737	39/139	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CZDW8	GO:0008017	2/139	microtubule binding	molecular_function	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
EOG8CZDW8	GO:0008352	2/139	katanin complex	cellular_component	"A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766]
EOG8CZDW8	GO:0007017	2/139	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8CZDW8	GO:0017111	1/139	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8CZDW8	GO:0031252	1/139	cell leading edge	cellular_component	"The area of a motile cell closest to the direction of movement." [GOC:pg]
EOG8CZDW8	GO:0005694	1/139	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG8CZDW8	GO:0016358	1/139	dendrite development	biological_process	"The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8CZDW8	GO:0005938	1/139	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8CZDW8	GO:0070462	1/139	plus-end specific microtubule depolymerization	biological_process	"The removal of tubulin heterodimers from the plus end of a microtubule." [GOC:krc, PMID:16906145, PMID:16906148]
EOG8CZDW8	GO:0000070	1/139	mitotic sister chromatid segregation	biological_process	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
EOG8CZDW8	GO:0022416	1/139	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8CZDW8	GO:0005875	1/139	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8CZDW8	GO:0035220	1/139	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8CZDW8	GO:0050775	1/139	positive regulation of dendrite morphogenesis	biological_process	"Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG8CZDW8	GO:0017022	1/139	myosin binding	molecular_function	"Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
EOG8CZDW8	GO:0007019	1/139	microtubule depolymerization	biological_process	"The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194]
EOG8CZDW8	GO:0006200	1/139	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8CZDW8	GO:0031122	1/139	cytoplasmic microtubule organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
EOG8CZDW8	GO:0016322	1/139	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG8CZDW8	GO:0030336	1/139	negative regulation of cell migration	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]
EOG8CZDW8	GO:0008582	1/139	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8CRPG3	GO:0016021	10/67	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F20JW	GO:0016021	38/62	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8F20JW	GO:0006810	36/62	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8F20JW	GO:0048193	2/62	Golgi vesicle transport	biological_process	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
EOG8F20JW	GO:0005215	2/62	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8F20JW	GO:0005783	1/62	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8F20JW	GO:0000003	1/62	reproduction	biological_process	"The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732]
EOG8F20JW	GO:0061357	1/62	positive regulation of Wnt protein secretion	biological_process	"Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]
EOG8F20JW	GO:0090263	1/62	positive regulation of canonical Wnt signaling pathway	biological_process	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]
EOG8F20JW	GO:0048042	1/62	regulation of post-mating oviposition	biological_process	"Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb, PMID:11932766]
EOG8F20JW	GO:0022008	1/62	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8V45NW	GO:0005097	27/125	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8XD676	GO:0005524	1/3	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8XD676	GO:0016887	1/3	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8NP9MD	GO:0043565	23/76	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NP9MD	GO:0005634	17/76	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8NP9MD	GO:0005622	6/76	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8NP9MD	GO:0006974	1/76	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8PCD84	GO:0034464	1/3	BBSome	cellular_component	"A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [GOC:BHF, PMID:17574030]
EOG8PCD84	GO:0035058	1/3	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG8QC3KP	GO:0005234	18/135	extracellular-glutamate-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8QC3KP	GO:0004970	13/135	ionotropic glutamate receptor activity	molecular_function	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
EOG8QC3KP	GO:0016020	12/135	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QC3KP	GO:0005215	9/135	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8QC3KP	GO:0015276	8/135	ligand-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
EOG8QC3KP	GO:0034220	8/135	ion transmembrane transport	biological_process	"A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
EOG8QC3KP	GO:0009593	8/135	detection of chemical stimulus	biological_process	"The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
EOG8QC3KP	GO:0016021	8/135	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QC3KP	GO:0035235	5/135	ionotropic glutamate receptor signaling pathway	biological_process	"A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732]
EOG8QC3KP	GO:0030425	5/135	dendrite	cellular_component	"A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
EOG8QC3KP	GO:0045211	5/135	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8QC3KP	GO:0035249	5/135	synaptic transmission, glutamatergic	biological_process	"The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv]
EOG8QC3KP	GO:0004971	3/135	AMPA glutamate receptor activity	molecular_function	"An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium." [GOC:mah, PMID:10049997, PMID:8804111]
EOG8QC3KP	GO:0032281	3/135	AMPA glutamate receptor complex	cellular_component	"An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef]
EOG8QC3KP	GO:0036081	3/135	extracellular ammonia-gated ion channel activity	molecular_function	"Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]
EOG8QC3KP	GO:0050909	2/135	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8QC3KP	GO:0008328	1/135	ionotropic glutamate receptor complex	cellular_component	"A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
EOG8QC3KP	GO:0017146	1/135	NMDA selective glutamate receptor complex	cellular_component	"An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
EOG8QC3KP	GO:0004972	1/135	NMDA glutamate receptor activity	molecular_function	"An ionotropic glutamate receptor activity that exhibits slow gating by glutamate, acts by opening a nonselective cation channel, and can be activated by L-aspartate." [GOC:mah, PMID:10049997]
EOG886BSK	GO:0005509	22/69	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG886BSK	GO:0004721	20/69	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG886BSK	GO:0050906	11/69	detection of stimulus involved in sensory perception	biological_process	"The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph]
EOG886BSK	GO:0005506	11/69	iron ion binding	molecular_function	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
EOG886BSK	GO:0030145	11/69	manganese ion binding	molecular_function	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
EOG886BSK	GO:0016787	2/69	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG886BSK	GO:0007602	1/69	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG886BSK	GO:0004722	1/69	protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
EOG886BSK	GO:0005516	1/69	calmodulin binding	molecular_function	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
EOG886BSK	GO:0016491	1/69	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG886BSK	GO:0043052	1/69	thermotaxis	biological_process	"The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
EOG886BSK	GO:0004723	1/69	calcium-dependent protein serine/threonine phosphatase activity	molecular_function	"Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [EC:3.1.3.16, GOC:mah]
EOG886BSK	GO:0016059	1/69	deactivation of rhodopsin mediated signaling	biological_process	"The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831]
EOG886BSK	GO:0006470	1/69	protein dephosphorylation	biological_process	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]
EOG886BSK	GO:0019722	1/69	calcium-mediated signaling	biological_process	"Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]
EOG886BSK	GO:0007601	1/69	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8CZDVR	GO:0005634	31/103	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CZDVR	GO:0018024	30/103	histone-lysine N-methyltransferase activity	molecular_function	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]
EOG8CZDVR	GO:0008270	25/103	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CZDVR	GO:0008168	2/103	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8CZDVR	GO:0018992	1/103	germ-line sex determination	biological_process	"The determination of sex and sexual phenotype in an organism's germ line." [GOC:ems]
EOG8CZDVR	GO:0016458	1/103	gene silencing	biological_process	"Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb]
EOG8CZDVR	GO:0000228	1/103	nuclear chromosome	cellular_component	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
EOG8CZDVR	GO:0003677	1/103	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8KPWQW	GO:0018149	31/132	peptide cross-linking	biological_process	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]
EOG8KPWQW	GO:0003810	29/132	protein-glutamine gamma-glutamyltransferase activity	molecular_function	"Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124]
EOG8KPWQW	GO:0046872	22/132	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8KPWQW	GO:0042381	1/132	hemolymph coagulation	biological_process	"Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949]
EOG8KPWQW	GO:0045087	1/132	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG88PQ0M	GO:0035556	24/111	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG88PQ0M	GO:0046872	24/111	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG88PQ0M	GO:0005089	23/111	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG88PQ0M	GO:0016477	1/111	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG88PQ0M	GO:0016740	1/111	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG88PQ0M	GO:0004697	1/111	protein kinase C activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]
EOG88PQ0M	GO:0072499	1/111	photoreceptor cell axon guidance	biological_process	"The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677]
EOG88PQ0M	GO:0007015	1/111	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG88PQ0M	GO:0032314	1/111	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG88PQ0M	GO:0007520	1/111	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG88PQ0M	GO:0007391	1/111	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG88PQ0M	GO:0007411	1/111	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG88PQ0M	GO:0007417	1/111	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG88PQ0M	GO:0031532	1/111	actin cytoskeleton reorganization	biological_process	"A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]
EOG88PQ0M	GO:0032863	1/111	activation of GTPase activity	biological_process	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]
EOG88PQ0M	GO:0030676	1/111	Rac guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG88PQ0M	GO:0007155	1/111	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG88PQ0M	GO:0007409	1/111	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG88PQ0M	GO:0007424	1/111	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG88PQ0M	GO:0035011	1/111	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG88PQ0M	GO:0008360	1/111	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG87H855	GO:0000079	1/4	regulation of cyclin-dependent protein serine/threonine kinase activity	biological_process	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]
EOG8P2SG2	GO:0008270	31/124	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8P2SG2	GO:0003677	22/124	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8P2SG2	GO:0004402	2/124	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8P2SG2	GO:0016589	1/124	NURF complex	cellular_component	"An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters." [GOC:bf, GOC:krc, PMID:10779516, PMID:11279013, PMID:15284901, PMID:16568949, PMID:21810179]
EOG8P2SG2	GO:0042766	1/124	nucleosome mobilization	biological_process	"The movement of nucleosomes along a DNA fragment." [PMID:12006495]
EOG8P2SG2	GO:0046331	1/124	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8P2SG2	GO:0006325	1/124	chromatin organization	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
EOG8P2SG2	GO:0045824	1/124	negative regulation of innate immune response	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
EOG8P2SG2	GO:0035064	1/124	methylated histone binding	molecular_function	"Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf, PMID:14585615]
EOG8P2SG2	GO:0006338	1/124	chromatin remodeling	biological_process	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]
EOG8P2SG2	GO:0007095	1/124	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8P2SG2	GO:0006351	1/124	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8P2SG2	GO:0048515	1/124	spermatid differentiation	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid]
EOG8P2SG2	GO:0035076	1/124	ecdysone receptor-mediated signaling pathway	biological_process	"The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf]
EOG8P2SG2	GO:0045747	1/124	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8P2SG2	GO:0030097	1/124	hemopoiesis	biological_process	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
EOG8P2SG2	GO:0006357	1/124	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8P2SG2	GO:0010468	1/124	regulation of gene expression	biological_process	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8P2SG2	GO:0048813	1/124	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8P2SG2	GO:0070577	1/124	lysine-acetylated histone binding	molecular_function	"Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]
EOG8P2SG2	GO:0016922	1/124	ligand-dependent nuclear receptor binding	molecular_function	"Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein." [GOC:mah, PMID:7776974]
EOG8P2SG2	GO:0046426	1/124	negative regulation of JAK-STAT cascade	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG8P2SG2	GO:0035073	1/124	pupariation	biological_process	"The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
EOG89KJ6P	GO:0008168	1/8	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG89CSR1	GO:0032504	1/68	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG89CSR1	GO:0015918	1/68	sterol transport	biological_process	"The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]
EOG89CSR1	GO:0045456	1/68	ecdysteroid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators]
EOG89CSR1	GO:0005615	1/68	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG88PQ0H	GO:0005869	2/120	dynactin complex	cellular_component	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]
EOG88PQ0H	GO:0007018	2/120	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG88PQ0H	GO:0045502	1/120	dynein binding	molecular_function	"Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules." [GOC:bf]
EOG88PQ0H	GO:0045198	1/120	establishment of epithelial cell apical/basal polarity	biological_process	"The specification and formation of the apicobasal polarity of an epithelial cell." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
EOG88PQ0H	GO:0031616	1/120	spindle pole centrosome	cellular_component	"A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah]
EOG88PQ0H	GO:0007067	1/120	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG88PQ0H	GO:0048491	1/120	retrograde synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron, along the cytoskeleton, toward the neuronal cell body." [GOC:jid, GOC:lmg]
EOG88PQ0H	GO:0005813	1/120	centrosome	cellular_component	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
EOG88PQ0H	GO:0048477	1/120	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG88PQ0H	GO:0051383	1/120	kinetochore organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG88PQ0H	GO:0005737	1/120	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG88PQ0H	GO:0042052	1/120	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG88PQ0H	GO:0007052	1/120	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG88PQ0H	GO:0005876	1/120	spindle microtubule	cellular_component	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]
EOG88PQ0H	GO:0000776	1/120	kinetochore	cellular_component	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
EOG88PQ0H	GO:0051299	1/120	centrosome separation	biological_process	"The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai]
EOG88PQ0H	GO:0006886	1/120	intracellular protein transport	biological_process	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
EOG88PQ0H	GO:0047497	1/120	mitochondrion transport along microtubule	biological_process	"The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd]
EOG88PQ0H	GO:0001709	1/120	cell fate determination	biological_process	"A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
EOG88PQ0H	GO:0051256	1/120	mitotic spindle midzone assembly	biological_process	"The cell cycle process, occurring during anaphase, in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone." [GOC:mtg_cell_cycle, GOC:vw]
EOG88PQ0H	GO:0051642	1/120	centrosome localization	biological_process	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
EOG88PQ0H	GO:0005818	1/120	aster	cellular_component	"An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt]
EOG88PQ0H	GO:0008090	1/120	retrograde axon cargo transport	biological_process	"The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194]
EOG88PQ0H	GO:0051225	1/120	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG88PQ0H	GO:0042051	1/120	compound eye photoreceptor development	biological_process	"The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
EOG88PQ0H	GO:0030496	1/120	midbody	cellular_component	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
EOG88PQ0H	GO:0034501	1/120	protein localization to kinetochore	biological_process	"Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]
EOG88PQ0H	GO:0035371	1/120	microtubule plus-end	cellular_component	"The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]
EOG88PQ0H	GO:0001754	1/120	eye photoreceptor cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators]
EOG88PQ0H	GO:0003774	1/120	motor activity	molecular_function	"Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
EOG88PQ0H	GO:0001751	1/120	compound eye photoreceptor cell differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
EOG88PQ0H	GO:0022008	1/120	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG88PQ0H	GO:0016330	1/120	second mitotic wave involved in compound eye morphogenesis	biological_process	"A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224]
EOG88PQ0H	GO:0051028	1/120	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG88PQ0H	GO:0035011	1/120	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG88PQ0H	GO:0030286	1/120	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG88PQ0H	GO:0005828	1/120	kinetochore microtubule	cellular_component	"Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194]
EOG89W4XP	GO:0003777	3/15	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG89W4XP	GO:0007018	3/15	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG89W4XP	GO:0005871	3/15	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG89W4XP	GO:0005524	3/15	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG89W4XP	GO:0005874	3/15	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG886BSH	GO:0048015	25/100	phosphatidylinositol-mediated signaling	biological_process	"A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]
EOG886BSH	GO:0005524	24/100	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG886BSH	GO:0016303	23/100	1-phosphatidylinositol-3-kinase activity	molecular_function	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.137, RHEA:12712]
EOG886BSH	GO:0046854	3/100	phosphatidylinositol phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]
EOG886BSH	GO:0010506	1/100	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG886BSH	GO:0016301	1/100	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG886BSH	GO:0000045	1/100	autophagosome assembly	biological_process	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]
EOG886BSH	GO:0006897	1/100	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG886BSH	GO:0033227	1/100	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG886BSH	GO:0035004	1/100	phosphatidylinositol 3-kinase activity	molecular_function	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring." [GOC:bf, PMID:10209156, PMID:9255069]
EOG886BSH	GO:0036092	1/100	phosphatidylinositol-3-phosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position." [CHEBI:26034, GOC:al, GOC:vw]
EOG886BSH	GO:0035032	1/100	phosphatidylinositol 3-kinase complex, class III	cellular_component	"A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI)." [GOC:bf, PMID:9255069]
EOG886BSH	GO:0009267	1/100	cellular response to starvation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]
EOG886BSH	GO:0016773	1/100	phosphotransferase activity, alcohol group as acceptor	molecular_function	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
EOG8284H5	GO:0016021	71/178	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG85XB8W	GO:0007018	83/336	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG85XB8W	GO:0003777	82/336	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG85XB8W	GO:0030286	71/336	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG85XB8W	GO:0005524	54/336	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG85XB8W	GO:0006072	10/336	glycerol-3-phosphate metabolic process	biological_process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]
EOG85XB8W	GO:0009331	10/336	glycerol-3-phosphate dehydrogenase complex	cellular_component	"An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3]
EOG85XB8W	GO:0016887	9/336	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG85XB8W	GO:0004368	9/336	glycerol-3-phosphate dehydrogenase activity	molecular_function	"Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol." [EC:1.1.5.3]
EOG85XB8W	GO:0042623	3/336	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG85XB8W	GO:0006200	3/336	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG85XB8W	GO:0005875	2/336	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG85XB8W	GO:0006302	1/336	double-strand break repair	biological_process	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]
EOG85XB8W	GO:2001019	1/336	positive regulation of retrograde axon cargo transport	biological_process	"Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol]
EOG85XB8W	GO:0005634	1/336	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85XB8W	GO:0005509	1/336	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG85XB8W	GO:0004527	1/336	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG85XB8W	GO:0007605	1/336	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG85XB8W	GO:0004519	1/336	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG85XB8W	GO:0052591	1/336	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	molecular_function	"Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." [MetaCyc:GLYC3PDEHYDROG-RXN]
EOG85XB8W	GO:0007126	1/336	meiotic nuclear division	biological_process	"One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324]
EOG85XB8W	GO:0030145	1/336	manganese ion binding	molecular_function	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
EOG8QC3KG	GO:0004872	24/102	receptor activity	molecular_function	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]
EOG8QC3KG	GO:0007275	23/102	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8QC3KG	GO:0016021	13/102	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8QC3KG	GO:0016020	11/102	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8QC3KG	GO:0008039	1/102	synaptic target recognition	biological_process	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
