GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0038023	signaling receptor activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0004872	receptor activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0003676	nucleic acid binding	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0004518	nuclease activity	Gains
GO:0015079	potassium ion transmembrane transporter activity	Gains
GO:0022836	gated channel activity	Gains
GO:0005216	ion channel activity	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0015267	channel activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0004519	endonuclease activity	Gains
GO:0008528	G-protein coupled peptide receptor activity	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0005249	voltage-gated potassium channel activity	Gains
GO:0005261	cation channel activity	Gains
GO:0001653	peptide receptor activity	Gains
GO:0008188	neuropeptide receptor activity	Gains
GO:0005267	potassium channel activity	Gains
GO:0042302	structural constituent of cuticle	Gains
GO:0003700	DNA binding transcription factor activity	Gains
GO:0008146	sulfotransferase activity	Gains
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Gains
GO:0005452	inorganic anion exchanger activity	Gains
GO:0004497	monooxygenase activity	Gains
GO:0003677	DNA binding	Gains
GO:0043565	sequence-specific DNA binding	Gains
GO:0005549	odorant binding	Gains
GO:1901363	heterocyclic compound binding	Gains
GO:0097159	organic cyclic compound binding	Gains
GO:0022843	voltage-gated cation channel activity	Gains
GO:0005244	voltage-gated ion channel activity	Gains
GO:0022832	voltage-gated channel activity	Gains
GO:0008270	zinc ion binding	Gains
GO:0004867	serine-type endopeptidase inhibitor activity	Gains
GO:0046914	transition metal ion binding	Gains
GO:0046906	tetrapyrrole binding	Gains
GO:0005230	extracellular ligand-gated ion channel activity	Gains
GO:0004745	retinol dehydrogenase activity	Gains
GO:0045289	luciferin monooxygenase activity	Gains
GO:0099516	ion antiporter activity	Gains
GO:0020037	heme binding	Gains
GO:0042562	hormone binding	Gains
GO:0005214	structural constituent of chitin-based cuticle	Gains
GO:0015297	antiporter activity	Gains
GO:0016782	transferase activity, transferring sulfur-containing groups	Gains
GO:0022824	transmitter-gated ion channel activity	Gains
GO:0022835	transmitter-gated channel activity	Gains
GO:0004970	ionotropic glutamate receptor activity	Gains
GO:0015276	ligand-gated ion channel activity	Gains
GO:0022834	ligand-gated channel activity	Gains
GO:0015075	ion transmembrane transporter activity	Gains
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
GO:0022891	substrate-specific transmembrane transporter activity	Gains
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Gains
GO:0008010	structural constituent of chitin-based larval cuticle	Gains
GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	Gains
GO:0022892	substrate-specific transporter activity	Gains
GO:0022857	transmembrane transporter activity	Gains
GO:0005215	transporter activity	Gains
GO:0050254	rhodopsin kinase activity	Gains
GO:0140110	transcription regulator activity	Gains
GO:0036081	extracellular ammonia-gated ion channel activity	Gains
GO:0008241	peptidyl-dipeptidase activity	Gains
GO:0070405	ammonium ion binding	Gains
GO:0008527	taste receptor activity	Gains
GO:0005534	galactose binding	Gains
GO:0003987	acetate-CoA ligase activity	Gains
GO:0034481	chondroitin sulfotransferase activity	Gains
GO:0022821	potassium ion antiporter activity	Gains
GO:0031208	POZ domain binding	Gains
GO:0015103	inorganic anion transmembrane transporter activity	Gains
GO:0015368	calcium:cation antiporter activity	Gains
GO:0004467	long-chain fatty acid-CoA ligase activity	Gains
GO:0004691	cAMP-dependent protein kinase activity	Gains
GO:0015645	fatty acid ligase activity	Gains
GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	Gains
GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Gains
GO:0004601	peroxidase activity	Gains
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	Gains
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Gains
GO:0046873	metal ion transmembrane transporter activity	Gains
GO:0016209	antioxidant activity	Gains
GO:0015491	cation:cation antiporter activity	Gains
GO:0016405	CoA-ligase activity	Gains
GO:0008509	anion transmembrane transporter activity	Gains
GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Gains
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
GO:0008066	glutamate receptor activity	Gains
GO:0004022	alcohol dehydrogenase (NAD) activity	Gains
GO:0000975	regulatory region DNA binding	Gains
GO:0001067	regulatory region nucleic acid binding	Gains
GO:0004523	RNA-DNA hybrid ribonuclease activity	Losses
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
GO:0046974	histone methyltransferase activity (H3-K9 specific)	Losses