EOG8DRCSF	GO:0004252	26/97	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8DRCSF	GO:0035103	1/97	sterol regulatory element binding protein cleavage	biological_process	"The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids." [GOC:bf, GOC:vw, PMID:12923525]
EOG8DRCSF	GO:0005794	1/97	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8DRCSF	GO:0006629	1/97	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8DRCSF	GO:0006508	1/97	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG86X1PH	GO:0008270	23/100	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG86X1PH	GO:0032312	23/100	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG86X1PH	GO:0008060	23/100	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG86X1PH	GO:0005737	6/100	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86X1PH	GO:0043547	1/100	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG86X1PH	GO:0016787	1/100	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG86X1PH	GO:0000902	1/100	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG86X1PH	GO:0016906	1/100	sterol 3-beta-glucosyltransferase activity	molecular_function	"Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol." [EC:2.4.1.173]
EOG86X1PH	GO:0006909	1/100	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG86X1PH	GO:0016021	1/100	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DRCSD	GO:0001726	2/7	ruffle	cellular_component	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]
EOG8DRCSD	GO:0005925	2/7	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8DRCSD	GO:0007016	2/7	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG8DRCSD	GO:0005200	2/7	structural constituent of cytoskeleton	molecular_function	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
EOG8DRCSD	GO:0005856	2/7	cytoskeleton	cellular_component	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
EOG8DRCSB	GO:0004252	26/87	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8DRCSB	GO:0006508	1/87	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8DRCSB	GO:0035187	1/87	hatching behavior	biological_process	"The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [GOC:pr, PMID:10436051]
EOG8DRCSB	GO:0016486	1/87	peptide hormone processing	biological_process	"The generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:mah]
EOG8DRCSB	GO:0005615	1/87	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8DRCSB	GO:0007218	1/87	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8DRCSB	GO:0035180	1/87	larval wandering behavior	biological_process	"The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction." [PMID:12848927, PMID:12956960]
EOG8DRCSB	GO:0002165	1/87	instar larval or pupal development	biological_process	"The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
EOG8DRCSB	GO:0008233	1/87	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8DRCSB	GO:0005576	1/87	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8DRCSB	GO:0033500	1/87	carbohydrate homeostasis	biological_process	"A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah]
EOG8P5NQM	GO:0004519	1/5	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8P5NQM	GO:0003723	1/5	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8P5NQM	GO:0003964	1/5	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8FXTP3	GO:0016021	19/50	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DRCSN	GO:0003723	10/55	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8DRCSN	GO:0003964	10/55	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8DRCSN	GO:0015074	6/55	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8DRCSN	GO:0008270	6/55	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8DRCSN	GO:0003676	2/55	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DRCSN	GO:0004190	1/55	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8V71ZR	GO:0016021	20/85	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8V71ZR	GO:2000311	1/85	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	biological_process	"Any process that modulates the frequency, rate or extent of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity." [GOC:BHF]
EOG8V71ZR	GO:0016247	1/85	channel regulator activity	molecular_function	"Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah]
EOG8V71ZR	GO:0051966	1/85	regulation of synaptic transmission, glutamatergic	biological_process	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
EOG8SXQWC	GO:0004930	65/251	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8SXQWC	GO:0016021	65/251	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8SXQWC	GO:0007186	4/251	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8SXQWC	GO:0005886	3/251	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8SXQWC	GO:0008366	2/251	axon ensheathment	biological_process	"Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437]
EOG8SXQWC	GO:0048148	2/251	behavioral response to cocaine	biological_process	"Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid]
EOG8SXQWC	GO:0004252	2/251	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8SXQWC	GO:0060857	1/251	establishment of glial blood-brain barrier	biological_process	"Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
EOG8SXQWC	GO:0007281	1/251	germ cell development	biological_process	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
EOG8SXQWC	GO:0035095	1/251	behavioral response to nicotine	biological_process	"Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus." [GOC:bf, ISBN:0198506732]
EOG8SXQWC	GO:0048149	1/251	behavioral response to ethanol	biological_process	"Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid]
EOG8SXQWC	GO:0008354	1/251	germ cell migration	biological_process	"The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
EOG8SXQWC	GO:0007419	1/251	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8SXQWC	GO:0030866	1/251	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8SXQWC	GO:0019991	1/251	septate junction assembly	biological_process	"The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312]
EOG8SXQWC	GO:0035234	1/251	ectopic germ cell programmed cell death	biological_process	"Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944]
EOG8SXQWC	GO:0005938	1/251	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8SXQWC	GO:0005919	1/251	pleated septate junction	cellular_component	"A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298]
EOG8SXQWC	GO:0007280	1/251	pole cell migration	biological_process	"The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
EOG8SXQWC	GO:0050254	1/251	rhodopsin kinase activity	molecular_function	"Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
EOG8SXQWC	GO:0007218	1/251	neuropeptide signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
EOG8ZCWK8	GO:0007165	21/84	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8ZCWK8	GO:0005509	21/84	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8ZCWK8	GO:0005578	21/84	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG8ZCWK8	GO:0030513	1/84	positive regulation of BMP signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators]
EOG8ZCWK8	GO:0043395	1/84	heparan sulfate proteoglycan binding	molecular_function	"Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732]
EOG8ZCWK8	GO:0044719	1/84	regulation of imaginal disc-derived wing size	biological_process	"Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
EOG8ZCWK8	GO:0030510	1/84	regulation of BMP signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah]
EOG8ZCWK8	GO:0008340	1/84	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8ZCWK8	GO:0030718	1/84	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8ZCWK8	GO:0005576	1/84	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8JT2M0	GO:0008236	14/71	serine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8JT2M0	GO:0004252	3/71	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG8CG2R8	GO:0003676	293/3952	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8CG2R8	GO:0015074	167/3952	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8CG2R8	GO:0008270	165/3952	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CG2R8	GO:0003723	66/3952	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8CG2R8	GO:0003964	66/3952	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8CG2R8	GO:0004190	48/3952	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8CG2R8	GO:0005634	3/3952	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8CG2R8	GO:0005509	3/3952	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8CG2R8	GO:0003677	3/3952	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CG2R8	GO:0016021	2/3952	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8CG2R8	GO:0007166	2/3952	cell surface receptor signaling pathway	biological_process	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
EOG8CG2R8	GO:0004842	2/3952	ubiquitin-protein transferase activity	molecular_function	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]
EOG8CG2R8	GO:0023051	2/3952	regulation of signaling	biological_process	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
EOG8CG2R8	GO:0046872	2/3952	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CG2R8	GO:0004871	2/3952	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8CG2R8	GO:0003700	1/3952	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8CG2R8	GO:0016620	1/3952	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
EOG8CG2R8	GO:0004527	1/3952	exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
EOG8CG2R8	GO:0005524	1/3952	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8CG2R8	GO:0055085	1/3952	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8CG2R8	GO:0043565	1/3952	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8CG2R8	GO:0004518	1/3952	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8CG2R8	GO:0004672	1/3952	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8CG2R8	GO:0004725	1/3952	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8CG2R8	GO:0005840	1/3952	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8CG2R8	GO:0006412	1/3952	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8CG2R8	GO:0022857	1/3952	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8CG2R8	GO:0019031	1/3952	viral envelope	cellular_component	"The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope]
EOG8CG2R8	GO:0003735	1/3952	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8CG2R8	GO:0016491	1/3952	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8CG2R8	GO:0005975	1/3952	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8BVV90	GO:0005262	4/8	calcium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8BVV90	GO:0016021	2/8	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8BVV90	GO:0016020	2/8	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8M67XH	GO:0005524	26/93	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8M67XH	GO:0004672	24/93	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8M67XH	GO:0004674	1/93	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8M67XH	GO:0061572	1/93	actin filament bundle organization	biological_process	"A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph]
EOG8M67XH	GO:0007015	1/93	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8M67XH	GO:0001578	1/93	microtubule bundle formation	biological_process	"A process that results in a parallel arrangement of microtubules." [GOC:dph]
EOG8M67XH	GO:0035160	1/93	maintenance of epithelial integrity, open tracheal system	biological_process	"Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process." [GOC:mtg_sensu, PMID:10694415, PMID:14681183]
EOG8M67XH	GO:0000902	1/93	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8M67XH	GO:0008384	1/93	IkappaB kinase activity	molecular_function	"Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein." [EC:2.7.11.10]
EOG8M67XH	GO:0004709	1/93	MAP kinase kinase kinase activity	molecular_function	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
EOG8M67XH	GO:0005515	1/93	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8M67XH	GO:0032456	1/93	endocytic recycling	biological_process	"The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635]
EOG8M67XH	GO:0006468	1/93	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8M67XH	GO:0008407	1/93	chaeta morphogenesis	biological_process	"The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators]
EOG8M67XH	GO:0043280	1/93	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	"Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8M67XH	GO:0036290	1/93	protein trans-autophosphorylation	biological_process	"The phosphorylation by a protein of a residue on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [GOC:jsg, PMID:20516151]
EOG8M67XH	GO:0045035	1/93	sensory organ precursor cell division	biological_process	"The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597]
EOG8M67XH	GO:0051493	1/93	regulation of cytoskeleton organization	biological_process	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
EOG8M67XH	GO:0008219	1/93	cell death	biological_process	"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as \"apoptotic bodies\"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo." [GOC:mah, GOC:mtg_apoptosis]
EOG8M67XH	GO:0051286	1/93	cell tip	cellular_component	"The region at either end of the longest axis of a cylindrical or elongated cell." [GOC:ai, GOC:mah]
EOG8M67XH	GO:0005737	1/93	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8M67XH	GO:0018105	1/93	peptidyl-serine phosphorylation	biological_process	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]
EOG8M67XH	GO:0016322	1/93	neuron remodeling	biological_process	"The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
EOG86HJS8	GO:0005524	50/177	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG86HJS8	GO:0019205	33/177	nucleobase-containing compound kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]
EOG86HJS8	GO:0006139	33/177	nucleobase-containing compound metabolic process	biological_process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
EOG86HJS8	GO:0004017	17/177	adenylate kinase activity	molecular_function	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]
EOG86HJS8	GO:0046034	14/177	ATP metabolic process	biological_process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]
EOG86HJS8	GO:0005737	14/177	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG86HJS8	GO:0046939	1/177	nucleotide phosphorylation	biological_process	"The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]
EOG86HJS8	GO:0004849	1/177	uridine kinase activity	molecular_function	"Catalysis of the reaction: ATP + uridine = ADP + UMP." [EC:2.7.1.48]
EOG8P5NQP	GO:0004518	11/86	nuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
EOG8P5NQP	GO:0003677	11/86	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8P5NQP	GO:0004519	2/86	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8P5NQP	GO:0016787	1/86	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG86X1PS	GO:0016747	73/270	transferase activity, transferring acyl groups other than amino-acyl groups	molecular_function	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
EOG86X1PS	GO:0003985	5/270	acetyl-CoA C-acetyltransferase activity	molecular_function	"Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [EC:2.3.1.9]
EOG86X1PS	GO:0005811	2/270	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG86X1PS	GO:0005739	2/270	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG86X1PS	GO:0005875	2/270	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG86X1PS	GO:0005777	1/270	peroxisome	cellular_component	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
EOG86X1PS	GO:0007052	1/270	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG86X1PS	GO:0003988	1/270	acetyl-CoA C-acyltransferase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [EC:2.3.1.16]
EOG86X1PR	GO:0046872	22/80	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG86X1PR	GO:0003677	13/80	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG86X1PR	GO:0005634	13/80	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG86X1PR	GO:0006355	13/80	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG86X1PR	GO:0006351	13/80	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG86X1PR	GO:0003676	7/80	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8DRCSZ	GO:0016787	7/11	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG876NHC	GO:0005634	2/62	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG876NHC	GO:0005694	2/62	chromosome	cellular_component	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
EOG876NHC	GO:0003677	1/62	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG876NHC	GO:0048813	1/62	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG876NHC	GO:0006325	1/62	chromatin organization	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
EOG876NHC	GO:0003680	1/62	AT DNA binding	molecular_function	"Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, PMID:2670564]
EOG876NHC	GO:0008301	1/62	DNA binding, bending	molecular_function	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]
EOG876NHC	GO:0007517	1/62	muscle organ development	biological_process	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
EOG8P5NQW	GO:0003723	25/95	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8P5NQW	GO:0000398	1/95	mRNA splicing, via spliceosome	biological_process	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
EOG8P5NQW	GO:0005634	1/95	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8P5NQW	GO:0004221	1/95	obsolete ubiquitin thiolesterase activity	molecular_function	"OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]
EOG8R26BZ	GO:0007186	5/31	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8R26BZ	GO:0003924	5/31	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8R26BZ	GO:0004871	5/31	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG8R26BZ	GO:0019001	5/31	guanyl nucleotide binding	molecular_function	"Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]
EOG8FJBRF	GO:0042302	572/1336	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8FJBRF	GO:0040003	37/1336	chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
EOG8FJBRF	GO:0008010	37/1336	structural constituent of chitin-based larval cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8FJBRF	GO:0031012	37/1336	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG8FJBRF	GO:0005576	13/1336	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8FJBRF	GO:0008363	8/1336	larval chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG8FJBRF	GO:0005215	7/1336	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8FJBRF	GO:0008011	2/1336	structural constituent of pupal chitin-based cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
EOG8FJBRF	GO:0005615	1/1336	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8FJBRF	GO:0032504	1/1336	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8FJBRF	GO:0042381	1/1336	hemolymph coagulation	biological_process	"Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949]
EOG8B8MTK	GO:0016905	2/93	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG8VQD57	GO:0005789	26/85	endoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
EOG8VQD57	GO:0016021	26/85	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8VQD57	GO:0016758	26/85	transferase activity, transferring hexosyl groups	molecular_function	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
EOG8VQD57	GO:0006506	26/85	GPI anchor biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
EOG86HJSG	GO:0006351	25/91	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG86HJSG	GO:0003899	5/91	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG86HJSG	GO:0006360	1/91	transcription from RNA polymerase I promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]
EOG86HJSG	GO:0005665	1/91	DNA-directed RNA polymerase II, core complex	cellular_component	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG86HJSG	GO:0007095	1/91	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG86HJSG	GO:0005666	1/91	DNA-directed RNA polymerase III complex	cellular_component	"RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG86HJSG	GO:0005736	1/91	DNA-directed RNA polymerase I complex	cellular_component	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
EOG86HJSG	GO:0006383	1/91	transcription from RNA polymerase III promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH]
EOG86HJSG	GO:0006366	1/91	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8FXTPX	GO:0005525	83/290	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8FXTPX	GO:0007264	81/290	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8FXTPX	GO:0005622	81/290	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8FXTPX	GO:0016020	77/290	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8FXTPX	GO:0005886	5/290	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8FXTPX	GO:0004767	4/290	sphingomyelin phosphodiesterase activity	molecular_function	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]
EOG8FXTPX	GO:0031532	4/290	actin cytoskeleton reorganization	biological_process	"A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]
EOG8FXTPX	GO:0005912	4/290	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8FXTPX	GO:0035099	4/290	hemocyte migration	biological_process	"The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551]
EOG8FXTPX	GO:0007391	4/290	dorsal closure	biological_process	"The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
EOG8FXTPX	GO:0090303	4/290	positive regulation of wound healing	biological_process	"Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF]
EOG8FXTPX	GO:0007254	4/290	JNK cascade	biological_process	"An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974]
EOG8FXTPX	GO:0007275	3/290	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8FXTPX	GO:0050770	3/290	regulation of axonogenesis	biological_process	"Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]
EOG8FXTPX	GO:0007394	3/290	dorsal closure, elongation of leading edge cells	biological_process	"The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138]
EOG8FXTPX	GO:0051017	3/290	actin filament bundle assembly	biological_process	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
EOG8FXTPX	GO:0006184	3/290	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8FXTPX	GO:0006909	3/290	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8FXTPX	GO:0008258	3/290	head involution	biological_process	"Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
EOG8FXTPX	GO:0003924	3/290	GTPase activity	molecular_function	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
EOG8FXTPX	GO:0045185	3/290	maintenance of protein location	biological_process	"Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf]
EOG8FXTPX	GO:0035011	3/290	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG8FXTPX	GO:0030032	3/290	lamellipodium assembly	biological_process	"Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194]
EOG8FXTPX	GO:0007390	3/290	germ-band shortening	biological_process	"The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138]
EOG8FXTPX	GO:0005515	3/290	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8FXTPX	GO:0046843	3/290	dorsal appendage formation	biological_process	"Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
EOG8FXTPX	GO:0035010	3/290	encapsulation of foreign target	biological_process	"Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920]
EOG8FXTPX	GO:0007435	3/290	salivary gland morphogenesis	biological_process	"The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid]
EOG8FXTPX	GO:0045860	3/290	positive regulation of protein kinase activity	biological_process	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
EOG8FXTPX	GO:0006974	2/290	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8FXTPX	GO:0007424	2/290	open tracheal system development	biological_process	"The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
EOG8FXTPX	GO:0050975	2/290	sensory perception of touch	biological_process	"The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]
EOG8FXTPX	GO:0002009	2/290	morphogenesis of an epithelium	biological_process	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
EOG8FXTPX	GO:0008045	2/290	motor neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]
EOG8FXTPX	GO:0007411	2/290	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8FXTPX	GO:0007015	2/290	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8FXTPX	GO:0007520	2/290	myoblast fusion	biological_process	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
EOG8FXTPX	GO:0002433	2/290	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	biological_process	"An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, GOC:mtg_15nov05, ISBN:0781735149]
EOG8FXTPX	GO:0031175	2/290	neuron projection development	biological_process	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]
EOG8FXTPX	GO:0007426	2/290	tracheal outgrowth, open tracheal system	biological_process	"The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8FXTPX	GO:0048813	2/290	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8FXTPX	GO:0030707	2/290	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8FXTPX	GO:0042067	2/290	establishment of ommatidial planar polarity	biological_process	"The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
EOG8FXTPX	GO:0030036	2/290	actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
EOG8FXTPX	GO:0016203	2/290	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8FXTPX	GO:0051491	2/290	positive regulation of filopodium assembly	biological_process	"Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
EOG8FXTPX	GO:0000902	2/290	cell morphogenesis	biological_process	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
EOG8FXTPX	GO:0016028	2/290	rhabdomere	cellular_component	"The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774]
EOG8FXTPX	GO:0097206	2/290	nephrocyte filtration	biological_process	"The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929]
EOG8FXTPX	GO:0032794	2/290	GTPase activating protein binding	molecular_function	"Interacting selectively and non-covalently with a GTPase activating protein." [GOC:nln]
EOG8FXTPX	GO:0030866	2/290	cortical actin cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
EOG8FXTPX	GO:0034334	2/290	adherens junction maintenance	biological_process	"The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah]
EOG8FXTPX	GO:0007266	2/290	Rho protein signal transduction	biological_process	"A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf]
EOG8FXTPX	GO:0007516	1/290	hemocyte development	biological_process	"The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
EOG8FXTPX	GO:0016199	1/290	axon midline choice point recognition	biological_process	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
EOG8FXTPX	GO:0007017	1/290	microtubule-based process	biological_process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
EOG8FXTPX	GO:0010592	1/290	positive regulation of lamellipodium assembly	biological_process	"Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG8FXTPX	GO:0051450	1/290	myoblast proliferation	biological_process	"The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle]
EOG8FXTPX	GO:0051963	1/290	regulation of synapse assembly	biological_process	"Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
EOG8FXTPX	GO:0007413	1/290	axonal fasciculation	biological_process	"The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh]
EOG8FXTPX	GO:0007617	1/290	mating behavior	biological_process	"The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph]
EOG8FXTPX	GO:0030041	1/290	actin filament polymerization	biological_process	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG8FXTPX	GO:0005829	1/290	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8FXTPX	GO:0060446	1/290	branching involved in open tracheal system development	biological_process	"The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph]
EOG8FXTPX	GO:0045177	1/290	apical part of cell	cellular_component	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
EOG8FXTPX	GO:0051726	1/290	regulation of cell cycle	biological_process	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
EOG8FXTPX	GO:0035320	1/290	imaginal disc-derived wing hair site selection	biological_process	"Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally." [GOC:mtg_transport, ISBN:0815340729, PMID:8947551]
EOG8FXTPX	GO:0008347	1/290	glial cell migration	biological_process	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
EOG8FXTPX	GO:0007422	1/290	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8FXTPX	GO:0007396	1/290	suture of dorsal opening	biological_process	"Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138]
EOG8FXTPX	GO:0010593	1/290	negative regulation of lamellipodium assembly	biological_process	"Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG8FXTPX	GO:0005938	1/290	cell cortex	cellular_component	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
EOG8FXTPX	GO:0071907	1/290	determination of digestive tract left/right asymmetry	biological_process	"Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:cvs]
EOG8FXTPX	GO:0048615	1/290	embryonic anterior midgut (ectodermal) morphogenesis	biological_process	"The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc]
EOG8FXTPX	GO:0042742	1/290	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8FXTPX	GO:0045200	1/290	establishment of neuroblast polarity	biological_process	"The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]
EOG8FXTPX	GO:0010883	1/290	regulation of lipid storage	biological_process	"Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
EOG8FXTPX	GO:0008360	1/290	regulation of cell shape	biological_process	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8FXTPX	GO:0048747	1/290	muscle fiber development	biological_process	"The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
EOG8FXTPX	GO:0007631	1/290	feeding behavior	biological_process	"Behavior associated with the intake of food." [GOC:mah]
EOG8FXTPX	GO:0030011	1/290	maintenance of cell polarity	biological_process	"The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8FXTPX	GO:0002118	1/290	aggressive behavior	biological_process	"A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd]
EOG8FXTPX	GO:0030031	1/290	cell projection assembly	biological_process	"Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
EOG8FXTPX	GO:0007286	1/290	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG8FXTPX	GO:0046331	1/290	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8FXTPX	GO:0019897	1/290	extrinsic component of plasma membrane	cellular_component	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]
EOG8FXTPX	GO:0048477	1/290	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG8FXTPX	GO:0045610	1/290	regulation of hemocyte differentiation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
EOG8FXTPX	GO:0071902	1/290	positive regulation of protein serine/threonine kinase activity	biological_process	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]
EOG8FXTPX	GO:0007274	1/290	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8FXTPX	GO:0007419	1/290	ventral cord development	biological_process	"The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
EOG8FXTPX	GO:0048675	1/290	axon extension	biological_process	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]
EOG8FXTPX	GO:0030426	1/290	growth cone	cellular_component	"The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194]
EOG8FXTPX	GO:0007409	1/290	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG8FXTPX	GO:0008078	1/290	mesodermal cell migration	biological_process	"The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047]
EOG8FXTPX	GO:0030833	1/290	regulation of actin filament polymerization	biological_process	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
EOG8FXTPX	GO:0035318	1/290	imaginal disc-derived wing hair outgrowth	biological_process	"Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair." [GOC:mtg_sensu, PMID:11064425, PMID:8947551]
EOG8FXTPX	GO:0008582	1/290	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8FXTPX	GO:0035212	1/290	cell competition in a multicellular organism	biological_process	"Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286]
EOG8FXTPX	GO:0030424	1/290	axon	cellular_component	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
EOG8FXTPX	GO:0016335	1/290	morphogenesis of larval imaginal disc epithelium	biological_process	"The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl]
EOG8FXTPX	GO:0001737	1/290	establishment of imaginal disc-derived wing hair orientation	biological_process	"Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]
EOG8FXTPX	GO:0045216	1/290	cell-cell junction organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8FXTPX	GO:0051301	1/290	cell division	biological_process	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
EOG8FXTPX	GO:0007298	1/290	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8FXTPX	GO:0042052	1/290	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8FXTPX	GO:0007179	1/290	transforming growth factor beta receptor signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
EOG8FXTPX	GO:0048814	1/290	regulation of dendrite morphogenesis	biological_process	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG8FXTPX	GO:0005737	1/290	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8FXTPX	GO:0050807	1/290	regulation of synapse organization	biological_process	"Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]
EOG8FXTPX	GO:0008283	1/290	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8FXTPX	GO:0042060	1/290	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8FXTPX	GO:0007164	1/290	establishment of tissue polarity	biological_process	"Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid]
EOG8FXTPX	GO:0046664	1/290	dorsal closure, amnioserosa morphology change	biological_process	"The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138]
EOG8FXTPX	GO:0007010	1/290	cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
EOG8FXTPX	GO:0007349	1/290	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG8FXTPX	GO:0005634	1/290	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BVV9M	GO:0003735	25/90	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8BVV9M	GO:0006412	25/90	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8BVV9M	GO:0005840	24/90	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8BVV9M	GO:0005730	1/90	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG8BVV9M	GO:0000228	1/90	nuclear chromosome	cellular_component	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
EOG8BVV9M	GO:0007052	1/90	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8BVV9M	GO:0000022	1/90	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG8BVV9M	GO:0022625	1/90	cytosolic large ribosomal subunit	cellular_component	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]
EOG8BVV9M	GO:0005737	1/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8R26BJ	GO:0015991	65/111	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8R26BJ	GO:0015078	65/111	hydrogen ion transmembrane transporter activity	molecular_function	"Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
EOG8R26BJ	GO:0033179	63/111	proton-transporting V-type ATPase, V0 domain	cellular_component	"A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]
EOG8R26BJ	GO:0016787	5/111	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8R26BJ	GO:0000220	2/111	vacuolar proton-transporting V-type ATPase, V0 domain	cellular_component	"The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG8R26BJ	GO:0033181	1/111	plasma membrane proton-transporting V-type ATPase complex	cellular_component	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
EOG8R26BJ	GO:0005886	1/111	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8PK4R4	GO:0016021	2/10	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8PK4R4	GO:0004930	2/10	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8FXTPF	GO:0016021	28/105	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FXTPF	GO:0043565	24/105	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8FXTPF	GO:0003700	23/105	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8FXTPF	GO:0005634	13/105	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FXTPF	GO:0006641	1/105	triglyceride metabolic process	biological_process	"The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732]
EOG8FXTPF	GO:0046889	1/105	positive regulation of lipid biosynthetic process	biological_process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
EOG8FXTPF	GO:0050291	1/105	sphingosine N-acyltransferase activity	molecular_function	"Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]
EOG8FXTPF	GO:0050995	1/105	negative regulation of lipid catabolic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
EOG8FXTPF	GO:0006355	1/105	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8FXTPF	GO:0003677	1/105	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8FXTPF	GO:0032933	1/105	SREBP signaling pathway	biological_process	"A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription." [GOC:bf, GOC:mah, GOC:signaling, GOC:vw, PMID:12923525, PMID:22017871]
EOG8FXTPF	GO:0046513	1/105	ceramide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]
EOG8RZ1FH	GO:0005272	33/82	sodium channel activity	molecular_function	"Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8RZ1FH	GO:0016021	27/82	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8RZ1FH	GO:0016020	6/82	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RZ1FH	GO:0005634	2/82	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RZ1FH	GO:0003700	2/82	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG86MDZQ	GO:0004561	2/92	alpha-N-acetylglucosaminidase activity	molecular_function	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides." [EC:3.2.1.50]
EOG86MDZQ	GO:0005975	1/92	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8RFP9H	GO:0005634	5/30	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8RFP9H	GO:0043565	5/30	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8RFP9H	GO:0003700	5/30	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8K0T47	GO:0008270	5/119	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8K0T47	GO:0003676	5/119	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K0T47	GO:0004190	2/119	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG8SR09W	GO:0005634	27/143	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SR09W	GO:0043704	1/143	photoreceptor cell fate specification	biological_process	"The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu]
EOG8SR09W	GO:0016319	1/143	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG8SR09W	GO:0005515	1/143	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8SR09W	GO:0007483	1/143	genital disc morphogenesis	biological_process	"The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238]
EOG8SR09W	GO:0042051	1/143	compound eye photoreceptor development	biological_process	"The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
EOG8SR09W	GO:0035263	1/143	genital disc sexually dimorphic development	biological_process	"The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781]
EOG8SR09W	GO:0010629	1/143	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8SR09W	GO:0048749	1/143	compound eye development	biological_process	"The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
EOG8SR09W	GO:0030182	1/143	neuron differentiation	biological_process	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
EOG8SR09W	GO:0007411	1/143	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8SR09W	GO:0006351	1/143	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8SR09W	GO:0007479	1/143	leg disc proximal/distal pattern formation	biological_process	"The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf]
EOG8SR09W	GO:0035215	1/143	genital disc development	biological_process	"Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318]
EOG8SR09W	GO:0035211	1/143	spermathecum morphogenesis	biological_process	"The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097]
EOG8SR09W	GO:0048098	1/143	antennal joint development	biological_process	"The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments." [GOC:jid]
EOG8RZ1FC	GO:0050909	3/12	sensory perception of taste	biological_process	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8RZ1FC	GO:0005886	3/12	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8RZ1FC	GO:0016021	3/12	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG84TRR1	GO:0005634	3/89	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG84TRR1	GO:0006351	2/89	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG84TRR1	GO:0006355	2/89	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG84TRR1	GO:0001104	1/89	RNA polymerase II transcription cofactor activity	molecular_function	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG84TRR1	GO:0006367	1/89	transcription initiation from RNA polymerase II promoter	biological_process	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]
EOG84TRR1	GO:0005515	1/89	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG84TRR1	GO:0016592	1/89	mediator complex	cellular_component	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
EOG84TRR1	GO:0006357	1/89	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG89CSRG	GO:0005643	47/96	nuclear pore	cellular_component	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
EOG89CSRG	GO:0000124	47/96	SAGA complex	cellular_component	"A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012]
EOG89CSRG	GO:0006406	47/96	mRNA export from nucleus	biological_process	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]
EOG89CSRG	GO:0070390	40/96	transcription export complex 2	cellular_component	"A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sus1p and Cdc31p." [GOC:dgf, GOC:mah, PMID:17786152]
EOG89CSRG	GO:0071819	40/96	DUBm complex	cellular_component	"A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p." [PMID:19226466, PMID:20395473]
EOG89CSRG	GO:0006368	40/96	transcription elongation from RNA polymerase II promoter	biological_process	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]
EOG89CSRG	GO:0016578	40/96	histone deubiquitination	biological_process	"The modification of histones by removal of ubiquitin groups." [GOC:ai]
EOG89CSRG	GO:0015031	39/96	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG89CSRG	GO:0045893	36/96	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG89CSRG	GO:0005737	28/96	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG89CSRG	GO:0043035	28/96	chromatin insulator sequence binding	molecular_function	"Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795]
EOG89CSRG	GO:0030374	28/96	ligand-dependent nuclear receptor transcription coactivator activity	molecular_function	"The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb]
EOG89CSRG	GO:0003713	19/96	transcription coactivator activity	molecular_function	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
EOG89CSRG	GO:0045944	12/96	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG89CSRG	GO:0031936	1/96	negative regulation of chromatin silencing	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah]
EOG89CSRG	GO:0016973	1/96	poly(A)+ mRNA export from nucleus	biological_process	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]
EOG89CSRG	GO:0034399	1/96	nuclear periphery	cellular_component	"The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah]
EOG89CSRG	GO:0070742	1/96	C2H2 zinc finger domain binding	molecular_function	"Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion." [GOC:BHF, GOC:mah, Pfam:PF00096]
EOG89CSRG	GO:0000785	1/96	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG89CSRG	GO:0003682	1/96	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG89CSRG	GO:0005634	1/96	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG89CSRG	GO:0001094	1/96	TFIID-class transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867]
EOG89CSRG	GO:0005515	1/96	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8KPWVN	GO:0006030	1/4	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8KPWVN	GO:0008061	1/4	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG8KPWVN	GO:0005576	1/4	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8PG8F0	GO:0015991	4/108	ATP hydrolysis coupled proton transport	biological_process	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]
EOG8PG8F0	GO:0000221	4/108	vacuolar proton-transporting V-type ATPase, V1 domain	cellular_component	"The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
EOG8PG8F0	GO:0046961	4/108	proton-transporting ATPase activity, rotational mechanism	molecular_function	"Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]
EOG8PG8F0	GO:0006457	1/108	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8ZSCH7	GO:0005524	27/97	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8ZSCH7	GO:0006435	26/97	threonyl-tRNA aminoacylation	biological_process	"The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
EOG8ZSCH7	GO:0005737	26/97	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZSCH7	GO:0004829	26/97	threonine-tRNA ligase activity	molecular_function	"Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [EC:6.1.1.3]
EOG8ZSCH7	GO:0022008	1/97	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8ZSCH7	GO:0016876	1/97	ligase activity, forming aminoacyl-tRNA and related compounds	molecular_function	"Catalysis of the joining of an amino acid and a nucleic acid (usually tRNA) or poly(ribitol phosphate), with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. The reaction forms an aminoacyl-tRNA or a related compound." [EC:6.1.1, GOC:mah]
EOG8ZSCH7	GO:0000166	1/97	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8ZSCH7	GO:0043039	1/97	tRNA aminoacylation	biological_process	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]
EOG8B2WGT	GO:0046872	1/3	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8K6JKH	GO:0051056	2/110	regulation of small GTPase mediated signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
EOG8K6JKH	GO:0005622	2/110	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8K6JKH	GO:0005096	2/110	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8K6JKH	GO:0032851	1/110	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8K6JKH	GO:0000139	1/110	Golgi membrane	cellular_component	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
EOG8K6JKH	GO:0035418	1/110	protein localization to synapse	biological_process	"Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf]
EOG8K6JKH	GO:0060078	1/110	regulation of postsynaptic membrane potential	biological_process	"Any process that modulates the potential difference across a post-synaptic membrane." [GOC:dph, GOC:ef]
EOG8K6JKH	GO:0017112	1/110	Rab guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8K6JKH	GO:0016021	1/110	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8K6JKH	GO:0017137	1/110	Rab GTPase binding	molecular_function	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
EOG8K6JKH	GO:0016023	1/110	cytoplasmic membrane-bounded vesicle	cellular_component	"A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
EOG8K6JKH	GO:0045467	1/110	R7 cell development	biological_process	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
EOG8K6JKH	GO:0005794	1/110	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8K6JKH	GO:0007411	1/110	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8K6JKH	GO:0050808	1/110	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG8K6JKH	GO:0032483	1/110	regulation of Rab protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]
EOG8QC3K3	GO:0030246	11/81	carbohydrate binding	molecular_function	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]