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
GO:0004521	endoribonuclease activity	Losses
GO:0098772	molecular function regulator	Losses
GO:0004133	glycogen debranching enzyme activity	Losses
GO:0004134	4-alpha-glucanotransferase activity	Losses
GO:0004135	amylo-alpha-1,6-glucosidase activity	Losses
GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
GO:0005096	GTPase activator activity	Losses
GO:0060589	nucleoside-triphosphatase regulator activity	Losses
GO:0008170	N-methyltransferase activity	Losses
GO:0046872	metal ion binding	Losses
GO:0004519	endonuclease activity	Losses
GO:0008047	enzyme activator activity	Losses
GO:0004430	1-phosphatidylinositol 4-kinase activity	Losses
GO:0003682	chromatin binding	Losses
GO:0043169	cation binding	Losses
GO:0005179	hormone activity	Losses
GO:0030695	GTPase regulator activity	Losses
GO:0016757	transferase activity, transferring glycosyl groups	Losses
GO:0016278	lysine N-methyltransferase activity	Losses
GO:0016279	protein-lysine N-methyltransferase activity	Losses
GO:0018024	histone-lysine N-methyltransferase activity	Losses
GO:0016740	transferase activity	Losses
GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
GO:0004674	protein serine/threonine kinase activity	Losses
GO:0140096	catalytic activity, acting on a protein	Losses
GO:0017016	Ras GTPase binding	Losses
GO:0004540	ribonuclease activity	Losses
GO:0031267	small GTPase binding	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0030234	enzyme regulator activity	Losses
GO:0043492	ATPase activity, coupled to movement of substances	Losses
GO:0043167	ion binding	Losses
GO:0008276	protein methyltransferase activity	Losses
GO:0004672	protein kinase activity	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0008194	UDP-glycosyltransferase activity	Losses
GO:0048365	Rac GTPase binding	Losses
GO:0030676	Rac guanyl-nucleotide exchange factor activity	Losses
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	Losses
GO:0008307	structural constituent of muscle	Losses
GO:0008017	microtubule binding	Losses
GO:0004803	transposase activity	Losses
GO:0005524	ATP binding	Losses
GO:0032559	adenyl ribonucleotide binding	Losses
GO:0042054	histone methyltransferase activity	Losses
GO:0101005	ubiquitinyl hydrolase activity	Losses
GO:0004843	thiol-dependent ubiquitin-specific protease activity	Losses
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	Losses
GO:0052742	phosphatidylinositol kinase activity	Losses
GO:0045296	cadherin binding	Losses
GO:0008013	beta-catenin binding	Losses
GO:0004012	phospholipid-translocating ATPase activity	Losses
GO:0008395	steroid hydroxylase activity	Losses
GO:0030554	adenyl nucleotide binding	Losses
GO:0048018	receptor ligand activity	Losses
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Losses
GO:0015631	tubulin binding	Losses
GO:0016301	kinase activity	Losses
GO:0015171	amino acid transmembrane transporter activity	Losses
GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Extinctions
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Extinctions
GO:0004521	endoribonuclease activity	Extinctions
GO:0004519	endonuclease activity	Extinctions
GO:0005179	hormone activity	Extinctions
GO:0015923	mannosidase activity	Extinctions
GO:0004540	ribonuclease activity	Extinctions
GO:0048018	receptor ligand activity	Extinctions
GO:0030545	receptor regulator activity	Extinctions
GO:0003777	microtubule motor activity	Extinctions
GO:0016085	myoinhibitory hormone activity	Extinctions
GO:0050700	CARD domain binding	Extinctions
GO:0018271	biotin-protein ligase activity	Extinctions
GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity	Extinctions
GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	Extinctions
GO:0072586	DNA topoisomerase (ATP-hydrolyzing) regulator activity	Extinctions
GO:0072587	DNA topoisomerase (ATP-hydrolyzing) activator activity	Extinctions
GO:0005184	neuropeptide hormone activity	Extinctions
GO:0016757	transferase activity, transferring glycosyl groups	Extinctions
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Extinctions
GO:0008194	UDP-glycosyltransferase activity	Extinctions
GO:0016798	hydrolase activity, acting on glycosyl bonds	Extinctions
GO:0004133	glycogen debranching enzyme activity	Extinctions
GO:0004134	4-alpha-glucanotransferase activity	Extinctions
GO:0004135	amylo-alpha-1,6-glucosidase activity	Extinctions
GO:0097322	7SK snRNA binding	Extinctions
GO:0004597	peptide-aspartate beta-dioxygenase activity	Extinctions
GO:0004511	tyrosine 3-monooxygenase activity	Extinctions
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	Extinctions
GO:0004644	phosphoribosylglycinamide formyltransferase activity	Extinctions
GO:0032093	SAM domain binding	Extinctions
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
GO:0004518	nuclease activity	Extinctions