EOG8QC3K3	GO:0016787	2/81	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8QC3K3	GO:0004714	1/81	transmembrane receptor protein tyrosine kinase activity	molecular_function	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]
EOG87H85J	GO:0070822	1/107	Sin3-type complex	cellular_component	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]
EOG88PQ02	GO:0005509	24/107	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG88PQ02	GO:0005089	7/107	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG88PQ02	GO:0045179	1/107	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG88PQ02	GO:0016740	1/107	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG88PQ02	GO:0005515	1/107	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG88PQ02	GO:0045860	1/107	positive regulation of protein kinase activity	biological_process	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
EOG88PQ02	GO:0005886	1/107	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG88PQ02	GO:0048488	1/107	synaptic vesicle endocytosis	biological_process	"An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah]
EOG88PQ02	GO:0000166	1/107	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG88PQ02	GO:0005737	1/107	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG88PQ02	GO:0008104	1/107	protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
EOG88PQ02	GO:0002052	1/107	positive regulation of neuroblast proliferation	biological_process	"Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph]
EOG88PQ02	GO:0051124	1/107	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG88PQ02	GO:0045746	1/107	negative regulation of Notch signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG88PQ02	GO:0008021	1/107	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG88PQ02	GO:0007269	1/107	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8P2SGH	GO:0003700	27/109	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8P2SGH	GO:0005667	27/109	transcription factor complex	cellular_component	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]
EOG8P2SGH	GO:0005634	27/109	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8P2SGH	GO:0007179	27/109	transforming growth factor beta receptor signaling pathway	biological_process	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]
EOG8P2SGH	GO:0006351	27/109	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8P2SGH	GO:0006355	4/109	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8P2SGH	GO:0005622	3/109	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8P2SGH	GO:0045887	1/109	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8P2SGH	GO:0005515	1/109	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8P2SGH	GO:0030509	1/109	BMP signaling pathway	biological_process	"A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PR:000000034]
EOG8P2SGH	GO:0009953	1/109	dorsal/ventral pattern formation	biological_process	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8P2SGH	GO:0009950	1/109	dorsal/ventral axis specification	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8P2SGH	GO:0043565	1/109	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8P2SGH	GO:0005737	1/109	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8P2SGH	GO:0008283	1/109	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8P2SGH	GO:0048666	1/109	neuron development	biological_process	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
EOG8P2SGH	GO:0030718	1/109	germ-line stem cell population maintenance	biological_process	"Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
EOG8P2SGH	GO:0045705	1/109	negative regulation of salivary gland boundary specification	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb]
EOG8P2SGH	GO:0042078	1/109	germ-line stem cell division	biological_process	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
EOG8P2SGH	GO:0030707	1/109	ovarian follicle cell development	biological_process	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8P2SGH	GO:0007480	1/109	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8P2SGH	GO:0031290	1/109	retinal ganglion cell axon guidance	biological_process	"The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs]
EOG8P2SGH	GO:0007507	1/109	heart development	biological_process	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
EOG8P2SGH	GO:0007476	1/109	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8P2SGH	GO:0035019	1/109	somatic stem cell population maintenance	biological_process	"Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089]
EOG8DBWTD	GO:0016021	28/140	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8DBWTD	GO:0005219	27/140	ryanodine-sensitive calcium-release channel activity	molecular_function	"Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb]
EOG8DBWTD	GO:0006874	27/140	cellular calcium ion homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah]
EOG8DBWTD	GO:0005509	22/140	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8DBWTD	GO:0016020	5/140	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8DBWTD	GO:0005262	4/140	calcium channel activity	molecular_function	"Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8DBWTD	GO:0035206	1/140	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8DBWTD	GO:0060047	1/140	heart contraction	biological_process	"The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph]
EOG8DBWTD	GO:0033017	1/140	sarcoplasmic reticulum membrane	cellular_component	"The lipid bilayer surrounding the sarcoplasmic reticulum." [GOC:rph]
EOG8DBWTD	GO:0005875	1/140	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8DBWTD	GO:0072347	1/140	response to anesthetic	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart]
EOG8DBWTD	GO:0006936	1/140	muscle contraction	biological_process	"A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]
EOG8DBWTD	GO:0007275	1/140	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8DBWTD	GO:0005216	1/140	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8DBWTD	GO:0006816	1/140	calcium ion transport	biological_process	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8TF300	GO:0022008	1/123	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8642SW	GO:0005975	33/55	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8642SW	GO:0016810	32/55	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	molecular_function	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
EOG8642SW	GO:0003824	1/55	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8ZW7RZ	GO:0016021	25/103	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZW7RZ	GO:0006839	19/103	mitochondrial transport	biological_process	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]
EOG8ZW7RZ	GO:0031966	19/103	mitochondrial membrane	cellular_component	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
EOG8ZW7RZ	GO:0055085	4/103	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8ZW7RZ	GO:0006810	2/103	transport	biological_process	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
EOG8ZW7RZ	GO:0005739	1/103	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG8ZW7RZ	GO:0030302	1/103	deoxynucleotide transport	biological_process	"The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell." [GOC:mah, ISBN:0198506732]
EOG8ZW7RZ	GO:0045333	1/103	cellular respiration	biological_process	"The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732]
EOG8ZW7RZ	GO:0006390	1/103	transcription from mitochondrial promoter	biological_process	"The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl]
EOG8ZW7RZ	GO:0040011	1/103	locomotion	biological_process	"Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
EOG8ZW7RZ	GO:0048311	1/103	mitochondrion distribution	biological_process	"Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid]
EOG8ZW7RZ	GO:0007005	1/103	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8HTC6V	GO:0016021	121/277	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HTC6V	GO:0032580	121/277	Golgi cisterna membrane	cellular_component	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]
EOG8HTC6V	GO:0006486	121/277	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG8HTC6V	GO:0008417	116/277	fucosyltransferase activity	molecular_function	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
EOG8HTC6V	GO:0017060	3/277	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	molecular_function	"Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.65]
EOG8HTC6V	GO:0018392	3/277	glycoprotein 3-alpha-L-fucosyltransferase activity	molecular_function	"Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H(+)." [EC:2.4.1.214, RHEA:24447]
EOG8HTC6V	GO:0005797	1/277	Golgi medial cisterna	cellular_component	"The middle Golgi cisterna (or cisternae)." [ISBN:0815316194]
EOG8HTC6V	GO:0033932	1/277	1,3-alpha-L-fucosidase activity	molecular_function	"Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins." [EC:3.2.1.111]
EOG8HTC6V	GO:0046920	1/277	alpha-(1->3)-fucosyltransferase activity	molecular_function	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]
EOG8HTC6V	GO:0007399	1/277	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG8HTC6V	GO:0036071	1/277	N-glycan fucosylation	biological_process	"The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains." [CHEBI:59520, GOC:sart, PMID:19948734]
EOG8S1WN2	GO:0007015	2/68	actin filament organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
EOG8S1WN2	GO:0016477	2/68	cell migration	biological_process	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]
EOG8S1WN2	GO:0007155	2/68	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8ZKN39	GO:0003723	31/120	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8ZKN39	GO:0030529	5/120	ribonucleoprotein complex	cellular_component	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
EOG8ZKN39	GO:0019013	4/120	viral nucleocapsid	cellular_component	"The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
EOG8ZKN39	GO:0007446	1/120	imaginal disc growth	biological_process	"The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387]
EOG8ZKN39	GO:0035107	1/120	appendage morphogenesis	biological_process	"The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]
EOG8ZKN39	GO:0005737	1/120	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZKN39	GO:0008134	1/120	transcription factor binding	molecular_function	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]
EOG8ZKN39	GO:0008283	1/120	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG8ZKN39	GO:0005634	1/120	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8ZKN39	GO:0003729	1/120	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8ZKN39	GO:0000381	1/120	regulation of alternative mRNA splicing, via spliceosome	biological_process	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
EOG8ZKN39	GO:0000785	1/120	chromatin	cellular_component	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
EOG8ZKN39	GO:0045165	1/120	cell fate commitment	biological_process	"The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
EOG8ZKN39	GO:0035062	1/120	omega speckle	cellular_component	"A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439]
EOG8Q5C4T	GO:0003993	9/17	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG8DBWTP	GO:0031931	21/94	TORC1 complex	cellular_component	"A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787]
EOG8DBWTP	GO:0031929	21/94	TOR signaling	biological_process	"A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]
EOG8DBWTP	GO:0003993	7/94	acid phosphatase activity	molecular_function	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
EOG8DBWTP	GO:0006974	1/94	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8DBWTP	GO:0045886	1/94	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8DBWTP	GO:0001934	1/94	positive regulation of protein phosphorylation	biological_process	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
EOG8DBWTP	GO:0007411	1/94	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8284G8	GO:0016021	294/728	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8284G8	GO:0055085	283/728	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8284G8	GO:0005215	14/728	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8284G8	GO:0015114	10/728	phosphate ion transmembrane transporter activity	molecular_function	"Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai]
EOG8284G8	GO:0005886	2/728	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8284G8	GO:0006814	2/728	sodium ion transport	biological_process	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8284G8	GO:0015293	2/728	symporter activity	molecular_function	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
EOG8284G8	GO:0005314	1/728	high-affinity glutamate transmembrane transporter activity	molecular_function	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.3.10.5]
EOG8284G8	GO:0015321	1/728	sodium-dependent phosphate transmembrane transporter activity	molecular_function	"Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions." [GOC:jl]
EOG8284G8	GO:0051938	1/728	L-glutamate import	biological_process	"The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah]
EOG8284G8	GO:0048190	1/728	wing disc dorsal/ventral pattern formation	biological_process	"The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid]
EOG8284G8	GO:0006541	1/728	glutamine metabolic process	biological_process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
EOG8284G8	GO:0035725	1/728	sodium ion transmembrane transport	biological_process	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
EOG8284G8	GO:0001666	1/728	response to hypoxia	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
EOG8284G8	GO:0007005	1/728	mitochondrion organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
EOG8284G8	GO:0035435	1/728	phosphate ion transmembrane transport	biological_process	"The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore." [GOC:vw]
EOG8284G8	GO:0044341	1/728	sodium-dependent phosphate transport	biological_process	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl]
EOG8284G8	GO:0005436	1/728	sodium:phosphate symporter activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai]
EOG8284G8	GO:0004930	1/728	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8P2SGX	GO:0005975	50/140	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8P2SGX	GO:0004553	43/140	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular_function	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
EOG8P2SGX	GO:0004566	7/140	beta-glucuronidase activity	molecular_function	"Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31]
EOG8P2SGX	GO:0032504	1/140	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8P2SGX	GO:0005615	1/140	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8HX7F3	GO:0005525	23/95	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8HX7F3	GO:0005622	23/95	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8HX7F3	GO:0007264	23/95	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8HX7F3	GO:0035011	1/95	melanotic encapsulation of foreign target	biological_process	"Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
EOG8NZX91	GO:0016301	1/64	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8M946T	GO:0004692	1/94	cGMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
EOG8M946T	GO:0016301	1/94	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8FN6XM	GO:0005085	23/88	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8FN6XM	GO:0007264	23/88	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8FN6XM	GO:0005622	23/88	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8FN6XM	GO:0048812	1/88	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8TXF7F	GO:0046872	9/77	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG80ZTF7	GO:0016021	47/169	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80ZTF7	GO:0016192	38/169	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG80ZTF7	GO:0031201	10/169	SNARE complex	cellular_component	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]
EOG80ZTF7	GO:0017156	9/169	calcium ion-dependent exocytosis	biological_process	"The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, requiring the presence of calcium ions." [GOC:go_curators]
EOG80ZTF7	GO:0016081	2/169	synaptic vesicle docking	biological_process	"The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342]
EOG80ZTF7	GO:0006887	2/169	exocytosis	biological_process	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
EOG80ZTF7	GO:0005886	2/169	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG80ZTF7	GO:0006906	2/169	vesicle fusion	biological_process	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]
EOG80ZTF7	GO:0000149	2/169	SNARE binding	molecular_function	"Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]
EOG80ZTF7	GO:0007269	2/169	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG80ZTF7	GO:0008021	2/169	synaptic vesicle	cellular_component	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
EOG80ZTF7	GO:0005484	2/169	SNAP receptor activity	molecular_function	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
EOG80ZTF7	GO:0030672	1/169	synaptic vesicle membrane	cellular_component	"The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]
EOG80ZTF7	GO:0030054	1/169	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG80ZTF7	GO:0005515	1/169	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG80ZTF7	GO:0004871	1/169	signal transducer activity	molecular_function	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
EOG80ZTF7	GO:0035149	1/169	lumen formation, open tracheal system	biological_process	"Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
EOG80ZTF7	GO:0043005	1/169	neuron projection	cellular_component	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
EOG80ZTF7	GO:0043195	1/169	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG8WQ3K4	GO:0032504	1/115	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8WQ3K4	GO:0005615	1/115	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG84QWG9	GO:0016117	1/11	carotenoid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators]
EOG84QWG9	GO:0055114	1/11	oxidation-reduction process	biological_process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
EOG8GTNSV	GO:0005097	28/103	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8GTNSR	GO:0007165	95/374	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8GTNSR	GO:0016021	55/374	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GTNSR	GO:0004721	6/374	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8GTNSR	GO:0046790	1/374	virion binding	molecular_function	"Interacting selectively and non-covalently with a virion, either by binding to components of the capsid or the viral envelope." [GOC:ai]
EOG8GTNSR	GO:0002227	1/374	innate immune response in mucosa	biological_process	"Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105]
EOG8GTNSR	GO:0006952	1/374	defense response	biological_process	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
EOG8GTNSR	GO:0005886	1/374	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8GTNSR	GO:0006955	1/374	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8GTNSR	GO:0002752	1/374	cell surface pattern recognition receptor signaling pathway	biological_process	"Any series of molecular signals generated as a consequence of a cell surface pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]
EOG8GTNSR	GO:0010508	1/374	positive regulation of autophagy	biological_process	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8GTNSR	GO:0019731	1/374	antibacterial humoral response	biological_process	"An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8GTNSR	GO:0048598	1/374	embryonic morphogenesis	biological_process	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]
EOG8GTNSR	GO:0009653	1/374	anatomical structure morphogenesis	biological_process	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]
EOG8GTNSR	GO:0004888	1/374	transmembrane signaling receptor activity	molecular_function	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
EOG8GTNSR	GO:0008329	1/374	signaling pattern recognition receptor activity	molecular_function	"Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity." [GOC:ar, PMID:12507420, PMID:12925128, PMID:14523544, Wikipedia:Pattern_recognition_receptor]
EOG8GTNSR	GO:0009897	1/374	external side of plasma membrane	cellular_component	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]
EOG8GTNSR	GO:0060049	1/374	regulation of protein glycosylation	biological_process	"Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr]
EOG8GTNSR	GO:0048935	1/374	peripheral nervous system neuron development	biological_process	"The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh]
EOG8GTNSR	GO:0007275	1/374	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8GTNSR	GO:0050688	1/374	regulation of defense response to virus	biological_process	"Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai]
EOG8GTNSR	GO:0051607	1/374	defense response to virus	biological_process	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
EOG8GTNSR	GO:0007155	1/374	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8GTNSR	GO:0005737	1/374	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG854CCX	GO:0004984	2/73	olfactory receptor activity	molecular_function	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
EOG854CCX	GO:0005549	2/73	odorant binding	molecular_function	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
EOG854CCX	GO:0016020	2/73	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG854CCX	GO:0046427	1/73	positive regulation of JAK-STAT cascade	biological_process	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
EOG8GTNSP	GO:0000166	10/63	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8GTNSP	GO:0003676	10/63	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8GTNSP	GO:0033904	1/63	dextranase activity	molecular_function	"Catalysis of the endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran." [EC:3.2.1.11]
EOG8577ND	GO:0003682	1/114	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8577ND	GO:0000793	1/114	condensed chromosome	cellular_component	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]
EOG8577ND	GO:0005085	1/114	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8577ND	GO:0005737	1/114	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8577ND	GO:0007417	1/114	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8577ND	GO:0046822	1/114	regulation of nucleocytoplasmic transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]
EOG8577ND	GO:0016301	1/114	kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
EOG8577ND	GO:0007346	1/114	regulation of mitotic cell cycle	biological_process	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8577ND	GO:0005634	1/114	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8577ND	GO:0050767	1/114	regulation of neurogenesis	biological_process	"Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]
EOG8577ND	GO:0007067	1/114	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG8577ND	GO:0022008	1/114	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8577ND	GO:0006607	1/114	NLS-bearing protein import into nucleus	biological_process	"The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai]
EOG805VF6	GO:0034472	1/90	snRNA 3'-end processing	biological_process	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]
EOG805VF6	GO:0022008	1/90	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8CVJRH	GO:0080019	2/7	fatty-acyl-CoA reductase (alcohol-forming) activity	molecular_function	"Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563]
EOG898XF8	GO:0016020	25/94	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG898XF8	GO:0016887	24/94	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG898XF8	GO:0005524	24/94	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8GXJ49	GO:0046872	13/71	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GXJ49	GO:0003677	7/71	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GXJ49	GO:0003676	3/71	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BCH3F	GO:0003700	27/104	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8BCH3F	GO:0005634	26/104	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BCH3F	GO:0000976	19/104	transcription regulatory region sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
EOG8BCH3F	GO:0043565	8/104	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8BCH3F	GO:0007411	1/104	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8BCH3F	GO:0004000	1/104	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG8BCH3F	GO:0048663	1/104	neuron fate commitment	biological_process	"The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph]
EOG898XF6	GO:0016905	1/154	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG80041V	GO:0005634	1/10	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG80041V	GO:0043565	1/10	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8GF5TZ	GO:0007165	23/85	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8GF5TZ	GO:0005096	23/85	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8GF5TZ	GO:0051056	22/85	regulation of small GTPase mediated signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
EOG8GF5TZ	GO:0005622	21/85	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8GF5TZ	GO:0007476	1/85	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8GF5TZ	GO:0046872	1/85	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8GF5TZ	GO:0046580	1/85	negative regulation of Ras protein signal transduction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
EOG8GF5TZ	GO:0002121	1/85	inter-male aggressive behavior	biological_process	"Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
EOG8GF5TZ	GO:0005634	1/85	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8GF5TZ	GO:0006351	1/85	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8GF5TZ	GO:0003677	1/85	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8GF5TZ	GO:0005737	1/85	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG841SR8	GO:0016567	1/112	protein ubiquitination	biological_process	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]
EOG841SR8	GO:0005634	1/112	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG841SR8	GO:0035212	1/112	cell competition in a multicellular organism	biological_process	"Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286]
EOG873S63	GO:0008270	19/457	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG873S63	GO:0046872	3/457	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG873S63	GO:0016020	1/457	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG873S63	GO:0007165	1/457	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG873S63	GO:0016192	1/457	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8HHRHG	GO:0016021	111/321	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8HHRHG	GO:0055085	111/321	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8HHRHG	GO:0008260	2/321	3-oxoacid CoA-transferase activity	molecular_function	"Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [EC:2.8.3.5]
EOG8HHRHG	GO:0005886	1/321	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8HHRHG	GO:0005215	1/321	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8HHRHG	GO:0006171	1/321	cAMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]
EOG8HHRHG	GO:0004016	1/321	adenylate cyclase activity	molecular_function	"Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]
EOG8BZQH6	GO:0045454	28/94	cell redox homeostasis	biological_process	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
EOG8BZQH6	GO:0015035	26/94	protein disulfide oxidoreductase activity	molecular_function	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]
EOG8BZQH6	GO:0006662	26/94	glycerol ether metabolic process	biological_process	"The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732]
EOG8BZQH6	GO:0016853	22/94	isomerase activity	molecular_function	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
EOG8BZQH6	GO:0003756	3/94	protein disulfide isomerase activity	molecular_function	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1]
EOG8BZQH6	GO:0005783	1/94	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8BZQH6	GO:0033741	1/94	adenylyl-sulfate reductase (glutathione) activity	molecular_function	"Catalysis of the reaction: AMP + glutathione disulfide + H(+) + sulfite = 5'-adenylyl sulfate + 2 glutathione." [EC:1.8.4.9, RHEA:14144]
EOG8BZQH6	GO:0005811	1/94	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8BZQH6	GO:0034976	1/94	response to endoplasmic reticulum stress	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]
EOG8BZQH6	GO:0006457	1/94	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8BZQH6	GO:2000427	1/94	positive regulation of apoptotic cell clearance	biological_process	"Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance." [GOC:obol]
EOG8BZQH5	GO:0005524	27/158	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8BZQH5	GO:0004674	23/158	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8BZQH5	GO:0050660	9/158	flavin adenine dinucleotide binding	molecular_function	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]
EOG8BZQH5	GO:0008812	8/158	choline dehydrogenase activity	molecular_function	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]
EOG8BZQH5	GO:0006066	8/158	alcohol metabolic process	biological_process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
EOG8BZQH5	GO:0004672	4/158	protein kinase activity	molecular_function	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
EOG8BZQH5	GO:0016614	2/158	oxidoreductase activity, acting on CH-OH group of donors	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
EOG8BZQH5	GO:0007348	1/158	regulation of syncytial blastoderm mitotic cell cycle	biological_process	"A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8BZQH5	GO:0051299	1/158	centrosome separation	biological_process	"The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai]
EOG8BZQH5	GO:0016321	1/158	female meiosis chromosome segregation	biological_process	"The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
EOG8BZQH5	GO:0004344	1/158	glucose dehydrogenase activity	molecular_function	"Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10]
EOG8BZQH5	GO:0007050	1/158	cell cycle arrest	biological_process	"A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]
EOG8BZQH5	GO:0042060	1/158	wound healing	biological_process	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
EOG8BZQH5	GO:0007095	1/158	mitotic G2 DNA damage checkpoint	biological_process	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]
EOG8BZQH5	GO:0051225	1/158	spindle assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
EOG8BZQH5	GO:0007444	1/158	imaginal disc development	biological_process	"The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238]
EOG8BZQH5	GO:0007093	1/158	mitotic cell cycle checkpoint	biological_process	"A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle]
EOG8BZQH5	GO:0009314	1/158	response to radiation	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation]
EOG8BZQH5	GO:0030162	1/158	regulation of proteolysis	biological_process	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
EOG8BZQH5	GO:0033314	1/158	mitotic DNA replication checkpoint	biological_process	"A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mtg_cell_cycle]
EOG8BZQH5	GO:0007349	1/158	cellularization	biological_process	"The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
EOG8BZQH5	GO:0001700	1/158	embryonic development via the syncytial blastoderm	biological_process	"The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
EOG8BZQH5	GO:0000075	1/158	cell cycle checkpoint	biological_process	"A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle]
EOG8BZQH5	GO:0004683	1/158	calmodulin-dependent protein kinase activity	molecular_function	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
EOG8BZQH5	GO:0005634	1/158	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8BZQH5	GO:0000077	1/158	DNA damage checkpoint	biological_process	"A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle]
EOG8BZQH5	GO:0006468	1/158	protein phosphorylation	biological_process	"The process of introducing a phosphate group on to a protein." [GOC:hb]
EOG8ZSCH9	GO:0051536	25/90	iron-sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
EOG8ZSCH9	GO:0008080	23/90	N-acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
EOG8ZSCH9	GO:0004402	2/90	histone acetyltransferase activity	molecular_function	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
EOG8ZSCH9	GO:0016407	1/90	acetyltransferase activity	molecular_function	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]
EOG8ZSCH9	GO:2000289	1/90	regulation of photoreceptor cell axon guidance	biological_process	"Any process that modulates the frequency, rate or extent of photoreceptor cell axon guidance." [GOC:mah]
EOG8ZSCH9	GO:0018394	1/90	peptidyl-lysine acetylation	biological_process	"The acetylation of peptidyl-lysine." [GOC:mah]
EOG8ZSCH9	GO:0006357	1/90	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8ZSCH9	GO:0008607	1/90	phosphorylase kinase regulator activity	molecular_function	"Modulation of the activity of the enzyme phosphorylase kinase." [EC:2.7.11.19]
EOG8ZSCH9	GO:0045202	1/90	synapse	cellular_component	"The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8ZSCH9	GO:0030431	1/90	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8ZSCH9	GO:0006351	1/90	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8ZSCH9	GO:0050808	1/90	synapse organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
EOG8ZSCH9	GO:0051124	1/90	synaptic growth at neuromuscular junction	biological_process	"The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]
EOG8ZSCH9	GO:0005737	1/90	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZSCH9	GO:0008023	1/90	transcription elongation factor complex	cellular_component	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]
EOG8ZSCH9	GO:0045859	1/90	regulation of protein kinase activity	biological_process	"Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
EOG8ZSCH9	GO:0003824	1/90	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8ZSCH9	GO:0048789	1/90	cytoskeletal matrix organization at active zone	biological_process	"The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane." [GOC:dh, GOC:ef, GOC:jid, PMID:12812759]
EOG8ZSCH9	GO:0046872	1/90	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8ZSCH9	GO:0007626	1/90	locomotory behavior	biological_process	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
EOG82FVZS	GO:0003676	2/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG82FVZS	GO:0016787	2/4	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG82FVZS	GO:0046872	2/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8323CD	GO:0007018	70/223	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8323CD	GO:0005524	70/223	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8323CD	GO:0003777	70/223	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8323CD	GO:0005874	70/223	microtubule	cellular_component	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
EOG8323CD	GO:0005871	69/223	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8323CD	GO:0008152	4/223	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8323CD	GO:0005875	2/223	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8323CD	GO:0030951	2/223	establishment or maintenance of microtubule cytoskeleton polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah]
EOG8323CD	GO:0048812	2/223	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8323CD	GO:0003774	2/223	motor activity	molecular_function	"Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
EOG8323CD	GO:0005737	2/223	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8323CD	GO:0008089	2/223	anterograde axon cargo transport	biological_process	"The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194]
EOG8323CD	GO:0007608	2/223	sensory perception of smell	biological_process	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
EOG8323CD	GO:0007165	1/223	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8323CD	GO:0035058	1/223	nonmotile primary cilium assembly	biological_process	"The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834]
EOG8323CD	GO:0005929	1/223	cilium	cellular_component	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:kmv, GOC:vw, ISBN:0198547684]
EOG8323CD	GO:0008289	1/223	lipid binding	molecular_function	"Interacting selectively and non-covalently with a lipid." [GOC:ai]
EOG8323CD	GO:0008569	1/223	ATP-dependent microtubule motor activity, minus-end-directed	molecular_function	"Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP." [EC:3.6.4.5, GOC:mah, GOC:vw]
EOG8323CD	GO:0007411	1/223	axon guidance	biological_process	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
EOG8323CD	GO:0007605	1/223	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG898XFX	GO:0004252	2/4	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG873S6G	GO:0016591	13/62	DNA-directed RNA polymerase II, holoenzyme	cellular_component	"Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA." [GOC:jl, PMID:15196470, Wikipedia:Rna_polymerase_ii]
EOG8M0HGM	GO:0005509	28/92	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8M0HGM	GO:0005703	1/92	polytene chromosome puff	cellular_component	"A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
EOG8M0HGM	GO:0032440	1/92	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8M0HGM	GO:0006325	1/92	chromatin organization	biological_process	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
EOG8M0HGM	GO:0005737	1/92	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8M0HGM	GO:0009047	1/92	dosage compensation by hyperactivation of X chromosome	biological_process	"Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577]
EOG8M0HGM	GO:0005700	1/92	polytene chromosome	cellular_component	"A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]
EOG8M0HGM	GO:0045893	1/92	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8M0HGM	GO:0005634	1/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8M0HGM	GO:0006265	1/92	DNA topological change	biological_process	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]
EOG84BDFZ	GO:0004867	27/131	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG84BDFZ	GO:0004222	25/131	metalloendopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG84BDFZ	GO:0008270	24/131	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG84BDFZ	GO:0005578	23/131	proteinaceous extracellular matrix	cellular_component	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
EOG84BDFZ	GO:0005576	3/131	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG84BDFZ	GO:0006030	3/131	chitin metabolic process	biological_process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG84BDFZ	GO:0008061	3/131	chitin binding	molecular_function	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
EOG84BDFZ	GO:0008233	2/131	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG84BDFZ	GO:0005201	1/131	extracellular matrix structural constituent	molecular_function	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
EOG84BDFZ	GO:0031012	1/131	extracellular matrix	cellular_component	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]
EOG84BDFZ	GO:0005604	1/131	basement membrane	cellular_component	"A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]
EOG84BDFZ	GO:0030198	1/131	extracellular matrix organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]
EOG84BDFZ	GO:0007275	1/131	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG8TTJZ2	GO:0007155	28/115	cell adhesion	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
EOG8TTJZ2	GO:0015629	28/115	actin cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
EOG8TTJZ2	GO:0005198	28/115	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG8TTJZ2	GO:0003779	1/115	actin binding	molecular_function	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
EOG8TTJZ2	GO:0048812	1/115	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8TTJZ2	GO:0005925	1/115	focal adhesion	cellular_component	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
EOG8TTJZ2	GO:0006909	1/115	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8TTJZ2	GO:0005737	1/115	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8TTJZ2	GO:0007016	1/115	cytoskeletal anchoring at plasma membrane	biological_process	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
EOG8TTJZ2	GO:0005886	1/115	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG854CJ4	GO:0005576	1/7	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG854CJ4	GO:0042742	1/7	defense response to bacterium	biological_process	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
EOG8N5ZDF	GO:0006457	2/40	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8F20GW	GO:0006909	1/100	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8F20GW	GO:0045771	1/100	negative regulation of autophagosome size	biological_process	"Any process that reduces autophagosome size." [GOC:autophagy, GOC:go_curators]
EOG8F20GW	GO:0005509	1/100	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8BZQHZ	GO:0005622	1/7	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8BZQHZ	GO:0005215	1/7	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8MD0HH	GO:0006644	1/7	phospholipid metabolic process	biological_process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]
EOG8MD0HH	GO:0016042	1/7	lipid catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
EOG8MD0HH	GO:0004623	1/7	phospholipase A2 activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
EOG8MD0HH	GO:0005576	1/7	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8MD0HH	GO:0005509	1/7	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8BCH36	GO:0003676	34/97	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8BCH36	GO:0004523	31/97	RNA-DNA hybrid ribonuclease activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
EOG8BCH36	GO:0000287	9/97	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8BCH36	GO:0090502	1/97	RNA phosphodiester bond hydrolysis, endonucleolytic	biological_process	"The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]
EOG82RGNK	GO:0006355	5/212	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG82RGNK	GO:0006200	3/212	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG82RGNK	GO:0007018	3/212	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG82RGNK	GO:0042623	3/212	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG82RGNK	GO:0030286	2/212	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG82RGNK	GO:0005875	2/212	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG82RGNK	GO:0007605	1/212	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG82FVZ1	GO:0016884	31/108	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	molecular_function	"Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532]
EOG82FVZ1	GO:0004040	4/108	amidase activity	molecular_function	"Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4]
EOG82FVZ1	GO:0005811	1/108	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG82FVZ1	GO:0016740	1/108	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG822D1C	GO:0042623	1/150	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG822D1C	GO:0030286	1/150	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG822D1C	GO:0006200	1/150	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG822D1C	GO:0007018	1/150	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8FR36H	GO:0042826	2/100	histone deacetylase binding	molecular_function	"Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl]
EOG8FR36H	GO:0010629	2/100	negative regulation of gene expression	biological_process	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
EOG8FR36H	GO:0005634	1/100	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8FR36H	GO:0008168	1/100	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8FR36H	GO:0005737	1/100	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8J3ZXS	GO:0016012	24/91	sarcoglycan complex	cellular_component	"A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609]
EOG8J3ZXS	GO:0005509	16/91	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG80CKX6	GO:0016021	222/694	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80CKX6	GO:0003333	7/694	amino acid transmembrane transport	biological_process	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
EOG80CKX6	GO:0015171	7/694	amino acid transmembrane transporter activity	molecular_function	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
EOG80CKX6	GO:0040007	2/694	growth	biological_process	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
EOG80CKX6	GO:0044719	1/694	regulation of imaginal disc-derived wing size	biological_process	"Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605]
EOG80CKX6	GO:0022008	1/694	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG82587N	GO:0046872	3/4	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG82587N	GO:0003676	3/4	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8K3P92	GO:0003777	4/28	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8K3P92	GO:0007018	4/28	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8B5RNM	GO:0042302	2/6	structural constituent of cuticle	molecular_function	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
EOG8FR36G	GO:0016021	86/188	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8FR36G	GO:0055085	85/188	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG8FR36G	GO:0005215	29/188	transporter activity	molecular_function	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
EOG8FR36G	GO:0031427	1/188	response to methotrexate	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732]
EOG8FR36G	GO:0052591	1/188	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	molecular_function	"Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." [MetaCyc:GLYC3PDEHYDROG-RXN]
EOG8FR36G	GO:0006072	1/188	glycerol-3-phosphate metabolic process	biological_process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]
EOG8FR36G	GO:0022857	1/188	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG8FR36G	GO:0009331	1/188	glycerol-3-phosphate dehydrogenase complex	cellular_component	"An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3]
EOG8935XR	GO:0003774	30/113	motor activity	molecular_function	"Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]
EOG8935XR	GO:0016459	29/113	myosin complex	cellular_component	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
EOG8935XR	GO:0032440	1/113	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG8935XR	GO:0030239	1/113	myofibril assembly	biological_process	"Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]
EOG8935XR	GO:0032982	1/113	myosin filament	cellular_component	"A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah]
EOG8935XR	GO:0008152	1/113	metabolic process	biological_process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
EOG8935XR	GO:0007498	1/113	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8935XR	GO:0030016	1/113	myofibril	cellular_component	"The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194]
EOG8HX7FC	GO:0005524	28/97	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8HX7FC	GO:0008026	27/97	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8HX7FC	GO:0003723	23/97	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8HX7FC	GO:0003676	5/97	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8HX7FC	GO:0004386	1/97	helicase activity	molecular_function	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
EOG8HX7FC	GO:0005730	1/97	nucleolus	cellular_component	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
EOG83V29M	GO:0008121	30/124	ubiquinol-cytochrome-c reductase activity	molecular_function	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]
EOG83V29M	GO:0051537	30/124	2 iron, 2 sulfur cluster binding	molecular_function	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]
EOG83V29M	GO:0005739	29/124	mitochondrion	cellular_component	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
EOG83V29M	GO:0046872	29/124	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG83V29M	GO:0070469	29/124	respiratory chain	cellular_component	"The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684]
EOG83V29M	GO:0005875	1/124	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG83V29J	GO:0003682	25/92	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG83V29J	GO:0003677	23/92	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG83V29J	GO:0022008	1/92	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG83V29J	GO:0048812	1/92	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG83V29J	GO:0005634	1/92	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8TXF74	GO:0016021	41/125	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8TXF74	GO:0016740	41/125	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8TXF74	GO:0006633	41/125	fatty acid biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]
EOG8TXF74	GO:0030497	1/125	fatty acid elongation	biological_process	"The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094]
EOG8TXF74	GO:0030176	1/125	integral component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]
EOG8TXF74	GO:0007283	1/125	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8TXF74	GO:0009922	1/125	fatty acid elongase activity	molecular_function	"Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb]
EOG8K9DV3	GO:0008612	29/99	peptidyl-lysine modification to peptidyl-hypusine	biological_process	"The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116]
EOG8K9DV3	GO:0045901	29/99	positive regulation of translational elongation	biological_process	"Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators]
EOG8K9DV3	GO:0045905	29/99	positive regulation of translational termination	biological_process	"Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]
EOG8K9DV3	GO:0006452	29/99	translational frameshifting	biological_process	"A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon." [GOC:hjd, ISBN:0195094425]
EOG8K9DV3	GO:0003746	29/99	translation elongation factor activity	molecular_function	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
EOG8K9DV3	GO:0043022	29/99	ribosome binding	molecular_function	"Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators]
EOG8K9DV3	GO:0003743	7/99	translation initiation factor activity	molecular_function	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
EOG8K9DV3	GO:0032504	1/99	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG8K9DV3	GO:0035071	1/99	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8K9DV3	GO:0035220	1/99	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG8K9DV3	GO:0042981	1/99	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8K9DV3	GO:0048102	1/99	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8K9DV3	GO:0005737	1/99	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG85F04B	GO:0016491	4/25	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG85F04B	GO:0043565	1/25	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8MSGGG	GO:0003676	2/235	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8MSGGG	GO:0005524	2/235	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8MSGGG	GO:0006094	1/235	gluconeogenesis	biological_process	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]
EOG8MSGGG	GO:0003968	1/235	RNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah]
EOG8MSGGG	GO:0004736	1/235	pyruvate carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847]
EOG8MSGGG	GO:0004075	1/235	biotin carboxylase activity	molecular_function	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]
EOG8MSGGG	GO:0003964	1/235	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8MSGGG	GO:0008026	1/235	ATP-dependent helicase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
EOG8MSGGG	GO:0019079	1/235	viral genome replication	biological_process	"Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534]
EOG83FK9T	GO:0033227	15/60	dsRNA transport	biological_process	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
EOG83FK9T	GO:0016021	15/60	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG83FK9T	GO:0051033	15/60	RNA transmembrane transporter activity	molecular_function	"Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]
EOG83FK9T	GO:0005524	1/60	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG83FK9T	GO:0004674	1/60	protein serine/threonine kinase activity	molecular_function	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
EOG8Q87CQ	GO:0006629	1/4	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG8DRCVB	GO:0007525	1/66	somatic muscle development	biological_process	"The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
EOG8DRCVB	GO:0000981	1/66	RNA polymerase II transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
EOG8DRCVB	GO:0005634	1/66	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8DRCVB	GO:0007498	1/66	mesoderm development	biological_process	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
EOG8DRCVB	GO:0043425	1/66	bHLH transcription factor binding	molecular_function	"Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210]
EOG8DRCVB	GO:0003677	1/66	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8DRCVB	GO:0007474	1/66	imaginal disc-derived wing vein specification	biological_process	"The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
EOG8DRCVB	GO:0046982	1/66	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8DRCVB	GO:0016203	1/66	muscle attachment	biological_process	"The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
EOG8DRCVB	GO:0033627	1/66	cell adhesion mediated by integrin	biological_process	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]
EOG8DRCVB	GO:0006355	1/66	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8DRCVB	GO:0006357	1/66	regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8DRCVB	GO:0006366	1/66	transcription from RNA polymerase II promoter	biological_process	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]
EOG8ZPHC1	GO:0016057	1/16	regulation of membrane potential in photoreceptor cell	biological_process	"Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb]
EOG8ZPHC1	GO:0005246	1/16	calcium channel regulator activity	molecular_function	"Modulates the activity of a calcium channel." [GOC:mah]
EOG8ZPHC1	GO:0016027	1/16	inaD signaling complex	cellular_component	"A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815]
EOG8ZPHC1	GO:0009416	1/16	response to light stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
EOG8ZPHC1	GO:0005515	1/16	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8ZPHC1	GO:0016028	1/16	rhabdomere	cellular_component	"The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774]
EOG8ZPHC1	GO:0033583	1/16	rhabdomere membrane	cellular_component	"The portion of the plasma membrane surrounding the rhabdomere." [GOC:mah]
EOG8VX4K0	GO:0004725	1/108	protein tyrosine phosphatase activity	molecular_function	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
EOG8VX4K0	GO:0042981	1/108	regulation of apoptotic process	biological_process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
EOG8VX4K0	GO:0007298	1/108	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8VX4K0	GO:0046331	1/108	lateral inhibition	biological_process	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
EOG8VX4K0	GO:0005622	1/108	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8VX4K0	GO:0019730	1/108	antimicrobial humoral response	biological_process	"An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
EOG8QFZV3	GO:0005975	201/525	carbohydrate metabolic process	biological_process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
EOG8QFZV3	GO:0043169	199/525	cation binding	molecular_function	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]
EOG8QFZV3	GO:0003824	188/525	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8QFZV3	GO:0032450	12/525	maltose alpha-glucosidase activity	molecular_function	"Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141]
EOG8QFZV3	GO:0016740	1/525	transferase activity	molecular_function	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
EOG8QFZV3	GO:0003677	1/525	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG866Z1D	GO:0016021	35/124	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG866Z1D	GO:0022857	28/124	transmembrane transporter activity	molecular_function	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
EOG866Z1D	GO:0022891	7/124	substrate-specific transmembrane transporter activity	molecular_function	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
EOG866Z1D	GO:0008643	7/124	carbohydrate transport	biological_process	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
EOG866Z1D	GO:0032440	1/124	2-alkenal reductase [NAD(P)] activity	molecular_function	"Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
EOG879HND	GO:0005783	24/87	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG879HND	GO:0006486	24/87	protein glycosylation	biological_process	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]
EOG879HND	GO:0016021	24/87	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG879HND	GO:0004579	24/87	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	molecular_function	"Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119]
EOG866Z1H	GO:0005868	29/105	cytoplasmic dynein complex	cellular_component	"Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:mah, PMID:12600311]
EOG866Z1H	GO:0007018	29/105	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG866Z1H	GO:0003777	29/105	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG866Z1H	GO:0007067	1/105	mitotic nuclear division	biological_process	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
EOG866Z1H	GO:0000226	1/105	microtubule cytoskeleton organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
EOG866Z1H	GO:0051028	1/105	mRNA transport	biological_process	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG866Z1H	GO:0007409	1/105	axonogenesis	biological_process	"De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
EOG866Z1H	GO:0048477	1/105	oogenesis	biological_process	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
EOG866Z1H	GO:0030286	1/105	dynein complex	cellular_component	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
EOG866Z1H	GO:0042623	1/105	ATPase activity, coupled	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
EOG866Z1H	GO:0048814	1/105	regulation of dendrite morphogenesis	biological_process	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
EOG866Z1H	GO:0006200	1/105	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG866Z1H	GO:0048813	1/105	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG866Z1H	GO:0008088	1/105	axon cargo transport	biological_process	"The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194]
EOG866Z1H	GO:0007052	1/105	mitotic spindle organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
EOG8PRW5B	GO:0035091	1/5	phosphatidylinositol binding	molecular_function	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]
EOG8PRW5B	GO:0003777	1/5	microtubule motor activity	molecular_function	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
EOG8PRW5B	GO:0007018	1/5	microtubule-based movement	biological_process	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]
EOG8PRW5B	GO:0005871	1/5	kinesin complex	cellular_component	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
EOG8HTC74	GO:0003964	161/557	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8HTC74	GO:0003723	161/557	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8HTC74	GO:0008270	5/557	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8HTC74	GO:0035556	1/557	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8HTC74	GO:0016787	1/557	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG8HTC74	GO:0000166	1/557	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8HTC74	GO:0004519	1/557	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8DBWX7	GO:0000737	1/76	DNA catabolic process, endonucleolytic	biological_process	"The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
EOG8DBWX7	GO:0003906	1/76	DNA-(apurinic or apyrimidinic site) lyase activity	molecular_function	"Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18]
EOG8DBWX7	GO:0046872	1/76	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8DBWX7	GO:0090305	1/76	nucleic acid phosphodiester bond hydrolysis	biological_process	"The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]
EOG8DBWX7	GO:0004520	1/76	endodeoxyribonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8DBWX7	GO:0008408	1/76	3'-5' exonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]
EOG8H1D9C	GO:0005509	28/92	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8H1D9C	GO:0006457	28/92	protein folding	biological_process	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
EOG8H1D9C	GO:0005783	27/92	endoplasmic reticulum	cellular_component	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
EOG8H1D9C	GO:0042048	1/92	olfactory behavior	biological_process	"The behavior of an organism in response to an odor." [GOC:jid, GOC:pr]
EOG8H1D9C	GO:0031987	1/92	locomotion involved in locomotory behavior	biological_process	"Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
EOG8H1D9C	GO:0048854	1/92	brain morphogenesis	biological_process	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
EOG8H1D9C	GO:0045169	1/92	fusome	cellular_component	"A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
EOG8H1D9C	GO:0007422	1/92	peripheral nervous system development	biological_process	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
EOG8H1D9C	GO:0030431	1/92	sleep	biological_process	"Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
EOG8H1D9C	GO:0005788	1/92	endoplasmic reticulum lumen	cellular_component	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]
EOG8H1D9C	GO:0007417	1/92	central nervous system development	biological_process	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
EOG8H1D9C	GO:0001964	1/92	startle response	biological_process	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
EOG8H1D9C	GO:0005811	1/92	lipid particle	cellular_component	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
EOG8H1D9C	GO:0007476	1/92	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8H1D9C	GO:0022008	1/92	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8H1D9C	GO:0005615	1/92	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8TB6RN	GO:0016149	25/94	translation release factor activity, codon specific	molecular_function	"A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684]
EOG8TB6RN	GO:0005737	24/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8TB6RN	GO:0006415	1/94	translational termination	biological_process	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]
EOG8TB6RN	GO:0035071	1/94	salivary gland cell autophagic cell death	biological_process	"The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130]
EOG8TB6RN	GO:0007224	1/94	smoothened signaling pathway	biological_process	"A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
EOG8TB6RN	GO:0005829	1/94	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8TB6RN	GO:0008079	1/94	translation termination factor activity	molecular_function	"Functions in the termination of translation." [GOC:ma]
EOG8TB6RN	GO:0048102	1/94	autophagic cell death	biological_process	"A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107]
EOG8V19G4	GO:0043565	30/102	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8V19G4	GO:0005634	30/102	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8V19G4	GO:0003700	28/102	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8V19G4	GO:0045944	2/102	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8V19G4	GO:0045893	2/102	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8V19G4	GO:0007283	2/102	spermatogenesis	biological_process	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]
EOG8V19G4	GO:0001077	2/102	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG8V19G4	GO:0005524	1/102	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8V19G4	GO:0005515	1/102	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8V19G4	GO:0019205	1/102	nucleobase-containing compound kinase activity	molecular_function	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]
EOG8V19G4	GO:0006139	1/102	nucleobase-containing compound metabolic process	biological_process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
EOG8Q87CD	GO:0016021	42/106	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8Q87CD	GO:0045747	2/106	positive regulation of Notch signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
EOG8Q87CD	GO:0007298	2/106	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8Q87CD	GO:0006909	1/106	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8Q87CD	GO:0007399	1/106	nervous system development	biological_process	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
EOG80KBDJ	GO:0008270	11/85	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80KBDJ	GO:0003676	10/85	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80KBDJ	GO:0004190	2/85	aspartic-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]
EOG80KBDJ	GO:0015074	1/85	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG80KBDJ	GO:0003964	1/85	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG80KBDJ	GO:0003723	1/85	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8TB6RD	GO:0005764	4/94	lysosome	cellular_component	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
EOG8TB6RD	GO:0045087	4/94	innate immune response	biological_process	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
EOG8TB6RD	GO:0006955	4/94	immune response	biological_process	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
EOG8TB6RD	GO:0006911	4/94	phagocytosis, engulfment	biological_process	"The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149]
EOG8TB6RD	GO:0097374	1/94	sensory neuron axon guidance	biological_process	"The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses." [CL:0000101, GOC:pr]
EOG8TB6RD	GO:0043524	1/94	negative regulation of neuron apoptotic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
EOG8TB6RD	GO:0031416	1/94	NatB complex	cellular_component	"A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471]
EOG8TB6RD	GO:0002253	1/94	activation of immune response	biological_process	"Any process that initiates an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
EOG8TB6RD	GO:0005737	1/94	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8TB6RD	GO:0010592	1/94	positive regulation of lamellipodium assembly	biological_process	"Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
EOG8TB6RD	GO:0007298	1/94	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG89PDF5	GO:0001682	1/49	tRNA 5'-leader removal	biological_process	"Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395]
EOG89PDF5	GO:0004526	1/49	ribonuclease P activity	molecular_function	"Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5]
EOG8H1D9H	GO:0004749	2/4	ribose phosphate diphosphokinase activity	molecular_function	"Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+)." [EC:2.7.6.1, RHEA:15612]
EOG8H1D9H	GO:0009156	2/4	ribonucleoside monophosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]
EOG8H1D9H	GO:0009165	2/4	nucleotide biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]
EOG8H1D9H	GO:0000287	2/4	magnesium ion binding	molecular_function	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
EOG8PVRF3	GO:0005634	27/85	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8PVRF3	GO:0006397	27/85	mRNA processing	biological_process	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]
EOG8PVRF3	GO:0004721	26/85	phosphoprotein phosphatase activity	molecular_function	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
EOG8PVRF3	GO:0016791	1/85	phosphatase activity	molecular_function	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]
EOG8PVRF3	GO:0070940	1/85	dephosphorylation of RNA polymerase II C-terminal domain	biological_process	"The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form." [GOC:krc, GOC:mah, PMID:17079683]
EOG8PVRF3	GO:0008420	1/85	CTD phosphatase activity	molecular_function	"Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate." [EC:3.1.3.16]
EOG879HNP	GO:0008241	1/87	peptidyl-dipeptidase activity	molecular_function	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]
EOG879HNP	GO:0016020	1/87	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG879HNP	GO:0008237	1/87	metallopeptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8M946F	GO:0003676	2/3	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8M946F	GO:0046872	2/3	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8NKF98	GO:0016021	134/389	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NKF98	GO:0007602	130/389	phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
EOG8NKF98	GO:0007601	128/389	visual perception	biological_process	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
EOG8NKF98	GO:0004930	128/389	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8NKF98	GO:0018298	122/389	protein-chromophore linkage	biological_process	"The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma]
EOG8NKF98	GO:0009881	116/389	photoreceptor activity	molecular_function	"The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators]
EOG8NKF98	GO:0009584	6/389	detection of visible light	biological_process	"The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
EOG8NKF98	GO:0008020	6/389	G-protein coupled photoreceptor activity	molecular_function	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]
EOG8NKF98	GO:0007186	6/389	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8NKF98	GO:0009589	3/389	detection of UV	biological_process	"The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:dos, GOC:go_curators, GOC:hb, ISBN:0198506732]
EOG8NKF98	GO:0016028	3/389	rhabdomere	cellular_component	"The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774]
EOG8NKF98	GO:0007604	2/389	phototransduction, UV	biological_process	"The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers." [GOC:go_curators, ISBN:0198506732]
EOG8NKF98	GO:0043153	2/389	entrainment of circadian clock by photoperiod	biological_process	"The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl]
EOG8NKF98	GO:0007605	2/389	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG8NKF98	GO:0005767	1/389	secondary lysosome	cellular_component	"Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, ISBN:0815316194]
EOG8NKF98	GO:0009642	1/389	response to light intensity	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:go_curators]
EOG8NKF98	GO:0008344	1/389	adult locomotory behavior	biological_process	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]
EOG8NKF98	GO:0042052	1/389	rhabdomere development	biological_process	"The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
EOG8NKF98	GO:0043052	1/389	thermotaxis	biological_process	"The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
EOG8NKF98	GO:0008594	1/389	photoreceptor cell morphogenesis	biological_process	"The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
EOG8NKF98	GO:0016027	1/389	inaD signaling complex	cellular_component	"A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815]
EOG8NKF98	GO:0009416	1/389	response to light stimulus	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
EOG8NKF98	GO:0030265	1/389	phospholipase C-activating rhodopsin mediated signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a rhodopsin molecule being activated by a photon, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:mah, GOC:signaling, PMID:22498302, PMID:8823931]
EOG8NKF98	GO:0046673	1/389	negative regulation of compound eye retinal cell programmed cell death	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
EOG8NKF98	GO:0042331	1/389	phototaxis	biological_process	"The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981]
EOG8NKF98	GO:0016038	1/389	absorption of visible light	biological_process	"The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm." [GOC:go_curators, ISBN:0198506732]
EOG8NKF98	GO:0005771	1/389	multivesicular body	cellular_component	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]
EOG8NKF98	GO:0016039	1/389	absorption of UV light	biological_process	"The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm." [GOC:go_curators, ISBN:0198506732]
EOG8NKF98	GO:0005791	1/389	rough endoplasmic reticulum	cellular_component	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]
EOG8NKF98	GO:0016023	1/389	cytoplasmic membrane-bounded vesicle	cellular_component	"A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
EOG8NKF98	GO:0009588	1/389	UV-A, blue light phototransduction	biological_process	"The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of 315 to 400 nm." [GOC:mah]
EOG8NKF98	GO:0016029	1/389	subrhabdomeral cisterna	cellular_component	"A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase." [PMID:11707492, PMID:8646774]
EOG8NKF98	GO:0005515	1/389	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8NKF98	GO:0000122	1/389	negative regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8NKF98	GO:0071632	1/389	optomotor response	biological_process	"Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish." [GOC:dos, PMID:12726833, PMID:2469195]
EOG8NKF98	GO:0005886	1/389	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8ZSCHG	GO:0007165	28/104	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8X3KHJ	GO:0008270	126/815	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8X3KHJ	GO:0003676	118/815	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8X3KHJ	GO:0003964	12/815	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8X3KHJ	GO:0003723	12/815	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8X3KHJ	GO:0003677	1/815	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8X3KHJ	GO:0016192	1/815	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8X3KHJ	GO:0015074	1/815	DNA integration	biological_process	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
EOG8X3KHJ	GO:0016020	1/815	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8V71WJ	GO:0016491	25/79	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG8V71WJ	GO:0006546	24/79	glycine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]
EOG8V71WJ	GO:0005737	24/79	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8V71WJ	GO:0004047	24/79	aminomethyltransferase activity	molecular_function	"Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10]
EOG8V71WJ	GO:0016787	1/79	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG82Z78H	GO:0005576	2/10	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG82Z78H	GO:0005198	2/10	structural molecule activity	molecular_function	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
EOG805VF3	GO:0005634	6/60	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG805VF3	GO:0008270	6/60	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG805VF3	GO:0003700	6/60	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG805VF3	GO:0003964	1/60	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG805VF3	GO:0003723	1/60	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG805VF2	GO:0016236	1/101	macroautophagy	biological_process	"The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure.  Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464]
EOG805VF2	GO:0006914	1/101	autophagy	biological_process	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
EOG805VF2	GO:0034273	1/101	ATG1/UKL1 kinase complex	cellular_component	"A protein complex consisting of ATG1/UKL1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, IntAct:EBI-2352849, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]
EOG8ZSCHM	GO:0016055	26/91	Wnt signaling pathway	biological_process	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
EOG8ZSCHM	GO:0042734	12/91	presynaptic membrane	cellular_component	"A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194]
EOG8ZSCHM	GO:0033157	12/91	regulation of intracellular protein transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah]
EOG8ZSCHM	GO:0007367	12/91	segment polarity determination	biological_process	"Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
EOG8ZSCHM	GO:0031228	12/91	intrinsic component of Golgi membrane	cellular_component	"The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
EOG8ZSCHM	GO:0045211	12/91	postsynaptic membrane	cellular_component	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
EOG8ZSCHM	GO:0050714	12/91	positive regulation of protein secretion	biological_process	"Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]
EOG8ZSCHM	GO:0030285	12/91	integral component of synaptic vesicle membrane	cellular_component	"The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZSCHM	GO:0005887	12/91	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8ZSCHM	GO:0031302	12/91	intrinsic component of endosome membrane	cellular_component	"The component of the endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
EOG8ZSCHM	GO:0031227	12/91	intrinsic component of endoplasmic reticulum membrane	cellular_component	"The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]
EOG8ZSCHM	GO:0031594	12/91	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8ZSCHM	GO:0030177	12/91	positive regulation of Wnt signaling pathway	biological_process	"Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]
EOG8ZSCHM	GO:0008587	12/91	imaginal disc-derived wing margin morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG8ZSCHM	GO:0017147	12/91	Wnt-protein binding	molecular_function	"Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]
EOG8ZSCHM	GO:0030054	12/91	cell junction	cellular_component	"A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8ZSCHM	GO:0001745	1/91	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8ZSCHM	GO:0005769	1/91	early endosome	cellular_component	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
EOG8ZSCHM	GO:0007480	1/91	imaginal disc-derived leg morphogenesis	biological_process	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
EOG8ZSCHM	GO:0007476	1/91	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8ZSCHM	GO:0005794	1/91	Golgi apparatus	cellular_component	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
EOG8ZSCHM	GO:0005771	1/91	multivesicular body	cellular_component	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]
EOG8ZSCHM	GO:0070062	1/91	extracellular exosome	cellular_component	"A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
EOG8ZSCHM	GO:0005886	1/91	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8ZSCHM	GO:0035017	1/91	cuticle pattern formation	biological_process	"The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf]
EOG8ZSCHM	GO:0002790	1/91	peptide secretion	biological_process	"The controlled release of a peptide from a cell or a tissue." [GOC:add]
EOG8ZSCHM	GO:0005515	1/91	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8BCH44	GO:0003954	1/91	NADH dehydrogenase activity	molecular_function	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
EOG8BCH44	GO:0008137	1/91	NADH dehydrogenase (ubiquinone) activity	molecular_function	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
EOG82Z742	GO:0003677	23/84	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG82Z742	GO:0006355	23/84	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8PG8HR	GO:0003964	4/50	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8PG8HR	GO:0003723	3/50	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8PG8HR	GO:0004519	1/50	endonuclease activity	molecular_function	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
EOG8PG8HR	GO:0008270	1/50	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZSCHT	GO:0008270	19/78	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8GMXBG	GO:0016021	21/124	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GMXBG	GO:0005249	17/124	voltage-gated potassium channel activity	molecular_function	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
EOG8GMXBG	GO:0005216	5/124	ion channel activity	molecular_function	"Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
EOG8GMXBG	GO:0008603	2/124	cAMP-dependent protein kinase regulator activity	molecular_function	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]
EOG8GMXBG	GO:0004692	2/124	cGMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]
EOG8GMXBG	GO:0005952	2/124	cAMP-dependent protein kinase complex	cellular_component	"An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732]
EOG8GMXBG	GO:0071805	1/124	potassium ion transmembrane transport	biological_process	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]
EOG8GMXBG	GO:0045938	1/124	positive regulation of circadian sleep/wake cycle, sleep	biological_process	"Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators]
EOG8GMXBG	GO:0007637	1/124	proboscis extension reflex	biological_process	"The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jid]
EOG8GMXBG	GO:0004691	1/124	cAMP-dependent protein kinase activity	molecular_function	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11]
EOG8GMXBG	GO:0004715	1/124	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8GMXBG	GO:0005887	1/124	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8GMXBG	GO:0014059	1/124	regulation of dopamine secretion	biological_process	"Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]
EOG8GMXBG	GO:0042391	1/124	regulation of membrane potential	biological_process	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
EOG8GMXBG	GO:0045475	1/124	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8GMXBG	GO:0008340	1/124	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8GMXBG	GO:0050802	1/124	circadian sleep/wake cycle, sleep	biological_process	"The part of the circadian sleep/wake cycle where the organism is asleep." [GOC:ai]
EOG8T4G85	GO:0005737	12/117	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8T4G85	GO:0005634	11/117	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8T4G85	GO:0048489	1/117	synaptic vesicle transport	biological_process	"The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr]
EOG8T4G85	GO:0005524	1/117	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8T4G85	GO:0000132	1/117	establishment of mitotic spindle orientation	biological_process	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
EOG8T4G85	GO:0016020	1/117	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8T4G85	GO:0042626	1/117	ATPase activity, coupled to transmembrane movement of substances	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
EOG8T4G85	GO:0048812	1/117	neuron projection morphogenesis	biological_process	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
EOG8T4G85	GO:0008088	1/117	axon cargo transport	biological_process	"The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194]
EOG889750	GO:0055085	1/4	transmembrane transport	biological_process	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]
EOG889750	GO:0016021	1/4	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG80S2WJ	GO:0016491	161/516	oxidoreductase activity	molecular_function	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
EOG80S2WJ	GO:0004032	11/516	alditol:NADP+ 1-oxidoreductase activity	molecular_function	"Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21]
EOG80S2WJ	GO:0035220	1/516	wing disc development	biological_process	"Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
EOG80S2WJ	GO:0047006	1/516	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	molecular_function	"Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone." [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN]
EOG80S2WJ	GO:0016319	1/516	mushroom body development	biological_process	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
EOG80S2WJ	GO:0008106	1/516	alcohol dehydrogenase (NADP+) activity	molecular_function	"Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2]
EOG80S2WJ	GO:0022416	1/516	chaeta development	biological_process	"The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]
EOG8CC6F4	GO:0007165	23/84	signal transduction	biological_process	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
EOG8CC6F4	GO:0005096	22/84	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8CC6F4	GO:0051056	21/84	regulation of small GTPase mediated signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
EOG8CC6F4	GO:0005622	21/84	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8CC6F4	GO:0051223	2/84	regulation of protein transport	biological_process	"Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8CC6F4	GO:0005829	2/84	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8CC6F4	GO:0005085	2/84	guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
EOG8CC6F4	GO:0006897	2/84	endocytosis	biological_process	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]
EOG8CC6F4	GO:0016020	2/84	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CC6F4	GO:0032794	2/84	GTPase activating protein binding	molecular_function	"Interacting selectively and non-covalently with a GTPase activating protein." [GOC:nln]
EOG8CC6F4	GO:0043087	2/84	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8CC6F4	GO:0032483	1/84	regulation of Rab protein signal transduction	biological_process	"Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]
EOG8CC6F4	GO:0017112	1/84	Rab guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8CC6F4	GO:0032313	1/84	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8KM1KB	GO:0005576	5/153	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8KM1KB	GO:0046982	2/153	protein heterodimerization activity	molecular_function	"Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
EOG8KM1KB	GO:0031395	2/153	bursicon neuropeptide hormone complex	cellular_component	"A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits." [GOC:rc]
EOG8KM1KB	GO:0007593	2/153	chitin-based cuticle sclerotization	biological_process	"The process of hardening of a chitin-based cuticle." [GOC:dos, GOC:mtg_sensu]
EOG8KM1KB	GO:0005179	1/153	hormone activity	molecular_function	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]
EOG8KM1KB	GO:0090175	1/153	regulation of establishment of planar polarity	biological_process	"Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb]
EOG8KM1KB	GO:0048067	1/153	cuticle pigmentation	biological_process	"Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
EOG8KM1KB	GO:0007186	1/153	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8KM1KB	GO:0018990	1/153	ecdysis, chitin-based cuticle	biological_process	"The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8KM1KB	GO:0001664	1/153	G-protein coupled receptor binding	molecular_function	"Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph]
EOG8KM1KB	GO:0043195	1/153	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG8X3KHR	GO:0030414	19/74	peptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
EOG8X3KHR	GO:0005576	19/74	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG8QZB18	GO:0005089	1/3	Rho guanyl-nucleotide exchange factor activity	molecular_function	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
EOG8QZB18	GO:0035556	1/3	intracellular signal transduction	biological_process	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
EOG8G1Q0V	GO:0007229	1/11	integrin-mediated signaling pathway	biological_process	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]
EOG8GMXBJ	GO:0016020	29/93	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG80S2WC	GO:0006629	148/439	lipid metabolic process	biological_process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
EOG80S2WC	GO:0005576	148/439	extracellular region	cellular_component	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
EOG80S2WC	GO:0008970	88/439	phosphatidylcholine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32]
EOG80S2WC	GO:0016787	52/439	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG80S2WC	GO:0052739	12/439	phosphatidylserine 1-acylhydrolase activity	molecular_function	"Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG:R04034]
EOG80S2WC	GO:0052740	12/439	1-acyl-2-lysophosphatidylserine acylhydrolase activity	molecular_function	"Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32]
EOG80S2WC	GO:0004806	11/439	triglyceride lipase activity	molecular_function	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]
EOG80S2WC	GO:0003824	3/439	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG80S2WC	GO:0003676	1/439	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG80S2WC	GO:0008270	1/439	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG80S2WC	GO:0022008	1/439	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8T4G8C	GO:0008270	24/105	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8T4G8C	GO:0000166	23/105	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8T4G8C	GO:0003723	22/105	RNA binding	molecular_function	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
EOG8T4G8C	GO:0046425	1/105	regulation of JAK-STAT cascade	biological_process	"Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf]
EOG8T4G8C	GO:0051297	1/105	centrosome organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
EOG8T4G8C	GO:0046872	1/105	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8T4G8C	GO:0003729	1/105	mRNA binding	molecular_function	"Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
EOG8T4G8C	GO:0003676	1/105	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8T4G8C	GO:0003964	1/105	RNA-directed DNA polymerase activity	molecular_function	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
EOG8NW22Z	GO:0016021	69/289	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NW22Z	GO:0004930	45/289	G-protein coupled receptor activity	molecular_function	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
EOG8NW22Z	GO:0004935	13/289	adrenergic receptor activity	molecular_function	"Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274]
EOG8NW22Z	GO:0005886	11/289	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8NW22Z	GO:0004993	7/289	serotonin receptor activity	molecular_function	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai]
EOG8NW22Z	GO:0043565	4/289	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8NW22Z	GO:0004715	4/289	non-membrane spanning protein tyrosine kinase activity	molecular_function	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]
EOG8NW22Z	GO:0003700	4/289	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8NW22Z	GO:0007186	3/289	G-protein coupled receptor signaling pathway	biological_process	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.  The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]
EOG8NW22Z	GO:0010579	3/289	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	biological_process	"Any process that increases the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G-protein coupled receptor signaling pathway." [GOC:dph, GOC:signaling, GOC:tb]
EOG8NW22Z	GO:0008227	3/289	G-protein coupled amine receptor activity	molecular_function	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
EOG8NW22Z	GO:0004989	3/289	octopamine receptor activity	molecular_function	"Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [CHEBI:17134, GOC:ai]
EOG8NW22Z	GO:0005887	3/289	integral component of plasma membrane	cellular_component	"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG8NW22Z	GO:0007189	3/289	adenylate cyclase-activating G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
EOG8NW22Z	GO:0004977	2/289	melanocortin receptor activity	molecular_function	"Combining with melanocortin to initiate a change in cell activity." [GOC:ai]
EOG8NW22Z	GO:0045886	1/289	negative regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG8NW22Z	GO:0007188	1/289	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194]
EOG8NW22Z	GO:0045887	1/289	positive regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
EOG87Q0MC	GO:0046872	20/87	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8CZDVQ	GO:0004198	53/173	calcium-dependent cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]
EOG8CZDVQ	GO:0005622	52/173	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8CZDVQ	GO:0005509	45/173	calcium ion binding	molecular_function	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
EOG8CZDVQ	GO:0005737	2/173	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8CZDVQ	GO:0006508	2/173	proteolysis	biological_process	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
EOG8CZDVQ	GO:0016540	2/173	protein autoprocessing	biological_process	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]
EOG8CZDVQ	GO:0007298	1/173	border follicle cell migration	biological_process	"The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
EOG8CZDVQ	GO:0009953	1/173	dorsal/ventral pattern formation	biological_process	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
EOG8CZDVQ	GO:0021919	1/173	BMP signaling pathway involved in spinal cord dorsal/ventral patterning	biological_process	"A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981]
EOG8CZDVQ	GO:0043025	1/173	neuronal cell body	cellular_component	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
EOG8CZDVQ	GO:0015629	1/173	actin cytoskeleton	cellular_component	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
EOG8CZDVQ	GO:0006909	1/173	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8CZDVQ	GO:0008340	1/173	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8CZDVQ	GO:0016020	1/173	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8CZDVQ	GO:0050832	1/173	defense response to fungus	biological_process	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
EOG8CZDVQ	GO:0042335	1/173	cuticle development	biological_process	"The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [ISBN:0192800825]
EOG8CZDVQ	GO:0005515	1/173	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8QZB1C	GO:0008168	26/87	methyltransferase activity	molecular_function	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]
EOG8QZB1C	GO:0016706	23/87	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular_function	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
EOG8QZB1C	GO:0000166	5/87	nucleotide binding	molecular_function	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
EOG8QZB1C	GO:0003676	4/87	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8QZB1C	GO:0030797	1/87	24-methylenesterol C-methyltransferase activity	molecular_function	"Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.143, RHEA:21047]
EOG80VZ54	GO:0005097	23/108	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG80VZ54	GO:0043195	1/108	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG80VZ54	GO:0031594	1/108	neuromuscular junction	cellular_component	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
EOG8SN45G	GO:0003682	14/229	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8SN45G	GO:0006915	3/229	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8SN45G	GO:0005634	3/229	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8SN45G	GO:0003677	3/229	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8SN45G	GO:0008270	1/229	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8MD0G3	GO:0005840	24/87	ribosome	cellular_component	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
EOG8MD0G3	GO:0003735	24/87	structural constituent of ribosome	molecular_function	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
EOG8MD0G3	GO:0006412	24/87	translation	biological_process	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
EOG8MD0G3	GO:0000022	1/87	mitotic spindle elongation	biological_process	"The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw]
EOG80VZ53	GO:0007605	1/102	sensory perception of sound	biological_process	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
EOG80VZ53	GO:0022008	1/102	neurogenesis	biological_process	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]
EOG8RZ1H0	GO:0003677	5/88	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8RZ1H0	GO:0008234	1/88	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8RZ1H0	GO:0003682	1/88	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
EOG8C8B8W	GO:0003676	1/6	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8C8B8W	GO:0008270	1/6	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8ZSCH2	GO:0003824	22/95	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8ZSCH2	GO:0003833	1/95	beta-alanyl-dopamine synthase activity	molecular_function	"Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732, PMID:12957543]
EOG8ZSCH2	GO:0006583	1/95	melanin biosynthetic process from tyrosine	biological_process	"The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators]
EOG8ZSCH2	GO:0016874	1/95	ligase activity	molecular_function	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
EOG8ZSCH2	GO:0045475	1/95	locomotor rhythm	biological_process	"The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
EOG8ZSCH2	GO:0048022	1/95	negative regulation of melanin biosynthetic process	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid]
EOG8ZSCH2	GO:0042417	1/95	dopamine metabolic process	biological_process	"The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
EOG8ZSCH2	GO:0043042	1/95	amino acid adenylylation by nonribosomal peptide synthase	biological_process	"Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor." [GOC:jl, PMID:9250661, PMID:9712910]
EOG8ZSCH2	GO:0048082	1/95	regulation of adult chitin-containing cuticle pigmentation	biological_process	"Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu]
EOG8ZSCH2	GO:0047462	1/95	phenylalanine racemase (ATP-hydrolyzing) activity	molecular_function	"Catalysis of the reaction: L-phenylalanine + ATP + H(2)O = D-phenylalanine + AMP + diphosphate + 2 H(+)." [EC:5.1.1.11, RHEA:20204]
EOG8ZSCH2	GO:0048066	1/95	developmental pigmentation	biological_process	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
EOG8ZSCH2	GO:0048067	1/95	cuticle pigmentation	biological_process	"Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
EOG8ZSCH2	GO:0001692	1/95	histamine metabolic process	biological_process	"The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
EOG8ZSCH2	GO:0007623	1/95	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG8ZSCH2	GO:0005737	1/95	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8ZSCH2	GO:0007593	1/95	chitin-based cuticle sclerotization	biological_process	"The process of hardening of a chitin-based cuticle." [GOC:dos, GOC:mtg_sensu]
EOG8ZSCH2	GO:0042440	1/95	pigment metabolic process	biological_process	"The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732]
EOG8B2WD3	GO:0003824	1/4	catalytic activity	molecular_function	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
EOG8B2WD3	GO:0004252	1/4	serine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
EOG85HVF8	GO:0003677	1/6	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG85HVF8	GO:0006355	1/6	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG85HVF8	GO:0005634	1/6	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG85HVF8	GO:0007275	1/6	multicellular organismal development	biological_process	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
EOG83N9TX	GO:0016905	1/15	myosin heavy chain kinase activity	molecular_function	"Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
EOG8HB12D	GO:0004197	1/6	cysteine-type endopeptidase activity	molecular_function	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
EOG8HB12D	GO:0006915	1/6	apoptotic process	biological_process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
EOG8N335V	GO:0043565	29/151	sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
EOG8N335V	GO:0003700	29/151	transcription factor activity, sequence-specific DNA binding	molecular_function	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
EOG8N335V	GO:0005634	15/151	nucleus	cellular_component	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
EOG8N335V	GO:0006351	13/151	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8N335V	GO:0010259	12/151	multicellular organismal aging	biological_process	"An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators]
EOG8N335V	GO:0019216	12/151	regulation of lipid metabolic process	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
EOG8N335V	GO:0030308	12/151	negative regulation of cell growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8N335V	GO:0006355	12/151	regulation of transcription, DNA-templated	biological_process	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8N335V	GO:0042593	12/151	glucose homeostasis	biological_process	"Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]
EOG8N335V	GO:0008285	12/151	negative regulation of cell proliferation	biological_process	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
EOG8N335V	GO:0046627	12/151	negative regulation of insulin receptor signaling pathway	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8N335V	GO:0005737	12/151	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8N335V	GO:0007049	11/151	cell cycle	biological_process	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
EOG8N335V	GO:0030154	10/151	cell differentiation	biological_process	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
EOG8N335V	GO:0009617	1/151	response to bacterium	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]
EOG8N335V	GO:0034599	1/151	cellular response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
EOG8N335V	GO:0008301	1/151	DNA binding, bending	molecular_function	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]
EOG8N335V	GO:0046626	1/151	regulation of insulin receptor signaling pathway	biological_process	"Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
EOG8N335V	GO:0016241	1/151	regulation of macroautophagy	biological_process	"Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc]
EOG8N335V	GO:0010888	1/151	negative regulation of lipid storage	biological_process	"Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
EOG8N335V	GO:0001578	1/151	microtubule bundle formation	biological_process	"A process that results in a parallel arrangement of microtubules." [GOC:dph]
EOG8N335V	GO:0036099	1/151	female germ-line stem cell population maintenance	biological_process	"The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart]
EOG8N335V	GO:2000253	1/151	positive regulation of feeding behavior	biological_process	"Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol]
EOG8N335V	GO:0005515	1/151	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8N335V	GO:0001077	1/151	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular_function	"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
EOG8N335V	GO:0008340	1/151	determination of adult lifespan	biological_process	"The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
EOG8N335V	GO:0009267	1/151	cellular response to starvation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]
EOG8N335V	GO:0007476	1/151	imaginal disc-derived wing morphogenesis	biological_process	"The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
EOG8N335V	GO:0006974	1/151	cellular response to DNA damage stimulus	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
EOG8N335V	GO:0046872	1/151	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8N335V	GO:0045944	1/151	positive regulation of transcription from RNA polymerase II promoter	biological_process	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
EOG8N335V	GO:0045893	1/151	positive regulation of transcription, DNA-templated	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]
EOG8N335V	GO:0005829	1/151	cytosol	cellular_component	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
EOG8N335V	GO:0045792	1/151	negative regulation of cell size	biological_process	"Any process that reduces cell size." [GOC:go_curators]
EOG8N335V	GO:0035206	1/151	regulation of hemocyte proliferation	biological_process	"Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
EOG8N335V	GO:0040008	1/151	regulation of growth	biological_process	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]
EOG8N335V	GO:0009888	1/151	tissue development	biological_process	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]
EOG8N335V	GO:0008286	1/151	insulin receptor signaling pathway	biological_process	"The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]
EOG8N335V	GO:0007389	1/151	pattern specification process	biological_process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
EOG8N335V	GO:0048813	1/151	dendrite morphogenesis	biological_process	"The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]
EOG8N335V	GO:0006171	1/151	cAMP biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]
EOG8N335V	GO:0006979	1/151	response to oxidative stress	biological_process	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
EOG8N335V	GO:0005977	1/151	glycogen metabolic process	biological_process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]
EOG8N335V	GO:0007623	1/151	circadian rhythm	biological_process	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
EOG8N335V	GO:0019901	1/151	protein kinase binding	molecular_function	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]
EOG8N335V	GO:0001745	1/151	compound eye morphogenesis	biological_process	"The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
EOG8N335V	GO:0034198	1/151	cellular response to amino acid starvation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]
EOG8N335V	GO:0001558	1/151	regulation of cell growth	biological_process	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
EOG8N335V	GO:0003677	1/151	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8N335V	GO:0010506	1/151	regulation of autophagy	biological_process	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
EOG8N335V	GO:1900078	1/151	positive regulation of cellular response to insulin stimulus	biological_process	"Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf]
EOG8N335V	GO:0040015	1/151	negative regulation of multicellular organism growth	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb]
EOG8H1D98	GO:0006511	10/65	ubiquitin-dependent protein catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]
EOG8H1D98	GO:0008234	9/65	cysteine-type peptidase activity	molecular_function	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
EOG8H1D98	GO:0008270	8/65	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8CJXZG	GO:0003899	2/211	DNA-directed RNA polymerase activity	molecular_function	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
EOG8CJXZG	GO:0003677	2/211	DNA binding	molecular_function	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
EOG8CJXZG	GO:0006351	2/211	transcription, DNA-templated	biological_process	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]
EOG8CJXZG	GO:0003676	1/211	nucleic acid binding	molecular_function	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
EOG8Z38VJ	GO:0005524	42/109	ATP binding	molecular_function	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
EOG8Z38VJ	GO:0017111	38/109	nucleoside-triphosphatase activity	molecular_function	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
EOG8Z38VJ	GO:0015031	2/109	protein transport	biological_process	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
EOG8Z38VJ	GO:0005737	2/109	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8Z38VJ	GO:0006200	2/109	obsolete ATP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
EOG8Z38VJ	GO:0007269	2/109	neurotransmitter secretion	biological_process	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]
EOG8Z38VJ	GO:0046872	2/109	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8Z38VJ	GO:0007274	2/109	neuromuscular synaptic transmission	biological_process	"The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
EOG8Z38VJ	GO:0016082	2/109	synaptic vesicle priming	biological_process	"The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342]
EOG8Z38VJ	GO:0016887	2/109	ATPase activity	molecular_function	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
EOG8Z38VJ	GO:0031629	1/109	synaptic vesicle fusion to presynaptic membrane	biological_process	"Fusion of the membrane of a synaptic vesicle with its target presynaptic membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [ISBN:0071120009]
EOG8Z38VJ	GO:0043195	1/109	terminal bouton	cellular_component	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]
EOG8Z38VJ	GO:0008233	1/109	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG8Z38VJ	GO:0008582	1/109	regulation of synaptic growth at neuromuscular junction	biological_process	"Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
EOG8Z38VJ	GO:0016192	1/109	vesicle-mediated transport	biological_process	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
EOG8Z38VJ	GO:0032403	1/109	protein complex binding	molecular_function	"Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:mah]
EOG8Z38VJ	GO:0035540	1/109	positive regulation of SNARE complex disassembly	biological_process	"Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb]
EOG8Z38VJ	GO:0051260	1/109	protein homooligomerization	biological_process	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
EOG8Z38VJ	GO:0007430	1/109	terminal branching, open tracheal system	biological_process	"Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
EOG8Z38VJ	GO:0048172	1/109	regulation of short-term neuronal synaptic plasticity	biological_process	"A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290]
EOG8Z38VJ	GO:0007030	1/109	Golgi organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
EOG8Z38VJ	GO:0006909	1/109	phagocytosis	biological_process	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
EOG8Z38VJ	GO:0034214	1/109	protein hexamerization	biological_process	"The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits." [GOC:ecd]
EOG8Z38VJ	GO:0060439	1/109	trachea morphogenesis	biological_process	"The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
EOG8N335D	GO:0005581	1/4	collagen trimer	cellular_component	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
EOG85MQMZ	GO:0016787	1/4	hydrolase activity	molecular_function	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
EOG866Z15	GO:0005615	76/159	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG866Z15	GO:0019239	72/159	deaminase activity	molecular_function	"Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl]
EOG866Z15	GO:0008283	5/159	cell proliferation	biological_process	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
EOG866Z15	GO:0008083	5/159	growth factor activity	molecular_function	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]
EOG866Z15	GO:0004000	5/159	adenosine deaminase activity	molecular_function	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
EOG866Z15	GO:0046103	5/159	inosine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators]
EOG866Z15	GO:0006154	5/159	adenosine catabolic process	biological_process	"The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]
EOG866Z15	GO:0043103	5/159	hypoxanthine salvage	biological_process	"Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis." [GOC:jl, ISBN:0198506732]
EOG866Z15	GO:0016021	1/159	integral component of membrane	cellular_component	"The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]
EOG866Z15	GO:0042386	1/159	hemocyte differentiation	biological_process	"The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723]
EOG866Z15	GO:0016020	1/159	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG866Z15	GO:0006109	1/159	regulation of carbohydrate metabolic process	biological_process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators]
EOG866Z15	GO:0043617	1/159	cellular response to sucrose starvation	biological_process	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose." [GOC:jl]
EOG866Z15	GO:0007286	1/159	spermatid development	biological_process	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
EOG8VX4KB	GO:0016324	1/216	apical plasma membrane	cellular_component	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
EOG8VX4KB	GO:0005080	1/216	protein kinase C binding	molecular_function	"Interacting selectively and non-covalently with protein kinase C." [GOC:jl]
EOG8VX4KB	GO:0008594	1/216	photoreceptor cell morphogenesis	biological_process	"The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
EOG8VX4KB	GO:0002009	1/216	morphogenesis of an epithelium	biological_process	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
EOG8VX4KB	GO:0035088	1/216	establishment or maintenance of apical/basal cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483]
EOG8VX4KB	GO:0016333	1/216	morphogenesis of follicular epithelium	biological_process	"The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl]
EOG8VX4KB	GO:0016334	1/216	establishment or maintenance of polarity of follicular epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah]
EOG8VX4KB	GO:0035509	1/216	negative regulation of myosin-light-chain-phosphatase activity	biological_process	"Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators]
EOG8VX4KB	GO:0005737	1/216	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8VX4KB	GO:0032033	1/216	myosin II light chain binding	molecular_function	"Interacting selectively and non-covalently with a light chain of a myosin II complex." [GOC:mah]
EOG8VX4KB	GO:0005886	1/216	plasma membrane	cellular_component	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
EOG8VX4KB	GO:0045176	1/216	apical protein localization	biological_process	"Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf]
EOG8VX4KB	GO:0005918	1/216	septate junction	cellular_component	"A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
EOG8VX4KB	GO:0034332	1/216	adherens junction organization	biological_process	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah]
EOG8VX4KB	GO:0001736	1/216	establishment of planar polarity	biological_process	"Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
EOG8VX4KB	GO:0016332	1/216	establishment or maintenance of polarity of embryonic epithelium	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah]
EOG8VX4KB	GO:0045494	1/216	photoreceptor cell maintenance	biological_process	"Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]
EOG8VX4KB	GO:0005635	1/216	nuclear envelope	cellular_component	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
EOG8VX4KB	GO:0007163	1/216	establishment or maintenance of cell polarity	biological_process	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
EOG8VX4KB	GO:0035209	1/216	pupal development	biological_process	"The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis." [GOC:bf, GOC:mtg_sensu]
EOG8VX4KB	GO:0005515	1/216	protein binding	molecular_function	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
EOG8VX4KB	GO:0016327	1/216	apicolateral plasma membrane	cellular_component	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
EOG8VX4KB	GO:0035003	1/216	subapical complex	cellular_component	"The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938]
EOG8VX4KB	GO:0005875	1/216	microtubule associated complex	cellular_component	"Any multimeric complex connected to a microtubule." [GOC:jl]
EOG8VX4KB	GO:0007043	1/216	cell-cell junction assembly	biological_process	"The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai]
EOG8VX4KB	GO:0005912	1/216	adherens junction	cellular_component	"A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]
EOG8VX4KB	GO:0045179	1/216	apical cortex	cellular_component	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
EOG8VX4KB	GO:0034334	1/216	adherens junction maintenance	biological_process	"The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah]
EOG8VX4KB	GO:0045186	1/216	zonula adherens assembly	biological_process	"Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf]
EOG8RNDS2	GO:0005525	26/112	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8RNDS2	GO:0007264	26/112	small GTPase mediated signal transduction	biological_process	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
EOG8RNDS2	GO:0008060	23/112	GTPase activator activity	molecular_function	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
EOG8RNDS2	GO:0032312	23/112	regulation of GTPase activity	biological_process	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
EOG8RNDS2	GO:0005622	23/112	intracellular	cellular_component	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
EOG8RNDS2	GO:0008270	23/112	zinc ion binding	molecular_function	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
EOG8RNDS2	GO:0016020	8/112	membrane	cellular_component	"A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
EOG8RNDS2	GO:0006184	8/112	obsolete GTP catabolic process	biological_process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]
EOG8RNDS2	GO:0043547	1/112	positive regulation of GTPase activity	biological_process	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]
EOG8HDW8G	GO:0005737	27/96	cytoplasm	cellular_component	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
EOG8HDW8G	GO:0046654	27/96	tetrahydrofolate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]
EOG8HDW8G	GO:0003934	27/96	GTP cyclohydrolase I activity	molecular_function	"Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate." [EC:3.5.4.16]
EOG8HDW8G	GO:0043095	1/96	regulation of GTP cyclohydrolase I activity	biological_process	"Any process that modulates the activity of the enzyme GTP cyclohydrolase I." [GOC:jl]
EOG8HDW8G	GO:0009880	1/96	embryonic pattern specification	biological_process	"The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
EOG8HDW8G	GO:0006728	1/96	pteridine biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732]
EOG8HDW8G	GO:0060308	1/96	GTP cyclohydrolase I regulator activity	molecular_function	"Modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate." [GOC:dph, GOC:tb]
EOG8HDW8G	GO:0035185	1/96	preblastoderm mitotic cell cycle	biological_process	"The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238]
EOG8HDW8G	GO:0005525	1/96	GTP binding	molecular_function	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
EOG8HDW8G	GO:0008363	1/96	larval chitin-based cuticle development	biological_process	"Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
EOG8HDW8G	GO:0035998	1/96	7,8-dihydroneopterin 3'-triphosphate biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate." [CHEBI:18372, GOC:yaf, UniPathway:UPA00848]
EOG8HDW8G	GO:0048067	1/96	cuticle pigmentation	biological_process	"Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid]
EOG8HDW8G	GO:0046872	1/96	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8HDW8G	GO:2000274	1/96	regulation of epithelial cell migration, open tracheal system	biological_process	"Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system." [GOC:obol]
EOG8HDW8G	GO:0048072	1/96	compound eye pigmentation	biological_process	"Establishment of a pattern of pigment in the compound eye." [GOC:jid]
EOG8HDW8G	GO:0006729	1/96	tetrahydrobiopterin biosynthetic process	biological_process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, GOC:go_curators, ISBN:0198506732]
EOG847JB4	GO:0004867	79/126	serine-type endopeptidase inhibitor activity	molecular_function	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
EOG847JB4	GO:0008233	4/126	peptidase activity	molecular_function	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
EOG847JB4	GO:0032504	1/126	multicellular organism reproduction	biological_process	"The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
EOG847JB4	GO:0005615	1/126	extracellular space	cellular_component	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
EOG8P2SKM	GO:0046872	1/6	metal ion binding	molecular_function	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]
EOG8P2SKM	GO:0003682	1/6	chromatin binding	molecular_function	"Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]